Gorska A.,Nicolaus Copernicus University |
Sloderbach A.,Nicolaus Copernicus University |
Marszall M.P.,Nicolaus Copernicus University
Trends in Pharmacological Sciences | Year: 2014
The ability of bacteria to develop resistance to antimicrobial agents poses problems in the treatment of numerous bacterial infections. One method to circumvent permeability-mediated drug resistance involves the employment of the 'Trojan horse' strategy. The Trojan horse concept involves the use of bacterial iron uptake systems to enter and kill bacteria. The siderophore-drug complex is recognized by specific siderophore receptors and is then actively transported across the outer membrane. The recently identified benefits of this strategy have led to the synthesis of a series of siderophore-based antibiotics. Several studies have shown that siderophore-drug conjugates make it possible to design antibiotics with improved cell transport and reduce the frequency of resistance mutants. Growing interest in siderophore-drug conjugates for the treatment of human diseases including iron overload, cancer, and malaria has driven the search for new siderophore-drug complexes. This strategy may have special importance for the development of iron oxide nanoparticle-based therapeutics. © 2014 Elsevier Ltd.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.50M | Year: 2015
Biomedical imaging is a research field that is producing ground breaking scientific discoveries that enhance the health and life quality of European citizens and have a huge economic impact. In order to maintain Europes leading position in the field, it is crucial to invest in the people who will lead R&D, and to promote the academic-private sector partnerships that will transfer the novel technologies to the market. In order to meet these needs, BE-OPTICAL will provide a unique and structured training programme to 14 ESRs in a wide range of optical imaging technologies and signal processing tools, including fluorescence spectroscopy and microscopy, optical coherence tomography, optogenetics, engineered nanomaterials and signal processing tools. The research is structured in 4 WPs: super-resolution optical imaging for the analysis of cellular processes (WP1), high-resolution optical imaging of cardiac tissue (WP2), advanced instrumentation for ophthalmic imaging (WP3), and optical components, methods and software for image analysis (WP4). Comprising 7 leading academic groups and 2 non-academic partners in 5 European countries, BE-OPTICAL brings together an interdisciplinary team of physicists, engineers and medical doctors, with complementary expertise in optical imaging, nanotechnology, computer science, complex systems and data analysis. The non-academic partners are a leading company in fluorescence instrumentation and an internationally recognised ophthalmology clinic, with the most advanced technology and expertise in ocular diseases. The training programme will provide the ESRs with a broad understanding of how a wide range of optical imaging technologies and data processing tools work, and will open for them a wide range of job opportunities. The ESRs will apply this knowledge to advance the early diagnosis of highly significant diseases. The ESRs will also gain insight into clinical studies of novel imaging technologies and the commercialization process.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.51M | Year: 2017
RadioNet is a consortium of 28 institutions in Europe, Republic of Korea and South Africa, integrating at European level world-class infrastructures for research in radio astronomy. These include radio telescopes, telescope arrays, data archives and the globally operating European Network for Very Long Baseline Interferometry (EVN). RadioNet is de facto widely regarded to represent the interests of radio astronomy in Europe. A comprehensive, innovative and ambitious suite of actions is proposed that fosters a sustainable research environment. Building on national investments and commitments to operate these facilities, this specific EC program leverages the capabilities on a European scale. The proposed actions include: - Merit-based trans-national access to the RadioNet facilities for European and for the first time also for third country users; and integrated and professional user support that fosters continued widening of the community of users. - Innovative R&D, substantially enhancing the RadioNet facilities and taking leaps forward towards harmonization, efficiency and quality of exploitation at lower overall cost; development and delivery of prototypes of specialized hardware, ready for production in SME industries. - Comprehensive networking measures for training, scientific exchange, industry cooperation, dissemination of scientific and technical results; and policy development to ensure long-term sustainability of excellence for European radio astronomy. RadioNet is relevant now, it enables cutting-edge science, top-level R&D and excellent training for its European facilities; with the Atacama Large Millimetre Array (ALMA) and the ESFRI-listed Square Kilometre Array (SKA) defined as global radio telescopes, RadioNet assures that European radio astronomy maintains its leading role into the era of these next-generation facilities by involving scientists and engineers in the scientific use and innovation of the outstanding European facilities.
