Nikkol Group Cosmos Technical Center Co.

Itabashi-ku, Japan

Nikkol Group Cosmos Technical Center Co.

Itabashi-ku, Japan
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Yamaguchi S.,Cosmos Technical Center Co. | Sakai K.,Tokyo University of Science | Sakai H.,Tokyo University of Science
Liaison Functions 2016 - Core Programming Area at the 2016 AIChE Annual Meeting | Year: 2016

We have previously reported a new preparation method of liposomes and niosomes (nonionic vesicles) using supercritical carbon dioxide (scCO2) as a solvent (scRPE method). In this study, niosomes were prepared by polyglycerol fatty acid ester (PG ester)-type nonionic surfactants, which are made from naturally-derived materials and have a high safety for a human body and environment, using the scRPE method with ethanol as co-solvent. Decaglycerol distearate (DG2S) and decaglycerol diisostearate (DG2IS) successfully formed niosomes using the scRPE method. On the other hands, decaglycerol monostearate (DG1S) with a high hydrophilic-lipophilic balance (HLB) value gave a spherical micellar solution, and decaglycerol tristearate (DG3S) with a low HLB value gave a gel-like solution. Niosomes of DG2IS had higher trapping efficiency and dispersion stability than DG2S niosomes because the membrane fluidity of DG2IS niosomes was higher than that of DG2S niosomes. The niosomes obtained in the present study would be a useful candidate for applying to cosmetics and drugs because they are formed by nonionic surfactants derived from natural sources and are prepared using the scRPE method without harmful organic solvents. © Copyright 2016 American Institute of Chemical Engineers. All rights reserved.


Wagemaker T.A.L.,University of Sao Paulo | Maia Campos P.M.B.G.,University of Sao Paulo | Shimizu K.,Group Technical Center Co. | Kyotani D.,Res Group, Inc. | Yoshida D.,Group Technical Center Co.
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2017

Cutaneous irritants exposure induces an excess of ROS in the skin and can ensue an inflammatory response. Topical antioxidant-based formulations can help to counteract ROS generation. This study evaluated the influence of antioxidant-based topical formulations on the inflammatory response of skin, using a combination of in vivo real-time non-invasive techniques. Nine test areas were defined on each volar forearm of the 25 Japanese volunteers. Measurements were performed before and after treatment with 15 μL of a 5% sodium dodecyl sulfate solution and 15 μL of the same based formulation or the vehicle with 1% of the antioxidants. Volunteers without antioxidant treatment showed more pronounced erythematous areas. Transepidermal water loss of areas treated with green tea polyphenol (GTP)-based formulation showed fully recovered skin. Skin barrier damage caused by repeated applications of SDS showed characteristic alterations, detectable by in vivo confocal microscopy such as desquamation, spongiosis and inflammatory infiltrates. The majority of confocal microscopy inflammation signs were found in skin without treatment followed by the vehicle. Ascorbyl tetraisopalmitate, Coenzyme Q10, GTP- and Resveratrol-based formulations reduced the anti-inflammatory cytokines release and attenuated inflammatory signs. The combination of techniques provides results that highlight the importance of antioxidant-based formulations for rapid skin recovery. © 2017 Elsevier B.V.


Masaki H.,Nikkol Group Cosmos Technical Center Co.
Journal of Dermatological Science | Year: 2010

Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually discussed in relation to UV exposure. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. In this review, the mechanisms of ROS generation and ROS elimination in the body are summarized. The effects of ROS generated in the skin and the roles of ROS in altering the skin are also discussed. In addition, the effects of representative antioxidants on the skin are summarized with a focus on skin aging. © 2010 Japanese Society for Investigative Dermatology.


Yahagi S.,Nikkol Group Cosmos Technical Center Co. | Koike M.,Nikkol Group Cosmos Technical Center Co. | Okano Y.,Nikkol Group Cosmos Technical Center Co. | Masaki H.,Nikkol Group Cosmos Technical Center Co. | Masaki H.,Nikko Chemicals Co.
International Journal of Cosmetic Science | Year: 2011

