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Nalgonda, India

Bellamakondi P.K.,Radiant Research Services Pvt Ltd | Godavarthi A.,Radiant Research Services Pvt Ltd | Ibrahim M.,Nizam Institute of Pharmacy | Kulkarni S.,Radiant Research Services Pvt Ltd | And 2 more authors.
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Caralluma species have been reported for various traditional claims; the scientific data for possible activities have not yet been studied thoroughly. However the toxicity of a plant has to be studied for further exploration of various biological activities. Extracts were studied for their toxicity by MTT and trypan blue dye exclusion models against a panel of cancer, normal origin cell lines and EAC cells. The extracts found to be moderately toxic and showed dose dependent response.

Bellamakondi P.K.,Radiant Research Services Pvt Ltd | Godavarthi A.,Radiant Research Services Pvt Ltd | Ibrahim M.,Nizam Institute of Pharmacy
BioImpacts | Year: 2014

Introduction: Hyperglycemia is a serious health problem prevailing in diabetes patients. Treatment for hyperglycemia by various oral anti-hyperglycemic drugs have associated with side effects, hence there is growing awareness towards the use of herbal products due to their efficacy, minimal side effects and relatively low costs. This study is designed to evaluate anti-hyperglycemic activity of Caralluma umbellata Haw, which is used as a traditional medicinal plant all over India through in vitro studies. Methods: Methanolic, aqueous and hydro methanolic extracts of Caralluma umbellata were prepared and studied for their anti hyperglycemic activity. The extracts were evaluated for glucose uptake in L6 myotubes in vitro. In addition, the inhibitory activity against alpha amylase and pancreatic lipase was also measured. Results: The methanolic extract (MCU) was found to have significant glucose uptake. Further, MCU was also found to have promising role in inhibiting alpha amylase and pancreatic lipase. Conclusion: The results of present study shows Caralluma umbellata has potential antidiabetic property, thus providing a further scope for study in animal model and understanding the mechanism of action. © 2014 The Author(s).

Ali Khan M.S.,Natural Products Research Laboratory | Ali Khan M.S.,University Putra Malaysia | Mat Jais A.M.,University Putra Malaysia | Mohtarrudin N.,University Putra Malaysia | And 2 more authors.
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas | Year: 2013

Sandalwood (Santalum album L.) is used in various traditional systems of medicine, like Ayurveda, Siddha and Unani medicine to treat a wide range of ailments. In Unani medicine, Safed Sandal is used to treat gastric ulcers, hence the present study was undertaken to confirm this claim. A limit test as per OECD guidelines was conducted at a dose of 5000 mg/kg to determine the acute toxic dose of Hydro-alcoholic extract from S. album stem (SASE). Two test doses of SASE (250 and 500 mg/kg) were subjected to screening of anti-ulcer activity by three in-vivo models namely - water immersion-restrain stress, ethanol and indomethacin induced gastric ulceration models in albino wistar rats. A proton-pump inhibitor, Omeprazole 10 mg/kg and H2 receptor antagonist, Ranitidine 50 mg/kg were employed as standard drugs. The results revealed an increase in gastric protection as a significant decrease (p < 0.001) in average number of ulcers, severity of ulcers and cumulative ulcer index was observed in the test groups. Histopathological evidences supported the above findings. The observed anti-ulcer effect of SASE at 500 mg/kg was comparable to that of standard drugs used in the experiments indicating significant anti-ulcer potential especially at higher concentration. © 2013 Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas.

Rasheed Ahemad S.,Nizam Institute of Pharmacy | Jayaveera K.N.,Jawaharlal Nehru Technological University Anantapur | Javeed M.Y.,Nizam Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Hydro alcoholic root extract from Nardostachys jatamansi was investigated for its antioxidant and anti cataleptic effects in the haloperidol-induced catalepsy rat model of the disease by measuring behavioral, biochemical parameters and neurotransmitter levels. Catalepsy was induced by administration of haloperidol (1 mg/kg, i.p) in male wistar rats. A significant (P < 0.01) reduction in the cataleptic scores were observed in all the drug-treated groups as compared to the haloperidol-treated group; with maximum reduction observed in the Nardostachys jatamansi (500 mg/kg body weight) administered group. Haloperidol administration increased generation of TBARS and significantly reduced GSH, which were restored to near normal level with the Nardostachys jatamansi treatment. Catalase and SOD levels were also increased to normal levels, having been reduced significantly by haloperidol administration. Haloperidol administration decreased the dopamine levels significantly, which were restored to near normal levels with the Nardostachys jatamansi treatment. Our findings of behavioral studies and biochemical estimations show that Nardostachys jatamansi reversed the haloperidol-induced catalepsy in rats.

Kiranmai M.,Nizam Institute of Pharmacy | Mahender Kumar C.B.,St. Marys College | Ibrahim M.D.,Nizam Institute of Pharmacy
Asian Journal of Pharmaceutical and Clinical Research | Year: 2011

Purpose: The aim of this study was to investigate the antioxidant activity of the root bark extract from the neem tree (Azadirachta indica A. Juss var., Meliaceae) using the 1, 1-diphenyl-2-picryl hydrazyl (DPPH) scavenging assay. Method: The root bark was extracted by soxhlet extraction method using 80% ethanol and the resultant extract was subjected to free radical scavenging activity by DPPH assay and total antioxidant activity. Qualitative analysis and thin-layer chromatography of the extract was also investigated. Result: The results showed that the root bark extract exhibited higher free radical scavenging effect on the DPPH assay with 50% scavenging activity at 27.3 μg/ml. The total antioxidant activity of this extract was found to be 0.58 mM of standard ascorbic acid. Conclusion: The results suggested that root bark extract of the neem tree have strong antioxidant potential. Thin-layer chromatography showed spot corresponding to quercetin.

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