Nizhny Novgorod Research Institute of Traumatology and Orthopedics

Nizhniy Novgorod, Russia

Nizhny Novgorod Research Institute of Traumatology and Orthopedics

Nizhniy Novgorod, Russia
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Ezhevskaya A.A.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Mlyavykh S.G.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Anderson D.G.,Thomas Jefferson University
Spine | Year: 2013

Study Design.: A prospective, randomized study was used to compare 2 anesthesia/analgesia methods for reconstructive spine surgery. Objective.: To assess the efficacy and influence of 2 anesthetic methods on clinical outcome and stress response during reconstructive spine surgery. Summary of Background Data.: Pain control is an important goal of the postoperative care after spinal surgery. Some prior studies have suggested that epidural anesthesia with or without postoperative epidural analgesia may blunt the surgical stress response after major surgery. This treatment approach has not been fully investigated for patients undergoing major spinal surgery. We hypothesized that the stress response after major spine surgery would be attenuated by continuous epidural anesthesia/analgesia with ropivacaine, fentanyl, and epinephrine. Methods.: Eighty-five patients were randomly allocated to 2 groups as follows: group E (n = 45) had epidural anesthesia and endotracheal anesthesia with sevoflurane during surgery and continuous epidural analgesia with ropivacaine, fentanyl, and epinephrine after surgery; group G (n = 40) had general anesthesia with sevoflurane and fentanyl and systemically administered opioids after surgery. Patient pain, nausea, mobility, and satisfaction were measured after surgery along with levels of cortisol, glucose, interleukin (IL)-1β, IL-6, and IL-10 during and after surgery. Results.: In group E, there were significantly less pain, less nausea, earlier mobility, and higher satisfaction than those in group G. Group E also experienced significantly less introperative and postoperative blood loss. Group E demonstrated lower levels of glucose, cortisol, IL-1β, IL-6, and IL-10 during the postoperative period. Conclusion.: Combined epidural/general anesthesia and postoperative epidural analgesia produced better pain control, less bleeding, and a lower surgical stress response than general anesthesia with postoperative systemically administered narcotic analgesia. This technique deserves further study in the setting of major spinal surgery. Copyright © 2013 Lippincott Williams & Wilkins.


Levin G.Ya.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Sosnina L.N.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Antibiotiki i Khimioterapiya | Year: 2014

The aim of the research was to develop a simple, available and rapid spectrophotometric method for measuring aminoglycoside concentration in blood plasma and to evaluate the antibiotic efficacy and susceptibility. The method is based on the ability of aminoglycosides, in particular amikacin, to change the color of Fast Blue B Salt Dye (SIGMA-ALDRICH). An antibiotic at various concentrations and the dye were added to blood plasma. The resulting mixture was filtered to separate the insoluble residue. After that the optical density of the filtrate were measured spectrophotometrically against the control specimen with no antibiotic at the wavelength of 450 run. It was demonstrated that an increase in the plasma antibiotic concentration led to a directly proportional increase of the antibiotic solution extinction. This is a simple, precise and rapid method.


Fraerman A.P.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Sovremennye Tehnologii v Medicine | Year: 2011

There have been presented clinical presentation of traumatic brain compression, and considered modern diagnostic and surgical approaches. Five variants of surgical approaches depending on the dynamics of clinical presentation, and the findings of instrumental investigations (CT, MRT) have been suggested. Indications and contradictions to conservative treatment of brain compression have been stated. There has been emphasized the aspects of the problem unsolved and under debate.


Belousov B.Y.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Sovremennye Tehnologii v Medicine | Year: 2011

The aim of the study is to develop a method to determine a projection angle of frontal inclination of pelvic component of an endoprosthesis. Materials and Methods. There has been made an experimental study using roentgenometry. Acetabular components of endoprostheses of different manufacturers have been tested. Results. A new X-ray angle metric index of frontal inclination of pelvic component of endoprostheses of different modifications is suggested. It enables to determine a frontal inclination angle of pelvic component of an endoprosthesis. The index corresponds to a true one and does not depend on design features of an endoprosthesis.


Bbogos'yan R.A.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Sovremennye Tehnologii v Medicine | Year: 2011

There have been shown the treatment possibilities of patients with post-burn and post-traumatic cicatricial deformity and defects of various localizations using the method of expander dermatension. The effectiveness of a new way of a dosage dermatension management in a constant mode by liquid pumping into a ballon-expander through infusomat (Patent No.2271157) has been studied. An optimal solution administration rate for different expanders has been selected. There has been described the way of objective control of soft tissue condition during distraction using thermovision studies (Patent No.2306847). The use of the techniques suggested enables to reduce the number of complication on dermatension stage and reduce the period of in-patient treatment by 1.5-2 times.


