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Bello B.,Nigerian Institute for Trypanosomiasis Research NITR | Wudil A.M.,Bayero University
International Journal of Pharma and Bio Sciences | Year: 2012

The effects of pretreatment and co-administration of aqueous extract of Daucus carota root on anti-tubercular drugs hepatotoxicity in rats were studied. Wistar albino rats were divided into six groups of three rats each. Groups 1 and 2 were normal and test control (administered with anti-tubercular drugs to induce hepatotoxicity) respectively. Groups 3 and 4 were pretreated with 100mg/kg bw and 200mg/kg bw of the extract for 28 days, then administered with antitubercular drugs isoniazid (INH) and rifampicin (RMP) at doses of 27mg/kg bw and 54mg/kg bw respectively for same duration. In groups 5 and 6, same doses of the extract and anti-tubercular drugs were administered concurrently for 28 days. Oral administration of the extract significantly (P 0.05) reduced serum ALT, AST, and ALP activities, and uBIL concentrations compared to the test control. The results suggested that aqueous extract of Daucus carota might have had an hepatoprotective effect on anti-tubercular drugs hepatotoxicity in rats.

Abedo J.A.,Nigerian Institute for Trypanosomiasis Research NITR | Jonah O.A.,Nigerian Institute for Trypanosomiasis Research NITR | Abdullahi R.S.,Nigerian Institute for Trypanosomiasis Research NITR | Mazadu M.R.,Nigerian Institute for Trypanosomiasis Research NITR | And 9 more authors.
Bioscience Research | Year: 2013

This investigation compared the various extracts obtained from different parts of Tapinanthus globiferus and Gongrenema latifolium for trypanocidal activity, in vitro and in vivo at different concentration on mice infected with Trypanosoma congolense. The methanolic extracts of stem bark of Gongrenema latifolium and Tapinanthus globiferus leaves had highest activity in vitro thus they were evaluated for in vivo activity. The albino mice were treated with extracts ranging from 100-400mg/kg body weight intraperitoneally for 7 consecutive days. The group treated with 400mg/kg of Tapinanthus globiferus had significant reduction In parasiteamia and their life's were prolong up to the 24th day before they culminated in death compared with those treated with the same dose of Gongrenema latifolium but all died by day 9th post treatment. The result also showed that, the group inoculated with parasite and extract of Tapinanthus globiferus simultaneously, did not develop parasiteamia while the experiment lasted. Groups treated with 100-200mg/kg and the control had increased in parasiteamia and they all died by day 9th post treatment. However the groups treated with 200mg/kg of Tapinanthus globiferus, had reduced parasiteamia by day 4 but was followed by a relapse causing the death of animals by day 10th. Phytochemical screening showed appreciable amount of alkaloids and flavonoids in the extract of Tapinanthus globiferus compared to that found in Gongrenema latifolium which are only in traces. Further fractionation of this extracts will be required in order to isolate the active component. ©ISISnet Publishers.

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