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Barriga G.D.C.,niversidade Estadual Paulista | Louzada-Neto F.,Federal University of São Carlos | Cancho V.G.,Icmcuniversidade Of So Paulo
Computational Statistics and Data Analysis | Year: 2011

In this paper we propose a new lifetime distribution which can handle bathtub-shaped, unimodal, increasing and decreasing hazard rate functions. The model has three parameters and generalizes the exponential power distribution proposed by Smith and Bain (1975) with the inclusion of an additional shape parameter. The maximum likelihood estimation procedure is discussed. A small-scale simulation study examines the performance of the likelihood ratio statistics under small and moderate sized samples. Three real datasets illustrate the methodology. © 2010 Elsevier B.V. All rights reserved.


Maia A.S.C.,niversidade Estadual Paulista | da Silva R.G.,Federal Rural University of the Semiarid Region | Nascimento S.T.,niversidade Estadual Paulista | Nascimento C.C.N.,niversidade Estadual Paulista | And 2 more authors.
International Journal of Biometeorology | Year: 2015

Notwithstanding the solar radiation is recognized as a detrimental factor to the thermal balance and responses of animals on the range in tropical conditions, studies on the amount of thermal radiation absorbed by goats therein associated with data on their production and heat exchange are still lacking. Metabolic heat production and the heat exchange of goats in the sun and in the shade were measured simultaneously, aiming to observe its thermal equilibrium. The results showed that black goats absorb twice as much as the white goats under intense solar radiation (higher than 800 W m−2). This observation leads to a higher surface temperature of black goats, but it must not be seen as a disadvantage, because they increase their sensible heat flow in the coat-air interface, especially the convection heat flow at high wind speeds. In the shade, no difference between the coat colours was observed and both presented a lower absorption of heat and a lower sensible heat flow gain. When solar radiation levels increases from 300 to 1000 W m−2, we observed an increase of the heat losses through latent flow in both respiratory and cutaneous surface. Cutaneous evaporation was responsible for almost 90 % of the latent heat losses, independently of the coat colour. Goats decrease the metabolic heat production under solar radiation levels up to 800 W m−2, and increase in levels higher than this, because there is an increase of the respiratory rate and of the respiratory flow, but the fractions of consumed oxygen and produced carbon dioxide are maintained stable. The respiratory rate of black goats was higher than the white ones, under 300 W m−2 (55 and 45 resp min−1) and 1000 W m−2 (120 and 95 resp min−1, respectively). It was concluded that shade or any protection against solar radiation levels above 800 Wm−2 is critical to guarantee goat’s thermal equilibrium. Strategies concerning the grazing period in accordance with the time of the day alone are not appropriate, because the levels of radiation depend on the latitude of the location. © 2014, ISB.


Loncar V.,University of Belgrade | Young L.E.S.,Santo Tomás University of Colombia | Young L.E.S.,niversidade Estadual Paulista | Skrbic S.,University of Novi Sad | And 3 more authors.
Computer Physics Communications | Year: 2016

We present new versions of the previously published C and CUDA programs for solving the dipolar Gross–Pitaevskii equation in one, two, and three spatial dimensions, which calculate stationary and non-stationary solutions by propagation in imaginary or real time. Presented programs are improved and parallelized versions of previous programs, divided into three packages according to the type of parallelization. First package contains improved and threaded version of sequential C programs using OpenMP. Second package additionally parallelizes three-dimensional variants of the OpenMP programs using MPI, allowing them to be run on distributed-memory systems. Finally, previous three-dimensional CUDA-parallelized programs are further parallelized using MPI, similarly as the OpenMP programs. We also present speedup test results obtained using new versions of programs in comparison with the previous sequential C and parallel CUDA programs. The improvements to the sequential version yield a speedup of 1.1–1.9, depending on the program. OpenMP parallelization yields further speedup of 2–12 on a 16-core workstation, while OpenMP/MPI version demonstrates a speedup of 11.5–16.5 on a computer cluster with 32 nodes used. CUDA/MPI version shows a speedup of 9–10 on a computer cluster with 32 nodes. © 2016 Elsevier B.V.


