Ningbo Fourth Hospital

Xiangshan, China

Ningbo Fourth Hospital

Xiangshan, China

Time filter

Source Type

Fang J.,Ningbo Fourth Hospital | Chen C.,Ningbo Fourth Hospital | Cheng H.,Ningbo Fourth Hospital | Wang R.,Ningbo Fourth Hospital | Ma L.,Shanghai Changzheng Hospital
American Journal of Emergency Medicine | Year: 2017

Purpose: The objective of this study was to assess the efficacy of paracetamol (acetaminophen) on body temperature in acute stroke. Methods: Medline, Cochrane Central Register of Controlled Trials, EMBASE, Chinese BioMedical Literature Database, China National Knowledge Infrastructure, and the World Health Organization (WHO) International Clinical Trials Registry Platform were searched electronically. Relevant journals and references of studies included were hand-searched for randomized controlled trials (RCT) and controlled clinical trials (CCT) regarding the efficacy of paracetamol (acetaminophen) on body temperature in acute stroke. Two reviewers independently performed data extraction and quality assessment. Data were analyzed using RevMan 5.3 software by the Cochrane Collaboration. Results: Five studies were included. To compare the efficacy of paracetamol (acetaminophen) in acute stroke, the pooled RR (Risk Ratio) and its 95% CI of body temperature reduction at 24. h from the start of treatment were -0.3 (95% CI: -0.52 to -0.08), with statistical significance (P = 0.007). Consistently, the pooled RR (Risk Ratio) and its 95% CI of body temperature at 24. h from the start of treatment were -0.22 (-0.29, -0.15), with statistical significance (P. <. 0.00001). When analyzing the body temperature reduction after 5. days from the start of treatment, the pooled RR (Risk Ratio) and its 95% CI were 0.04 (95% CI: -0.20 to 0.29), with no statistical significance (P = 0.73). For functional outcome (mRS. ≤. 2) analysis, the pooled RR and its 95% CI were 1.08 (0.88, 1.32), with no statistical significance (P = 0.45). In addition, the difference of serious adverse events between acetaminophen and placebo was 0.86 (95% CI: 0.62 to 1.2), with no statistical significance (P = 0.27). Conclusion: Acetaminophen was revealed to have some favorable influence in body temperature reduction in acute stroke, but showed no important effect on improving functional outcome and reducing adverse events of patients. What this paper adds: What is already known on this subject?Paracetamol (acetaminophen) is one of the most commonly used antipyretic drugs and has some capability to reduce body temperature through acting on central nervous system. What this study adds: Acetaminophen showed some capability to decrease body temperature for acute stroke.Acetaminophen could not improve functional outcome and reduce adverse events of patients with acute stroke. © 2017 Elsevier Inc.


Hu L.,Wenzhou University | Wang F.,Peking University | Xu J.,Wenzhou University | Wang X.,Wenzhou University | And 11 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Nonalcoholic fatty liver disease (NAFLD) is often associated with dyslipidemia. Metabolic disequilibrium, resulting from being overweight and obesity, increases risk to cardiovascular system and chronic liver disease. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) are standard clinical markers for liver injury. In this study, we examined association of body mass index (BMI) and metabolic markers with serum ALT, AST and GGT activity in an overweight and obese Chinese population. A total of 421 overweight and obese Chinese adults (211 males and 210 females) from The First Affiliated Hospital of Wenzhou Medical University were recruited in this study in 2014. All participants underwent anthropometric measures and phlebotomy after an overnight fast. Elevated ALT, AST and GGT levels were found in 17%, 5% and 24%, respectively. There were significant correlations between ALT and BMI, plasma triglycerides (TG), cholesterol, HDL and glucose, and between AST and plasma TG and cholesterol. GGT also correlated with plasma TG, cholesterol and glucose. The levels of ALT, AST and GGT could be predicted by BMI, plasma TG, cholesterol, HDL and glucose using the back propagation artificial neural network model (BP-ANN). These data suggest that abnormal metabolic markers could be used to monitor liver function to determine whether liver damage has occurred in overweight and obese individuals. This approach has clinical utility with respect to early scanning of liver injury or NAFLD based on routinely available metabolic data in overweight and obese population. © 2015, E-Century Publishing Corporation. All rights reserved.


