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Dan A.,Nil Ratan Sircar Medical College and Hospital
German Journal of Psychiatry | Year: 2012

Background and Objective: Lithium has been used effectively in the treatment of Bipolar Affective Disorder since seven decades. Despite its remarkable efficacy in this condition, lithium treatment leads to various side effects and often toxicity involving various organ systems of our body. The risk of toxicity is higher in elderly patients with compromised renal function and receiving other concomitant medications such as loop or thiazide diuretics, non-steroidal anti inflammatory drugs (NSAIDS), or others. We aim to present a case of lithium toxicity in an elderly lady with concomitant thiazide diuretic and NSAID therapy. Case description: An elderly lady suffering from Bipolar Affective Disorder and maintaining well on lithium and quetiapine prophylaxis was prescribed an NSAID (aceclofenac and paracetamol) and a thiazide diuretic (hydrochlorthiazide) for comorbid knee joint osteoarthritis and hypertension, respectively. She developed signs and symptoms of lithium toxicity after a week and was treated with hemodialysis in an emergency setup. Conclusion: The index case suggests patients receiving lithium should be prescribed NSAID and thiazide diuretic with great caution if at all with proper monitoring of serum lithium level.


Shukla R.M.,Nil Ratan Sircar Medical College and Hospital | Mukhopadhyay B.,Nil Ratan Sircar Medical College and Hospital | Mandal K.C.,Nil Ratan Sircar Medical College and Hospital | Barman S.S.,Nil Ratan Sircar Medical College and Hospital
Urology Annals | Year: 2011

Congenital penile urethrocutaneous fistula is described as an unusual developmental anomaly in children who present with an abnormal opening on the ventral aspect of penis with a normal foreskin and an absence of chordee and hypospadias. The authors present a discussion on the etiology, embryology, and management of this entity along with a description of three cases. We emphasize meticulous clinical examination for the diagnosis and to rule out other associated anomalies.


Bandyopadhyay R.,Medical College | Bandyopadhyay S.,Nil Ratan Sircar Medical College and Hospital | Maity P.K.,Nil Ratan Sircar Medical College and Hospital
Indian Pediatrics | Year: 2011

Gaucher's disease is a rare lysosomal storage disorder characterized by abnormal accumulation of lipid-laden macrophages in different organs. Though hepatosplenomegaly is commonly found, symptomatic presentation with portal hypertension is rare. We report a child with liver cirrhosis and bleeding esophageal varices who was diagnosed with Gaucher's disease disease.


Bandyopadhyay S.K.,Nil Ratan Sircar Medical College and Hospital
The Journal of the Association of Physicians of India | Year: 2010

A family with hereditary (familial) hypoparathyroidism is reported where three of the total four siblings were affected and each presented with different manifestation-one brother with refractory epilepsy since early childhood, another brother with unilateral extrapyramidal features in adult life, and their only sister having recurrent attacks of tingling and numbness due to hypocalcemia since 12 years of age.


Saha P.,Nil Ratan Sircar Medical College and Hospital | Datta P.,Nil Ratan Sircar Medical College and Hospital | Ayan S.,Nil Ratan Sircar Medical College and Hospital | Garg A.K.,Nil Ratan Sircar Medical College and Hospital | And 2 more authors.
Indian Journal of Orthopaedics | Year: 2014

Background: With changing trends in treatment of displaced midshaft clavicle fractures (DMCF), plating remains the standard procedure for fixation. An attracting alternative method of fixation is the titanium elastic nailing (TEN). However, prospective randomized studies comparing the two methods of fixation are lacking. We assessed the effectiveness of minimally invasive antegrade TEN and plating technique for the treatment of DMCF. Materials and Methods: 80 unilateral displaced midclavicular fractures operated between October 2010 and May 2013 were included in study. This prospective comparative study was approved by the local ethical committee. Followups were at 2nd and 6th weeks and subsequently at 3, 6, 12, 18 and 24 months postoperatively. Primary outcome was measured by the Constant score, union rate and difference in clavicular length after fracture union. Secondary outcome was measured by operative time, intraoperative blood loss, wound size, cosmetic results and complications. Results: During analysis, we had 37 patients in the plate group and 34 patients in the TEN group. There was no significant difference in Constant scores between the two groups. However, faster fracture union, lesser operative time, lesser blood loss, easier implant removal and fewer complications were noted in the TEN group. Conclusion: The use of minimally invasive antegrade TEN for fixation of displaced midshaft clavicle fractures is recommended in view of faster fracture union, lesser morbidity, better cosmetic results, easier implant removal and fewer complications; although for comminuted fractures plating remains the procedure of choice.


