Ningbo Yinzhou Second Hospital

Ningbo, China

Ningbo Yinzhou Second Hospital

Ningbo, China
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Wang H.,Ningbo Yinzhou Second Hospital | Chen Z.,Ningbo Yinzhou Peoples Hospital | Chen Y.,Ningbo Yinzhou Peoples Hospital
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2015

OBJECTIVE: This study was to evaluate the differential diagnostic value of serum Hepcidin in elderly patients with iron deficiency anemia (IDA)and anemia of chronic disease (ACD).METHODS: The group of IDA consisted of 28 elderly patients, and the group of ACD consisted of 21 elderly patients, the control group included 25 healthy elderly people. Hepcidin was measured by ELISA; WBC,RBC counts were assayed by haematology analyzer; the serum ferritin level was measured by using radioimmunoassay; C-reaction protein(CRP) and serum iron levels were assayed by a biochemical analyzer.RESULTS: Hepcidin level between the three groups was significantly different (P < 0.01); serum ferritin,WBC and CRP levels in ACD patients were significantly higher than that in IDA patients (P < 0.01); according to the receivers operating characteristic (ROC) curve, the best threshold in diagnosis of IDA was 93.31 µg/L with the sensitivity of 88% and the specificity of 89%; the best threshold diagnosis of ACD was 130.05 µg/L with the sensitivity of 72% and the specificity of 96%.CONCLUSIONS: serum Hepcidin has a certain value in the differential diagnosis of IDA and ACD in elderly patients.


PubMed | Ningbo No 2 Hospital, Ningbo Yinzhou Second Hospital and Zhejiang Hospital
Type: | Journal: Complementary therapies in medicine | Year: 2016

Report of an uncommon complication of acupuncture and wet cupping.A 54-year-old man presented with neck pain and fever. Magnetic resonance imaging of the cervical spine revealed an epidural abscess at C4 to T2.The symptoms related to epidural abscess resolved partially after treatment with antibiotics.Acupuncture and wet-cupping therapy should be taken into consideration as a cause of spinal epidural abscesses in patients who present with neck pain and fever. Furthermore, acupuncture and wet-cupping practitioners should pay attention to hygienic measures.