Wang J.,Wenzhou University | Wang F.,Peking University | Liu Y.,Wenzhou University | Xu J.,Wenzhou University | And 6 more authors.
Experimental and Clinical Endocrinology and Diabetes | Year: 2016

Background: Overweight individuals are at higher risk for developing type II diabetes than the general population. We conducted this study to analyze the correlation between blood glucose and biochemical parameters, and developed a blood glucose prediction model tailored to overweight patients. Methods: A total of 346 overweight Chinese people patients ages 18-81 years were involved in this study. Their levels of fasting glucose (fs-GLU), blood lipids, and hepatic and renal functions were measured and analyzed by multiple linear regression (MLR). Based the MLR results, we developed a back propagation artificial neural network (BP-ANN) model by selecting tansig as the transfer function of the hidden layers nodes, and purelin for the output layer nodes, with training goal of 0.5×10-5. Results: There was significant correlation between fs-GLU with age, BMI, and blood biochemical indexes (P<0.05). The results of MLR analysis indicated that age, fasting alanine transaminase (fs-ALT), blood urea nitrogen (fs-BUN), total protein (fs-TP), uric acid (fs-BUN), and BMI are 6 independent variables related to fs-GLU. Based on these parameters, the BP-ANN model was performed well and reached high prediction accuracy when training 1 000 epoch (R=0.9987). Conclusions: The level of fs-GLU was predictable using the proposed BP-ANN model based on 6 related parameters (age, fs-ALT, fs-BUN, fs-TP, fs-UA and BMI) in overweight patients. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart New York.


Kang Y.,Inner Mongolia University | Wang F.,Peking University | Li C.,Inner Mongolia University | Hu L.,Wenzhou University | And 11 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Objective: Excessive and chronic alcohol use has been associated with damage to major organs and is a leading cause of death in industrialized countries. Research has indicated that alcohol dependence (AD) is related to both heritable and environmental factors. Previous studies have suggested that neuropeptide Y receptors (NPYR) are associated with AD, however, few studies have investigated the associations between NPY2R gene variants and AD in detail. The present study evaluated the association between NPY2R gene variations and AD in a genetically homogeneous Chinese Han population. Methods: All of AD patients were diagnosed using Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria, and the two single nucleotide polymorphisms (SNPs) of NPY2R were genotyped in healthy controls (n = 633) and AD patients (n = 547) using the TaqManTM probe. The two SNPs selected, rs6857715 and rs4425326, were located on the 5’-flanking region of NPY2R. Results: The allele and genotype frequencies of all loci did not significantly differ between controls and AD patients (P > 0.05). Interestingly, linkage disequilibrium analysis revealed that one possible haplotype is present between in rs6857715 and rs4425326 on NPY2R gene (D’ = 0.974, r2 = 0.488). Conclusion: These results suggest that the two SNPs of the NPY2R gene do not play a role in the northern Chinese Han population with AD. © 2016, E-Century Publishing Corporation. All rights reserved.


PubMed | Ningbo Fourth Hospital, Wenzhou University, Inner Mongolia University and Peking University
Type: Journal Article | Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association | Year: 2016

Overweight individuals are at higher risk for developing type II diabetes than the general population. We conducted this study to analyze the correlation between blood glucose and biochemical parameters, and developed a blood glucose prediction model tailored to overweight patients.A total of 346 overweight Chinese people patients ages 18-81 years were involved in this study. Their levels of fasting glucose (fs-GLU), blood lipids, and hepatic and renal functions were measured and analyzed by multiple linear regression (MLR). Based the MLR results, we developed a back propagation artificial neural network (BP-ANN) model by selecting tansig as the transfer function of the hidden layers nodes, and purelin for the output layer nodes, with training goal of 0.510(-5).There was significant correlation between fs-GLU with age, BMI, and blood biochemical indexes (P<0.05). The results of MLR analysis indicated that age, fasting alanine transaminase (fs-ALT), blood urea nitrogen (fs-BUN), total protein (fs-TP), uric acid (fs-BUN), and BMI are 6 independent variables related to fs-GLU. Based on these parameters, the BP-ANN model was performed well and reached high prediction accuracy when training 1000 epoch (R=0.9987).The level of fs-GLU was predictable using the proposed BP-ANN model based on 6 related parameters (age, fs-ALT, fs-BUN, fs-TP, fs-UA and BMI) in overweight patients.


PubMed | Ningbo Fourth Hospital, University of Wollongong, Xiangyang Central Hospital, Beijing Hui Long Guan Hospital and 4 more.
Type: | Journal: Neuroscience letters | Year: 2016

Alcohol dependence (AD) is a common chronic brain disorder precipitated by complex interactions between biological, genetic, and environmental risk factors. Aggression often occurs in the context of AD. Previous studies have shown that Oxytocin (OXT) and OXT receptor (OXTR) are involved in the regulation of aggression. The present study investigated whether variations and interactions of OXT and OXTR genes were associated with AD-related aggression in a genetically homogeneous northern Chinese Han population.Three hundred and twenty-four male AD patients and 510 male healthy controls (HCs) were recruited. A Chinese version of the Buss-Perry Aggression Questionnaire was used as a subjective measurement of aggressive behavior. Three variations, rs2254298, rs53576, and rs6133010 were genotyped using TaqMan and ligase detection reaction for all subjects. Generalized Multifactor Dimensionality Reduction was used to detect interactions between genetic attributes and environmental attributes.The frequencies of alleles and genotypes of rs6133010 were significantly different between AD patients and HCs (p<0.001). In HCs, the effect of genotype GG of rs53576 on hostility aggression was significantly stronger than that of genotype AA and AG (p=0.001 and p=0.004, respectively), and the subjects with the interaction combination of rs6133010AArs2254298GGrs53576AG exhibited significant effect on physical aggression (p=0.0107).The present study found that rs6133010 in the OXT gene is associated with AD in the northern Chinese Han population. The polymorphisms of OXT/R may play a key role in the susceptibility of AD-related aggression.


