Ningbo Yinzhou Peoples Hospital

Ningbo, China

Ningbo Yinzhou Peoples Hospital

Ningbo, China
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Wang H.,Ningbo Yinzhou Second Hospital | Chen Z.,Ningbo Yinzhou Peoples Hospital | Chen Y.,Ningbo Yinzhou Peoples Hospital
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2015

OBJECTIVE: This study was to evaluate the differential diagnostic value of serum Hepcidin in elderly patients with iron deficiency anemia (IDA)and anemia of chronic disease (ACD).METHODS: The group of IDA consisted of 28 elderly patients, and the group of ACD consisted of 21 elderly patients, the control group included 25 healthy elderly people. Hepcidin was measured by ELISA; WBC,RBC counts were assayed by haematology analyzer; the serum ferritin level was measured by using radioimmunoassay; C-reaction protein(CRP) and serum iron levels were assayed by a biochemical analyzer.RESULTS: Hepcidin level between the three groups was significantly different (P < 0.01); serum ferritin,WBC and CRP levels in ACD patients were significantly higher than that in IDA patients (P < 0.01); according to the receivers operating characteristic (ROC) curve, the best threshold in diagnosis of IDA was 93.31 µg/L with the sensitivity of 88% and the specificity of 89%; the best threshold diagnosis of ACD was 130.05 µg/L with the sensitivity of 72% and the specificity of 96%.CONCLUSIONS: serum Hepcidin has a certain value in the differential diagnosis of IDA and ACD in elderly patients.


PubMed | Ningbo Yinzhou Peoples Hospital and Ningbo Yinzhou Second Hospital
Type: Journal Article | Journal: Zhongguo shi yan xue ye xue za zhi | Year: 2015

This study was to evaluate the differential diagnostic value of serum Hepcidin in elderly patients with iron deficiency anemia (IDA)and anemia of chronic disease (ACD).The group of IDA consisted of 28 elderly patients, and the group of ACD consisted of 21 elderly patients, the control group included 25 healthy elderly people. Hepcidin was measured by ELISA; WBC,RBC counts were assayed by haematology analyzer; the serum ferritin level was measured by using radioimmunoassay; C-reaction protein(CRP) and serum iron levels were assayed by a biochemical analyzer.Hepcidin level between the three groups was significantly different (P < 0.01); serum ferritin,WBC and CRP levels in ACD patients were significantly higher than that in IDA patients (P < 0.01); according to the receivers operating characteristic (ROC) curve, the best threshold in diagnosis of IDA was 93.31 g/L with the sensitivity of 88% and the specificity of 89%; the best threshold diagnosis of ACD was 130.05 g/L with the sensitivity of 72% and the specificity of 96%.serum Hepcidin has a certain value in the differential diagnosis of IDA and ACD in elderly patients.


Shao Y.,Ningbo University | Shao Y.,Zhejiang University | Ye M.,Ningbo University | Jiang X.,Ningbo University | And 12 more authors.
Cancer | Year: 2014

BACKGROUND Long noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA-AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of gastric tumorigenesis. METHODS Total RNA in 860 specimens from patients and healthy controls was extracted. Levels of AA174084 in 134 paired GC tissues, 127 gastric mucosal tissues, 335 plasma samples, and 130 gastric juice samples at each stage of gastric tumorigenesis were measured using real-time reverse transcriptase-polymerase chain reaction analysis. The potential association between AA174084 levels and patients' clinicopathologic features were analyzed. A receiver operating characteristic (ROC) curve was constructed for differentiating GC patients from controls. RESULTS Expression levels of AA174084 were down-regulated significantly in 95 of 134 GC tissues (71%) compared with the levels in paired, adjacent, normal tissues (P <.001). AA174084 levels had significant, negative correlations with age (P =.031), Borrmann type (P =.016), and perineural invasion (P =.032). Plasma AA174084 levels in patients with GC dropped markedly on day 15 after surgery compared with preoperative levels (P <.001) and were associated with invasion (P =.049) and lymphatic metastasis (P =.042). AA174084 levels in gastric juice from patients with GC were significantly higher than the levels in normal mucosa or in patients with minimal gastritis, gastric ulcers, and atrophic gastritis (P <.001). The area under ROC was up to 0.848 (P <.001). CONCLUSIONS AA174084 may have potential as marker for the early diagnosis of GC. © 2014 American Cancer Society.


