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Huang Z.,Lihuili Hospital of Ningbo Medical Center | Zhang X.,Lihuili Hospital of Ningbo Medical Center | Lu H.,Lihuili Hospital of Ningbo Medical Center | Wu L.,Lihuili Hospital of Ningbo Medical Center | And 3 more authors.
BMC Gastroenterology | Year: 2014

Background: The search for better non-invasive biomarkers for gastric cancer remains ongoing. We investigated the predictive power of serum trefoil factor (TFF) levels as biomarkers for gastric cancer in comparison with the pepsinogen (PG) test.Methods: Patients with gastric cancer, chronic atrophic gastritis (CAG) or chronic non-atrophic gastritis (CNAG), and healthy people were recruited. Serum concentrations of TFFs, PG I, and PG II, as well as the presence of antibodies against Helicobacter pylori, were measured by enzyme-linked immunosorbent assays (ELISA). Receiver operating characteristics (ROC) were used to compare the predictive powers of the selected factors.Results: The serum concentrations of TFF1, TFF2, and TFF3 in the control groups were significantly lower than those in the gastric cancer group with the exception of TFF2 which was elevated in CAG. The area under the ROC curve for TFF3 was greater than that for the PG I/II ratio (0.81 vs 0.78). TFF3 also had a significantly higher predictive power for distinguishing gastric cancer than the PG test (odds ratio: 10.33 vs 2.57). Moreover, combining the serum TFF3 and PG tests for gastric cancer had better predictive power than either alone.Conclusions: Serum TFF3 may be a better predictor of gastric cancer than the PG test, while the combined testing of serum PG and TFF3 could further improve the efficacy of gastric cancer screening. © 2014 Huang et al.; licensee BioMed Central Ltd. Source


Gan Y.-L.,Ningbo Diagnostic Pathology Center | Ge R.,Ningbo Diagnostic Pathology Center
Journal of Practical Oncology | Year: 2013

To summarize experience from frozen section diagnosis of lung lesions. The data of 427 lung lesions frozen section diagnoses were analyzed retrospectively. The accurate rate of the frozen section method for lung lesions was 96.7%, the uncertain rate 0.9%, the inaccurate rate 2.3%. In the 10 misdiagnosed cases, the lesions with the highest misdiagnosis rate were sclerosing hemangioma (36.4%), adenocarcinoma (3.9%) and squamous cell carcinoma (1.7%). Frozen section can be an effective method in histologic diagnosis of lung lesions during operation. Comprehensive clinical data, sufficient specimen and careful observation are the basis of correct diagnosis. The rich pathological knowledge and abundant practical experience of pathologists are the key in assuring the accuracy of frozen section diagnosis. Source


Gan Y.-L.,Ningbo Diagnostic Pathology Center | Ge R.,Ningbo Diagnostic Pathology Center | Ding J.-H.,Ningbo Medical Center Li Huili Hospital | Liu C.-F.,Ningbo Diagnostic Pathology Center
Journal of Practical Oncology | Year: 2013

To investigate the clinicopathologic features and prognosis of encapsulated papillary carcinoma (EPC). The clinical presentation and pathological characteristics of 15 cases (1 male and 14 females) with breast EPC were analyzed and followed up. The typical tissue was chosen for immunohistochemical staining. Fifteen patients aged from 40 to 79 years, and the mean age was 64 years. The tumor had a diameter of 1.5~6.0 cm with an averaged of 3.4 cm. Histologically, the EPC was enclosed by a rim of fibrous connective tissue and the majority were demonstrated as papillary architecture, composed of columnar epithelial cells with disorderly arrangement and absence of myoepithelium. Some neoplastic epithelium appeared as solid, cribriform hyperplasia and micropapillary growth, containing slender fibrovascular stalks. Immunohistochemically, the tumor cells were diffusely strong positive for ER and PR, but negative for myoepithelial markers such as CK5/6, p63 and calponin within and at the periphery of the tumor. The Ki-67 labeling index was 5%~30%. Twelve patients were available during a 5 to 48 months follow-up, and only one patient with microinvasion undergone recurrence. EPC can be regarded as a special type of invasive carcinoma, characterized by indolent behavior and excellent prognosis, and can be treated similar to the therapy of ductal carcinoma in situ. Source


Ruan Y.-J.,Ningbo Diagnostic Pathology Center | Pan D.,Ningbo Diagnostic Pathology Center | Xia Z.-X.,Ningbo Diagnostic Pathology Center
Journal of Practical Oncology | Year: 2013

To study the values of immunocytochemistry staining by cell block sections in pleural effusion of patients with pulmonary and pleural malignant tumors. The samples of malignant pleural effusions were collected and made into cell blocks. PV-600 immunohistochemical technique was used to detect the expression of TTF-1, CK5/6, CK7, CEA, p63, D2-40, WT-1, Calretinin, CD56, Syn and CgA. TTF-1 strongly expressed in 14/14 cases of pulmonary adenocarcinoma, in which CK7 expressed in 12/14 cases. In 2 cases of malignant mesothelioma, D2-40, CK5/6, Calretinin were positively expressed, and WT-1 was positive in one case. CK5/6 and p63 were positively expressed in one case of pulmonary squamous cell carcinoma. All the antibodies were negative in 2 cases of metastasis carcinoma. Combined detection of TTF-1, CK7, CEA; CK5/6, p63; D2-40, WT-1, Calretinin, CK5/6; CD56, Syn, CgA shows a high specificity and sensitivity for primary pulmonary adenocarcinoma, pulmonary squamous cell carcinoma, mesothelioma and small cell carcinoma, which can be used as the routine primary antibodies for differential diagnosis of the primary origins of tumor cells in pleural fluid. Source


Fang J.-C.,Ningbo Diagnostic Pathology Center | Zhou J.,Ningbo Diagnostic Pathology Center | Li Z.,Ningbo Diagnostic Pathology Center | Xia Z.-X.,Ningbo Diagnostic Pathology Center
Diagnostic Pathology | Year: 2014

Natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report a case of 'nasal type' NK/T cell lymphoma arising in the uterus with adenomyosis in a 41-year-old woman with fever and hypogastralgia. The histologic analysis demonstrated a highly aggressive tumor with characteristic angiocentric/angiodestructive growth pattern and focal necrosis. The lymphoma cells displayed a CD3ε{lunate}/CD56/TIA-1/granzyme-B/Perforin-positive and CD20/CD79a/CD4/CD8-negative immunophenotype and positive for Epstein-Barr virus by EBER in situ hybridization. Clinically, the disease was limited to the uterus at the initial diagnosis, but progressed rapidly. The patient died on day 54 after hysterectomy, irrespective of intensive chemotherapy. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1323474831125945. © 2014 Fang et al.; licensee BioMed Central Ltd. Source

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