Tanaka M.H.,niversidade Estadual Paulista | Rodrigues T.O.,niversidade Estadual Paulista | Finoti L.S.,niversidade Estadual Paulista | Teixeira S.R.L.,University of Sao Paulo | And 3 more authors.
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2015

Periodontal disease (PD) is induced by a complex microbiota, such as Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola (together called the red complex), which triggers intense inflammatory reaction. Down syndrome (DS) individuals demonstrate a high prevalence of PD compared with those who are otherwise chromosomally normal (euploids). This pilot study aimed to evaluate the effect of non-surgical periodontal treatment in DS chronic periodontitis patients on clinical and microbiological parameters. Patients with chronic periodontitis, 23 DS and 12 euploids (control group), were submitted to non-surgical mechanical periodontal treatment, followed by maintenance for 45 days. Clinical parameters after periodontal treatment were similar in diseased and healthy sites, independent of the genetic background. Diseased sites of DS and control patients harbored similar levels of P. gingivalis and T. forsythia at baseline, but significantly higher levels of T. denticola were found in DS patients. Increased levels of P. gingivalis at healthy sites were found in DS individuals. Non-surgical periodontal therapy decreased the levels of red complex microorganisms and improved the tested clinical parameters of diseased sites in both groups. However, the levels of red complex bacteria were higher in diseased sites of DS patients after the periodontal treatment. We conclude in this pilot study that, although the mechanical periodontal treatment seemed to be effective in DS subjects over a short-term period, the red complex bacteria levels did not decrease significantly in diseased sites, as occurred in controls. Therefore, for DS patients, it seems that the conventional non-surgical periodontal therapy should be improved by utilizing adjuvants to reduce the presence of periodontopathogens. © 2014, Springer-Verlag Berlin Heidelberg.


Rocha P.L.,Federal University of Maranhão | Batista Barbosa D.A.,Federal University of Maranhão | de Oliveira Lima J.R.,Federal University of Maranhão | Piedade Prazeres G.M.,Federal University of Maranhão | And 5 more authors.
Materials Letters | Year: 2016

Bi2WO6 (BWO) powders synthesized via hydrothermal processes were studied in order to determine the effect of structure on photoluminescence (PL). BWO samples were characterized using X-Ray Powder Diffraction, UV–vis diffuse reflectance, field emission scanning electron microscopy, and PL intensity measurements. Orthorhombic structures were observed in all samples. A change in crystal microstructure and optical band gap was observed. The PL intensity obtained with different samples varied, with the highest intensity obtained with BWO fabricated with polyvinylpyrrolidone (PVP). Using Raman spectroscopy, a change in the microcrystal symmetry from P21ab to B2cb was observed and found to be responsible for the increase in photoluminescence. © 2016 Elsevier B.V.


de Batista P.R.,Federal University of Espirito Santo | Castiglia Y.M.M.,niversidade Estadual Paulista
Obesity Surgery | Year: 2015

Background: We compared the effects of two anesthesia protocols in both immediate recovery time (IRT) and postoperative respiratory complications (PRCs) after laparotomy for bariatric surgery, and we determined the association between the longer IRT and the increase of PRC incidence. Methods: We conducted the study in two stages: (i) in a randomized controlled trial (RCT), patients received either intervention (sevoflurane-remifentanil-rocuronium-ropivacaine) or control protocol (isoflurane-sufentanil-atracurium-levobupivacaine). All patients received general anesthesia plus continuous epidural anesthesia and analgesia. Treatment was masked for all, except the provider anesthesiologist. We defined IRT as time since anesthetics discontinuation until tracheal extubation. Primary outcomes were IRT and PRCs incidence within 15 days after surgery. We also analyzed post-anesthesia care unit (PACU) and hospital length of stays; (ii) after the end of the RCT, we used the available data in an extension cohort study to investigate IRT > 20 min as exposure factor for PRCs. Results: Control protocol (n = 152) resulted in longer IRT (30.4 ± 7.9 vs 18.2 ± 9.6 min; p < 0.0001), higher incidence of PRCs (6.58 vs 2.5 %; p = 0.048), and longer PACU and hospital stays than intervention protocol (n = 200); PRC relative risk (RR) = 2.6. Patients with IRT > 20 min (n = 190) presented higher incidence of PRCs (7.37 vs 0.62 %; p < 0.0001); RR = 12.06. Conclusions: Intervention protocol, with short-acting anesthetics, was more beneficial and safe compared to control protocol, with long-acting drugs, regarding the reduction of IRT, PRCs, and PACU and hospital stays for laparotomy in bariatric patients. We identified a 4.5-fold increase in the relative risk of PRCs when morbid obese patients are exposed to an IRT > 20 min. © 2015, Springer Science+Business Media New York.


Marquez-Legorreta E.,University of Salamanca | Horta-Junior J.A.C.,niversidade Estadual Paulista | Berrebi A.S.,West Virginia University | Saldana E.,University of Salamanca
Frontiers in Neuroanatomy | Year: 2016

