NIMS Institute of Pharmacy

Jaipur, India

NIMS Institute of Pharmacy

Jaipur, India
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Upadhyay N.,NIMS University | Upadhyay N.,NIMS Institute of Pharmacy | Shukla T.P.,NIMS University | Mathur A.,NIMS University | And 2 more authors.
International Journal of Pharmaceutical Sciences Review and Research | Year: 2011

Pharmaceutical co-crystals are nonionic supramolecular complexes and can be used to altered physical property issues such as solubility, stability and bioavailability in pharmaceutical development without affecting chemical composition of API. co-crystal comprising of API and desired stoichiometric acceptable co-crystal that can be made by various types of interaction like hydrogen bounding, pi-stacking and Vander wall forces. Pharmaceutical co-crystal is more thermodynamically stable than crystal form of drugs. The recent advancement in the co-crystal development arises the possibility to produce material by designing with an improved physical property.co-crystal not only provide a technique for improvement of physiochemical property but also provide opportunity to the researchers of pharmaceutical companies regarding intellectual property.co-crystal approach especially used to enhance the specific properties of pharmaceutical solids such as dissolution rate of poorly water soluble API and the physical stability of moisture liable APIs. Cocrystalization property creates opportunity for polymorphs, hydrate and also for salt selection. The various factors which will affect co-crystal stability will be taken in consideration and can be managed with the help of crystal engineering and thermodynamically stable product only accepted. Phase transformation during processing affect the mechanism of conversion of crystalline drugs to co-crystal.


Singh M.K.,NIMS Institute of Pharmacy | Mohd F.,NIMS Institute of Pharmacy | Ayaz A.,NIMS Institute of Pharmacy | Ankur S.,NIMS Institute of Pharmacy | Jyoti Y.,NIMS Institute of Pharmacy
International Journal of Drug Development and Research | Year: 2012

In the present study it was aimed to evaluate the combined effect of simvastatin (SIM) and hydro alcoholic seeds extract of Lagenaria siceraria (H.L.S.S.E.) in doxorubicin (DOX) induced cardio toxicity in Wister rats. DOX 10 mg/ kg i.p. single dose was given to cause cardiac damage and the levels of cardiac biomarker enzyme viz LDH, CK, CK-MB and total protein & antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and lipid peroxidation (LPO) were observed and in the end of experiment histopathology was carried out for heart. SIM (15 mg/kg) and (H.L.S.S.E. 200 & 400mg/kg) were given in combination with DOX 10 mg/ kg i.p. single dose to rats at the 30th day of experiment and as a pretreatment for 29 days (H.L.S.S.E. 200 & 400mg/kg) were given orally. Pretreatment with SIM and (H.L.S.S.E) significantly (P<0.001) reduced the elevated cardiac toxicity biomarker enzyme level and raised the level of antioxidants viz CAT, GSH, SOD and decrease LPO in the extract treated groups as compared to the disease control group.In the histopathological studies H.L.S.S.E and SIM showed protection against myocardial toxicity induced by doxorubicin. The result obtained from the present study indicates that the pretreatment of SIM and H.L.S.S.E may significantly reduse the (DOX) induced cardiotoxicity. © 2012 IJDDR, Singh M. K et al.


Gupta N.,NIMS Institute of Pharmacy | Subhramanyam E.V.S.,GSM Institute of Pharmaceutical science | Jha S.,NIMS Institute of Pharmacy | Bhatia V.,NIMS Institute of Pharmacy | Narang E.,NIMS Institute of Pharmacy
Journal of Chemical and Pharmaceutical Research | Year: 2011

This study indicates that Leucas aspera and Glycosmis pentaphylla extracts have good antipyretic activity. Ethanolic extract of Leucas aspera and Glycosmis pentaphylla exhibited significant anti-pyretic activities in Brewer's yeast induced pyrexia in rats. The maximum antipyretic activity throughout the test period of 6 hours was produced by ethanolic extract of plant Leucas aspera (200 mg/kg) and standard (paracetamol treated) group. In general, nonsteroidal anti-inflammatory drugs produce their antipyretic action through the inhibition of prostaglandin synthetase within the Hypothalamus. Therefore, the antipyretic activity of extracts of Leucas aspera and Glycosmis pentaphylla is probably by inhibition of prostaglandin synthesis in hypothalamus.


Patel H.V.,NIMS Institute of Pharmacy | Narang E.,NIMS Institute of Pharmacy
Journal of Chemical and Pharmaceutical Research | Year: 2011

As quality is the most important aspect of any manufacturing process, it becomes necessary to validate or examine all the peripherals connected to the manufacturing instruments used in pharmaceutical industries. Among all the peripherals connected to the manufacturing instruments, computer is the main equipment, as it controls and handles all the activities of manufacturing process starting from input to finalized output. This article explains validation processes of any computer systems to avoid any risk to product identity, purity, strength and efficacy by providing consistent and secure operation and reducing the potential of human error.


