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Zheng D.-W.,Zhejiang University | Zheng D.-W.,Ningbo Medical Center Lihuili Hospital | Shao G.-F.,Ningbo Medical Center Lihuili Hospital | Feng Q.,Zhejiang University | Ni Y.-M.,Zhejiang University
Chinese Medical Journal | Year: 2013

Background Although most patients with tetralogy of Fallot undergo radical repair during infancy and childhood, patients that remain undiagnosed and untreated until adulthood can still be treated. This study aimed to evaluate longterm outcomes of adult patients with tetralogy of Fallot who were treated surgically, and to determine the predictors of postoperative pulmonary regurgitation. Methods Fifty-six adult patients underwent complete surgical repair. Forty-three patients (76.8%) required a transannular patch. Systolic, diastolic, and mean pressure in the main pulmonary artery were measured after repair. Results The early mortality rate was 3.6%. The 16-year survival rate was (84.4±11.5)%. Late echocardiography revealed 41 patients with transannular patch who had pulmonary regurgitation, consisting of mild pulmonary regurgitation in 28 patients, moderate in eight, and severe regurgitation in five patients. In addition, there was right ventricular outflow tract stenosis in nine patients, moderate/severe tricuspid valve regurgitation in seven, and residual ventricular septal defect in five. Logistic regression analysis demonstrated that the mean pulmonary pressure measured just after repair predicted late pulmonary regurgitation. Conclusions The long-term survival of surgically treated adult patients with tetralogy of Fallot is acceptable. The mean pressure >20 mmHg in the main pulmonary artery measured right after surgical repair may be a feasible reference to time the reconstruction of the pulmonary valve. Source


Wu Q.P.,Ningbo Medical Center Lihuili Hospital
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology | Year: 2012

To explore the diagnostic value of the measurement of serum Golgi protein 73 (GP73) in the diagnosis of hepatocellular carcinoma (HCC). Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum GP73 in the 81 cases of HCC, 71 cases of chronic hepatitis or cirrhosis (CH/LC) and 65 cases of healthy blood donors, and to evaluate the sensitivity and specificity in the diagnosis of HCC through the ROC curves. The average levels of serum GP73 in HCC, CH/LC and Normal groups were (152.67 +/- 33.59) ng/ml, (93.15 +/- 20.02) ng/ml and (58.95 +/- 17.29) ng/ml(o) After calculating through the ROC curves, 120 ng/ml was set as the optimal cut-off point, GP73 has a sensitivity of 77.80% and a specificity of 78.00%. GP73 as a serum marker in the diagnosis of HCC had a higher sensitivity than AFP, and the combined detection of GP73 and AFP could improve HCC diagnosis. Source


Li N.,Ningbo Medical Center Lihuili Hospital | Lian J.,Ningbo Medical Center Lihuili Hospital | Zhao S.,Yinzhou Second Hospital | Zheng D.,Ningbo Medical Center Lihuili Hospital | And 10 more authors.
BioMed Research International | Year: 2015

This study compared microRNA (miRNA) expression profiles between rheumatic heart disease (RHD) patients and healthy controls to investigate their differential expression and help elucidate their mechanisms of action. Microarray analysis was used to measure miRNA expression, and a total of 133 miRNAs were shown to be significantly upregulated in RHD patients compared with controls, including miR-1183 and miR-1299. A total of 137 miRNAs, including miR-4423-3p and miR-218-1-3p, were significantly downregulated in RHD patients. Quantitative real-time-PCR confirmed microarray findings for miR-1183 and miR-1299 in both tissue and plasma. Bioinformatic predictions were also made of differentially expressed miRNAs as biomarkers in RHD by databases and GO/pathway analysis. Furthermore, we investigated miR-1183 and miR-1299 expression in RHD patients with secondary pulmonary hypertension (PAH). Our findings identified an important role for miR-1299 as a direct regulator of RHD, while the observed difference in expression of miR-1183 between RHD-PAH patients with high or low pulmonary artery pressure suggests that miR-1183 overexpression may reflect pulmonary artery remodeling. miR-1183 and miR-1299 appear to play distinct roles in RHD pathogenesis accompanied by secondary PAH and could be used as potential biological markers for disease development. © 2015 Ni Li et al. Source