Purkait R.,Nil Ratan Sircar Medical College and Hospital | Saha A.,Nil Ratan Sircar Medical College and Hospital | Tripathy I.,Nil Ratan Sircar Medical College and Hospital | Roy B.,Nil Ratan Sircar Medical College and Hospital
Journal of Indian Association of Pediatric Surgeons | Year: 2014

Medium chain triglyceride (MCT)-based diet, total parenteral nutrition (TPN) and repeated paracentesis are considered as supportive management for congenital chylous ascites (CCA). TPN is considered where therapy with oral MCT is poorly tolerated by the patient especially young infant with unstable hemodynamic. Surgery is recommended when medical therapy fails. Herein, we report a 2-month-old infant with CCA, treated successfully with octreotide intravenous infusion after the initial failure to response to conventional conservative therapy with MCT-enriched formula and paracentesis.


Mandal A.,Nil Ratan Sircar Medical College and Hospital | Ghosh A.,Nil Ratan Sircar Medical College and Hospital | Sengupta G.,Nil Ratan Sircar Medical College and Hospital | Bera T.,Nil Ratan Sircar Medical College and Hospital | And 2 more authors.
Indian Journal of Community Medicine | Year: 2012

Context: Performance of medical students in developing nations like India is perceived to have largely declined. Aims: We attempted to assess the reasons behind such trends. Settings and Design: Students in their third year of medical study were given a predesigned, pretested structured and validated questionnaire that they filled in anonymously. The key areas assessed were concentration, interest and understanding of the subject and other perceived causes of poor performance. Tests for descriptive statistics were applied for evaluation. Results and Conclusions: One hundred and fifty students participated in the study. Fifty-five (36.66%) students performed poorly. Male gender, inability to clear the previous professional examination at the first attempt, difficulty in understanding medium of instruction, self-assessed depression, sleep disorders and perceived parental and peer pressure and dissatisfaction with career choice were significantly linked with poor performance (P<0.05 for each factor). Socioeconomic status and regularity in class were not linked to academic performance.


PubMed | Nil Ratan Sircar Medical College and Hospital and Nil Ratan Sircar Medical College And Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

Tuberculous osteomyelitis affecting long bones is a rare form of tuberculosis. Among infants born in endemic region, often it is difficult to diagnose owing to its subtle clinical features. Here, a case of tuberculous osteomyelitis affecting the distal radial metaphysis is reported, presenting as a cystic lesion in a nine-month-old male infant. Open biopsy with curettage was performed followed by filling of the cavity with synthetic bone substitute (beta tricalcium phosphate granules). The diagnosis was confirmed by histopathological examination and demonstration of acid fast bacilli. Further treatment with anti-tubercular drugs led to clinical and radiological improvement. This case report highlights the importance of keeping tuberculosis as a differential diagnosis while dealing with cases with similar presentation in an endemic region.


PubMed | Nil Ratan Sircar Medical College and Hospital and Saha Institute of Nuclear Physics
Type: | Journal: Molecular and cellular biochemistry | Year: 2016

ApoA1 is a player in reverse cholesterol transport that initiates multiple cellular pathways on binding to its receptor ABCA1. Its relation to neuronal injury is however unclear. We found ApoA1 to be increasingly abundant at a later time point in the secondary phase of traumatic spinal cord injury. In a cellular injury model of neuroblastoma, ApoA1 showed an initial diminished expression after infliction of injury, which sharply increased thereafter. Subsequently, ApoA1 was shown to alter wound healing dynamics in neuroblastoma injury model. It was observed that an initial lag in scratch wound closure was followed by rapid healing in the ApoA1 treatment group. Activation of ERK pathway and Actin polymerisation by ApoA1 corroborated its role in healing after neuronal injury. We propose that ApoA1 is increasingly expressed and secreted as a delayed response to neuronal injury, and this is a self-protecting mechanism of the injured system.


PubMed | Nil Ratan Sircar Medical College and Hospital and Lane College
Type: Journal Article | Journal: The Indian journal of surgery | Year: 2016

Here, we present a pictorial description of a rare case of patent urachus in a neonate and its management.

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