NIHHIS

Eumseong, South Korea
Eumseong, South Korea

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Park Y.H.,Gangwon Provincial Agricultural Research and Extention Services | Lim S.H.,Gangwon Provincial Agricultural Research and Extention Services | Kim H.Y.,Gangwon Provincial Agricultural Research and Extention Services | Park M.H.,Gangwon Provincial Agricultural Research and Extention Services | And 4 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2011

We investigated the biological activities of extracts from the flowers of Angelica gigas Nakai. The IC 50 of the DPPH radical scavenging activity was 3,535 and 105.0 μg/mL in the water and ethanol extracts, respectively, whereas it was 12.7 μg/mL for ascorbic acid. The results showed that the total polyphenol content of the ethanol extracts (48.43±0.18 mg/g) was higher than that of the water extracts (39.03±0.69 mg/g). The flavonoid content of the ethanol extracts (67.02±4.38 mg/g) was higher than that of the water extracts (50.32±1.24 mg/g). The ethanol extract showed a 34.45% lower α-glucosidase inhibition activity than that for acarbose. The ethanol extract showed a 23.62% lower α-amylase inhibition activity compared with that for acarbose. The water extract showed 16.76% lower pancreatic lipase inhibition activity. Anti-cancer and anti-inflammatory activity was also lower. These results suggest that the flower of Angelica gigas Nakai may be useful as an anti-oxidative agent.


Chung I.-M.,Konkuk University | Kim H.-J.,Konkuk University | Ahn Y.-S.,NIHHIS | Ahmad A.,Konkuk University
Asian Journal of Chemistry | Year: 2013

Two compounds 1-oleo-2, 3-dilinoleioglyceride (1) and 1,2-dioleo-3- linolenioglyceride (2) have been isolated from the ethyl acetate extract of fruits of Lycium chinense. Their structures have been elucidated with the help of 600 MHz NMR using 1D spectral method viz., 1H and 13C, aided by FAB MS and IR spectroscopy. The compounds 1-2 are reported for the first time in the fruits of L. chinense.


Park Y.H.,Agriproduct Processing Experiment Station Gangwon do Agicultural Research and Experiment Services | Kim H.Y.,Agriproduct Processing Experiment Station Gangwon do Agicultural Research and Experiment Services | Lim S.H.,Agriproduct Processing Experiment Station Gangwon do Agicultural Research and Experiment Services | Kim K.H.,Agriproduct Processing Experiment Station Gangwon do Agicultural Research and Experiment Services | And 5 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2011

In this study, we investigated the anti-obesity activity of Aceriphyllum rossii ethanol extract on rat fed a high fat diet. Male SD rats were divided into four groups. Group 1 was the control. Group 2 was fed a high-fat diet. Group 3 was the positive control, fed a high-fat diet supplemented with Garcinia Cambogia extracts. Group 4 was fed a high fat diet supplemented with ethanol extracts of Aceriphyllum rossii (EEAR). Precisely 166 mg/kg of powdered Garcinia Cambogia extracts was used for Group 3. Also, 250 mg/kg of EEAR was used for Group 4. The Body weight increased Group 2, but decreased Group 4. The serum total cholesterol in Group 2 increased by 15.26% when compared to Group 1, but only increased 5.29% in Group 3 and 4.29% in Group 4. The liver and mesenteric adipose tissue weights of Group 2 increased compared to Group 1, whereas they decreased in Group 3 and Group 4. As a result of measuring the concentration of triglycerides in extracted livers, Group 2 showed a significant increase compared to the Group 1, and Groups 3 and 4 showed significant decrease compared Group 2. These results suggest that Aceriphyllum rossii ethanol extracts may be useful as an anti-obesity agent.


Chung I.-M.,Konkuk University | Kim S.H.,Konkuk University | Ahn Y.S.,NIHHIS | Ahmad A.,Konkuk University
Asian Journal of Chemistry | Year: 2012

One compound β-D-glucuronopyranosyl-β-D-(6→1)- glucopyranosyl-β-D-(6→1)-β-D-glucopyranosyl-(6→1) -β-D-glucopyranosyl- (6→1)-β-D-glucopyranosyl-(6→1)-β- D-glucopyranoside (1) has been isolated for the first time from the ethyl acetate extract of fruits of Lycium chinense. Their structure has been elucidated with the help of 600 MHz NMR using 1D and 2D spectral methods viz: 1H and 13C, aided by FAB MS and IR spectroscopy.