Agency: European Commission | Branch: FP7 | Program: CSA-CA | Phase: Fission-2013-6.0.1 | Award Amount: 1.22M | Year: 2013
The objective of PLATENSO is to provide a proposal towards establishing the legal base for a European Entity on Socio-Economic matters linked to nuclear technology and to develop recommendations for research strategies in PLATENSO countries. Thereby the capabilities of research institutes in Central and Eastern European countries to take part in EU research with respect to governance, social and societal aspects is enhanced. Initially, lessons learned from earlier projects, what is the state of knowledge in societal, social and governance issues, are reviewed and summarized. The research infrastructures within which project activities and future research are to take place are mapped and efforts are made to make sure research actors frame their approaches broad enough. Research strategies are formed for research in governance, social and societal issues in which participation in EU programmes is an integrated part. The strategies are tested with case studies to make sure they are feasible to implement. A number of networking activities are carried through as a major step toward actual foundation of the strategies in PLATENSO countries. In each country a PLATENSO partner will take responsibility for building a network of research institutions in its respective country. Establishment of the legal base for a European Entity on Socio-Economic matters linked to nuclear technology has potential to overcome the barriers that still exist for taking them fully into account and to make the awareness of the social and political challenges to come to action. On the basis of exploratory studies focusing on Central and Eastern Europe and contacts with relevant stakeholders in all EU, the project will analyze main aspects with regard to the implementation of the entity (organization, legal form, communication structure, content, etc.). Major areas on social, societal and governance issues for the envisaged Entity will be proposed. A nuclear energy scenario based on the Generation 4 ALLEGRO reactor concept will be given special attention as a pilot case for the European Entity giving support to ALLEGRO in social, societal and governance issues, which will include testing the draft strategy for research. The exact forms for this will be developed in close cooperation between PLATENSO and the ALLIANCE project.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.91M | Year: 2015
We need to increase the crop yield while reducing pesticide and use of inorganic fertiliser to meet the challenges of world population growth and climate change. Plant endophytic microorganisms can improve plant yield and enhance plant tolerance to abiotic stress as well as to pathogens under experimental conditions, but these effects are often not sufficiently stable for practical application. How do we boost the stability and reliability of the positive effects of endophytes on plants? We need to understand the genetic basis of beneficial interactions between crops and endophytes and extent this basis exhibits phenotypic plasticity at all interaction levels from the cellular to the field environment. This requires increasing our knowledge of the molecular mechanisms underlying the effects of endophytes, including intra and inter-kingdom exchange and distribution of resources (nutrients), signalling and possibly regulation between and inside the partners, the mutual induced production of secondary metabolites and the environmental cues which influence crop-endophyte interactions. The genetic variation and its plasticity in host and microbe will be exploited in to establish crop breeding and inoculum production processes for boosting the establishment and stability of plant-microbe mutualisms to benefit crop development, stress tolerance, pathogen resistance and quality. In this project we will provide fundamental biological as well as practical knowledge about interactions between endophytes and plants. This improved understanding will pave the way for increased use of endophytes to improve sustainability and plant productivity in a reliable way. The participants in this project comprise many of the key institutions and industries working with these problems and provide a uniquely strong consortium to address the key issues. Furthermore, the consortium will train a new generation of scientists who have the insight and skills to continue this task in their careers.
Agency: European Commission | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.21. | Award Amount: 11.58M | Year: 2012
RadioNet is an I3 that coordinates all of Europes leading radio astronomy facilities in an integrated cooperation to achieve transformational improvement in the quality and quantity of the scientific research of European astronomers. RadioNet3 includes 27 partners operating world-class radio telescopes and/or performing cutting-edge R&D in a wide range of technology fields important for radio astronomy. RadioNet3 proposes a work plan that is structured into 6 NAs, 7 TNAs and 4 JRAs with the aim to integrate and optimise the use and development of European radio astronomy infrastructures. The general goals of RadioNet3 are to: - facilitate, for a growing community of European researchers, access to the complete range of Europes world-leading radio-astronomical facilities, including the ALMA telescope; - secure a long-term perspective on scientific and technical developments in radio astronomy, pooling resources and expertise that exist among the partners; - stimulate new R&D activities for the existing radio infrastructures in synergy with ALMA and the SKA; - contribute to the implementation of the vision of the ASTRONET Strategic Plan for European Astronomy by building a sustainable and world leading radio astronomical research community. RadioNet3 builds on the success of two preceeding I3s under FP6 and FP7, but it also takes a leap forward as it includes facilitation of research with ALMA via a dedicated NA, and 4 pathfinders for the SKA in its TNA Program. It has a transparent and efficient management structure designed to optimally support the implementation of the project. RadioNet is now recognized by funding agencies and international project consortia as the European entity representing radio astronomy and facilitating the access to and exploitation of excellent facilities in this field. This is of paramount importance, as a dedicated, formal European radio astronomy organisation to coordinate and serve the needs of this community does not yet exist.
Kobus J.,Nicolaus Copernicus University
Computer Physics Communications | Year: 2013
The newest version of the two-dimensional finite difference Hartree-Fock program for atoms and diatomic molecules is presented. This is an updated and extended version of the program published in this journal in 1996. It can be used to obtain reference, Hartree-Fock limit values of total energies and multipole moments for a wide range of diatomic molecules and their ions in order to calibrate existing and develop new basis sets, calculate (hyper)polarizabilities (αz, βz, γz, Az, Bzz,zz) of atoms, homonuclear and heteronuclear diatomic molecules and their ions via the finite field method, perform DFT-type calculations using LDA or B88 exchange functionals and LYP or VWN correlations ones or the self-consistent multiplicative constant method, perform one-particle calculations with (smooth) Coulomb and Krammers-Henneberger potentials and take account of finite nucleus models. The program is easy to install and compile (tarball+configure+make) and can be used to perform calculations within double- or quadruple-precision arithmetic. 7 © 2012 Elsevier B.V. All rights reserved.