Dong H.,Ningbo Medical Center Lihuili Hospital | Xu H.,Ningbo Medical Center Lihuili Hospital | Zhang Y.,Ningbo Medical Center Lihuili Hospital | Li Y.,Ningbo Medical Center Lihuili Hospital | Li H.,Ningbo Medical Center Lihuili Hospital
National Medical Journal of China | Year: 2014

Objective: To compare the application value between reduced field-of-view diffusion weighted imaging (rFOV DWI) and single-shot echo-planar-imaging diffusion weighted imaging (SS-EPI DWI) of the breast. Methods: 78 cases (68 normal breast, 10 breast cancer) were canned with SS-EPI DWI (FOV 360 mm × 360 mm), rFOV DWI1 (FOV 360 mm × 180 mm) and rFOV DWI2 (FOV 280 mm × 140 mm). Image quality and ADC values of breast were compared with three groups. SNR were compared with rFOV DWI1 and rFOV DWI2. Results: The image quality score of 78 cases was 4.74 by rFOV DWI1, 3.59 by SS-EPI DWI and 3.55 by rFOV DWG. The mean ADC value of 68 normal breast was 1.832 × 10-3 mm2/s by SS-EPI DWI, 1.701 × 10-3 mm2/s by rFOV DWI1 and 1.615 × 10-3 mm2/s by rFOV DWI2. The mean ADC value of 10 breast cancer was 1.345 × 10-3 mm2/s by SS-EPI DWI, 1.220 × 10-3 mm2/s by rFOV DWI1 and 1.149 × 10-3 mm2/s by rFOV DWT2. SNR of rFOV DWI1 images was much higher than FOV DWI2. Conclusion: Sizeable rFOV DWI has higher resolution, less distortion than SS-EPI DWI, rFOV DWI will be useful in the diagnosis of the breast diseases. Copyright © 2014 by the Chinese Medical Association. Source


Jin C.-H.,Ningbo Medical Center Lihuili Hospital | Liu K.,Ningbo Medical Center Lihuili Hospital | Yu K.-Z.,Ningbo Medical Center Lihuili Hospital | Tian H.,Ningbo Medical Center Lihuili Hospital | And 2 more authors.
Thoracic and Cardiovascular Surgeon | Year: 2014

Objective The objective of this study is to assess the use of a novel, double-lumen electrocautery tube (DLET) device for ablating the sympathetic nerve chain in patients with primary palmar hyperhidrosis (PPH). Methods Forty-six patients with severe PPH were recruited into the study between November 2010 and February 2012. All patients underwent single port, bilateral video-assisted thoracoscopic sympathicotomy. Twenty-four patients were randomized to receive sympathicotomy using a conventional 5-mm electrocautery hook (hook group) and 22 patients were randomized to the DLET group. Results The mean postoperative follow-up period was 8.1 months (range: 1 to 15 months). After surgery the hands of all patients became dry and warm. Mean incision size was 10.6 ± 1.0 in the hook group and 6.5 ± 0.5 mm in the DLET group (p = 0.001). The mean pain score was 1.4 ± 0.6 with hook surgery and 0.9 ± 0.6 with the DLET device (p = 0.016). The mean operative time was longer in the hook group (36.8 ± 3.4 min) than in the DLET group (30.5 ± 3.9 min; p = 0.001). There were no significant differences between the two procedures in terms of hospital stay and compensatory sweating, or patient satisfaction. Pneumothorax occurred in two (8.3%) patients in the hook group and in one (4.5%) patient in the DLET group. None of the patients required chest drainage and none developed Horner syndrome. Conclusions Single-port video-assisted thoracoscopic sympathicotomy using hook or DLET procedures is effective, safe, and minimally invasive method for palmar hyperhidrosis. The DLET device allows a shorter operation time, smaller incision, better cosmetic results, less pain, and better clarity of video, making it suitable for single-port thoracoscopic sympathicotomy. © Georg Thieme Verlag KG Stuttgart · New York. Source

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