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Therese S.K.,Nirmala College for Women | Geethamalika G.,Nirmala College for Women
Oriental Journal of Chemistry | Year: 2017

The hydrazone Schiff base analogues namely benzoic acid (4-allyloxy-benzylidene)-hydrazide and its series were designed and synthesized. The structures of newly synthesized compounds were characterized by analytical methods and spectral analysis and subjected to antibacterial and docking studies. The synthesized molecules were subjected to molecular docking studies using enoyl-acyl-carrier protein reductase (NADH) from mycobacterium tuberculosis as the receptor. The docking results confirm the binding affinity of the synthesized compounds with the selected receptor. Preliminary in-vitro anti bacterial studies were carried out with Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Benzoic acid (4-allyloxy-benzylidene)-hydrazide was found to be most potent anti tuberculosis agent at 200 and 100μg per ml, the percentage of inhibition was 98.7% and 97.9%. The designed synthesized molecules were considered for evaluation for the molecular docking studies of their binding pattern with enoyl-acyl-carrier protein reductase from Mycobacterium tuberculosis. The antimycobacterial screening was performed against MTB H37Rv an isoniazid-resistant clinical isolate of MTB was used for the study. © 2017, Oriental Scientific Publishing Company. All rights reserved.


Gunavathy N.,Nirmala College for Women | Murugavel S.C.,PSG College of Technology
E-Journal of Chemistry | Year: 2012

The inhibition effect of unripe fruit peel extract of Musa acuminate (Cultivar variety - Nendran) (MNP) on corrosion of mild steel in 1 N HCl has been investigated by weight loss and electrochemical impedance spectroscopy (EIS) with various concentrations of the extract. The effect of temperature on the corrosion inhibition of mild steel in the temperature range of 30 °C - 80 °C was carried out. The results indicate that MNP extract act as an effective inhibitor in the acid environment and is of mixed type inhibitor having efficiency as high as 96% at 2% inhibitor concentration. The inhibition efficiency of MNP extract increases with the increase of concentration but decreases with the increase in temperature. The inhibitor achieves its inhibition by physical adsorption of nutrients of the peel extract on the surface of the mild steel. The experimental data revealed that the adsorption occurred according to the Langmuir and Temkin adsorption isotherm.


Arockiarani I.,Nirmala College for Women
2014 IEEE Conference on Norbert Wiener in the 21st Century: Driving Technology's Future, 21CW 2014 - Incorporating the Proceedings of the 2014 North American Fuzzy Information Processing Society Conference, NAFIPS 2014, Conference Proceedings | Year: 2014

The focus of this paper is to explore the notion of fuzzy neutrosophic sets and soft sets. A novel approach is proposed to meet the challenges in medical diagnosis. The calculation of distances, a new score function are all defined to discuss in decision making problem. A topological structure on fuzzy neutrosophic soft set is considered as a tool to derive some of their characterizations. © 2014 IEEE.


Anbarasi K.,Nirmala College for Women
Oriental Journal of Chemistry | Year: 2016

The influence of the acid extract of peel of Cucurbita maxima (PCM) on the corrosion of mild steel in 1N H2SO4 was investigated by weight loss, polarization and impedance methods and SEM analysis. The inhibition efficiency increases with extract concentration and immersion period. Weight loss and corrosion rates of mild steel decreased as the concentration of inhibitor increased. The results showed that PCM was potential corrosion inhibitor and maximum inhibition efficiency (IE %) obtained was 98% for 3%PCM at 1h. Impedance measurement results an increase in charge transfer resistance (Rct), which also confirms the corrosion inhibitive nature of the plant extract. Potentiodynamic study showed that PCM acts as a mixed type of inhibitor, which controls both the anodic and cathodic reactions. Scanning electron microscopic studies provided the evidence of improved surface condition for the corrosion protection, due to the adsorption. © 2016, Oriental Scientific Publishing Company. All rights reserved.


Nair D.N.,Nirmala College for Women | Padmavathy S.,Nirmala College for Women
The Scientific World Journal | Year: 2014

Endophytes are microorganisms (bacteria or fungi or actinomycetes) that dwell within robust plant tissues by having a symbiotic association. They are ubiquitously associated with almost all plants studied till date. Some commonly found endophytes are those belonging to the genera Enterobacter sp., Colletotrichum sp., Phomopsis sp., Phyllosticta sp., Cladosporium sp., and so forth. Endophytic population is greatly affected by climatic conditions and location where the host plant grows. They produce a wide range of compounds useful for plants for their growth, protection to environmental conditions, and sustainability, in favour of a good dwelling place within the hosts. They protect plants from herbivory by producing certain compounds which will prevent animals from further grazing on the same plant and sometimes act as biocontrol agents. A large amount of bioactive compounds produced by them not only are useful for plants but also are of economical importance to humans. They serve as antibiotics, drugs or medicines, or the compounds of high relevance in research or as compounds useful to food industry. They are also found to have some important role in nutrient cycling, biodegradation, and bioremediation. In this review, we have tried to comprehend different roles of endophytes in plants and their significance and impacts on man and environment. © 2014 Dhanya N. Nair and S. Padmavathy.


