Entity

Time filter

Source Type


Shitara K.,Niigata Prefectural Tokamachi Hospital | Fukunari H.,Niigata Prefectural Tokamachi Hospital | Kato T.,Niigata Prefectural Tokamachi Hospital | Yoshino J.,Niigata Prefectural Tokamachi Hospital | And 4 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2014

We encountered a rare case of gastric cancer consisting predominantly of undifferentiated carcinoma. The patient was a 64-year-old man who underwent various tests because of symptoms of dysphagia in September 2012. We found a subcir-cumferential type II tumor at the gastroesophageal junction. A total gastrectomy, splenectomy, and Roux-en-Y reconstruction were performed. Adhesiotomy was also performed for the ileus on postoperative day (POD) 2. The patient subsequently experienced septic shock with disseminated intravascular coagulation (DIC) and acute kidney failure due to complications of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia and MRSA colitis. As a consequence, the patient required respiratory management and continuous hemodiafiltration (CHDF). In addition, the patient experienced hemorrhage from the Roux-en-Y-anastomotic site in the contact with the ileus tube during treatment for septicemia on POD14, which was resolved with endoscopic treatment. Moreover, a cholecystectomy was performed on POD52 for gangrenous cholecystitis. The patient's progress was satisfactory. The pathology results revealed an undifferentiated carcinoma with the following characteristics: pT4a (SE), Iy1, v0, pPM1, pDMO, type 2, 80×75 mm, UE, Less. In addition, immunostaining results revealed a tumor consisting of at least 90% of undifferentiated carcinoma tissue. Four months after surgery, local recurrence at the site of the esophagojejunostomy, disseminated recurrence around the left kidney, and metastases in the left adrenal gland appeared. The partial response (PR) was maintained by treatment with CPT-11+cisplatin (CDDP)-Hrastuzumab. However, left adrenalectomy was performed 1 year and 4 months after the initial surgery was performed for metastasis to the left adrenal gland that started 10 months after surgery. One year and 10 months after the initial surgery, the patient continues to receive treatment with trastuzumab and has not exhibited signs of recurrence. Source


Nakajima Y.,Niigata Prefectural Tokamachi Hospital | Fukunari H.,Niigata Prefectural Tokamachi Hospital | Kato T.,Niigata Prefectural Tokamachi Hospital | Yoshino J.,Niigata Prefectural Tokamachi Hospital | And 5 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2014

The first patient was of a 71-year-old woman who was examined for abdominal protuberance. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a giant tumor almost occupying the entire abdomen. En-bloc resection was performed. The tumor was 30 cm in size and weighed 6,500 g. The histological diagnosis was a well-differentiated liposarcoma. The second patient was a 72-year-old woman who visited our hospital after she had been diagnosed with an abdominal tumor by her family doctor. CT and MRI revealed a massive tumor involving various components. The tumor had invaded the left ureter and descending colon; therefore, we performed tumorectomy, left nephrectomy, and descending colectomy. The histopathological findings indicated a well-differentiated, myxoid, pleomorphic liposarcoma. The tumor recurred 4, 5, and 7 years after the first operation. By the fourth operation, the histological subtype of the tumor had changed to a dedifferentiated type. Source


Yoshino J.,Niigata Prefectural Tokamachi Hospital | Fukunari H.,Niigata Prefectural Tokamachi Hospital | Kato T.,Niigata Prefectural Tokamachi Hospital | Nakajima Y.,Niigata Prefectural Tokamachi Hospital | And 3 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2014