Wojtkowski M.,Nicolaus Copernicus University
Applied Optics | Year: 2010
In the past decade we have observed a rapid development of ultrahigh-speed optical coherence tomography (OCT) instruments, which currently enable performing cross-sectional in vivo imaging of biological samples with speeds of more than 100,000 A-scans/s. This progress in OCT technology has been achieved by the development of Fourier-domain detection techniques. Introduction of high-speed imaging capabilities lifts the primary limitation of early OCT technology by giving access to in vivo three-dimensional volumetric reconstructions on large scales within reasonable time constraints. As result, novel tools can be created that add new perspective for existing OCT applications and open new fields of research in biomedical imaging. Especially promising is the capability of performing functional imaging, which shows a potential to enable the differentiation of tissue pathologies via metabolic properties or functional responses. In this contribution the fundamental limitations and advantages of time-domain and Fourier-domain interferometric detection methods are discussed. Additionally the progress of high-speed OCT instruments and their impact on imaging applications is reviewed. Finally new perspectives on functional imaging with the use of state-of-the-art high-speed OCT technology are demonstrated. © 2010 Optical Society of America.
Agency: European Commission | Branch: H2020 | Program: MSCA-IF-EF-ST | Phase: MSCA-IF-2015-EF | Award Amount: 146.46K | Year: 2016
The acute toxicity and radioactivity of actinide compounds complicate experimental studies of the soup of nuclear waste produced in nuclear reactors. This motivates research into computational approaches for determining molecular properties and reactivity of actinide compounds. Unfortunately, the computational resources required by standard quantum chemistry methods grow exponentially with system size, an effect known as the curse of dimension. Since the actinide-containing molecules of relevance to nuclear chemistry contain hundreds of electrons, innovative new approaches that break the curse of dimension must be developed. One such approach models many-electron molecules as collections of noninteracting electron pairs, called geminals. Standard geminal methods are inappropriate for actinide chemistry, however, and must be extended to include (i) computationally efficient ways to account for relativistic effects, (ii) correlations between electrons beyond electron-pairing effects (weak correlation), (iii) electronically excited states, and (iv) the description of unpaired electrons. Specifically, weak correlation will be captured using Coupled Cluster-type approaches, excited states are accessible through an Equation-of-Motion formalism, and open-shell extensions will use generalized quasi-particles as building blocks for the electronic wavefunction. The extended geminal models thus developed will provide the first direct, atomistic, and quantitative computational model for understanding nuclear waste reprocessing and will provide the essential insights that are needed to guide the synthesis of new actinide compounds that can be used to separate actinides from the other components in the soup of nuclear waste. The developed models will be robust, computationally cheap, and black-box-like and can be used in many other areas of chemistry and materials physics like lanthanide and transition-metal chemistry, biochemistry, and semiconductor physics.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 8.16M | Year: 2015
IPERION CH aims to establish the unique pan-European research infrastructure in Heritage Science by integrating national world-class facilities at research centres, universities and museums. The cross-disciplinary consortium of 23 partners (from 12 Member States and the US) offers access to instruments, methodologies and data for advancing knowledge and innovation in the conservation and restoration of cultural heritage. Fourth in a line of successful projects (CHARISMA-FP7, Eu-ARTECH-FP6 and LabS-TECH network-FP5), IPERION CH widens trans-national access by adding new providers with new expertise and instruments to the three existing complementary platforms ARCHLAB, FIXLAB and MOLAB. The quality of access services will be improved through joint research activities focused on development of new advanced diagnostic techniques and (with DARIAH ERIC) tools for storing and sharing scientific cultural heritage data. Networking activities will (a) promote innovation through technology transfer and dynamic involvement of SMEs; (b) improve access procedures by setting up a coordinated and integrated approach for harmonising and enhancing interoperability among the facilities; (c) identify future scientific challenges, best practices and protocols for measurements; (d) optimise the use of digital tools in Heritage Science. To advance the international role of EU cultural heritage research, IPERION CH will generate social and cultural innovation by training a new generation of researchers and professionals and by worldwide dissemination and communication to diverse audiences. To ensure long-term sustainability, the advanced community of IPERION CH will work towards inclusion in the new ESFRI Roadmap and constitution of a RI with its own EU legal entity (e.g. ERIC). Synergies with national and local bodies, and with managing authorities in charge of ESIF, will expand the scope and impact of IPERION CH in terms of competitiveness, innovation, growth and jobs in ERA.