Yang X.,Beijing Jishuitan Hospital | Hu L.,Wenzhou University | Kang Y.,Inner Mongolia University | Xu J.,Wenzhou University | And 11 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Background and aims: The hepatokine fibroblast growth factor 21 (FGF21) is induced in patients with metabolic diseases. FGF21 is part of a complex network of hormones that includes adiponectin, leptin and neuropeptide Y (NPY). This network modulates energy metabolism, particularly glucose and lipid metabolism. Nevertheless, our understanding of these hormones and their interrelationships in different organs remains incomplete. The current study investigated relationships between the metabolic regulators FGF21, adiponectin, leptin and NPY in the cerebrospinal fluid (CSF) of Chinese subjects. Materials and methods: Sixty-nine subjects (37 males and 32 females) were recruited for this study. The CSF levels of FGF21, adiponectin, leptin and NPY were measured in all patients by radioimmunoassay. Results: Significant differences were not observed between male and female subjects in the CSF levels of FGF21, adiponectin, leptin and NPY. However, our measurements indicate the existence of positive linear correlations between the CSF concentrations of these metabolic regulators. Conclusions: The CSF concentrations of each of the metabolic regulators investigated in this study could be predicted using the concentrations of the other three regulators and back propagation artificial neural networks (BP-ANN). Our observations have important implications for our current understanding of these molecules. Additionally, these findings may serve as the basis for future analysis of the roles played by these metabolic regulators in hormonal network regulation in the central nervous system. © 2016, E-Century Publishing Corporation. All rights reserved.


PubMed | Inner Mongolia University, Henan Provincial Peoples Hospital, Ningbo Fourth Hospital and Wenzhou University
Type: Journal Article | Journal: Balkan journal of medical genetics : BJMG | Year: 2016

Thyroid cancer is a very common form of endocrine system malignancy. To date, the molecular mechanism underlying thyroid cancer remains poorly understood. Studies of oncocytic tumors have led to a hypothesis which proposes that defects in oxidative phosphorylation (OX- PHOS) may result in a compensatory increase in mitochondrial replication and gene expression. As a result, mitochondrial DNA (mtDNA) mutation analysis has become a useful tool to explore the molecular basis of this disease. Among these mutations, mitochondrial transfer RNAs (mttRNAs) are the hot spots for pathogenic mutations associated with thyroid cancer. However, due to its high mutation rate, the role of mt-tRNA variants in thyroid cancer is still controversial. To address this problem, in this study, we reassessed seven reported mt-tRNA variants: tRNA


PubMed | Ningbo Fourth Hospital, Henan Provincial Peoples Hospital, Inner Mongolia University, Wenzhou University and Beijing Jishuitan Hospital
Type: Journal Article | Journal: Neuro endocrinology letters | Year: 2016

Oxytocin (OT) is primarily synthesized in the paraventricular nucleus of the hypothalamus and supraoptic nucleus of the hypothalamus in the central nervous system and exhibits a wide spectrum of central and peripheral activities. OT is involved in lipid metabolism and glucose homeostasis and plays a protective role against liver damage.In this study, we investigated whether CSF OT levels correlates with peripheral glucose, lipid profiles, and/or liver enzymes in Chinese subjects. Sixty-nine subjects (n=36 males; n=33 females) who were recruited from Beijing Jishuitan Hospital participated in the study. Their levels of CSF OT and peripheral parameters were assayed by radioimmunoassay and continuous monitoring assay, respectively.There was no significant difference in CSF OT levels between males (53.096.88 nmol/mL) and females (52.346.87 nmol/mL), and no correlation found between CSF OT levels and peripheral glucose and lipid profiles. Significant negative correlation was observed between CSF OT levels and peripheral ALT and AST concentration in females but not in males.Our results support the physiological role of neuropeptides acting on brain sites to regulate liver enzymes, and shed new light on the brain-liver interaction.


PubMed | Inner Mongolia University, Shaoxing University, Henan Provincial Peoples Hospital, Ningbo Fourth Hospital and Wenzhou University
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2016

Mitochondrial DNA mutations have been found to play important roles in carcinogenesis. The most common G10398A mutation, a non-conservative amino acid substitution from Thr to Ala, seems to be involved in the tumorigenesis of breast cancer. Results from studies concerning this mutation remain inconclusive. In the current study, we first took clinical and molecular datasets from case-control studies to determine the association between the G10398A mutation and breast cancer. We further used the Phylotree to determine the haplogroups of this mutation. The frequencies of this mutation in 500 unrelated healthy controls were also screened. We found that this mutation is very common in the human population, and may be a polymorph.

Loading Ningbo Fourth Hospital collaborators
Loading Ningbo Fourth Hospital collaborators