Entity

Time filter

Source Type

Netanya, Israel

Kopelman D.,Technion - Israel Institute of Technology | Kopelman Y.,Gastroenterology and hepatology institute | Peled D.,Niti Surgical Solutions | Willenz U.,Lahav Research Institute | And 2 more authors.
Surgical Innovation | Year: 2013

Background: There are limited large animal models for the research of novel anastomotic technologies. Subtotal colectomy requires the anastomosis of relatively remote segments of the alimentary tract that are different anatomically, histologically, and pose significant physiological challenge. The quest for a foreign material-free anastomotic line reintroduced nitinol compression anastomosis into clinical use in the last decade. Objective: To evaluate the safety, histological, and physiological parameters of side-to-side ileocolic nitinol compression anastomosis in a newly developed large animal model, mimicking the human subtotal colectomy. Intervention: Resection of the entire spiral colon with an ileocolic side-to-side compression anastomosis in 12 animals, compared to resection of a short ileal segment in 6 animals. All anastomoses were constructed by using a novel nitinol-based compression device. The animals were followed up to 30 days postoperatively and were reoperated and sacrificed. Results: All 12 animals underwent successful subtotal colectomy with side-to-side nitinol compression anastomosis. No signs of abdominal infection were found. The increase in the colectomized animals' bodyweight over the postoperative course was significantly lower and the animals presented with longer periods of diarrhea. The histopathology revealed minimal inflammation and foreign body reaction with good alignment of the bowel wall layers in both groups. The anastomotic line width was shown to be reduced during the healing course of the compression anastomoses. Conclusions: Side-to-side nitinol compression anastomosis is safe and demonstrates favorable functional and histopathological features. The porcine model of subtotal colectomy can be used for further research of novel anastomotic technologies. © The Author(s) 2013. Source


Trademark
Niti Surgical Solutions | Date: 2009-11-08

Surgical apparatus and instruments for connecting tissues by compression. Performing surgical treatment procedures and methods for connecting tissues by compression.


Trademark
Niti Surgical Solutions | Date: 2012-03-22

Pharmaceutical preparations for the treatment of disorders of the gastrointestinal tract; colonic preparations; plasters for medical purposes; sanitary preparations for medical purposes; disinfectants. Suture materials; medical and surgical devices for the evaluation, diagnosis and treatment of disorders of the gastrointestinal tract; rigid and flexible medical endoscopes; trocars; anastomosis devices; endoscopic retrograde cholangiopancreatograpy; suture materials; surgical meshes; ROTH nets and other endoscopic ancillary devices. Medical services; hygienic care for human beings.


Trademark
Niti Surgical Solutions | Date: 2012-03-22

Pharmaceutical preparations for the treatment of disorders of the gastrointestinal tract; colonic preparations; plasters for medical purposes; sanitary preparations for medical purposes; disinfectants. Suture materials; medical and surgical devices for the evaluation, diagnosis and treatment of disorders of the gastrointestinal tract; rigid and flexible medical endoscopes; trocars; anastomosis devices; endoscopic retrograde cholangiopancreatograpy; suture materials; surgical meshes; ROTH nets and other endoscopic ancillary devices. Medical services; hygienic care for human beings.


Gi

Trademark
Niti Surgical Solutions | Date: 2012-03-22

Pharmaceutical preparations for the treatment of disorders of the gastrointestinal tract; colonic preparations; plasters for medical purposes; sanitary preparations for medical purposes; disinfectants. Suture materials; medical and surgical devices for the evaluation, diagnosis and treatment of disorders of the gastrointestinal tract; rigid and flexible medical endoscopes; trocars; anastomosis devices; endoscopic retrograde cholangiopancreatograpy; suture materials; surgical meshes; ROTH nets and other endoscopic ancillary devices. Medical services; hygienic care for human beings.

Discover hidden collaborations