Rabeque C.S.,Bharathiar University | Padmavathy S.,Nirmala College For Women
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: The primary objective of this study was to investigate the hypoglycaemic activity of S. caryophyllatum in alloxan induced diabetic mice. Methods: Alloxan was administered as a single dose (60mg/kg, b. wt) to induce diabetes. Methanol extracts from S. caryophyllatum (250mg/kg body weight/day) was administered for 14 days to alloxan induced diabetic mice and the body weight changes and fasting blood sugar levels were monitored on 0, 7th and 14th day. Glycosylated haemoglobin levels also estimated. Result: The results suggest that the administration of S. caryophyllatum have hypoglycaemic activity in alloxan induced diabetic mice and their effect was equivalent to that of reference drug Glibenclamide. Conclusions: Methanol extract of S. caryophyllatum possesses anti-diabetic effect on Alloxan induced diabetic mice due to the presence of secondary metabolites.


Singh M.J.,Nirmala College for Women | Padmavathy S.,Nirmala College for Women
Journal of Radioanalytical and Nuclear Chemistry | Year: 2014

Microremediation of harmful radioactive waste such as uranium has been carried out by the endophytic actinomycetes strains isolated from the unnoticed fallen leaves of commonly available medicinal plant Azadirachta indica, which are considered as unique source. Among six actinobacteria isolates, one microbe (A5) effectively removed uranium in 12 h at temperature 30 °C and pH 8–9. Molecular characterization and phylogenetic analysis support the classification of the isolate A5 as a new strain which was named as Streptomyces sp. MINIYAA7 (Genbank accession number KF909129). © 2014, Akadémiai Kiadó, Budapest, Hungary.


Dhanalakshmi B.,Nirmala College for Women
Journal of Industrial Pollution Control | Year: 2010

Solid wastes encompass industrial wastes, agro wastes, municipal wastes, hospital wastes and domestic wastes. Rapid industrisilation and urbanization has resulted in the generation of large quantity of solid wastes. All high yielding crops require the application of enormous quantity of chemical fertilizers and pesticides, which has created a serious problem in the ecosystem. Now a days, earthworms has been widely used in the breaking down of this wide range of organic residues including sewage, animal waste, crop residues and industrial refuse in producing vermicompost in the name of Vermiculture technology. This epigeic species called Eudrilus eugeniae is an African species mostly utilized for the solid waste management and vermicompost production due to its high pollutant tolerance. Vermiculture technology is one of the important bioremediation technique for sewage treatment. In the present study the N, P and K, organic carbon and the worm population increased significantly on the 60th day when compared to 30th and initial day. © EM International.


Sharmila S.,Nirmala College for Women | Arockiarani I.,Nirmala College for Women
International Journal of Oceans and Oceanography | Year: 2016

In this paper we present an approach of Inter Criteria Analysis (ICA)for the pollution of river Ganges in India. The approach is based on the apparatus of the index matrices and the intuitionistic fuzzy sets. We have applied the ICA to establish the basic pollution relations (the model structure) based on different criteria involved in the Ganga river. The results have shown that the criteria are independent, they are time functions. Based on this we have developed an adequate mathematical model of the Ganga river pollution. The Method of the least squares is used for a parametric identification. © Research India Publications.


Dhanalakshmi B.,Nirmala College for Women | Chitra G.,Nirmala College for Women
International Journal of Pharma and Bio Sciences | Year: 2015

The present study was conducted for microbiological assessment of six selected marine species from Nagapattinam district. Total viable colony count, E.coli, Vibrio species, Salmonella species, total yeast count and total mould count were determined in Stolephorus commorsonnii, Hilsa ilisha, Otolithes ruber, Sardinella longiceps, Ilisha elongata and Penaeus indicus. The total viable colony count of the raw fishes and prawn varied from 0.10- 8.30% and the dry fishes and prawn varied from 0.10-1.20%. The E.coli of the raw fishes and prawn varied from 0.20-0.80% and the dry fishes and prawn varied from 0.08 to 0.20%. The vibrio species of raw fishes and prawn varied from 1-4% and the dry fishes and prawn varied from 0.2 - 0.20%.In the present study salmonella, yeast and mold were not detected in both fresh and dried samples. The total viable colony count, E.coli and vibrio species were reduced in the dry fishes while E.coli was completely absent in Stolephorus commersonnii, Sardinella longiceps and Ilisha elongata.

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