Tokyo, Japan
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Patent
Kyushu University and Nippon Chemiphar Co. | Date: 2016-10-28

A P2X_(4 )receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating neuropathic pain associated with Guillain-Barr syndrome: wherein R^(1 )is hydrogen, a C_(1-8 )alkyl group, or the like;


Patent
Kyushu University and Nippon Chemiphar Co. | Date: 2017-02-22

A P2X_(4) receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating zoster-associated pain in acute phase:^(1) is hydrogen, a C_(1-8) alkyl group, or the like;each of R^(2) and R^(3) is hydrogen, a C_(1-8) alkyl group, or the like;each of R^(4) and R^(5) is hydrogen or the like; andW is a five-membered or six-membered heterocyclic ring optionally having one or more substituents and comprising one to four nitrogen atoms as the members of the ring.


The present invention provides a prophylactic or therapeutic agent for giant cell tumors occurring in a bone and soft tissue or for chondrosarcoma, which comprises a non-steroidal anti-inflammatory agent or thiazolidine derivative as an active ingredient, and the like


Patent
Nippon Chemiphar Co. and Kyushu University | Date: 2016-05-18

The present invention relates to a compound represented by the following general formula (II), wherein, in the formula, R^(1a) to R^(6a) represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, and the like, X^(a) represents C or N, Y^(a) represents N or C(=O), provided that when X^(a) is C, Y^(a) represents N, and when X^(a) is N, Y^(a) represents C(=O), the double line consisting of the solid line and the broken line represents a single bond or double bond, A^(a) represents benzene ring, pyridine ring, and the like, D^(a) represents tetrazole ring, imidazole ring, and the like, E^(a) represents-(CR^(9a) R^(10a))_(p) -T^(a) -, and G^(a) represents benzene ring, pyridine ring, and the like, which has a P2X4 receptor antagonistic activity.


Patent
Kyushu University and Nippon Chemiphar Co. | Date: 2015-07-24

A P2X_(4 )receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating zoster-associated pain in acute phase: wherein R^(1 )is hydrogen, a C_(1-8 )alkyl group, or the like;


Patent
Nippon Chemiphar Co. | Date: 2015-03-04

The present invention relates to a method for preparing zaltoprofen or a zaltoprofen derivative by a Friedel-Crafts reaction type intramolecular cyclization reaction in an industrial scale at an industrially acceptable yield and a purity sufficient for use as an active ingredient of medicaments in a simple and economical manner, without generating a detectable amount of impurities such as dimmers, by using polyphosphoric acid in an amount of 6.5 times or less of amount of a starting material compound before cyclization. More specifically, the present invention relates to such a method for preparing zaltoprofen or a zaltoprofen derivative as mentioned above, which comprises cyclizing a starting material compound before cyclization by an intramolecular cyclization reaction thereof in the presence of one or more kinds of organic solvents selected from the group consisting of 1,1,2-trichloroethene, methylcyclohexane, cyclohexane, n-heptane and the like.


Patent
Nippon Chemiphar Co. and Kyushu University | Date: 2016-05-18

The present invention relates to a compound represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R^(1), R^(2) and R^(3) represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(=O), provided that when X is C, Y represents N, and when X is N, Y represents C(=O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).


The present invention provides an agent for prophylactic treatment, therapeutic treatment, or prevention of metastasis of giant cell tumor occurring in a bone and soft tissue, chondrosarcoma, or bone sarcoma, a local infusion for artery embolization, and an artificial bone, which comprises a substance having a PPAR-agonistic activity and/or a PPAR expression-inducing activity as an active ingredient. The agent for prophylactic treatment, therapeutic treatment, or prevention of metastasis, the local infusion for artery embolization, and the artificial bone of the present invention are a radical therapeutic agent or radical therapeutic material that can cause apoptosis in giant cell tumor occurring in a bone and soft tissue, chondrosarcoma, or bone sarcoma to make the tumor disappear, and can induce differentiation of the tumor into fat cells to make the tumor disappear.


Patent
Nippon Chemiphar Co. | Date: 2016-06-08

The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R^(1 )and R^(2 )represent hydrogen atom and the like, or R^(1 )and R^(2 )bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R^(3 )and R^(4 )represent hydrogen atom and the like, R^(5 )represents hydrogen atom and the like, R^(6 )and R^(7 )represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof and a P2X4 receptor antagonist.


Patent
The Kitasato Institute and Nippon Chemiphar Co. | Date: 2016-01-13

The present invention relates to a morphinan derivative represented by the following general formula (I), wherein R^(1) represents hydrogen, C_(1-6) alkyl, C_(6-10) aryl, etc., R^(2) and R^(3), which are the same or different, represent hydrogen, hydroxy, ect., R^(4) and R^(5) represent hydrogen, C_(1-6) alkyl, etc., R^(6) represents hydrogen, hydroxy, C_(1)-_(6) alkyl, etc., X represents O or CH_(2), Y represents C=O, C(=O)O, etc., and m and n, which are the same or different, represent an integer of 0 to 2 (m and n are not 0 at the same time), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as an analgesic, antianxiety drug, etc. containing the same as an active ingredient.

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