Niigata University is a national university in Niigata, Niigata Prefecture, Japan. It was established in 1949 and has its major origins in Niigata Medical College and in Niigata Higher School . It is one of the largest Japanese national universities on the Sea of Japan.The university comprises nine faculties and seven graduate schools . The student enrollment is about 12,000.The faculties, graduate schools are concentrated in Ikarashi Campus to the west of the city. The medical faculties are located in Asahimachi Campus in the downtown. Attached schools are located in Nishi Ohata district next to Asahimachi Campus . In a building next to Niigata Station there is a small campus named Tokimate , whose main purpose is to offer courses of lifelong learning for adults. Wikipedia.
Takahashi M.,Niigata University
Blood | Year: 2013
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), and the viral oncoprotein Tax plays key roles in the immortalization of human T cells, lifelong persistent infection, and leukemogenesis. We herein identify the ubiquitin-specific protease 10 (USP10) as a Tax-interactor in HTLV-1-infected T cells. USP10 is an antistress factor against various environmental stresses, including viral infections and oxidative stress. On exposure to arsenic, an oxidative stress inducer, USP10 is recruited into stress granules (SGs), and USP10-containing SGs reduce reactive oxygen species (ROS) production and inhibit ROS-dependent apoptosis. We found that interaction of Tax with USP10 inhibits arsenic-induced SG formation, stimulates ROS production, and augments ROS-dependent apoptosis in HTLV-1-infected T cells. These findings suggest that USP10 is a host factor that inhibits stress-induced ROS production and apoptosis in HTLV-1-infected T cells; however, its activities are attenuated by Tax. A clinical study showed that combination therapy containing arsenic is effective against some forms of ATL. Therefore, these findings may be relevant to chemotherapy against ATL.
Hagiwara H.,Niigata University
Synlett | Year: 2012
Homogeneous catalysts were immobilized to the pores of amorphous inorganic supports with the aid of an ionic liquid as Pd-, Cu-, and Ru-supported ionic liquid phase catalyst (SILPC), which is a benign method to immobilize sophisticated but unstable homogeneous catalysts so far difficult to load in an inorganic support by simple impregnation method. By immobilizing as a SILPC, sustainability and reactivity of catalysts increased in Mizoroki-Heck reaction, Suzuki-Miyaura reaction, Huisgen [3+2] cycloaddition (click reaction) without external ligand in aqueous media and ambient atmosphere, and olefin metathesis reactions. In addition, palladium was immobilized on nano-silica gel dendrimer as a nano-SILPC, which was highly active to Suzuki-Miyaura reaction. Moreover, MacMillan imidazolidinone organomolecular catalyst was immobilized as a Mac-SILPC to enable sustainable asymmetric Diels-Alder reaction. SILPCs could be repeatedly used by filtration. 1 Introduction 2 Recyclable Mizoroki-Heck Reaction in an Ionic Liquid Catalyzed by Pd/C 3 Immobilization of Pd in an Amorphous Inorganic Oxide with the Aid of an Ionic Liquid - Preparation of Pd-SILPC 4 Mizoroki-Heck Reaction Catalyzed by Pd-SILPC 5 Mizoroki-Heck Reaction in Water Catalyzed by Pd-SILPC 6 Suzuki-Miyaura Reaction Catalyzed by Pd-SILPC 7 Immobilization of Pd in Nano-Silica Gel Dendrimer as Pd-Nano-SILPC and Suzuki-Miyaura Reaction 8 Polymer-Coated Pd-SILPC and Suzuki-Miyaura Reaction 9 Catalytic Hydrogenation Catalyzed by Pd-SH-SILPC 10 Immobilization of Cu as Cu-SILPC and Huisgen [3+2] Cycloaddition 11 Immobilization of Grubbs Catalyst as Ru-SILPC and Olefin Metathesis Reaction 12 Immobilization of MacMillan Organocatalyst as Mac-SILPC and Asymmetric Diels-Alder Reaction 13 Conclusions. © Georg Thieme Verlag Stuttgart . New York.
Mase K.,Niigata University
IEEE Communications Magazine | Year: 2011
This article sheds light on communication needs of evacuees in shelters during a post-disaster period and advocates that it is essential to develop a completely new communication service for those in shelters to maintain communication channels with those outside shelters as well as with those in other shelters. We then present assumptions and requirements in developing such service and show a service and system concept, termed Shelter Communication System. SCS is composed of a computer (termed Shelter Server) connected to the Internet and a set of personal computers (termed shelter PCs), one in each shelter, also connected to the Internet via an appropriate Internet access connection such as High Speed Packet Access. Shelter Server and Shelter PCs cooperatively provide a message communication service for those in shelters and those outside shelters. A prototype of SCS is presented to demonstrate feasibility of SCS. A simple evaluation shows that SCS potentially provides a message communication service for enormous number of evacuees in shelters in the case of large-scale disasters and surpasses other message communication services such as cellular phone mail and facsimile. © 2006 IEEE.
Yoshida K.,Niigata University
Physical Review C - Nuclear Physics | Year: 2014
L=0 proton-neutron (pn) pair-addition and pair-removal strengths in Ca40 and Ni56 are investigated by means of the pn particle-particle random-phase approximation employing a Skyrme energy-density functional. It is found that the collectivity of the lowest Jπ=1+ state in the adjacent odd-odd nuclei becomes stronger as the strength of the isoscalar (T=0) pairing interaction increases. The results suggest the emergence of the T=0 pn-pairing vibrational mode as a possible critical phenomenon toward the T=0 pairing condensation. © 2014 American Physical Society.
Matsuo M.,Niigata University
Physical Review C - Nuclear Physics | Year: 2015
I formulate a many-body theory to calculate the cross section of direct radiative neutron capture reaction by means of the Hartree-Fock-Bogoliubov mean-field model and the continuum quasiparticle random-phase approximation (QRPA). A focus is put on very-neutron-rich nuclei and low-energy neutron kinetic energy in the range from 1 keV to several MeV, which is relevant to the rapid neutron capture process of nucleosynthesis. I begin with the photoabsorption cross section and the E1 strength function. Next, in order to apply the reciprocity theorem, I decompose the cross section into partial cross sections corresponding to different channels of one- and two-neutron emission decays of photo-excited states. A numerical example is shown for the photo-absorption of Sn142 and the neutron capture of Sn141. © 2015 American Physical Society.