Ningbo Academy Of Inspection And Quarantine Of The Pr China

Ningbo, China

Ningbo Academy Of Inspection And Quarantine Of The Pr China

Ningbo, China
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Li K.,Shanghai Ocean University | Li K.,Copenhagen University | Liu L.,Shanghai Ocean University | Zhan J.,Ningbo Academy Of Inspection And Quarantine Of The Pr China | And 4 more authors.
Science of the Total Environment | Year: 2017

Antimicrobial contamination in aquaculture products constitutes a food safety hazard, but little is known about the introduction and accumulation of antimicrobials in integrated fish-pig aquaculture. This study, conducted in 2013, aimed to determine the residues of 11 types of antimicrobials by UPLC-MS/MS analysis in fish feed (n = 37), pig feed (n = 9), pig manure (n = 9), pond sediment (n = 20), fish skin (n = 20) and muscle tissue (n = 20) sampled from integrated tilapia-pig farms, non-integrated tilapia farms and fish feed supply shops. There was a higher occurrence of antimicrobial residues in fish skin from both integrated and non-integrated farms, and in pig manure. Enrofloxacin (3.9–129.3 μg/kg) and sulfadiazine (0.7–7.8 μg/kg) were commonly detected in fish skin and muscle, pig manure and pond sediment from integrated farms, with different types of antimicrobials found in pig manure and tilapia samples. In non-integrated farms, sulfadiazine (2.5–89.9 μg/kg) was the predominant antimicrobial detected in fish skin and muscle, fish feed and pond sediment. In general, antimicrobials seemed not to be commonly transmitted from pig to fish in tilapia-pig integrated farms, and fish feed, pig feed and pond sediment did not seem as important sources of the antimicrobials found in fish from both systems. The frequent findings of antimicrobial residues in fish skin compared with fish muscle was probably due to different pharmacokinetics in different tissue types, which have practical food safety implications since antimicrobial residues monitoring is usually performed analyzing mixed skin and fish muscle samples. © 2017 Elsevier B.V.


Zhan J.,Ningbo Academy Of Inspection And Quarantine Of The Pr China | Zhan J.,Zhejiang University | Xu D.-M.,Ningbo Academy Of Inspection And Quarantine Of The Pr China | Wang S.-J.,Ningbo Academy Of Inspection And Quarantine Of The Pr China | And 7 more authors.
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment | Year: 2013

A quantitative multi-class analytical method covering more than 226 veterinary drugs and other contaminants in muscle, belonging to different drug families, was developed. The method is based on liquid-liquid extraction, purification by low-temperature clean-up and dispersive solid-phase extraction (D-SPE), and analysis was conducted in two analytical runs by column-switching UPLC coupled with electrospray ionisation and tandem mass spectrometry (UPLC-ESI-MS/MS). For most of the target analytes, the optimised pre-treatment processes led to no significant interference from the sample matrix. The limit of quantification varied from 0.05 to 10 μg kg-1. Statistical evaluation indicated that average recoveries spiked into pork were in the range from 62.4% to 138.8%, and the relative standard deviations were in the range from 2.8% to 26.6% (intra-day precision). The availability of this method will contribute to a better safety assurance of meat with a significant reduction of both effort and time. © 2013 Taylor & Francis.

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