Nizhny Novgorod regional oncologic dispensary

Nizhniy Novgorod, Russia

Nizhny Novgorod regional oncologic dispensary

Nizhniy Novgorod, Russia

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Terentiev I.G.,Nizhny Novgorod State Medical Academy | Kuznetsov S.S.,Na Semashko Nizhny Novgorod Regional Clinical Hospital | Bazanov K.V.,Nizhny Novgorod Regional Oncologic Dispensary
Sovremennye Tehnologii v Medicine | Year: 2011

The aim of the investigation is to study the peculiarities of cell proliferation in breast cancer, cell loss factor, and the correlation of these values, and on the basis of the obtained quantitative parameters - to develop mathematical model showing the dynamics of tumour growth that enables to determine the periods of the highest sensitivity to the administered treatment and so to prognosticate chemotherapy effect. Materials and Methods. There have been carried out clinical, morphological and morphometric examinations of 17 women with metastatic breast cancer aged 33-72 years. All the patients had previous radical mastectomy. All women have undergone chemotherapy, and 6 patients - radiotherapy on the area of postoperative scar and the areas of regional metastasis. Results. There has been developed a mathematical model in which the tumour growth is considered as a complex balance between the division and death of tumour cells. There have been analyzed the combination of the parameters of proliferative cell activity and cell loss in which a maximum effect in cytoreductive treatment is possible to be achieved. And there have been discussed the failure origin in a number of cases in chemotherapeutic treatment of disseminated breast cancer.


Slugaryov V.V.,Nizhny Novgorod regional oncologic dispensary | Gamayunov S.V.,Nizhny Novgorod regional oncologic dispensary | Denisenko A.N.,Nizhny Novgorod regional oncologic dispensary | Terentiev I.G.,Nizhny Novgorod State Medical Academy | And 2 more authors.
Sovremennye Tehnologii v Medicine | Year: 2010

The esophagoenterostomy insufficiency is still one of the most serious complications of a gastrectomy with the lethality high values. The standard methods of that complication correction have several demerits. The authors have described an experience of the esophagoenterostomy insufficiency successful treatment with a use of the ELLA esophageal stent.


Diyakonova E.M.,Nizhny Novgorod State Medical Academy | Petrov A.B.,Nizhny Novgorod regional oncologic dispensary
Sovremennye Tehnologii v Medicine | Year: 2010

Aim of investigation is a study of immune status at the tamoyfen antiestrogen and letrosol estrogen synthesis inhibitor use as an adjuvant monotherapy of a mammary gland cancer. Materials and methods. 26 patients with a mammary gland cancer of a stage T1-3H1-2M0, undergoing the adjuvant monotherapy with the tamoxyfen or letrosol preparations after a radical mastectomy, are included into investigation. A complex assessment of immune status was made prior to beginning of a hormonotherapy and in 4 months of treatment. The lymphocyte subpopulations were detected with a use of monoclonal antibodies, the immunoglobulins A, M, G - with a method of radial immunodiffusion. Aresults. A tamoxyfen increases not only a general quantity of the T-lymphocytes, but a relative quantity of the T-lymphocytes-helpers, and also the T-lymphocytes-supressors, T-lymphocytes with receptors to interleukin-2 and a tumor necrosis factor, decreasing at the same time a number of NK-lymphocytes. An increase of the IgG concentration in a blood serum, and a decrease of the IgA and IgM concentration are registered at the background of tamoxyfen. A letrosol stipulates a decrease of the T-lymphocyte general quantity, a relative quantity of the T-lymphocytes-supressors, NK-lymphocytes, T-lymphocytes with receptors to a tumor necrosis factor and T-lymphocytes-helpers, not altering a number of T-lymphocytes with receptors to interleukin-2. An increase of the IgM concentration and a decrease of the IgA and IgG content are also observed at a letrosol use. Conclusion. A certain direction of revealed alterations is characteristic of each of investigated preparations, which testifies to necessity of the immunologic value dynamic control and a corresponding corrugated therapy.


Gamayunov S.V.,Nizhny Novgorod regional oncologic dispensary | Onoprienko O.V.,Nizhny Novgorod regional oncologic dispensary | Slugaryov V.V.,Nizhny Novgorod regional oncologic dispensary | Denisenko A.N.,Nizhny Novgorod regional oncologic dispensary | And 2 more authors.
Sovremennye Tehnologii v Medicine | Year: 2010

For a long time a low-invasive access was not widely spread in oncology. The Authors analyze the «pro» and «contra» arguments of a laparoscopy and thoracoscopy use in oncologic practice, the possible ways of development and a proper experience of the method use.

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