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Jaipur, India

NIMS University is a Private university located in Jaipur, Rajasthan, India. Wikipedia.

Bansal V.K.,NIMS University | Goel R.K.,Punjabi University
Asian Pacific Journal of Tropical Medicine | Year: 2012

Objective: To systematically evaluate antiulcer potential of Acacia nilotica in different ulcer models in rats. Methods: Different extracts [ethanolic, 50% hydroethanolic (50:50), 70% hydroethanolic (70:30) and aqueous] of young seedless pods were examined in pylorus ligation induced gastric ulcers in rats. Various parameters like, volume of gastric acid secretion, pH, free acidity, total acidity, ulcer index, mucin content and antioxidant studies were determined and were compared between extract treated, standard and vehicle control following ulcer induction. The most active extract was also evaluated in swimming stress induced and NSAID induced gastric ulceration. Results: Among different extracts of young seedless pods only hydroethanolic extracts showed significant antiulcer activity in pyloric ligation induced ulceration. Even more the 70% hydroethanolic extract showed better protection as compared to 50% hydroethanolic extract. Further 70 % hydroethanolic extract also showed significant mucoprotection in swimming stress induced and nonsteroidal antiinflammatory drugs induced gastric ulceration. Conclusion: The results of present study concluded that the hydroethanolic extract of young seedless pods of Acacia nilotica has antiulcer activity in pylorus ligation, swimming stress and NSAID induced rat ulcer models. The extract containing more amount of phenolic components show high antiulcer activity, indicating the phenolic component of the extract to be responsible for the activity of the extracts. © 2012 Hainan Medical College. Source

Singh S.,NIMS University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To characterize thermal property of natural gums obtained from the seeds of Diospyros melonoxylon (D. melonoxylon) Roxb, Buchanania lanzan (B. lanzan) spreng and Manilkara zapota (M. zapota) (Linn.) P. Royen syn. Methods: Natural gums were thermally characterized using differential scanning calorimetry (DSC), differential thermal analysis (DTA) and thermo-gravimetric analysis (TGA) under nitrogen atmosphere. Major thermal transitions as well as activation energies of the major decomposition stages were determined. Elemental analysis was performed in order to determine the composition of carbon, hydrogen, nitrogen and sulfur. Results: DSC traces indicated a major intense exothermic transition (around 200 °C) followed by weaker exotherm(s). Thermogravimetric analysis showed two phase of weight loss. The first phase has minor weight loss in samples is attributed to the loss of adsorbed and structural water of biopolymers or due to desorption of moisture as hydrogen bound water to the saccharide structure. The second weight loss event may be attributed to the polysaccharide decomposition. The initial decomposition temperature (IDT) was calculated from thermograms obtained of TGA, seed Polysaccharide of D. melonoxylon (IDT 221.21 °C), B. lanzan (IPDT 170.4 °C) and M. zapota (IPDT 178.6 °C) were obtained. According to the integral procedural decomposition temperature (IPDT) values calculated based on the TGA thermograms; D. melonoxylon (IPDT 563.3 °C), B. lanzan (IPDT 598.1 °C) and M. zapota (IPDT 600.6 °C) were obtained respectively. The elemental analysis study shows that the isolated natural Polysaccharides consist of certain percentage of carbon, nitrogen, sulphur and hydrogen in all the gums. Conclusions: The results of the present investigation reveal that the natural gums are thermally stable and these gums can be used as release modifiers in various dosage forms. © 2012 Asian Pacific Tropical Biomedical Magazine. Source

Tomar B.S.,NIMS University
Indian Journal of Pediatrics | Year: 2014

Intolerance to foods which contain lactose can cause a range of intestinal and systemic symptoms. These symptoms are caused by Lactase deficiency which is encoded by a single gene (LCT) of ≈ 50 kb located on chromosome 2q21. In some food items, lactose has been missed because of "hidden" lactose due to inadequately labeled, confusing diagnosis of lactose intolerance based on dietary restriction of dairy foods. Two polymorphisms, C/T13910 and G/A22018, linked to hypolactasia, correlate with breath hydrogen and symptoms after lactose. The key in the management of lactose intolerance is the dietary removal of lactose. Patients diagnosed as lactose intolerant must be advised of "risk" foods, inadequately labeled, including processed meats, bread, cake mixes, soft drinks, and lagers. This review highlights the types, symptoms and management of lactose intolerance and also highlights differences from milk allergy which closely mimics the symptoms of lactose intolerance. © 2014 Dr. K C Chaudhuri Foundation. Source

Kumar K.,NIMS University | Rai A.K.,Pranveer Singh Institute of Technology
Tropical Journal of Pharmaceutical Research | Year: 2011

Purpose: To develop a proniosomal carrier system of curcumin for transdermal delivery. Methods: Proniosomes of curcumin were prepared by encapsulation of the drug in a mixture of Span 80, cholesterol and diethyl ether by ether injection method, and then investigated as a transdermal drug delivery system (TDDS). The formulated systems were characterized for size, drug entrapment, angle of repose, hydration rate and vesicular stability under various storage conditions. In vitro release studies were performed using albino rat skin. Results: The method used for preparing proniosome resulted in an encapsulation yield of 82.3 - 86.8%. Scanning electron microscopy analysis showed that the surface of the particles was smooth. Stability data following storage under different conditions showed that the drug content of the proniosomes varied from 99.5% under refrigerated condition to 99.2 and 93% at room and elevated temperatures, respectively. One of the formulations (PG1) showed prolonged in vitro drug release of 61.8% over a period of 24 h. Conclusion: It is evident from this study that proniosomes are very stable and promising prolonged delivery system for curcumin. © Pharmacotherapy Group. Source

Azam F.,NIMS University | Amer A.M.,Misurata University | Rabulifa A.,Misurata University | Elzwawi M.M.,Misurata University
Drug Design, Development and Therapy | Year: 2014

Ginger (Zingiber officinale), despite being a common dietary adjunct that contributes to the taste and flavor of foods, is well known to contain a number of potentially bioactive phytochemicals having valuable medicinal properties. Although recent studies have emphasized their benefits in Alzheimer’s disease, limited information is available on the possible mechanism by which it renders anti-Alzheimer activity. Therefore, the present study seeks to employ molecular docking studies to investigate the binding interactions between active ginger components and various anti-Alzheimer drug targets. Lamarckian genetic algorithm methodology was employed for docking of 12 ligands with 13 different target proteins using AutoDock 4.2 program. Docking protocol was validated by re-docking of all native co-crystallized ligands into their original binding cavities exhibiting a strong correlation coefficient value (r2=0.931) between experimentally reported and docking predicted activities. This value suggests that the approach could be a promising computational tool to aid optimization of lead compounds obtained from ginger. Analysis of binding energy, predicted inhibition constant, and hydrophobic/hydrophilic interactions of ligands with target receptors revealed acetylcholinesterase as most promising, while c-Jun N-terminal kinase was recognized as the least favorable anti-Alzheimer’s drug target. Common structural requirements include hydrogen bond donor/acceptor area, hydrophobic domain, carbon spacer, and distal hydrophobic domain flanked by hydrogen bond donor/acceptor moieties. In addition, drug-likeness score and molecular properties responsible for a good pharmacokinetic profile were calculated by Osiris property explorer and Molinspiration online toolkit, respectively. None of the compounds violated Lipinski’s rule of five, making them potentially promising drug candidates for the treatment of Alzheimer’s disease. © 2014 Azam et al. Source

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