目的: 研究酸性成纤维细胞生长因子1(FGF1)纳米脂质体结合超声靶向微泡爆破技术(UTMD)对于糖尿病心肌病(DCM)的治疗效果。 方法: 健康雄性Sprague Dawley大鼠75只,随机数字表法选择15只作为正常对照组(对照组),其余大鼠腹腔注射链脲佐菌素(70 mg/kg)建立糖尿病模型,成模后继续饲养16周,通过超声心动图筛选出DCM大鼠模型。将DCM大鼠按随机数字表法分为4组,即DCM模型组(DCM组,给予生理盐水治疗)、FGF1溶液治疗组(FGF1溶液组)、FGF1纳米脂质体治疗组(FGF1纳米脂质体组)和FGF1纳米脂质体+UTMD治疗组(FGF1纳米脂质体+UTMD组),每组15只。采用水包水型乳化法结合冷冻干燥技术制备FGF1载药纳米脂质体。药物干预2周再继续饲养2周后,采用心导管评价各组大鼠心功能。处死大鼠后取出心肌组织,分别通过Masson胶原染色、TUNEL凋亡染色及CD31免疫组织化学染色测定各组大鼠心肌胶原容积分数(CVF)、心肌凋亡指数及心肌微血管密度(MVD)。 结果: (1)FGF1纳米脂质体质量评价结果:扫描电镜观察空白及载药纳米脂质体均呈标准的椭球形,分散均匀且包封率高稳定性好。(2)各组大鼠心功能的心导管检测结果:FGF1纳米脂质体+UTMD组大鼠左心室收缩末期压力、左心室内压最大上升和下降速率均明显高于DCM组、FGF1溶液组和FGF1纳米脂质体组(P均<0.05),而左心室舒张末期压力则明显低于DCM组、FGF1溶液组和FGF1纳米脂质体组(P均<0.05)。(3)各组大鼠心肌CVF的测定结果:DCM组大鼠心肌CVF明显大于对照组(P<0.05)。FGF1溶液组、FGF1纳米脂质体组和FGF1纳米脂质体+UTMD组大鼠心肌CVF均明显小于DCM组(P均<0.05)。而FGF1纳米脂质体+UTMD组大鼠心肌CVF则进一步小于FGF1溶液组和FGF1纳米脂质体组(P均<0.05)。(4)各组大鼠心肌组织MVD的检测结果:DCM组大鼠心肌组织MVD明显低于对照组(P<0.05)。FGF1溶液组、FGF1纳米脂质体组和FGF1纳米脂质体+UTMD组大鼠心肌组织MVD均明显高于DCM组(P均<0.05)。FGF1纳米脂质体+UTMD组大鼠心肌组织MVD则明显高于FGF1溶液组和FGF1纳米脂质体组(P均<0.05)。(5)各组大鼠心肌细胞凋亡情况的检测结果:DCM组大鼠心肌细胞凋亡指数明显高于对照组(P<0.05)。FGF1溶液组、FGF1纳米脂质体组和FGF1纳米脂质体+UTMD组大鼠心肌细胞凋亡指数均明显低于DCM组(P均<0.05)。而FGF1纳米脂质体+UTMD组大鼠心肌细胞凋亡指数则进一步低于FGF1溶液组和FGF1纳米脂质体组(P均<0.05)。 结论: FGF1纳米脂质体结合UTMD可有效改善DCM大鼠心功能和心肌结构,有望成为治疗DCM的一种新方法。.Objective: The therapeutic effect of acid fibroblast growth factor 1(FGF1) on rats with diabetic cardiomyopathy (DCM) was evaluated by using nano-liposomes combined with ultrasound-targeted microbubble destruction technique (UTMD). Methods: The FGF1-loaded nano-liposomes were prepared by water-in-water emulsion method combined with lyophilization technique.TypeⅠdiabetes model was induced by intraperitoneal injection of streptozotocin (STZ, 70 mg/kg) in 60 male SD rats.Sixteen weeks later, diabetic rats were randomly divided into: placebo group (saline treatment), FGF1 group, FGF1-loaded nano-liposomes group, and FGF1-loaded nano-liposomes plus UTMD group (n=15 each). After two weeks of intervention followed by 2 weeks intervention stop, all rats underwent cardiac catheterization, and the left ventricular end-systolic pressure (LVESP), left ventricular end-diastolic pressure (LVEDP) and the maximal increase/decrease rate of left ventricular pressure (LV±dp/dtmax) were measured.Then, the rats were sacrificed and myocardial tissue were obtained for Masson trichrome staining, TUNEL apoptotic staining and CD31 immunohistochemistry staining to quantify myocardial collagen fraction (CVF), cardiac myocyte apoptotic index and myocardial microvascular density (MVD). Results: (1)Scanning electron microscope results revealed good morphology and FGF1 encapsulation efficiency (84.3±2.8)% with high stability and dispensability of FGF1 loaded nano-liposomes.(2)The hemodynamic evaluation showed that LVESP, LV + dp/dt(max) and LV -dp/dt(max) were all significantly higher, while LVEDP was significantly lower in the FGF1-loaded nano-liposome+ UTMD group than in DCM group, FGF1 solution group, and FGF1 nano-liposome group(all P<0.05). (3)The Masson trichrome staining demonstrated that CVF was significantly higher in all DCM groups than in control group and was significantly lower in the FGF1-loaded nano-liposome+ UTMD group than in DCM group, FGF1 solution group, and FGF1 nano-liposome group (all P<0.05). (4)The CD31 immunohistochemical staining results showed that MVD was significantly lower in all DCM groups than in control group and was significantly higher in the FGF1-loaded nano-liposome+ UTMD group than in DCM group, FGF1 solution group, and FGF1 nano-liposome group (all P<0.05). (5)The TUNEL results showed that apoptotic index was significantly higher in all DCM groups than in control group and was significantly lower in the FGF1-loaded nano-liposome + UTMD group than in DCM group, FGF1 solution group, and FGF1 nano-liposome group (all P<0.05). Conclusion: FGF1 nano-liposomes combining with UTMD technique can significantly improve cardiac functions and attenuate myocardial CVF and apoptosis and enhance myocardial MVD in DCM rats.