Synopsis Recent studies have demonstrated that lysophospholipids (LPL) play critical roles in several biological signal transduction pathways to maintain the homoeostasis of cells, tissues and organs. Among them, lysophosphatidic acid (LPA) has been identified as a lipid mediator that induces morphological improvement in the epidermis in mice. In this study, we examined the effects of LPL (soybean-derived phospholipids modified with phospholipase A2 and C) compared with LPA. We initially examined the effects of LPA on normal human epidermal keratinocytes (NHEK) focusing on the expression of profilaggrin and serine palmitoyltransferase (SPT) mRNAs. LPA enhanced the expression of profilaggrin and SPT mRNAs via the modulation of Ca2+ influx. Based on those results, the influence of LPL on NHEK was examined and was expanded to analyse the expression of two tight junction-related proteins, occludin and claudin-1. LPL had similar effects to increase profilaggrin and SPT mRNA expression and also stimulated the expression of occludin and claudin-1 at the mRNA and protein levels. In accordance with these results, LPL elicited significant improvements in surface water content in human skin. These findings indicate that LPL has the potential to strengthen the skin moisturizing capability by up-regulating the expression of mRNAs encoding components important to skin barrier function and skin hydration. © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie.


Oode C.,Utsunomiya University | Shimada W.,Tokyo University of Agriculture and Technology | Shimada W.,Nikkol Group Cosmos Technical Center Co. | Izutsu Y.,Nikkol Group Cosmos Technical Center Co. | And 4 more authors.
European Journal of Medicinal Chemistry | Year: 2014

Dihydroresveratrol glucoside 1 isolated from Camellia oleifera and its xyloside derivative 2 were synthesized for the first time in 5 steps from TBS-protected aldehyde 4. Natural product 1 is a potent melanogenesis inhibitor in B16F0 melanoma cells (approximately 40 fold more potent than kojic acid). In contrast, the synthetic product 2 stimulates melanogenesis, suggesting that a single hydroxymethyl group in the glycoside substituent of dihydroresveratrols is responsible for inhibition or activation of melanogenesis. © 2014 Elsevier Masson SAS.


PubMed | Utsunomiya University, Tokyo University of Agriculture and Technology and Nikkol Group Cosmos Technical Center Co.
Type: | Journal: Carbohydrate research | Year: 2016

Dihydroresveratrol cellobioside and xylobioside, whose structures were designed based on that of the naturally occurring melanogenesis-controlling agent dihydroresveratrol glucoside, were synthesized via Schmidt glycosylation as the key step. Both analogues stimulated melanogenesis with efficacies comparable to that of 8-methoxypsoralen, a well-known melanogenesis activator. This suggests that diglycosyl modification of the 4-OH on the dihydroresveratrol skeleton leads to the activation of melanogenesis, both with and without hydroxymethyl groups in the sugar moieties.


PubMed | Nikkol Group Cosmos Technical Center Co.
Type: Journal Article | Journal: Journal of dermatological science | Year: 2010

Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually discussed in relation to UV exposure. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. In this review, the mechanisms of ROS generation and ROS elimination in the body are summarized. The effects of ROS generated in the skin and the roles of ROS in altering the skin are also discussed. In addition, the effects of representative antioxidants on the skin are summarized with a focus on skin aging.


PubMed | Nikkol Group Cosmos Technical Center Co
Type: Clinical Trial | Journal: International journal of cosmetic science | Year: 2011

Recent studies have demonstrated that lysophospholipids (LPL) play critical roles in several biological signal transduction pathways to maintain the homoeostasis of cells, tissues and organs. Among them, lysophosphatidic acid (LPA) has been identified as a lipid mediator that induces morphological improvement in the epidermis in mice. In this study, we examined the effects of LPL (soybean-derived phospholipids modified with phospholipase A2 and C) compared with LPA. We initially examined the effects of LPA on normal human epidermal keratinocytes (NHEK) focusing on the expression of profilaggrin and serine palmitoyltransferase (SPT) mRNAs. LPA enhanced the expression of profilaggrin and SPT mRNAs via the modulation of Ca(2+) influx. Based on those results, the influence of LPL on NHEK was examined and was expanded to analyse the expression of two tight junction-related proteins, occludin and claudin-1. LPL had similar effects to increase profilaggrin and SPT mRNA expression and also stimulated the expression of occludin and claudin-1 at the mRNA and protein levels. In accordance with these results, LPL elicited significant improvements in surface water content in human skin. These findings indicate that LPL has the potential to strengthen the skin moisturizing capability by up-regulating the expression of mRNAs encoding components important to skin barrier function and skin hydration.

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