Jha S.K.,NIMS Institute of Pharmacy | Bhatia V.,NIMS Institute of Pharmacy | Shukla T.P.,NIMS Institute of Pharmacy
Journal of Global Pharma Technology | Year: 2010

Oral route delivery remains the preferred route of drug delivery inspite of the associated disadvantages. In the recent past several novel technologies have emerged with improved performance, improved patient compliance and reduced adverse effects. One such approach is to develop orally disintegrating tablets, a dosage form that dissolve or disintegrates rapidly in oral cavity, resulting in solution or suspension without the need of water. The demand for orally disintegrating tablets has been growing over other oral dosage forms among pediatric, geriatric, dysphagic, psychotic and non-cooperative patients and travellers. The present review article focuses on significance of advancement in oral drug delivery and the techniques and technologies available for their manufacturing. © 2009, JGPT.


Kinja K.,NIMS Institute of Pharmacy | Gupta N.,NIMS Institute of Pharmacy
International Journal of Pharmaceutical Sciences Review and Research | Year: 2011

Biomarker is a biochemical feature or facet that can be used to measure the progress of disease or the effects of treatment. A biomarker can be a substance that is introduced into an organism as a means to examine organ function or other aspects of health. Biomarkers provide a dynamic and powerful approach to understanding the spectrum of neurological disease with applications in observational and analytic epidemiology, randomized clinical trials, screening and diagnosis and prognosis. These markers offer the means for homogeneous classification of a disease and risk factors, and the can extend our base information about the underlying pathogenesis of disease. Biomarkers can also reflect the entire spectrum of disease from the earliest manifestations to the terminal stages. This brief review describes the major uses of biomarkers in clinical investigation. Issues that affect the analysis of biomarkers are discussed along with recommendations on how to deal with bias and confounding.


Khan G.H.,Novartis | Aqil M.,Hamdard University | Pillai K.K.,Hamdard University | Ahmad M.A.,Hamdard University | And 4 more authors.
Asian Pacific Journal of Tropical Disease | Year: 2014

Objective: To determine the drug utilization patterns and outcomes of treatment in terms of metabolic control in the type 2 diabetic patients on oral hypoglycemic agents in the outpatient department in the teaching hospital of Hamdard University, New Delhi, India. Methods: Patients with established type 2 diabetes (n=184) visiting the outpatient department were interviewed using a structured questionnaire over a period of five months. Results: Majority of the type 2 diabetic patients in this setting were treated with a multiple oral hypoglycemic agents. The most commonly prescribed oral hypoglycemic agent was biguanides (metformin) followed by sulfonylureas (glimepiride), thiazolidinediones (pioglitazone), alpha-glucosidase inhibitors (miglitol) and dipeptidyl peptidase-4 inhibitors (vildagliptin). As monotherapy metformin was the most common choice followed by glimepiride and voglibose, the most prevalent multiple therapy was a three-drug combination of glimepiride + metformin + pioglitazone. The study showed poor compliance to the prescribed therapy. Conclusions: This study prospected the need of patient education and counselled to enhance the patient compliance for prescribed oral hypoglycemic agents and concomitant drugs. There is need for diet control as well as blood glucose and HbA1c monitoring. Metabolic control was found to be poor in the study population. HbA1c monitoring was underutilized. Clinical monitoring of patient's adherence to the prescribed treatment to achieve good glycemic control is recommended. Measures should be taken to improve patient's adherence to the prescribed treatment. © 2014 Asian Pacific Tropical Medicine Press.


Gupta N.,NIMS Institute of Pharmacy | Subhramanyam E.V.S.,NGSM Institute of Pharmaceutical science | Bhattacharya S.,NIMS Institute of Pharmacy | Sharma R.K.,NIMS Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

The wound healing effect of different extracts of Leucas aspera was studied. Three wound models viz. incision, excision and dead space wounds were used in this study. Parameters studied were breaking strength in case of incision wounds, epithelialization and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead space wound. Extracts of Leucas aspera exhibited wound healing activity in all three models used in rats, but the significant and maximum wound healing activity was produced by petroleum ether extract of plant Leucas aspera.


Kinja K.,NIMS Institute of Pharmacy | Faisal M.,NIMS Institute of Pharmacy | Singh M.,NIMS Institute of Pharmacy | Gupta N.,NIMS Institute of Pharmacy | Sharma R.K.,NIMS Institute of Pharmacy
International Journal of Pharmacy and Technology | Year: 2011

Parkinsonism is an Idiopathic, Chronic, Progressive, Degenerative disorder of basal ganglia or nigrostriatal pathway. Parkinson disease is a brain disorder. Parkinsons disease occurs when certain nerve cells (neurons) in substantia nigra(a part of brain) die or become impaired. These cells produce a vital chemical known as dopamine which allows smooth, coordinated function of the body's muscles and movement. When approx. 80% of these nerve cells (dopamine producing cells) are damaged, the symptoms of parkinson disease appear. It develops gradually, often starting with a barely noticeable tremor in just one hand. But while tremor may be the most well-known sign of Parkinson's disease, the disorder also commonly causes a slowing or freezing of movement. Friends and family may notice that your face shows little or no expression and your arms don't swing when you walk. Speech often becomes soft and mumbling. Parkinson's symptoms tend to worsen as the disease progresses. While there is no cure for Parkinson's disease, many different types of medicines can treat its symptoms. In some cases, your doctor may suggest surgery.

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