NIER Ingegneria SpA

Bologna, Italy

NIER Ingegneria SpA

Bologna, Italy
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Grant
Agency: European Commission | Branch: H2020 | Program: Shift2Rail-RIA | Phase: S2R-OC-IP1-02-2016 | Award Amount: 6.68M | Year: 2016

SAFE4RAIL will provide the baseline for a fundamentally simplified embedded computing and networked TCMS platform, for modular integration and certification of all safety-, time- and mission-critical train functions, including distributed hard real-time controls, safety signals and functions up to SIL4. The generic embedded platform architecture provided by SAFE4RAIL will allow mixed-criticality integration and virtualization to host critical and non-critical functions on reconfigurable computing and networking resources. The SAFE4RAIL simulation and testing environment is based on the hardware abstraction and domain separation concepts allowing rapid deployment and testing of applications, e.g. by supporting early functional integration testing long before vehicle integration. The results of SAFE4RAIL are demonstrated with a SIL4 brake-by-wire system safety concept. Finally, the project will provide recommendations for standardization and certification of next generation TCMS embedded platform. SAFE4RAIL reduces TCMS system lifecycle and operating costs and minimizes time-to-market by: (1) minimized physical complexity: reduced weight, wiring, connector and computer count, increased part commonality, reliability and availability (2) supporting streamlined approaches to verification/testing, validation, reuse, and (re)certification (3) incorporating reconfiguration and modular certification to reduce system integration and recommissioning costs. SAFE4RAIL results will encourage interoperability, efficient, safe and secure interconnection of technical solutions among European railway providers, boosting the worldwide competitiveness and preserving the global leadership of the European transport industry. SAFE4RAIL is driven by a European cross-industry consortium of 11 academic and industrial partners (including 4 SMEs), with experts from automotive, aerospace, railway to ensure synergies with existing and developing architectural concepts and technologies.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-EID | Phase: MSCA-ITN-2014-EID | Award Amount: 1.52M | Year: 2015

The EID WAKEUPCALL has been set up with the knowledge that, in the WAKE of the financial crisis, a reconsideration of fundamental assumptions that have been standard in the mathematical models for the valuation of financial and insurance products, like CALLs is taking place. The crisis alerted to reiterate models, assumptions and computations. It is now better understood that the usual paradigm, in which financial risks can be mitigated, spread, or even hedged away perfectly, is too simplistic for markets under stressed conditions. Lead by the Basel Committee on Banking Supervision, financial and insurance institutions are currently implementing new paradigms regarding risk management. Many of the updates in the risk measures involve sophisticated mathematics. In this sense, the crisis has provided important feedback on appropriate directions for the required mathematical improvements. As regards to hedging and risk mitigation, which are important steps in the risk management chain, nowadays even the hedging of basic financial instruments has become a complicated task. More sophisticated models are needed if hedging programs are to remain effective under financial stress. We wish to bring together academic researchers in financial mathematics and high level professionals in financial and insurance industries, discuss and interact by means of early-stage researchers (ESRs). We are interested in the mathematical models, as well as in advanced solution techniques used for pricing and risk measurement. We wish to educate young experts in modern risk measures and management. Advanced courses by academic and professional lecturers will be selected for the education of the ESRs. We will additionally work on providing entrepeneurial skills to ESRs as they will have a unique knowledge of applied mathematics on practically relevant research questions in computational finance. All ESRs will produce software, according to latest standards in high performance computing.


Pantaleo M.A.,University of Bologna | Lolli C.,University of Bologna | Nannini M.,University of Bologna | Astolfi A.,University of Bologna | And 20 more authors.
Genetics in Medicine | Year: 2015

A subset of patients with KIT/PDGFRA wild-type gastrointestinal stromal tumors show loss of function of succinate dehydrogenase, mostly due to germ-line mutations of succinate dehydrogenase subunits, with a predominance of succinate dehydrogenase subunit A. The clinical outcome of these patients seems favorable, as reported in small series in which patients were individually described. This work evaluates a retrospective survival analysis of a series of patients with metastatic KIT/PDGFRA wild-type succinate dehydrogenase-deficient gastrointestinal stromal tumors.Methods:Sixty-nine patients with metastatic gastrointestinal stromal tumors were included in the study (11 KIT/PDGFRA wild-type, of whom 6 were succinate dehydrogenase deficient, 5 were non-succinate dehydrogenase deficient, and 58 were KIT/PDGFRA mutant). All six succinate dehydrogenase-deficient patients harbored SDHA mutations. Kaplan-Meier curves and log-rank tests were used to compare the survival of patients with succinate dehydrogenase subunit A-mutant gastrointestinal stromal tumors with that of KIT/PDGFRA wild-type patients without succinate dehydrogenase deficiency and patients with KIT/PDGFRA-mutant gastrointestinal stromal tumors.Results:Follow-up ranged from 8.5 to 200.7 months. The difference between succinate dehydrogenase subunit A-mutant gastrointestinal stromal tumors and KIT/PDGFRA-mutant or KIT/PDGFRA wild-type non-succinate dehydrogenase deficient gastrointestinal stromal tumors was significant considering different analyses (P = 0.007 and P = 0.033, respectively, from diagnosis of gastrointestinal stromal tumor for the whole study population; P = 0.005 and P = 0.018, respectively, from diagnosis of metastatic disease for the whole study population; P = 0.007 for only patients who were metastatic at diagnosis).Conclusion:Patients with metastatic KIT/PDGFRA wild-type succinate dehydrogenase-deficient gastrointestinal stromal tumors harboring succinate dehydrogenase subunit A mutations present an impressively long survival. These patients should be identified in clinical practice to better tailor treatments and follow-up over time. © American College of Medical Genetics and Genomics.