Zhao M.,Ningbo Yinzhou Second Hospital | Zhao M.,Zhejiang Provincial Peoples Hospital | Gu Q.,Ningbo Yinzhou Second Hospital | Li C.,Ningbo Yinzhou Second Hospital | And 2 more authors.
International Journal of Clinical and Experimental Pathology | Year: 2014

Cystic lymphangioma of the adrenal gland is a rare and benign lesion, most often found incidentally during abdominal imaging studies, abdominal surgery or at autopsy. We aimed to retrospectively review all adrenal lymphangioma cases at our hospital, further document their lymphatic origin by immunohistochemical staining and discuss the differential diagnosis with other cystic adrenal gland lesions. A total of 3 adrenal lymphangioma cases were identified. All three patients were men and adults at time of diagnosis aged 41 years, 43 years, and 66 years, respectively. All were incidentally identified during investigating for unrelated reasons, two of which were discovered by routine radiologic check-up while the last one was found during imaging detection of ureteral cancer. The average size of an adrenal lymphangioma lesion was 3.2 cm (range, 2.5-4.6 cm). Histologically, all three cases showed a typical multicystic architecture with dilated spaces lined by flattened, bland, simple lining. The cystic spaces occasionally contained proteinaceous material but lacked red blood cell content. On immunohistochemical stains, D2-40 cytoplasmic staining was positive in all three lesions, whereas AE1/AE3 was negative, thus, confirming their lymphatic nature.


Zhao M.,Zhejiang University of Science and Technology | Li C.,Zhejiang University of Science and Technology | Zheng J.,Zhejiang University of Science and Technology | Yan M.,Ningbo Yinzhou Second Hospital | And 2 more authors.
International Journal of Clinical and Experimental Pathology | Year: 2013

Adenomatoid tumors (AT) are uncommon, benign tumors of mesothelial origination most frequently encountered in the genital tracts of both sexes. Their occurrences in the extragenital sites are much rarer and could elicit a variety of differential diagnosis both clinically and morphologically. With regard to the adrenal gland, to the best knowledge of us, only 31 cases of AT have been reported in the English literature. Several histologic growth patterns have been documented in AT, among which cystic type is the least common one. We herein present a further case of AT arising in the adrenal of a 62-year-old Chinese man with a medical history for systemic hypertensive disease. The tumor was incidentally identified during routine medical examination. An abdomen computed tomography scan revealed a solitary mass in the right adrenal. Grossly, the poorly-circumscribed mass measured 3.0 x 3.0 x 2.0 cm with a cut surface showing a gelatinous texture with numerous tiny cystic structures. Microscopic examination showed an infiltrated lesion with honeycomb appearance mimicking a lymphangioma, which composed predominantly of variably sized and shaped anastomosing small cystic spaces lined by flattened endothelial-like cells, without any epithelioid or signet-ring like components present. Foci of extraadrenal tumor extension, lymphoid aggregates with occasional germinal centre formation, intralesional fat tissue, stromal myoid proliferation and ossification were also observed. Immunohistochemical analyses confirmed the mesothelial differentiation of this tumor and indicated a diagnosis of cystic lymphangiomatoid AT of the adrenal.


Zhao M.,Ningbo Yinzhou Second Hospital | Williamson S.R.,Ford Motor Company | Sun K.,Zhejiang University | Zhu Y.,Ningbo Yinzhou Second Hospital | And 6 more authors.
Human Pathology | Year: 2014

Myopericytoma is a benign mesenchymal neoplasm thought to comprise part of a spectrum of perivascular myoid cell neoplasms with myofibroma, angioleiomyoma, and glomus tumor. We describe 2 such neoplasms involving the urinary tract: 1 incidentally identified in the kidney of a 59-year-old woman and 1 in the urinary bladder of a 52-year-old woman who presented with urinary frequency and dysuria. Histologically, the bladder tumor was composed of numerous blood vessels surrounded by plump perivascular myoid cells, as in subcutaneous myopericytoma. The renal tumor showed similar morphology centrally and a symplastic glomus tumor-like growth pattern at the periphery. Immunohistochemically, both tumors were reactive for markers of smooth muscle differentiation, such as smooth muscle actin and caldesmon/calponin but negative for CD34, cathepsin K, and S100 protein. Both patients are free of disease 14 and 39 months after resection, respectively. Our findings broaden the morphologic spectrum of myopericytoma. © 2014 Elsevier Inc.


