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Meignan M.,University Paris Est Creteil | Itti E.,University Paris Est Creteil | Gallamini A.,Nice University | Gallamini A.,Scientific Research Committee | Younes A.,Sloan Kettering Cancer Center
European Journal of Nuclear Medicine and Molecular Imaging | Year: 2015

FDG PET/CT has changed the management of FDG-avid lymphoma and is now recommended as the imaging technique of choice for staging and restaging. The need for tailoring therapy to reduce toxicity in patients with a favourable outcome and for improving treatment in those with high-risk factors requires accurate diagnostic methods and a new prognostic algorithm to identify different risk categories. New drugs are used in relapsed/refractory patients. The role of FDG PET/CT as a biomarker in this context is summarized in this review. New trends in FDG metabolic imaging in lymphoma are addressed including metabolic tumour volume measurement at staging and integrative PET which combines PET data with clinical and molecular markers or other imaging techniques. The quantitative approach for response assessment which is under investigation and is used in large ongoing trials is compared with visual criteria. The place of FDG in the era of targeted therapy is discussed. © 2014, Springer-Verlag Berlin Heidelberg.

Rozelot J.P.,Nice University | Kosovichev A.,New Jersey Institute of Technology | Kilcik A.,Akdeniz University
Astrophysical Journal | Year: 2015

Recent solar radius determinations from space observations of Mercury and Venus transits have been made by different teams in 2003, 2006, 2012, and 2014. Seemingly the results are not consistent: the authors interpreted the discrepancies as caused by the different methods of analysis. However, looking at the wavelength dependence and adding other available observations from X-EUV up to radio, a typical wavelength dependence can be found, reflecting the different heights at which the lines are formed. Measurements obtained during different periods of time would, in principle, allow us to detect a signature of radius temporal dependence. However, the available data are not sufficiently numerous to detect a significant dependence, at least at the level of the uncertainty at which the observations were made. Lastly, no unique theoretical model is available today to reproduce the strong wavelength dependence of the solar radius, which shows an unexpected minimum at around (6.6 ±1.9) μm, after a parabolic fit. © 2015. The American Astronomical Society. All rights reserved..

Lebrun C.,Nice University | Blanc F.,University of Strasbourg | Brassat D.,Toulouse 1 University Capitole | Zephir H.,Lille University | De Seze J.,University of Strasbourg
Multiple Sclerosis | Year: 2010

Background: Radiologically isolated syndrome (RIS) is characterized by patients with asymptomatic T2 hypersignals detected by brain MRI fulfilling dissemination in space criteria and is suggestive of subclinical multiple sclerosis (MS). In previous studies, it was demonstrated that visual evoked potential and cerebrospinal fluid help to identify pejorative markers in converting to MS. Objective: To date the cognitive function has never been investigated in a cohort of RIS. The objective of this study was to investigate cognitive function in a cohort of 26 RIS patients. Methods: We prospectively assessed the BCcogSEP (a French adaptation of the Brief Repeatable Battery (BRB) including eight cognitive tests) of 26 patients with RIS, compared with 26 MS patients and 26 healthy subjects matched for age, sex and level of education. Results: When comparing the three groups, the cognitive performance was significantly lower in the RIS and MS groups compared with healthy subjects for the Paced Auditory Serial Addition Test (PASAT) 3 seconds (p = 0.002), phonemic fluencies (p = 0.02), the code of the WAIS (p = 0.05), the direct (p = 0.002) or indirect (p = 0.007) digit span test, the cross-taping test (p = 0.019) and Go-No-Go (p = 0.001). When we compared RIS and MS, the cognitive performance was significantly lower in MS patients for the direct span number (p = 0.003) and cross-tapping test (p = 0.05). We did not find significant differences between the three groups for the other tests. We did not find a correlation between clinical, biological and MRI results and cognitive dysfunctions. Conclusions: This study confirms the recently developed concept of RIS patients who present similar features to MS patients. Further studies are necessary to confirm these initial results and to correlate cognitive disorders with MRI surrogate markers. © 2010 The Author(s).

Lukacs B.,University Paris - Sud | Loeffler J.,Nice University | Bruyre F.,University of Tours | Blanchet P.,Pointe a Pitre University hospital | And 9 more authors.
European Urology | Year: 2012

Background: Evidence supporting the widespread use of GreenLight High Performance System (HPS) 120-W photoselective vaporization of the prostate (PVP) is lacking. Objective: To assess the noninferiority of PVP compared with transurethral resection of the prostate (TURP) on urinary symptoms and the superiority of PVP over TURP on length of hospital stay. Design, setting, and participants: A multicenter randomized controlled trial was conducted. Intervention: Patients underwent monopolar TURP or PVP with the GreenLight HPS 120-W laser. Measurements: International Prostate Symptom Score (IPSS), Euro-QOL questionnaire, uroflowmetry, Danish Prostate Symptom Score Sexual Function Questionnaire, sexual satisfaction, and adverse events were collected at 1, 3, 6, and 12 mo. The two groups were compared using the 95% confidence interval (CI) of median difference for testing noninferiority of the IPSS at 12 mo and the student t test for testing the difference in length of hospital stay. Results and limitations: A total of 139 patients (70 vs 69 men in each group) were randomized. Median IPSS scores at 12-mo follow-up were 5 (interquartile range [IQR]: 3-8) for TURP versus 6 (IQR: 3-9) for PVP, and the 95% CI of the difference of the median was equal to -2 to 3. Because the upper limit of the 95% CI was >2 (the noninferiority margin), the hypothesis of noninferiority could not be considered demonstrated. Median length of stay was significantly shorter in the PVP group than in the TURP group, with a median of 1 (IQR: 1-2) versus 2.5 (IQR: 2-3.5), respectively (p < 0.0001). Uroflowmetry parameters and complications were comparable in both groups. Sexual outcomes were slightly better in the PVP group without reaching statistical significance. Conclusions: The present study failed to demonstrate the noninferiority of 120-W GreenLight PVP versus TURP on prostate symptoms at 1 yr but showed that PVP was associated with a shorter length of stay in the hospital. © 2012 European Association of Urology.

Kostakoglu L.,Mount Sinai Medical Center | Gallamini A.,Nice University
Journal of Nuclear Medicine | Year: 2013

Hodgkin lymphoma (HL) is a curable disease with currently available chemotherapy regimens. Major late morbidities can potentially be avoided in most limited-stage HL patients if the treatment can be adapted to the patient's early response profile. The therapy efficacy can also be increased early during therapy in nonresponding HL patients with the addition of involved-field radiation therapy or a switch to an escalated therapy protocol, particularly in advancedstage or unfavorable-risk patients. 18F-FDG PET is a well-established surrogate for tumor chemosensitivity early during therapy. The ongoing PET-adaptive clinical trials are testing the hypothesis that a decision can reliably be made on escalating or deescalating therapy based on interim PET results. Discussed in this review is the integral role of interim 18F-FDG PET in HL, challenges, critical issues to improve its accuracy, and the observations from completed interim PET studies and ongoing PET-adaptive clinical trials. © 2013 by the Society of Nuclear Medicine.

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