PubMed | University of New South Wales, Modena University Hospital Trust, University of Bologna, NIER Ingegneria SpA and 2 more.
Type: Journal Article | Journal: Genetics in medicine : official journal of the American College of Medical Genetics | Year: 2015

A subset of patients with KIT/PDGFRA wild-type gastrointestinal stromal tumors show loss of function of succinate dehydrogenase, mostly due to germ-line mutations of succinate dehydrogenase subunits, with a predominance of succinate dehydrogenase subunit A. The clinical outcome of these patients seems favorable, as reported in small series in which patients were individually described. This work evaluates a retrospective survival analysis of a series of patients with metastatic KIT/PDGFRA wild-type succinate dehydrogenase-deficient gastrointestinal stromal tumors.Sixty-nine patients with metastatic gastrointestinal stromal tumors were included in the study (11 KIT/PDGFRA wild-type, of whom 6 were succinate dehydrogenase deficient, 5 were non-succinate dehydrogenase deficient, and 58 were KIT/PDGFRA mutant). All six succinate dehydrogenase-deficient patients harbored SDHA mutations. Kaplan-Meier curves and log-rank tests were used to compare the survival of patients with succinate dehydrogenase subunit A-mutant gastrointestinal stromal tumors with that of KIT/PDGFRA wild-type patients without succinate dehydrogenase deficiency and patients with KIT/PDGFRA-mutant gastrointestinal stromal tumors.Follow-up ranged from 8.5 to 200.7 months. The difference between succinate dehydrogenase subunit A-mutant gastrointestinal stromal tumors and KIT/PDGFRA-mutant or KIT/PDGFRA wild-type non-succinate dehydrogenase deficient gastrointestinal stromal tumors was significant considering different analyses (P = 0.007 and P = 0.033, respectively, from diagnosis of gastrointestinal stromal tumor for the whole study population; P = 0.005 and P = 0.018, respectively, from diagnosis of metastatic disease for the whole study population; P = 0.007 for only patients who were metastatic at diagnosis).Patients with metastatic KIT/PDGFRA wild-type succinate dehydrogenase-deficient gastrointestinal stromal tumors harboring succinate dehydrogenase subunit A mutations present an impressively long survival. These patients should be identified in clinical practice to better tailor treatments and follow-up over time.


Albano P.G.,University of Bologna | Albano P.G.,NIER Ingegneria SpA | D'Occhio P.,University of Bologna | Strazzari G.,NIER Ingegneria SpA | And 2 more authors.
Journal of Molluscan Studies | Year: 2014

While central and northern European land-mollusc forest communities have received considerable research effort, southern Europe has enjoyed much less attention. Despite the extent of Italian forests in terms of altitude and latitude, there has been only one previous quantitative study of their molluscan faunas. This paper describes the molluscan communities of six forest habitats in northern Italy along an altitudinal transect. Species richness had its highest values at low elevations, especially in maritime woodland and in riverine poplar woodland. Species abundance decreased from lowland to montane habitats, possibly as a consequence of a transition from eutrophic to oligotrophic habitats and from calcareous to acidic soils. Compared with the central and northern European forests, the Italian forests were poorer as far as species richness is concerned, but showed greater diversity among locations as the Jaccard presence/absence similarity index among habitats is equal or lower than 0.5. Considering abundances, all molluscan communities were significantly different in pairwise comparisons, with the single exception of the montane mixed-deciduous and beech forests. The low faunal similarity among sites and the high percentage of species found in only one habitat support the need for a network of diverse protected areas to preserve land-mollusc biodiversity. © 2013 © The Author 2014. Published by Oxford University Press on behalf of The Malacological Society of London, all rights reserved.


Albano P.G.,University of Bologna | Albano P.G.,NIER Ingegneria SpA | Strazzari G.,NIER Ingegneria SpA | D'Occhio P.,University of Bologna | Succetti F.,University of Bologna
Italian Journal of Zoology | Year: 2015

Estimations of site occupancy of species and their vital rates, and of species richness of a community, are biased if detection probability is not taken into account. Models that allow the joint estimation of occupancy and detectability were used in a land mollusc survey in six forest habitats in northern Italy, allowing estimations for 55 species of land snails. Most species were poorly detectable (p ≤ 0.3). Detectability varied among habitats and collecting techniques. Taking into account detectability, occupancy estimations may be from 15 to 85% larger than the naïve occupancy values computed by dividing the number of stations at which the species was detected by the total number of stations (0.13–0.42 in absolute terms), significantly altering our understanding of species rarity. In several habitats the share of spatially rare species was remarkably high, above 30%, with peaks above 60%; at the regional scale 62.7% for visual sampling and 46.7% for leaf litter and soil sampling. The sampling effort to monitor occupancy for the numerous uncommon to rare species is well above what would be satisfactory in terms of saturation of species inventory. Visual search gave higher estimates of detectability for species above 1 cm in size, while leaf litter and soil sorting gave higher estimates for species below 1 cm. Consideration of fresh empty shells along with living individuals allowed us to improve the estimates, but when interpreting results the bias induced by taphonomic processes has to be considered. When detection probabilities are unknown, an estimate of their order of magnitude may be obtained by relative abundances, while shell size does not correlate significantly with detectability. © 2015 Unione Zoologica Italiana

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