Niigata, Japan
Niigata, Japan

Niigata University is a national university in Niigata, Niigata Prefecture, Japan. It was established in 1949 and has its major origins in Niigata Medical College and in Niigata Higher School . It is one of the largest Japanese national universities on the Sea of Japan.The university comprises nine faculties and seven graduate schools . The student enrollment is about 12,000.The faculties, graduate schools are concentrated in Ikarashi Campus to the west of the city. The medical faculties are located in Asahimachi Campus in the downtown. Attached schools are located in Nishi Ohata district next to Asahimachi Campus . In a building next to Niigata Station there is a small campus named Tokimate , whose main purpose is to offer courses of lifelong learning for adults. Wikipedia.


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Patent
Stelic Institute & Co. and Niigata University | Date: 2016-08-19

The present invention provides methods for retaining and expressing physiologically active substances in a target tissue-specific-manner, by administering the physiologically active substances to target submucous tissue. Specifically, the present inventors demonstrated that, when physiologically active substances were directly administered into submucous tissues without using a carrier, the physiologically active substances were effectively and safely retained at the administration sites over long periods without loss and diffusion, and produced the effect acting in a reservoir-like fashion. The physiologically active substances administered as described above were demonstrated to produce the therapeutic effect without having an influence on organs other than the administered organ.


Patent
Stelic Institute & Co. and Niigata University | Date: 2016-06-22

It is intended to provide a method which comprises administering a physiologically active substance to a target submucosal tissue and thus fixing and expressing the physiologically active substance specifically to the tissue. It has been found out that when a physiologically active substance is directly administered to a submucosal tissue without using a carrier, the physiologically active substance is safely and effectively fixed to the administration site over a long time without disappearing or diffusing and, moreover, plays a reservoir-like role to thereby exert its effect. It has been also found out that the physiologically active substance having been administered in the above-described manner would not affect organs other than the organ to which it is to be administered, thereby exerting a therapeutic effect.


Patent
EA Pharma Co. and Niigata University | Date: 2016-07-21

The present invention includes cilastatin or a pharmaceutically acceptable salt thereof as an active component and a suppressant for renal impairment or inner ear disorders, induced via megalin by at least one megalin ligand which is selected from the group consisting of polymyxins, aminoglycoside antibiotics, glycopeptide antibiotics, cisplatin, and pharmaceutically acceptable salts thereof


Patent
EA Pharma Co. and Niigata University | Date: 2016-11-30

The present invention includes cilastatin or a pharmaceutically acceptable salt thereof as an active component and a suppressant for renal impairment or inner ear disorders, induced via megalin by at least one megalin ligand which is selected from the group consisting of polymyxins, aminoglycoside antibiotics, glycopeptide antibiotics, cisplatin, and pharmaceutically acceptable salts thereof


Providing a modified-graphene-like carbon material into which hydroxyl groups are introduced. By reacting a graphene-like carbon material with hydrogen peroxide, a hydroxyl group is introduced into the graphene-like carbon material.


Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), and the viral oncoprotein Tax plays key roles in the immortalization of human T cells, lifelong persistent infection, and leukemogenesis. We herein identify the ubiquitin-specific protease 10 (USP10) as a Tax-interactor in HTLV-1-infected T cells. USP10 is an antistress factor against various environmental stresses, including viral infections and oxidative stress. On exposure to arsenic, an oxidative stress inducer, USP10 is recruited into stress granules (SGs), and USP10-containing SGs reduce reactive oxygen species (ROS) production and inhibit ROS-dependent apoptosis. We found that interaction of Tax with USP10 inhibits arsenic-induced SG formation, stimulates ROS production, and augments ROS-dependent apoptosis in HTLV-1-infected T cells. These findings suggest that USP10 is a host factor that inhibits stress-induced ROS production and apoptosis in HTLV-1-infected T cells; however, its activities are attenuated by Tax. A clinical study showed that combination therapy containing arsenic is effective against some forms of ATL. Therefore, these findings may be relevant to chemotherapy against ATL.


