Cluj-Napoca, Romania
Cluj-Napoca, Romania

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Parv A.,Heart Institute Niculae Stancioiu | Anchidin O.,Heart Institute Niculae Stancioiu | Ober C.,Heart Institute Niculae Stancioiu | Bindea D.,Heart Institute Niculae Stancioiu | And 3 more authors.
Medical Ultrasonography | Year: 2012

Transthoracic Doppler echocardiography (TDE) is a non-invasive and easy reproducible method to assess the left internal mammary artery (LIMA) graft patency after coronary artery bypass graft surgery (CABG). LIMA graft dysfunction is rare, its rate being 10% at 10 to 15 years after revascularization. The most common cause of graft dysfunction is the competitive flow with the native coronary artery, when the stenosis of the bypassed vessels is not severe. We present two cases of LIMA graft dysfunction diagnosed by TDE and confirmed by angiography, with two particular pulsed-wave color Doppler flow signals.

Rosianu S.H.,University of Medicine and Pharmacy, Cluj-Napoca | Buzoianu A.D.,University of Medicine and Pharmacy, Cluj-Napoca | Rosianu A.,Heart Institute Niculae Stancioiu | Capalneanu R.,University of Medicine and Pharmacy, Cluj-Napoca
Human and Veterinary Medicine | Year: 2011

The sinus node dysfunction is associated with conduction system disease and supraventricular tachyarrhythmias (atrial fibrillation and atrial flutter). The only effective treatment for patients with chronic symptomatic sinus node dysfunction is pacemaker therapy. In tachy-brady syndrome patients, in addition to pacemaker therapy, the pharmacological treatment is necessary to avoid tachycardia episodes. Because of the frequent paroxysmal atrial fibrillation episodes a good choice to maintain the sinus rhythm is represented by sotalol. This article will present three patients that provide examples of beneficial effects of sotalol and also on the risk of severe adverse events in some cases.

Parv A.,Medical V Hospital | Ober C.,Heart Institute Niculae Stancioiu | Bindea D.,Heart Institute Niculae Stancioiu | Duncea C.,Medical V Hospital
Medical Ultrasonography | Year: 2013

Assessment of the left internal mammary artery (LIMA) graft patency currently requires invasive investigation through coronary angiography. In the last years the successful application of noninvasive Doppler spectrum analysis has been reported for patency assessment of the LIMA graft after myocardial revascularization. Echocardiography is considered to be a sensitive noninvasive screening modality to diagnose critical narrowing of LIMA grafts and angiography should be reserved for cases in which Doppler echocardiography fails to visualize the LIMA or reveals an abnormal flow pattern.

PubMed | University of Medicine and Pharmacy, Cluj-Napoca and Heart Institute Niculae Stancioiu
Type: Journal Article | Journal: Clujul medical (1957) | Year: 2015

Experimental and clinical studies have shown the importance of inflammation in the pathophysiology of atrial fibrillation (AF). The renin-angiotensin-aldosterone system (RAAS) may play an important role in the pathogenesis of AF in correlation with the inflammatory process. RAAS inhibition may have important therapeutic value in limiting AF. The aim of this study was the correlation between inflammatory markers and recurrent episodes of AF in patients with known paroxysmal atrial fibrillation, with and without treatment with RAAS inhibitors.We studied 82 patients with paroxysmal AF recorded at Niculae Stancioiu Heart Institute Cluj-Napoca, divided into two groups: group A treated with angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB) and group B without this medication. All patients underwent clinical examination, ECG, echocardiography and determination of plasma levels of inflammatory markers represented by high sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6). In the group treated with ACE inhibitors/ARBs, AF burden was significantly lower than in patients without treatment. We obtained a strong positive correlation between blood levels of high-sensitivity CRP and those of IL-6 (r=0.64, p<0.001), the number of yearly AF episodes (r=0.570, p<0.001), LA diameter (r=0.5, p<0.001) and LA volume (r=0.5, p<0.001). We found moderate positive correlations between blood levels of IL-6 and LA diameter (r=0.305, p=0.01), LA volume (r=0.314, p=0.01), the number of yearly AF episodes (r=0.489, p<0.001), the total number of AF episodes (r=0.304, p<0.001), BMI (r=0.473, p<0.001), LA area (r=0.458, p<0.001), LA area index (r=0.334, p=0.007) and LA volume index (r=0.304, p=0.01). The number of yearly AF episodes and BMI values influenced IL-6 blood levels (t=3.46, p=0.001, respectively t=2.17, p=0.03).Inflammation is present in patients with AF, with or without treatment with RAAS inhibitors and is correlated with longer duration of AF, left atrial diameter and left atrial volume. ACE inhibitors and ARBs, acting on cardiac substrate and reducing the inflammatory process, may have a therapeutic protective role of decreasing AF burden.

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