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Hyderabad, India

Chennaiah M.,Nizam College Ou | Veeraiah T.,SAP | Venkateshwarlu G.,Nizam College Ou
Journal of the Chilean Chemical Society | Year: 2012

Six spectrophotometric methods for determination of eszopiclone have been developed, validated and applied for the assay of the drug in pharmaceuticals. Methods A, B, C and D are based on ion pair complexation of drug, in acidic buffers, with triphenylmethane dyes viz., Bromothymol blue(BTB), Bromophenol blue(BPB), Bromocresol green(BCG) and Bromocresol purple(BCP). The complexes are extracted into chloroform and absorbance is measured around at 415 nm as function of concentration of the drug. The stoichiometry of the complex is found 1:1 in each case. Method E depends upon charge transfer complexation of neutralized drug with iodine which produces iodide ion whose absorbance at 366 nm is measured as function of concentration of the drug. This complex, too, has 1:1 composition as determined by Job's method. Method F is developed on the basis of oxidation of the drug with alkaline KMnO4 which generates green colored manganate ion with lmax 610 nm. As the intensity of green color increased with increasing time kinetics of the reaction is followed and calibration curves are constructed by using initial rate and fixed time methods. Excellent recovery studies with high accuracy and precession indicate that the methods can be successfully used in industries for the assay of drug in pure form and pharmaceuticals. Source

Chennaiah M.,Nizam College Ou | Veeraiah T.,SAP | Singh T.C.,Nizam College Ou | Venkateshwarlu G.,Nizam College Ou
Journal of the Chilean Chemical Society | Year: 2011

Three simple and sensitive extractive spectrophotometric methods have been described for the assay of Rasagiline mesylate either in pure form or in pharmaceutical formulations. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with bromothymol blue (BTB), bromophenol blue (BPB) and bromocresol green (BCG) in acidic medium. The extracted complexes showed absorbance maxima at 414 nm for all three methods. Beer's law is obeyed in the concentration ranges 3.0-30, 3.0.0-30 and 2.0-25μg/ml with BTB, BPB and BCG respectively. The effect of concentration of dye, pH, and interference of excipients have been studied and optimized. The limits of detection and quantification have been determined for three methods. All the three methods have been validated as per the guidelines of ICH. The methods have been applied to the determination of drug in commercial tablets and results of analysis were validated statistically through recovery studies. Source

Prashanthi M.,Nizam College Ou | Charan Singh T.,Gnarayanamma Institute Of Technology And Science | Venkateshwarlu G.,Nizam College Ou
International Journal of ChemTech Research | Year: 2014

Simple, specific, accurate and precise UV-visible spectrophotometric methods have been developed for the estimation of five drugs viz., Amlodepine besylate, Esmolol hydrochloride, Olmesartan medoxomil, Phenyl ephrine hydrochloride and Tramadol hydrochloride. These methods involve the addition of a known excess of NBS to the drugs in acid medium followed by estimation of residual NBS by reacting with a fixed amount of Amaranth and measuring the absorbance of the dye at 520nm. The proposed methods were found to be successful for the estimation of these drugs in bulk and their formulations. The results of analysis have been validated statistically for linearity, accuracy, precision, LOD and LOQ. Source

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