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Nikkō, Japan

Omae K.,Keio University | Nakano M.,Keio University | Tanaka A.,Kyushu University | Hirata M.,Kyushu University | And 2 more authors.
International Archives of Occupational and Environmental Health | Year: 2011

Purpose: The present review is aimed to introduce an new occupational lung disease, Indium Lung. Methods: We searched case reports and epidemiological studies concerning indium-related lung diseases and reviewed. Results: Up to March, 2010, 7 cases of interstitial pneumonia in Japanese indium-exposed workers, two cases of pulmonary alveolar proteinosis (PAP) in US indium-exposed workers, one case of PAP in a Chinese indium-exposed worker, and 4 cross-sectional surveys in Japan had been published. All cases and epidemiological studies in Japan indicate that exposure to hardly soluble indium compounds causes interstitial as well as emphysematous lung damages, which we call "Indium Lung". Based on the epidemiological studies, the Japan Society for Occupational Health proposed 3 μg/l of indium in serum as an occupational exposure limit based on biological monitoring to prevent significant increase of KL-6. Comments: Long-term follow-up of currently and formerly indium-exposed workers is essential not only to clarify the natural history of indium lung but also to trace the incidence of lung cancer. It is also necessary to elucidate the mechanism of indium lung and difference in clinical manifestations between Japanese and US cases. © 2010 Springer-Verlag.

Tei K.,Hokkaido University | Sakakibara N.,Nikko Memorial Hospital | Yamazaki Y.,Hokkaido University | Ohiro Y.,Hokkaido University | And 2 more authors.
Journal of Oral and Maxillofacial Surgery | Year: 2012

Purpose: The present study aimed to measure postsurgical swallowing function in patients 5 years after the surgical treatment of tongue carcinoma. Patients and Methods: Using a retrospective cohort study design, the investigators enrolled postsurgical patients treated for tongue carcinomas in Hokkaido University Hospital. The primary outcome variable was oropharyngeal swallow efficiency (OPSE) determined by videofluoroscopic evaluation, and OPSE at follow-up was compared with that at discharge. Other variables included current nutritional status (body mass index, serum albumin), dietary intake, self-rating of current swallowing function, and occurrence of pneumonia. Statistical analysis used the paired t test and the Spearman rank correlation. Results: Swallowing function was assessed in 20 patients (11 men and 9 women) who underwent the surgical treatment of tongue carcinomas; the median age was 70 years (range, 56 to 90 yrs). The mean OPSE values for liquid and paste at follow-up were 26.6 ± 21.2 and 21.9 ± 22.5, respectively. The mean values for the body mass index and serum albumin at presentation were 22.2 ± 3.4 kg/m2 and 4.5 ± 0.3 g/dL, respectively. All patients had a full oral intake of foods, with a mean self-rated value of 6.4 ± 2.5, a value acceptable to the patients. Pneumonia requiring hospitalization did not occur in these patients. Conclusions: The long-term follow-up of patients after the surgical treatment of tongue carcinomas showed acceptable levels of oral function and nutritional status despite objective measurements of poor swallowing efficiency assessed using videofluoroscopy. © 2012 American Association of Oral and Maxillofacial Surgeons.

Sato K.-I.,Nikko Memorial Hospital | Nishimura S.-I.,Nikko Memorial Hospital
Open Ophthalmology Journal | Year: 2013

We report the incidence of lacrimal passage impairment and specific features of corneal epitheliopathy as adverse effects of the oral anticancer drug S-1, and examine the relationship between the two pathologies. We conducted a retrospective chart review of 84 patients prescribed the anticancer drug S-1. The incidence of lacrimal passage impairment and corneal epitheliopathy was 8% and 6%, respectively. Three patients experienced both pathologies, demonstrating a moderate probability of both occurring in the same patient (kappa coefficient = 0.46). The findings show that lacrimal passage impairment and specific features of corneal epitheliopathy are likely to occur in the same individual as adverse effects of S-1. © Sato and Nishimura; Licensee Bentham Open.

Sato K.-I.,Nikko Memorial Hospital | Tabira K.,Nikko Memorial Hospital
Open Ophthalmology Journal | Year: 2012

For five consecutive eyes from five patients with liquefied aftercataract, Nd: YAG laser treatment significantly reduced high-order aberrations. Two eyes showing a reduction in positive spherical-like aberrations after treatment showed a postoperative myopic shift, while three eyes showing no change in spherical-like aberrations demonstrated hyperopic or only a slight myopic shift. © Sato and Tabira.

Nawa T.,Hitachi General Hospital | Nakagawa T.,Hitachi Health Care Center | Mizoue T.,International Clinical Research Center | Kusano S.,Hitachi Health Care Center | And 3 more authors.
Lung Cancer | Year: 2012

The effectiveness of lung cancer screening using low-dose chest computed tomography (CT) remains elusive. The present study examined the prognosis of patients with lung cancer detected on CT screening in Japanese men and women. Subjects were 210 patients with primary lung cancer identified on CT screening at two medical facilities in Hitachi, Japan, where a total of 61,914 CT screenings were performed among 25,385 screenees between 1998 and 2006. Prognostic status of these patients was sought by examining medical records at local hospitals, supplemented by vital status information from local government. The 5-year survival rate was estimated according to the characteristics of patients and lung nodule. A total of 203 (97%) patients underwent surgery. During a 5.7-year mean follow-up period, 19 patients died from lung cancer and 6 died from other causes. The estimated 5-year survival rate for all patients and for those on stage IA was 90% and 97%, respectively. Besides cancer stage, smoking and nodule appearance were independent predictors of a poor survival; multivariable-adjusted hazard ratio (95% confidence interval) was 4.7 (1.3, 16.5) for current and past smokers versus nonsmokers and 4.6 (1.6, 13.9) for solid nodule versus others. Even patients with solid shadow had a 5-year survival of 82% if the lesion was 20. mm or less in size. Results suggest that lung cancers detected on CT screening are mostly curative. The impact of CT screening on mortality at community level needs to be clarified by monitoring lung cancer deaths. © 2011 Elsevier Ireland Ltd.

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