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Khan G.H.,Novartis | Aqil M.,Hamdard University | Pillai K.K.,Hamdard University | Ahmad M.A.,Hamdard University | And 4 more authors.
Asian Pacific Journal of Tropical Disease | Year: 2014

Objective: To determine the drug utilization patterns and outcomes of treatment in terms of metabolic control in the type 2 diabetic patients on oral hypoglycemic agents in the outpatient department in the teaching hospital of Hamdard University, New Delhi, India. Methods: Patients with established type 2 diabetes (n=184) visiting the outpatient department were interviewed using a structured questionnaire over a period of five months. Results: Majority of the type 2 diabetic patients in this setting were treated with a multiple oral hypoglycemic agents. The most commonly prescribed oral hypoglycemic agent was biguanides (metformin) followed by sulfonylureas (glimepiride), thiazolidinediones (pioglitazone), alpha-glucosidase inhibitors (miglitol) and dipeptidyl peptidase-4 inhibitors (vildagliptin). As monotherapy metformin was the most common choice followed by glimepiride and voglibose, the most prevalent multiple therapy was a three-drug combination of glimepiride + metformin + pioglitazone. The study showed poor compliance to the prescribed therapy. Conclusions: This study prospected the need of patient education and counselled to enhance the patient compliance for prescribed oral hypoglycemic agents and concomitant drugs. There is need for diet control as well as blood glucose and HbA1c monitoring. Metabolic control was found to be poor in the study population. HbA1c monitoring was underutilized. Clinical monitoring of patient's adherence to the prescribed treatment to achieve good glycemic control is recommended. Measures should be taken to improve patient's adherence to the prescribed treatment. © 2014 Asian Pacific Tropical Medicine Press.

Gupta N.,NIMS Institute of Pharmacy | Subhramanyam E.V.S.,NGSM Institute of Pharmaceutical science | Bhattacharya S.,NIMS Institute of Pharmacy | Sharma R.K.,NIMS Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

The wound healing effect of different extracts of Leucas aspera was studied. Three wound models viz. incision, excision and dead space wounds were used in this study. Parameters studied were breaking strength in case of incision wounds, epithelialization and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead space wound. Extracts of Leucas aspera exhibited wound healing activity in all three models used in rats, but the significant and maximum wound healing activity was produced by petroleum ether extract of plant Leucas aspera.

Kinja K.,NIMS Institute of Pharmacy | Faisal M.,NIMS Institute of Pharmacy | Singh M.,NIMS Institute of Pharmacy | Gupta N.,NIMS Institute of Pharmacy | Sharma R.K.,NIMS Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

Parkinsonism is an Idiopathic, Chronic, Progressive, Degenerative disorder of basal ganglia or nigrostriatal pathway. Parkinson disease is a brain disorder. Parkinsons disease occurs when certain nerve cells (neurons) in substantia nigra(a part of brain) die or become impaired. These cells produce a vital chemical known as dopamine which allows smooth, coordinated function of the body's muscles and movement. When approx. 80% of these nerve cells (dopamine producing cells) are damaged, the symptoms of parkinson disease appear. It develops gradually, often starting with a barely noticeable tremor in just one hand. But while tremor may be the most well-known sign of Parkinson's disease, the disorder also commonly causes a slowing or freezing of movement. Friends and family may notice that your face shows little or no expression and your arms don't swing when you walk. Speech often becomes soft and mumbling. Parkinson's symptoms tend to worsen as the disease progresses. While there is no cure for Parkinson's disease, many different types of medicines can treat its symptoms. In some cases, your doctor may suggest surgery.

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