In October 2007, a 69-year-old woman underwent right hemicolectomy and D3 lymph node dissection for the treatment of adenocarcinoma (type 2, por2>>tub2, pSS, pN3, fStage Eb). Serum carcinoembryonic antigen (CEA) concentration was 152.8 ng/mL preoperation, but returned to normal after the operation. Adjuvant chemotherapy using 450 mg/day UFT-E was added. Computed tomography (CT) examination revealed a swollen paraaortic lymph node 3 months after the operation, while serum CEA concentration had increased to 92.7 ng/mL. After the chemotherapy was changed to FOLFOX, the paraaortic lymph node shrank and serum CEA concentration decreased. However, after 6 courses, serum CEA concentration increased again and bevacizumab-FOLFIRI therapy was initiated. After 3 courses of bevacizumab-FOLFIRI were not effective, paraaortic lymph node dissection was performed in February 2009. Pathological examination of the resected specimen showed metastatic adenocarcinoma. At present, the patient is alive without any signs of recurrence. Although the effectiveness of chemotherapy for paraaortic lymph node metastasis of colorectal cancer has been described, complete cure has not been reported. Thus, surgical resection has the potential to cure solitary recurrence of paraaortic lymph node metastasis, and therefore, should be considered in the treatment of such cases. Source


Yamamoto Y.,Niigata Prefectural Tokamachi Hospital | Hayashi T.,Niigata Prefectural Tokamachi Hospital | Kato T.,Niigata Prefectural Tokamachi Hospital | Nakao K.,Niigata Prefectural Tokamachi Hospital | And 4 more authors.
Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2015

We encountered a case of colorectal cancer with macroscopic invasion to the adjacent organs. A 61-year-old man with abdominal pain and nausea was diagnosed as having sigmoid colon cancer invading the ileum, ureter, internal iliac artery, and external iliac vein. A lower anterior resection and resection of the small bowel, ureter, external iliac vein, and internal iliac artery was performed and succeeded in an R0 resection. The patient was discharged from the hospital in 29 POD. Pathology results revealed an adenocarcinoma, pT4b, pSI, INF b, int, ly0, v, pPM0, pDM0, pN0, Type 2, Stage Ⅱ. Four courses of XELOX plus bevacizumab were administered. The patient underwent ileostomy closure, and is currently free of relapse 3 years 2 months after resection. The survival rate of patients with combined resection of the invaded organs is significantly higher than that of patients with a non-combined resection. The survival rate after curative resection is also significantly higher compared with non-curative resection. Aggressive resection of invaded organs seems to be important for a good outcome. Source


Shitara K.,Niigata Prefectural Tokamachi Hospital | Fukunari H.,Niigata Prefectural Tokamachi Hospital | Kato T.,Niigata Prefectural Tokamachi Hospital | Yoshino J.,Niigata Prefectural Tokamachi Hospital | And 4 more authors.
Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2014

We encountered a rare case of gastric cancer consisting predominantly of undifferentiated carcinoma.The patient was a 64-year-old man who underwent various tests because of symptoms of dysphagia in September 2012.We found a subcircumferential type II tumor at the gastroesophageal junction.A total gastrectomy, splenectomy, and Rouxen-Y reconstruction were performed.Adhesiotomy was also performed for the ileus on postoperative day (POD)2.The patient subsequently experienced septic shock with disseminated intravascular coagulation (DIC) and acute kidney failure due to complications of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia and MRSA colitis.As a consequence, the patient required respiratory management and continuous hemodiafiltration (CHDF). In addition, the patient experienced hemorrhage from the Roux-en-Y-anastomotic site in the contact with the ileus tube during treatment for septicemia on POD14, which was resolved with endoscopic treatment.Moreover, a cholecystectomy was performed on POD52 for gangrenous cholecystitis.The patient's progress was satisfactory.The pathology results revealed an undifferentiated carcinoma with the following characteristics: pT4a (SE), ly1, v0, pPM1, pDM0, type 2, 80 × 75 mm, UE, Less.In addition, immunostaining results revealed a tumor consisting of at least 90% of undifferentiated carcinoma tissue.Four months after surgery, local recurrence at the site of the esophagojejunostomy, disseminated recurrence around the left kidney, and metastases in the left adrenal gland appeared. The partial response (PR) was maintained by treatment with CPT-11+ cisplatin (CDDP) + trastuzumab.However, left adrenalectomy was performed 1 year and 4 months after the initial surgery was performed for metastasis to the left adrenal gland that started 10 months after surgery.One year and 10 months after the initial surgery, the patient continues to receive treatment with trastuzumab and has not exhibited signs of recurrence. Source

Discover hidden collaborations