Zhao M.,Ningbo Yinzhou Second Hospital | Li C.,Ningbo Yinzhou Second Hospital | Zheng J.,Ningbo Yinzhou Second Hospital | Sun K.,Zhejiang University
International Journal of Clinical and Experimental Pathology | Year: 2013

Anastomosing hemangioma is a recently described, unusual variant of capillary hemangioma which seems to be unique for the genitourinary system, with a particular proclivity for the kidney. Histologically, it is characterized by a unique sinusoidal architecture reminiscent of splenic parenchyma that can lead to concern for angiosarcoma. We herein report a further case of anastomosing hemangioma originating in the right kidney of a 48-yearold Chinese man. The patient had a past medical history significant for hepatocellular carcinoma; this tumor was incidentally identified as an asymptomatic right renal mass during the periodical surveillance of the hepatic cancer. The resected tumor measured 2.5cm in maximum diameter and microscopically demonstrated an overall lobulated growth pattern with alternating cellular areas composed of anastomosing sinusoidal capillary-sized vessels lined by hobnail endothelial cells, and edematous, hyaline paucicellular areas. Cytologically the tumor cells were generally bland and exhibited positivity for CD31, CD34 immunohistochemically. The patient had been in a good status without evidence of tumor recurrence 12 months after the surgery. This rare variant renal hemangioma is in need of more recognition and should not be over-diagnosed as a malignance, particularly angiosarcoma.


Zhao M.,Ningbo Yinzhou Second Hospital | Williamson S.R.,Indiana University | Yu J.,Ningbo Yinzhou Second Hospital | Xia W.,Ningbo Yinzhou Second Hospital | And 6 more authors.
Human Pathology | Year: 2013

Hemangioblastoma is a benign, morphologically distinctive neoplasm of disputed histogenesis that typically occurs in the central nervous system either in the setting of von Hippel-Lindau disease or more often sporadically. Extraneural hemangioblastoma is exceptional and raises a challenging differential diagnosis. Herein, we report a primary renal hemangioblastoma occurring in 51-year-old woman without stigmata of von Hippel-Lindau disease. Histologically, the tumor was composed of sheets of polygonal epithelioid stromal cells with ample pale or eosinophilic, vacuolated cytoplasm in an arborizing capillary network. Tumor cells showed variable nuclear pleomorphism, intranuclear cytoplasmic invaginations, scattered hyaline globules, and psammoma-like calcifications. Some areas showed branching hemangiopericytoma- like vessels with tumor cells radiating from the wall, while other areas were edematous and hyalinized with sparse stromal cells and abundant reticular vessels. Immunohistochemically, the tumor cells reacted strongly and diffusely with antibodies to PAX8, CD10, α-inhibin, S100 protein, neuron-specific enolase, and vimentin, and they showed focal positivity with antibodies to epithelial membrane antigen and AE1/AE3. Tumor cells were negative for CK7, CK8/18, RCC antigen, synaptophysin, chromogranin, c-kit, D2-40, HMB45, melan-A, cathepsin K, SMA, desmin, CD31, CD34, and estrogen and progesterone receptors. Positive immunoreactivity for PAX8 is unexpected and contrasts to central nervous system (CNS) hemangioblastomas, which are essentially always negative for PAX8. This novel finding adds support to the hypothesis that the immunoprofile of extraneural hemangioblastoma varies with site of origin, perhaps as a result of tumor cell lineage and retention of organ-specific markers or acquisition of site-specific antigens due to local factors. © 2013 Elsevier Inc.

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