Nisshin Pharma Inc

Fujimino, Japan

Nisshin Pharma Inc

Fujimino, Japan
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Patent
Nisshin Pharma Inc. and Chiba University | Date: 2010-02-10

This invention provides a composition having preventive and/or therapeutic effects on liver disease, which is highly effective, free of side effects, easily ingestible, and capable of long-term ingestion from the viewpoint of a cost and safety. This invention relates to a peptide having the amino acid sequence represented by the following formula: pyroGlu-(X)n-A, wherein X is the same or different and represents Gln or Asn; A represents Gln, Asn, Leu, Ile, or Val; and n is an integer from 0 to 2 or a salt thereof.


Katayanagi Y.,Nisshin Pharma Inc. | Yasui K.,Nisshin Pharma Inc. | Ikemoto H.,Nisshin Pharma Inc. | Taguchi K.,University of Shizuoka | And 4 more authors.
Food Chemistry | Year: 2013

The present study was performed to investigate the immune-modulating activities of extracts from green soybean (Glycine max) in a 2,4-toluene diisocyanate (TDI)-inducing guinea pig rhinitis model and a human trial study for allergic rhinitis. Hot water extracts of green soybean were chosen for animal experimentation on the basis of their ability to regulate the production of B cell-activating factor of the TNF family and a proliferation-inducing ligand in mouse spleen cells. Green soybean extracts significantly decreased the levels of ovalubumin (OVA)-specific IgE in mice and significantly suppressed the TDI-induced nasal mucosa secretion. An open-label human pilot study was performed on 16 subjects, using Japanese cedar pollinosis. The symptom scores for Japanese cedar pollinosis were better in the long-term green soybean extracts intake group than in the withdrawal short-term intake group. Green soybean extracts had great potential as an orally active immune modulator for the treatment of various allergic diseases. © 2012 Elsevier Ltd. All rights reserved.


Patent
Nisshin Pharma Inc. | Date: 2010-02-17

A composition for effectively preventing or treating peptic ulcers not caused by Helicobacter pylori that does not cause any adverse reaction and thus is highly safe is provided. The present invention relates to a composition for preventing and/or treating peptic ulcers not caused by Helicobacter pylori, which comprises as an active ingredient a browning reaction product of a sugar and a protein.


Patent
Nisshin Pharma Inc. | Date: 2010-02-24

A plant-growth promoting agent is provided, which is lower in environmental pollution, highly safe and harmless to human bodies, and which exhibits an excellent plant growth promoting action even under wide temperature conditions from low temperatures to high temperatures. And also the plant growth-promoting agent is provided, which has an ability to store ubiquinone, as an active ingredient of the plant-growth promoting agent, in a stable state and can be dispersed and stably present in a medium such as a soil or an aqueous liquid which supplies nutrition to the plant, especially in an initial stage in which a plant body is grown after germination.


Patent
Nisshin Pharma Inc. | Date: 2013-03-13

Provision of a composition stably comprising a high concentration of sulfur amino acid derived from a plant belonging to the genus Allium. A method for producing a sulfur amino acid-comprising composition comprising: heating a plant belonging to the genus Allium; treating the plant belonging to the genus Allium thus heated with a -glutamyl bond cleaving enzyme; and subjecting the resulting enzyme-treated product to ion exchange chromatography.


Patent
Kyoto University and Nisshin Pharma Inc. | Date: 2014-08-26

Provided is an 3 desaturase having a high enzymatic activity even at normal temperature. A polypeptide consisting of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and having 3 desaturation activity, and a gene therefor.


Patent
Nisshin Pharma Inc. | Date: 2015-01-28

Provision of a composition stably comprising a high concentration of sulfur amino acid derived from a plant belonging to the genus Allium. A method for producing a sulfur amino acid-comprising composition comprising: heating a plant belonging to the genus Allium; treating the plant belonging to the genus Allium thus heated with a -glutamyl bond cleaving enzyme; and subjecting the resulting enzyme-treated product to ion exchange chromatography.


Patent
Nisshin Pharma Inc. | Date: 2010-03-03

A method for conveniently and efficiently producing quinones, and particularly menaquinone, from a microorganism is provided. The present invention relates to a method for producing quinones, comprising culturing a microorganism that produces quinones in the presence of a porous carrier.


The present invention provides a composition having a high content of highly unsaturated fatty acid alkyl ester. A method for producing a composition comprising a highly unsaturated fatty acid alkyl ester, the method comprising contacting a raw material comprising a highly unsaturated fatty acid alkyl ester with an aqueous solution comprising a silver salt and subsequently recovering an aqueous phase; adding an organic solvent to the aqueous phase, and subsequently recovering an organic solvent phase; and rectifying the organic solvent phase at a temperature of 170 to 190 C. and a column top vacuum degree of 1 Pa or less to recover the highly unsaturated fatty acid alkyl ester from the organic solvent phase.


Patent
Kyoto University and Nisshin Pharma Inc. | Date: 2016-07-06

Provided is an 3 desaturase having a high enzymatic activity even at normal temperature. A polypeptide consisting of an amino acid sequence having an identity of 80% or more with the amino acid sequence represented by SEQ ID NO: 2 and having 3 desaturation activity, and a gene therefor.

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