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Matsuzaki C.,Ishikawa Prefectural University | Hayakawa A.,Ishikawa Prefectural University | Matsumoto K.,Ishikawa Prefectural University | Katoh T.,Ishikawa Prefectural University | And 2 more authors.
Journal of Agricultural and Food Chemistry | Year: 2015

Leuconostoc mesenteroides strain NTM048 has been shown to have intestinal IgA-inducing ability. In this study, we investigated the immunostimulant potency of an exopolysaccharide secreted from strain NTM048 (NTM048 EPS) in vitro and in vivo in a murine model. NTM048 EPS ranges in size from 10 to 40 kDa and is speculated to be mainly composed of glucose and fructose. The in vitro study revealed that NTM048 EPS induced total and antigen-specific IgA production by Peyer′s patch cells and influenced Th1 and Th2 cell-mediated response in splenocytes. Oral administration of NTM048 EPS dose-dependently induced fecal IgA production accompanied by the up-regulation of retinoic acid synthase and transforming growth factor-β receptor genes in Peyer′s patch cells. Flow cytometric analysis of the splenocytes revealed an increase of the CD3+ T-cell population and the ratio of CD4+ T-cells/CD8+ T-cells. These results indicate that NTM048 EPS could enhance the mucosal barrier and influence the systemic immune response. © 2015 American Chemical Society.

Kyoto University and Nitto Pharmaceutical Industries Ltd. | Date: 2012-11-06

The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase) derived from

Kyoto University and Nitto Pharmaceutical Industries Ltd. | Date: 2014-02-13

The present invention provides an intestinal tract-protecting agent, an agent for the prophylaxis or improvement of a disease caused by damage in intestinal tract barrier function, which contains hydroxylated fatty acid, particularly hydroxylated unsaturated fatty acid, having a hydroxyl group at the 10-position and/or the 12-position, which is an intermediate of the metabolism of unsaturated fatty acid by

Kyoto University and Nitto Pharmaceutical Industries Ltd. | Date: 2013-10-14

The present invention provides a metabolism improving agent comprising an oxo fatty acid having 18 carbon atoms and a carbonyl group at the 10- or 12-position, and/or a hydroxy fatty acid having 18 carbon atoms and a hydroxyl group at the 10- and/or 12-position(s), and use of the metabolism improving agent as a food, a pharmaceutical product and the like.

Nitto Pharmaceutical Industries Ltd. | Date: 2014-06-16

Chemicals; adhesives not for stationery or household purposes; plant growth regulating preparations; fertilizers; higher fatty acids; chemical compositions for developing, printing and enlarging photographs; unprocessed plastics plastics in primary form. Solid lubricants; grease for shoes and boots; leather preserving oil and grease; solid fuels; liquid fuels; gaseous fuels; mineral oils and greases for industrial purposes not for fuel; non-mineral oils and greases for industrial purposes not for fuel. Pharmaceutical preparations other than for agricultural purposes; reagent paper for medical purposes; oiled paper for medical purposes; wrapping wafers for medicine doses; gauze for dressings; empty capsules for pharmaceuticals; eyepatches for medical purposes; ear bandages; menstruation bandages; menstruation tampons; sanitary napkins; sanitary panties; absorbent cotton; adhesive plasters; bandages for dressings; liquid dressings; breast-nursing pads; dental materials; dietary supplements for humans; dietetic beverages adapted for medical purposes; dietetic food adapted for medical purposes; beverages for babies; food for babies; dietary supplements for animals. Edible oils and fats; milk products; meat for human consumption fresh, chilled or frozen; fresh, chilled or frozen edible aquatic animals not live; processed meat products; processed seafood products for human consumption (other than blocks of boiled, smoked and then dried bonitos katsuo-bushi, dried pieces of agar jelly kanten, flakes of dried fish meat kezuri-bushi, fishmeal for human consumption, edible shavings of dried kelp tororo-kombu, sheets of dried laver hoshi-nori, dried brown alga hoshi-hijiki, dried edible seaweed hoshi-wakame and toasted sheets of laver yaki-nori); processed vegetables and fruits; proteins for use as food additives.

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