The zone of transition between the pretectum, derived from prosomere 1, and the thalamus, derived from prosomere 2, is structurally complex and its understanding has been hampered by cytoarchitectural and terminological confusion. Herein, using a battery of complementary morphological approaches, including cytoarchitecture, myeloarchitecture and the expression of molecular markers, we pinpoint the features or combination of features that best characterize each nucleus of the pretectothalamic transitional zone of the rat. Our results reveal useful morphological criteria to identify and delineate, with unprecedented precision, several [mostly auditory] nuclei of the posterior group of the thalamus, namely the pretectothalamic lamina (PTL; formerly known as the posterior limitans nucleus), the medial division of the medial geniculate body (MGBm), the suprageniculate nucleus (SG), and the ethmoid, posterior triangular and posterior nuclei of the thalamus. The PTL is a sparsely-celled and fiber rich flattened nucleus apposed to the lateral surface of the anterior pretectal nucleus (APT) that marks the border between the pretectum and the thalamus; this structure stains selectively with the Wisteria floribunda agglutinin (WFA), and is essentially immunonegative for the calcium binding protein parvalbumin (PV). The MGBm, located medial to the ventral division of the MGB (MGBv), can be unequivocally identified by the large size of many of its neurons, its dark immunostaining for PV, and its rather selective staining for WFA. The SG, which extends for a considerable caudorostral distance and deviates progressively from the MGB, is characterized by its peculiar cytoarchitecture, the paucity of myelinated fibers, and the conspicuous absence of staining for calretinin (CR); indeed, in many CR-stained sections, the SG stands out as a blank spot. Because most of these nuclei are small and show unique anatomical relationships, the information provided in this article will facilitate the interpretation of the results of experimental manipulations aimed at the auditory thalamus and improve the design of future investigations. Moreover, the previously neglected proximity between the MGBm and the caudal region of the scarcely known PTL raises the possibility that certain features or roles traditionally attributed to the MGBm may actually belong to the PTL. © 2016 Márquez-Legorreta, Horta-Júnior, Berrebi and Saldaña.


Ferreira L.M.B.,niversidade Estadual Paulista | Kobelnik M.,Centro Universitario do Norte Paulista | Regasini L.O.,niversidade Estadual Paulista | Dutra L.A.,niversidade Estadual Paulista | And 2 more authors.
Journal of Thermal Analysis and Calorimetry | Year: 2016

Flavonoids in the broad sense of the term are virtually universal plant pigments. Synthesis of flavanone and 6-hydroxyflavanone was carried out and identified by H and C NMR. Details concerning the thermal behavior were evaluated by thermogravimetry under oxygen and nitrogen purge gases. Additionally, the kinetic studies were evaluated from several heating rates (5, 10 and 20 °C min−1) and sample mass of 2 mg in open crucibles. The obtained data were evaluated with the isoconversional method, where the values of activation energy (Ea/kJ mol−1) were plotted in function of the conversion degree (α). The results of thermal behavior of the flavanone under a nitrogen purge gas showed that this compound has a homogeneous degradation process while the hydroxyl group in the aromatic ring of 6-hydroxyflavanone there are two mass losses. © 2016 Akadémiai Kiadó, Budapest, Hungary


Gomes L.D.A.,University Federal do Para | Moraes P.H.G.,University Federal do Para | do Nascimento L.D.C.S.,University Federal do Para | O'Dwyer L.H.,niversidade Estadual Paulista | And 5 more authors.
Ticks and Tick-borne Diseases | Year: 2016

This study aimed to optimize molecular methods for detecting DNA of Hepatozoon spp. as well as identify the phylogenetic relationships of Hepatozoon strains naturally infecting domestic dogs in Belém, Pará, northern Brazil. Blood samples were collected from 138 dogs, and screened for Hepatozoon spp. using a new nested PCR assay. Positive samples were subjected to genetic characterization based on amplification and sequencing of approximately 670 bp of the Hepatozoon spp. 18S rRNA. Of the positive dogs, four shared the haplotype Belém 01, one dog presented the haplotype Belém 02 and two dogs shared the haplotype Belém 03. A Bayesian inference indicates that haplotypes Belém 01 and Belém 02 are phylogenetically related to H. canis, while Belém 03 is related to H. americanum. Overall, based on the first molecular evidence of H. americanum in Brazilian domestic dogs, the proposed protocol may improve the epidemiological investigation of canine hepatozoonosis. © 2016 Elsevier GmbH


De Souza R.A.,niversidade Estadual Paulista | Mauro A.E.,niversidade Estadual Paulista | Netto A.V.G.,niversidade Estadual Paulista | Da Cunha G.A.,niversidade Estadual Paulista | De Almeida E.T.,Federal University of Alfenas
Journal of Thermal Analysis and Calorimetry | Year: 2011

Palladium(II) coordination compounds of general formula trans-[PdX 2(isn)2], X = Cl- (1), N3- (2), SCN- (3), NCO- (4), isn = isonicotinamide; were synthesized and characterized in solid state by elemental analysis, infrared spectroscopy, and simultaneous TGDTA. TG experiments reveal that the compounds 14 undergo thermal decomposition in three or four stages, yielding Pd0 as final residue, according to calculus and identification by X-ray powder diffraction. © 2011 Akadémiai Kiadó, Budapest, Hungary.

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