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Niigata-shi, Japan

Hasegawa M.,Niigata Kobari Hospital | Hasegawa M.,Niigata University of Health and Welfare | Sasaki H.,Diabetes Center | Kobayashi M.,Niigata Kobari Hospital | And 6 more authors.
Journal of the Japan Diabetes Society | Year: 2010

We studied nutrition education glycemic control effects using self-monitoring of blood glucose (SMBG) on 49 obese outpatients aged 30 to 69 years with type 2 diabetes and HbAlc of 6.5 to 8.9% and BMI ≧ 25 kg/m 2 undergoing treatment without insulin therapy. Subjects were randomly divided into intervention and control groups with final analysis of 19 in the intervention group and 21 in the control group. The intervention group conducted SMBG 2 hours postprandially 2 evenings a week for 6 months and underwent nutrition training on meals versus postprandial blood glucose levels every 2 months. HbAlc in the intervention group decreased from 7.3 ± 0.5% to 7.1 ± 0.7% (mean ± SD) compared to an increase in the control group of 7.3 ± 0.7% to 8.1 ± 1.1% (p < 0.001), showing a significant intergroup difference in pre- and postintervention HbAlc change (p <0.001). In the intervention group, BMI decreased from 28.4 ± 3.0 kg/m2 to 28.0 ± 3.1 kg/m2 (p = 0.036) and diet, nutrition, self-efficacy, and dietary knowledge and behavior improved. Satisfaction with diabetes treatment also increased (p = 0.012). Source

Ariumi A.,Niigata Kobari Hospital | Ariumi A.,Niigata University | Sato T.,Niigata Kobari Hospital | Kobayashi K.,Niigata University | And 4 more authors.
Journal of Orthopaedic Science | Year: 2010

Background: Although assessment of lower extremity alignment is important for the treatment and evaluation of diseases that present with malalignment of the lower extremity, it has generally been performed using only plain radiographs seen in two dimensions (2D). In addition, there is no consensus regarding the criteria for quantitative three-dimensional (3D) evaluation of the relative angle between the femur and tibia. The purpose of this study was to establish assessment methods and criteria for quantitatively evaluating lower extremity alignment in 3D and to obtain reference data from normal elderly subjects. Methods: The normal alignment of 82 limbs of 45 healthy elderly subjects (24 women, 21 men; mean age 65 years, range 60-81 years) was analyzed in 3D with regard to flexion, adduction-abduction, and rotational angle of the knee in the weight-bearing, standing position. The obtained computed tomography (CT) and biplanar computed radiography (CR) data were used to define several anatomical axes of the femur and tibia as references. Results: In the sagittal plane, the mean extension-flexion angle was significantly more recurvatum in women than in men. In the coronal plane, the mean 3D hip-knee-ankle angle was more varus by several degrees in this Japanese series than that in a Caucasian series reported previously. Regarding rotational alignment, the mean angle between the anteroposterior axis of the tibia and the transepicondylar axis of the femur in this series was slightly larger (externally rotated) than that of previously reported Japanese series examined in the supine position. Conclusions: These data are believed to represent important references for 3D evaluation of morbid lower extremity alignment in the weight-bearing, standing position and are important for biomechanical research (e.g., 3D analyses of knee kinematics) because the relative angles between the femur and tibia are assessed three-dimensionally. © 2010 The Japanese Orthopaedic Association. Source

Okazaki K.,Niigata University | Fu Y.-J.,Niigata University | Nishihira Y.,Niigata University | Endo M.,Niigata University | And 6 more authors.
Neuropathology | Year: 2010

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Corticobasal degeneration (CBD) is a rare neurodegenerative disease affecting adults, being characterized clinically by a combination of extrapyramidal signs and focal cortical syndromes. In both diseases, tau deposits are a characteristic neuropathological feature. We report two new patients with autopsy-proven AD, in whom clinical diagnoses of CBD were made during life. The ages of the patients at onset were 52 and 67 years, and the disease durations were 9 and 15 years, respectively. At autopsy, both cases exhibited marked cortical atrophy with evident neuronal loss in the convex areas of the frontal and parietal lobes. Immunohistochemically, AT8-positive neurofibrillary tangles (NFTs) and Aβ-positive senile plaques (SPs) were widespread and abundant in the cerebral cortex (Alzheimer pathology stage VI/C of Braak and Braak), leading us to the final pathological diagnosis of AD. No tau lesions suggestive of CBD were observed, and the deep gray matter areas, including the substantia nigra, were unremarkable (exceptionally, only mild neuronal loss was noted in the putamen in case 2). These findings further strengthen the idea that in AD, neurodegeneration with tau and Aβ deposits may begin in the fronto-parietal neocortical areas, which are often preferentially affected in CBD, earlier than, or as early as the medial temporal lobe, and that extrapyramidal signs, such as rigidity and tremor, can occur in the absence of neuronal loss in the basal ganglia and substantia nigra. © 2009 Japanese Society of Neuropathology. Source

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