Kinki University, Educational Corporation Mukogawa Gakuin and Nipro Corporation | Date: 2016-11-02
The present invention provides a hemiacetal ester prodrug of the pyridone carboxylic acid antibacterial drug, wherein the prodrug is characterized in that, (i) it is hydrolyzed promptly after intestinal absorption and regenerates the pyridone carboxylic acid antibacterial drug as a drug substance, (ii) a one-dose package is possible by preventing chelate-formation in intestines in an oral administration, and (iii) the normal bacterial flora of the intestinal bacterial flora is not influenced at all until the ester is absorbed, because the hemiacetal-type esterification is executed on the carboxylic acid which is a center of the antibacterial action, resulting in prevention of the pseudomembranous colitis. The prodrug is an alkoxy carbonyl hemiacetal-type ester represented by the chemical formula (I), which is useful as a prodrug for inhibiting the enteric-bacterium-shift side effect, and can be used in combination with polyvalent metal-containing medicines.
Tokai University and Nipro Corporation | Date: 2016-03-30
Provided is a stent having a novel structure, the stent simultaneously having both the stability of shape against the action of external force, such as compression force, tensile force, or torsional force, and high flexibility in the direction of twisting of the stent. Connection groups (20) are provided at three or more positions set at circumferentially equally-spaced intervals, the connection groups (20) each comprising connection sections (14) which are disposed circumferentially close to each other between axially adjacent tubular divided bodies (12c). The connection groups on both sides axially of each of the tubular divided bodies (12c) are provided at positions circumferentially offset from each other while at least one turning portion (18) is present between the connection groups.
Nipro Corporation | Date: 2016-07-27
A burner (10) for inner surface treatment of a medical glass container, comprising a burner body (11) having a first flow path (13) through which a fuel is circulated; anda second flow path (16) to be connected to the first flow path of the burner body, the burner having a long and narrow nozzle (12) that can be inserted into the internal space of a medical glass container or an intermediate product thereof as a processing target, and the nozzle being formed of ceramic.
Nipro Corporation | Date: 2016-05-18
A connector (2) which is detachably connected to a cylindrical section (5) is prevented from being unintentionally disconnected and from breaking. The connector (2) has an inner cylinder member (10) and an outer cylinder member (40). The inner cylinder member (10) has an engagement plate (30) protruding from the inner peripheral surface of an inner cylinder body (20) and engaging with a recess (7) formed in the outer peripheral surface of the cylindrical section (5), and also has slits (11) arranged radially and extending from the engagement plate (30) to a part of the inner cylinder body (20). The engagement between the recess (7) and the engagement plate (30) restricts the axial movement of the inner cylinder member (10) relative to the cylindrical section (5). In a state in which the outer cylinder member (40) is mounted on the inner cylinder member (10), the inner peripheral surface of the outer cylinder member is in contact with the outer peripheral surface of the inner cylinder member, and thus the displacement of the engagement plate (30) in the diameter expansion direction is restricted.
Nipro Corporation | Date: 2016-04-20
A method of determining an ESA dose, which allows a hemoglobin concentration in the blood to be stably maintained at a target value, and which can decrease a range of fluctuation of the hemoglobin concentration with respect to the target value. The method comprises the steps of: setting the target value of the hemoglobin concentration in the blood; calculating a target value of a hemoglobin production rate which allows the hemoglobin concentration to reach the target value; calculating a serum ESA concentration which allows the hemoglobin production rate to reach the target value, from a relationship between the hemoglobin production rate and the ESA concentration; and calculating an amount of administration of an ESA which gives the serum ESA concentration, from a relationship between the ESA concentration and the amount of administration of the ESA, to determine an ESA dose which allows the hemoglobin concentration to reach the target value.
Nipro Corporation | Date: 2016-11-30
To provide a blood treatment filter device capable of efficiently utilizing a blood treatment filter. A blood treatment filter device 20 has a filter sheet 26 through which a specific component among components forming blood is harder to pass than other components and a spacer sheet 27 through which the specific component is easier to pass than through the filter sheet 26. The filter sheet 26 has filter through-holes 39 disposed at intervals. The filter sheet 26 and the spacer sheet 27 are spirally wound in an overlapped state. The filter device 20 has seals 31 sealing both end portions in the longitudinal direction of a wound body 25 formed by the filter sheet 26 and the spacer sheet 27 which are spirally wound in a fluid-tight manner. The outer peripheral surface of the wound body 25 is formed by the filter sheet 26.
Nipro Corporation | Date: 2016-11-02
A stent (32) configured to be placed in a body lumen and having a tubular shape formed by a structure that is expandable and contractible skeleton (18, 19) in a radial direction, the skeleton (18, 19) having a heteromorphic structure due to changes of a cross section shape thereof in a thickness direction. A stent (10) that is expandable and contractible in the radial direction while being configured to be placed in a body lumen, the stent (10) having a heteromorphic tubular shape, a cross section shape of which changes in a lengthwise direction, and having a metal skeleton (18, 19) formed by at least one of electroforming and etching.
Nipro Corporation | Date: 2016-04-14
An injection needle 1 made of an alloy containing cobalt and molybdenum is manufactured as follows. First, a lancet cut is carried out to a pipe-like metallic material composed of the alloy containing cobalt and molybdenum to form a blade tip 3 and a blade part 5. Then, a distal end part 1A including the blade tip 3 is mechanically polished, and thereafter, the distal end part 1A is immersed in an electrolytic solution and electrolytically polished. Thus, burrs at the blade tip 3 or the like generated during mechanical polishing are removed. Since the injection needle 1 is composed of the alloy containing cobalt and molybdenum, compared to a conventional injection needle made of stainless steel, an injection needle in which the surface roughness of an inner peripheral surface of the injection needle is low and smooth can be provided.
Nipro Corporation | Date: 2016-08-24
[Object] To provide an ablation system capable of suppressing heat damages to the lumen intima. [Solution] An ablation system 10 has an ablation device 11 in which a balloon 21 is provided on the distal end side of a shaft 22 and an in-side tube 27 causing a fluid to flow into the balloon 21, the internal space of the shaft 22 causing a fluid to flow out of the balloon 21, and an optical fiber 29 guiding laser light into the balloon 21 are individually provided along the shaft 22, a laser light generating unit 12 emitting laser light to the optical fiber 29, and a fluid returning unit 13 returning a fluid into the internal space of the balloon 21. The ablation device 11 has a reflector 33 reflecting laser light emitted from the optical fiber 29 in the balloon 21, in which the reflector 33 is movable along the axial direction 191 in the balloon 21 and is rotatable in the axial direction 101 as the axis line.
Nipro Corporation | Date: 2016-12-14
[Object] To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel. [Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.