Cai X.,Lishui Central Hospital | Guan J.,Yanbian University | Ren S.,Lishui Central Hospital | Wei Y.,Lishui Central Hospital | And 3 more authors.
Experimental and Therapeutic Medicine | Year: 2016

Internal carotid artery dissection (ICAD) is a major cause of ischemic stroke in young and middle-aged patients. Patients may be asymptomatic or present with symptoms ranging from headache and neck pain to severe cerebral ischemic events. Conventional treatment is medical anticlotting therapy or involves the use of interventional tools, such as endovascular treatment. Anticoagulation or antiplatelet therapy are the primary treatment modalities used to prevent thromboembolic complications from arterial dissections, however, they are unsuitable in certain cases of dissecting aneurysms. In the current study reports the case of a 52-year-old male patient presenting with the primary complaint of left limb weakness. Computed tomography angiography revealed a right ICAD located in the oropharyngeal segment. Subsequently, digital subtraction angiography was performed to assess the oropharyngeal segment. Antithrombotic therapy resulted in no improvement; therefore, endovascular treatment with the insertion of a Willis covered stent was performed, resulting in an improved outcome. © 2016, Experimental and Therapeutic Medicine. All rights reserved.


PubMed | Lishui Central Hospital, Yanbian University and Ningbo Yinzhou Peoples Hospital
Type: Journal Article | Journal: Experimental and therapeutic medicine | Year: 2016

Internal carotid artery dissection (ICAD) is a major cause of ischemic stroke in young and middle-aged patients. Patients may be asymptomatic or present with symptoms ranging from headache and neck pain to severe cerebral ischemic events. Conventional treatment is medical anticlotting therapy or involves the use of interventional tools, such as endovascular treatment. Anticoagulation or antiplatelet therapy are the primary treatment modalities used to prevent thromboembolic complications from arterial dissections, however, they are unsuitable in certain cases of dissecting aneurysms. In the current study reports the case of a 52-year-old male patient presenting with the primary complaint of left limb weakness. Computed tomography angiography revealed a right ICAD located in the oropharyngeal segment. Subsequently, digital subtraction angiography was performed to assess the oropharyngeal segment. Antithrombotic therapy resulted in no improvement; therefore, endovascular treatment with the insertion of a Willis covered stent was performed, resulting in an improved outcome.


PubMed | Ningbo Yinzhou Peoples Hospital and Ningbo University
Type: | Journal: OncoTargets and therapy | Year: 2016

Epithelial cadherin (encoded by the


Hu Y.,Wenzhou Medical College | Wang H.,Ningbo Yinzhou Peoples Hospital | Chen E.,Wenzhou Medical College | Xu Z.,Wenzhou Medical College | And 2 more authors.
Cancer Medicine | Year: 2016

Thyroid cancer is one of the most common carcinomas of the endocrine system with an increasing incidence. A growing number of studies have focused on the diagnostic and prognostic values of dysregulated microRNAs (miRNAs) in thyroid carcinoma. However, differences in the measurement platforms, variations in lab protocols, and small sample sizes can make gene profiling data incomparable. A meta-review of the published studies that compared miRNA expression data of thyroid carcinoma and paired normal tissues was performed to identify potential miRNA biomarkers of thyroid carcinoma with the vote-counting strategy. Two hundred and thirty-six aberrantly expressed miRNAs were reported in 19 microRNA expression profiling studies. Among them, 138 miRNAs were reported in at least two studies. We also provided a meta-signature of differentially expressed miRNAs between individual histological types of thyroid carcinoma and normal tissues. The experimental validation with qRT-PCR analysis verified that the profiles identified with the meta-review approach could effectively discriminate papillary thyroid carcinoma tissues from paired noncancer tissues. The meta-review of miRNA expression profiling studies of thyroid carcinoma would provide information on candidate miRNAs that could potentially be used as biomarkers in thyroid carcinoma. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.