Solovyova A.G.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Zimin Y.V.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Sovremennye Tehnologii v Medicine | Year: 2012

The aim of the investigation is to develop a new way of the estimation of blood metabolism dynamic of patients with heat injuries that allows detecting early disturbances of energy reactions. Materials and methods. There has been examined the blood of 20 patients aged from 20 to 60 years with burn area of 25-50% of body surface (II-III A, B degrees of injury). The activity of lactate dehydrogenase in erythrocytes hemolysate and the value of enzyme relation in direct and reverse reactions have been determined. Results. There has been suggested a new estimation method of blood metabolism dynamics in patients with heat injuries. The technique determines lactate dehydrogenase activity and calculates a balance coefficient of energy reactions.


Ezhov M.Y.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Sovremennye Tehnologii v Medicine | Year: 2012

The aim of the investigation is to increase the efficiency of treatment of osteoarthrosis deformans of foot and ankle joints by developing and applying new hi-tech methods of treatment - individual replacement of the foot bones and joints. Materiales and methods. 39 patients with the specified pathology were surveyed. Standard total ankle replacement was performed in two of them (STAR, W. Link), 16 patients underwent the first MTP joint replacement with Total toe system. In five cases with the 1st MTPJ arthrosis there was observed total, subtotal and polylocal aseptic necrosis of the head of the first metatarsal bone. 10 patients had a similar picture of damage of the talus due to trauma. For these patients individual artificial implants of the talus and endoprostheses of the first MTPJ were developed. Modern techniques (CT, MRT) were used to early radiodiagnosis of posttraumatic talus damage. Results and Discussion. There were developed new methods of surgical treatment of such consequences of trauma of the talus as total, subtotal and polylocal aseptic necrosis - individual total replacement of the talus by original patented technique and replacement of the first MTP joint in cases of severe aseptic necrosis of the 1st metatarsal bone's head with the implant with the long stem (when standard joint replacement is noneffective). Pre-production models of implants and tools were made, and technical tests of designs were carried out.


Shlivko I.L.,Nizhny Novgorod State Medical Academy | Kamensky V.A.,RAS Institute of Applied Physics | Donchenko E.V.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Agrba P.,RAS Institute of Applied Physics
Skin Research and Technology | Year: 2014

Background/purpose: The present study aimed to investigate the influence of topical corticosteroid therapy and tacrolimus on morphological indices of different skin phototypes and to optimize topical therapy using the OCT technique. Methods: Twenty healthy volunteers aging from 20 to 30 (14 men and 6 women) took part in the study: 10 persons with skin phototype I, II and 10 persons with skin phototype V, VI. Morphological state of the skin was assessed before and during application of topical steroids of different strength and calciumneurin inhibitors for 49 days. Morphological state was studied in vivo using the optical coherence tomograph. Results: Morphological manifestations of skin atrophy with the use of clobetasol propionate appear earlier than with the use of hydrocortisone 17-butyrate; this process was faster in representatives of groups V, VI. Epidermal thinning in the zone of tacrolimus application was not recorded in any phototype. Conclusion: Recording of early preclinical signs of epidermis thinning in the course of OCT follow-up may be an indication for changing the corticosteroid therapy by calciumneurin inhibitors, which will permit to individualize the therapy, to increase its efficacy, and to minimize the possibility of complications in each particular case. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


Martusevich A.K.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Peretyagin S.P.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Biophysics (Russian Federation) | Year: 2013

The aim of this work is to estimate crystallogenic properties of human blood serum processed by gas nitric oxide. Blood samples of ten healthy patients were processed by cold plasma with NO (800 μg/L). The true and initiated (by 0.9% sodium chloride solution) crystallogenesis of non- and NO-processed blood serum was estimated. It was stated, that as a result of gas nitric oxide processing crystallogenic properties of blood serum undergo a series of specific and nonspecific transformations, the most obvious one is the formation of a raised band in the marginal zone of the facia. © 2013 Pleiades Publishing, Inc.


Martusevich A.K.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Solovyova A.G.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics | Peretyagin S.P.,Nizhny Novgorod Research Institute of Traumatology and Orthopedics
Sovremennye Tehnologii v Medicine | Year: 2013

The aim of the investigation was to perform a comparative analysis of free and bound nitric oxide effects on erythrocyte energy metabolic parameters in vitro. Materials and Methods. Two series of experiments were carried out. In the first series we processed blood samples (5 ml) by gaseous nitric oxide (800 μg/l) using three regimens of Plazon apparatus (Russia). In the second series we saturated three aliquot blood samples by 0.05; 0.1 and 0.2 ml of dinitrozyl iron complexes (DNIC) respectively (concentration of the compound was 3 mmol/l). We determined lactate dehydrogenase activity in direct and indirect reactions and lactate level in blood and erythrocytes. A number of derived coefficients were calculated to estimate energy metabolic changes. Results. High concentrations of free nitric oxide were found to inhibit the activity of enzyme systems related to energy metabolism. On the contrary, DNIC have a stimulating effect on erythrocytes energy metabolism.

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