Chung I.-M.,Konkuk University | Nagella P.,Konkuk University | Ahn Y.-S.,NIHHIS | Kim S.-J.,Konkuk University | Ahmad A.,Konkuk University
Journal of Medicinal Plant Research | Year: 2011

The essential oil and petroleum ether extract from the fruits of Lycium chinense Mill. (Solanaceae), were analyzed by gas chromatography-mass spectrometry (GC-MS). Out of 42 peaks, 40 components, which constituted 99.81%, were identified in the oil. The oil was dominated by acid and esters which accounted for 66.61 and 8.43%, respectively. The major constituents were hexadecanoic acid methyl ester (4.92%), hexadecanoic acid ethyl ester (9.92%), ethyl linoleate (3.45%), tetradecanoic acid (3.72%) and hexadecanoic acid (62.89%). Forty components, which constitute 99.50%, were identified in the petroleum ether extract. The major components of petroleum ether extract were hexadecanoic acid (17.43%), hexadecanoic acid ethyl ester (9.51%), hexadecanoic acid methyl ester (3.72%), ethyl linoleate (10.26%), and phytol (3.58%). The petroleum ether extract components were identified for the first time. The identity of constituents of essential oil and petroleum ether extract was confirmed on the basis of retention time and mass and supplemented library. Extracts of different polarity from fruits of L. chinense were investigated for their antioxidant activity. Two different bioassays were used, namely scavenging of the diphenylpicrylhydrazyl (DPPH) radical method and the other reducing power of Fe3+ method. The total phenolic content was quantified of each extract as well. Butanol, ethyl acetate and methanolic extracts contributed to the strongest antioxidant activity. The fruit extracts of medicinal plant (L. chinense) has potential as a natural antioxidant and thus inhibit unwanted oxidation process. ©2011 Academic Journals.


Chung I.-M.,Konkuk University | Yang Y.-S.,Konkuk University | Nagella P.,Konkuk University | Ahn Y.-S.,NIHHIS | And 3 more authors.
Asian Journal of Chemistry | Year: 2014

Lycium chinense, a famous Chinese medicinal herb, has long history of use as a traditional remedy for many diseases. One compound as a-D-glucopyranosyl-(2 → 1′)-α-L-arabinopyranosyl-(2′ → 1″)-α-L-arabinopyranosyl-(2″ → 1′″)-″- L-arabinopyranoside (1) was isolated from the butanol fraction of methanol extract of fruits of L. chinense. The compound 1 was investigated for scavenging of the diphenylpicrylhydrazyl (DPPH•) radical scavenging activity, reducing power and the phosphomolybdenum activity and the results demonstrate that the compound (1) has potential as a natural antioxidant.


Park Y.H.,Gangwon do Agicultural Research and Experiment Services | Kim H.Y.,Gangwon do Agicultural Research and Experiment Services | Lim S.H.,Gangwon do Agicultural Research and Experiment Services | Kim K.H.,Gangwon do Agicultural Research and Experiment Services | And 3 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2012

The effects of ethanol extract from leaves of Eleutherococcus senticosu were evaluated on hyperlipidemic rats. Male SD rats were divided into a normal group, control (AIN-76 diet) group, Garcinia cambogia extract group, and AIN-76 diet group supplemented with ethanol extract from Eleutherococcus senticosu(EEES). The body weight of the AIN-76 group increased, whereas those of the Garcinia and EEES groups decreased. The serum total cholesterol of the AIN-76 group increased by 28.36% compared to the normal group, but decreased by only 27.15% in the Garcinia group and 25.47% in the EEES group. The serum triglyceride level of the AIN-76 group increased by 35.04% compared to the normal group, but decreased by only 26.76% in the Garcinia group and 37.54% in the EEES group. The serum HDL-cholesterol levels of the Garcinia and EEES groups increased compared to that of the AIN-76 group. The liver and epididymal adipose tissue weights of the EEES group decreased compared to those of the AIN-76 group. In measuring the concentration of triglycerides and total cholesterol level in the liver extracts, the AIN-76 group showed significant increases compared to the normal group, whereas the Garcinia and EEES groups showed a significant decrease compared to the AIN-76 group. These results indicate that the EEES group may improve lipid metabolism and reduce fat accumulation and body weight.

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