Wu B.,Zhejiang University | Wu B.,Ningbo Yinzhou Peoples Hospital | Mao J.,Zhejiang University | Shen H.,Zhejiang University | And 6 more authors.
Nephrology | Year: 2015

Aim The treatment strategy for steroid-resistant nephrotic syndrome remains uncertain at present, especially in those with calcineurin inhibitor resistance or intolerance. To date, few studies have been published using multiple combination therapy of immunosuppressive reagents for children with calcineurin inhibitor-resistant or -intolerant nephrotic syndrome.Methods Eighteen consecutive children with steroid- and tacrolimus (TAC)-resistant (n = 10) or TAC-sensitive but frequent relapsing nephrotic syndrome (n = 8) were randomly recruited in the present study. All of them received further triple-combination therapy by cyclophosphamide (CTX, n = 6), mycophenolate mofetil (MMF, n = 5) or leflunomide (LEF, n = 7). Their clinical data were collected and efficacy of triple-combination therapy was evaluated.Results Compared with previous double-combination therapy of prednisone (Pre) and TAC, the short-term remission rate in all 18 patients was significantly improved after the triple-combination therapy, while the frequent relapse rate in the following 12 months was also significantly decreased. Among three different subgroups with CTX, MMF or LEF therapy, no significant difference was found in short-term remission rate and the relapse rate within 1 year follow up by Kaplan-Meier plot.Conclusion Triple-combination therapy with Pre + TAC + CTX/MMF/LEF is effective for short-term response and 1 year remission, without significant additional side-effects seen in children with steroid-resistant and tacrolimus-resistant or tacrolimus-sensitive but frequently relapsing nephrotic syndrome. Further study for evaluating long-term efficacy and safety of triple-combination therapy with Pre + TAC + CTX/MMF/LEF would be necessary for these patients. Summary at a Glance Treatment for children with SRNS is a major concern in the field of paediatric nephrology. The manuscript by Mao et al. described the possible treatment option of triple immunosuppressive therapy (PSL + TAC + MMF or CTX or LEF) to paediatric patients with SRNS. © 2014 Asian Pacific Society of Nephrology.


Shan A.,Ningbo Yinzhou Peoples Hospital | Zhou C.,Ningbo Yinzhou Peoples Hospital | He Y.,Ningbo Yinzhou Peoples Hospital | Feng W.,Ningbo Yinzhou Peoples Hospital | And 2 more authors.
Renal Failure | Year: 2013

Objective: To investigate the expression and clinical significance of both matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (tissue inhibitor of metalloproteinase-2 (TIMP-2)) in tunica media of radial artery in uremic patients. Methods: The modified radial arteries from 80 uremic patients during internal arteriovenous fistula surgery were selected and used as experimental specimens. The calcification of tunica media was observed by alizarin red staining, and the expression status of MMP-2, TIMP-2, osteoprotegerin (OPG), and osteopontin (OPN) in tunica media of radial arteries of these patients was detected by immunohistochemical method. The semiquantitative analysis and comparison were conducted based on the calcification grading and the expression of each test protein in tunica media of radial artery. Results: Of the 80 cases of radial artery specimens, 37 cases were presented with various degrees of calcification of tunica media, and the calcification rate was 46.25%; the expression of MMP-2, TIMP-2, OPG, and OPN could be detected in the calcificated tunica media of the radial artery and was positively correlated with the degree of vascular calcification (p < 0.05). Conclusion: The incidence of vascular calcification in uremic patients was high. The occurrence of calcification in tunica media of the radial artery was correlated with the expression of MMP-2 and TIMP-2. © 2013 Informa Healthcare USA, Inc.


PubMed | Ningbo Yinzhou Peoples Hospital
Type: Comparative Study | Journal: Renal failure | Year: 2013

To investigate the expression and clinical significance of both matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (tissue inhibitor of metalloproteinase-2 (TIMP-2)) in tunica media of radial artery in uremic patients.The modified radial arteries from 80 uremic patients during internal arteriovenous fistula surgery were selected and used as experimental specimens. The calcification of tunica media was observed by alizarin red staining, and the expression status of MMP-2, TIMP-2, osteoprotegerin (OPG), and osteopontin (OPN) in tunica media of radial arteries of these patients was detected by immunohistochemical method. The semiquantitative analysis and comparison were conducted based on the calcification grading and the expression of each test protein in tunica media of radial artery.Of the 80 cases of radial artery specimens, 37 cases were presented with various degrees of calcification of tunica media, and the calcification rate was 46.25%; the expression of MMP-2, TIMP-2, OPG, and OPN could be detected in the calcificated tunica media of the radial artery and was positively correlated with the degree of vascular calcification (p < 0.05).The incidence of vascular calcification in uremic patients was high. The occurrence of calcification in tunica media of the radial artery was correlated with the expression of MMP-2 and TIMP-2.

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