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Eniwa, Japan

Takeshima T.,Hokkaido University | Takeshima T.,Nissei Bio Co. | Takeshima T.,University of Texas Southwestern Medical Center | Tada Y.,Nissei Bio Co. | And 4 more authors.
Nanomaterials | Year: 2015

Silver (Ag) nanoparticles were produced using DNA extracted from salmon milt as templates. Particles spherical in shape with an average diameter smaller than 10 nm were obtained. The nanoparticles consisted of Ag as the core with an outermost thin layer of DNA. The DNA/Ag hybrid nanoparticles were immobilized over the surface of cotton based fabrics and their antibacterial efficiency was evaluated using E. coli as the typical Gram-negative bacteria. The antibacterial experiments were performed according to the Antibacterial Standard of Japanese Association for the Functional Evaluation of Textiles. The fabrics modified with DNA/Ag nanoparticles showed a high enough inhibitory and killing efficiency against E. coli at a concentration of Ag ≥ 10 ppm. © 2014 by the authors; licensee MDPI, Basel, Switzerland. Source


Yan H.,Japan National Institute of Advanced Industrial Science and Technology | Kakuta S.,Tokyo Medical University | Nishihara M.,Nissei Bio Co. | Sugi M.,Nissei Bio Co. | And 4 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2011

Kjellmaniella crassifolia Miyabe (gagome) is a brown alga. Oral gagome administration (oral gagome) resulted in significant upregulation of IL-10 and IFNγ production by Peyer's patch cells. To assess the adjuvant activity of oral gagome, treated mice were subcutaneously injected with ovalbumin (OVA). The production of cytokines from antigen (Ag)-specific T cells in draining lymph nodes (dLN) and their proliferative response were significantly increased as compared with the control group. These enhancements were associated with increased CD44 hiCD62L - activated/memory T cells in dLN as well as upregulation of Ag-specific IgA level in luminal contents. No upregulation of cytokine production by dLN T cells was observed in dectin-1- deficient mice, suggesting that the effect of gagome on cytokine production is largely dependent on the dectin-1 pathway despite its composite constituents. Our findings indicate that gagome is an effective immunomodulator and a potent adjuvant for both the intestinal and the systemic immune response. Source


Nishimura D.,Nissei Bio Co. | Nishimura D.,Gene Trophology Institute | Takahashi C.,Nissei Bio Co. | Takahashi C.,Gene Trophology Institute | Kohzai Y.,New Drug Research Center Inc
Nippon Shokuhin Kagaku Kogaku Kaishi | Year: 2015

Society as a whole is developing a more nocturnal lifestyle as a result of advances in information technology and the increasing number of nighttime jobs. These changes in lifestyle have ledto delayedbed time andd eclining hours of sleep. A relationship between sleep disturbance and the deterioration in physical and mental health has recently been reported; specifically, the negative effects of sleep disturbance on brain and/or immune functions as well as lifestyle disease pathogenesis. Furthermore, the number of individuals with sleep disorders has been increasing with aging, representing a problem that needs to be addressed. We conducted a double-blind crossover study in 10 male subjects (age range, 40-69 years) who reported dissatisfaction with their sleep. Our aim was to determine the effect of asparagus cladophylls intake on sleep disturbance. The Pittsburgh Sleep Quality Index questionnaire revealed a significant reduction in sleep disturbance in response to cladophylls intake. Thus, asparagus cladophylls intake was foundto improve sleep. Copyright © 2015, Japanese Society for Food Science and Technology. Source


Takeshima T.,Hokkaido University | Sun L.,Hokkaido University | Wang Y.,Hokkaido University | Yamada Y.,Nissei Bio Co. | And 3 more authors.
Polymer Journal | Year: 2014

A wet-chemical approach using DNA extracted from salmon milt as a template to mass produce Ag nanoparticles was developed. Spherical Ag nanoparticles with a main diameter of less than 10 nm were obtained. The concentration of Ag nanoparticles in the as-produced colloidal suspension was as high as 5.3 × 10-2 mol l-1. This simple and effective procedure should offer an alternative route to the mass production of Ag nanoparticles for practical applications. © 2014 The Society of Polymer Science, Japan (SPSJ) All rights reserved. Source

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