Yukawa M.,Niigata University
IEEE Transactions on Signal Processing | Year: 2012

This paper exemplifies that the use of multiple kernels leads to efficient adaptive filtering for nonlinear systems. Two types of multikernel adaptive filtering algorithms are proposed. One is a simple generalization of the kernel normalized least mean square (KNLMS) algorithm , adopting a coherence criterion for dictionary designing. The other is derived by applying the adaptive proximal forward-backward splitting method to a certain squared distance function plus a weighted block l 1 norm penalty, encouraging the sparsity of an adaptive filter at the block level for efficiency. The proposed multikernel approach enjoys a higher degree of freedom than those approaches which design a kernel as a convex combination of multiple kernels. Numerical examples show that the proposed approach achieves significant gains particularly for nonstationary data as well as insensitivity to the choice of some design-parameters. © 1991-2012 IEEE.


Yamaguchi Y.,Niigata University
Proceedings of the IEEE | Year: 2012

This paper presents scattering power decomposition images of fully polarimetric synthetic aperture radar (SAR) data for disaster monitoring. Utilization of fully polarimetric data can derive full color images with red-green-blue color coding, red for the double-bounce power, green for the volume scattering power, and blue for the surface scattering power, for which each color brightness corresponds to the magnitude. Since disaster events cause the changes of each scattering power, it becomes straightforward for everyone to recognize the changes of the color in the polarimetric decomposed images provided time series data sets are made available. After applying the four-component scattering power decomposition to fully polarimetric image data sets acquired with the Advanced Land Observing Satellite (ALOS) Phased-Array-type L-band SAR (PALSAR), several images are presented for natural disaster monitoring of volcanic activity, snow accumulation, landslides, and tsunami effects caused by great earthquakes. It is seen in the polarimetric decomposition images that the surface scattering power becomes predominant in most disaster areas compared to those in normal situations. © 2012 IEEE.


Purpose: The conversion of the computed tomography (CT) number to electron density is one of the main processes that determine the accuracy of patient dose calculations in radiotherapy treatment planning. However, the CT number and electron density of tissues cannot be generally interrelated via a simple one-to-one correspondence because the CT number depends on the effective atomic number as well as the electron density. The purpose of this study is to present a simple conversion from the energy-subtracted CT number (ΔHU) by means of dual-energy CT (DECT) to the relative electron density (ρe) via a single linear relationship. Methods: The ΔHU-ρe conversion method was demonstrated by performing analytical DECT image simulations that were intended to imitate a second-generation dual-source CT (DSCT) scanner with an additional tin filtration for the high-kV tube. The ΔHU-ρe calibration line was obtained from the image simulation with a 33 cm-diameter electron density calibration phantom equipped with 16 inserts including polytetrafluoroethylene, polyvinyl chloride, and aluminum; the elemental compositions of these three inserts were quite different to those of body tissues. The ΔHU-ρe conversion method was also applied to previously published experimental CT data, which were measured using two different CT scanners, to validate the clinical feasibility of the present approach. In addition, the effect of object size on ρe- calibrated images was investigated by image simulations using a 25 cm-diameter virtual phantom for two different filtrations: with and without the tin filter for the high-kV tube. Results: The simulated ΔHU-ρe plot exhibited a predictable linear relationship over a wide range of ρe from 0.00 (air) to 2.35 (aluminum). Resultant values of the coefficient of determination, slope, and intercept of the linear function fitted to the data were close to those of the ideal case. The maximum difference between the ideal and simulated ρe values was -0.7. The satisfactory linearity of ΔHU-ρe was also confirmed from analyses of the experimental CT data. In the experimental cases, the maximum difference between the nominal and simulated ρe values was found to be 2.5 after two outliers were excluded. When compared with the case without the tin filter, the ΔHU-ρe conversion performed with the tin filter yielded a lower dose and more reliable ρe values that were less affected by the object-size variation. Conclusions: The ΔHU-ρe calibration line with a simple one-to-one correspondence would facilitate the construction of a well-calibrated ρe image from acquired dual-kV images, and currently, second generation DSCT may be a feasible modality for the clinical use of the ΔHU-ρe conversion method. © 2012 American Association of Physicists in Medicine.


Patent
Niigata University | Date: 2016-07-13

Provided is a method for producing ambrein, comprising reacting tetraprenyl--curcumene cyclase with 3-deoxyachilleol A to obtain ambrein.

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