University of Tokyo, Kyushu University and NH Foods Ltd. | Date: 2017-02-01
An anti-aging agent derived from a natural product is provided. The agent uses at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for improving a neuropsychologic function, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for changing expression of a transporter such as SLC23A2, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof, and an agent for controlling blood concentration of a cytokine such as IP-10, which contains at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof, as well as an expression analysis method for detecting improvement or degradation of a neuropsychologic function, and a kit for detecting improvement or degradation of a neuropsychologic function.
News Article | May 5, 2017
Parmalat subsidiary LAG Holding has announced the $130m acquisition of two US-based dairy companies, including a production facility in Turlock, California. Based in Italy, Parmalat is engaged in the production and distribution of dairy products and fruit beverages. Japan-based meat processing company NH Foods has reached an agreement with Gibraltar-based Hoxton Holdings to acquire a 100% stake in the latter’s meat processing company Breeders & Packers Uruguay for $135m. Mail.Ru Group has entered an agreement with ZakaZaka to acquire the remaining 90.09% stake in the company for $18m in an all-cash transaction. Both based in Russia, Mail.Ru is an internet company, while ZakaZaka is a food delivery firm.
PubMed | Hiroshima University, Meiji University and NH Foods Ltd.
Type: Journal Article | Journal: Molecular reproduction and development | Year: 2016
Myostatin (MSTN) is a negative regulator of myogenesis, and disruption of its function causes increased muscle mass in various species. Here, we report the generation of MSTN-knockout (KO) pigs using genome editing technology combined with somatic-cell nuclear transfer (SCNT). Transcription activator-like effector nuclease (TALEN) with non-repeat-variable di-residue variations, called Platinum TALEN, was highly efficient in modifying genes in porcine somatic cells, which were then used for SCNT to create MSTN KO piglets. These piglets exhibited a double-muscled phenotype, possessing a higher body weight and longissimus muscle mass measuring 170% that of wild-type piglets, with double the number of muscle fibers. These results demonstrate that loss of MSTN increases muscle mass in pigs, which may help increase pork production for consumption in the future.
PubMed | Kanagawa Dental University, NH Foods Ltd. and Japan National Institute of Health Sciences
Type: | Journal: Journal of biomedical materials research. Part B, Applied biomaterials | Year: 2016
The purpose of this study was to accurately quantify the risk of endotoxin contamination in biomaterials for bone regeneration in order to establish the acceptable endotoxin limit. Collagen sheets containing varying amounts of purified endotoxin from Escherichia coli and dried, heat-killed E. coli or Staphylococcus aureus cells were implanted into cranial or femoral defects in rats. These defects were artificially prepared to a size of 5 5 mm or a diameter of 1 mm, respectively. The degree of osteoanagenesis was assessed by soft X-ray radiography and histopathology at 1 and 4 weeks after implantation. The collagen sheet containing the dried E. coli cells showed a dose-dependent delay in cranial and/or femoral osteoanagenesis at endotoxin activities of more than 33.6 EU/mg, at which no inflammatory response was observed. In contrast, no such observation occurred with the collagen sheet containing S. aureus cells. These results suggest that endotoxins may affect the process of osteoanagenesis. Additionally, the no-observed-adverse-effect level was 9.6 EU/mg, corresponding to 255 EU/kg body weight in rats. Interestingly, no delay in osteoanagenesis was induced by the implantation of collagen sheets containing purified endotoxin at any dose tested. This suggested that pure endotoxin implanted into tissues having poor circulation of bodily fluids without bleeding may not be recognized as a foreign substance and may not induce a significant biological response. 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.
PubMed | Japan National Institute of Agrobiological Science, Osaka University, NH Foods Ltd., Nihon University and Tokushima University
Type: Journal Article | Journal: Science advances | Year: 2016
Genetically modified pigs for biomedical applications have been mainly generated using the somatic cell nuclear transfer technique; however, this approach requires complex micromanipulation techniques and sometimes increases the risks of both prenatal and postnatal death by faulty epigenetic reprogramming of a donor somatic cell nucleus. As a result, the production of genetically modified pigs has not been widely applied. We provide a simple method for CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 gene editing in pigs that involves the introduction of Cas9 protein and single-guide RNA into in vitro fertilized zygotes by electroporation. The use of gene editing by electroporation of Cas9 protein (GEEP) resulted in highly efficient targeted gene disruption and was validated by the efficient production of Myostatin mutant pigs. Because GEEP does not require the complex methods associated with micromanipulation for somatic reprogramming, it has the potential for facilitating the genetic modification of pigs.
Okiura T.,NH Foods Ltd. |
Oishi Y.,NH Foods Ltd. |
Takemura A.,Kyoto University |
Ishihara A.,Kyoto University
Journal of Musculoskeletal Neuronal Interactions | Year: 2016
Objectives: Effects of collagen hydrolysate (CHD) on the oxidative capacity of the tibialis anterior muscle and the cortical and trabecular density of the femur were investigated in senescence-accelerated mouse prone 6 (SAMP6). Methods: Sixteen-week-old male SAMP6 mice were divided into control (CON) and CHD groups. The CON group was given normal water, while the CHD group was given water containing CHD. Fibre cross-sectional areas (CSAs), fibre succinate dehydrogenase (SDH) staining intensity, and SDH activity of the tibialis anterior muscle were determined at 42 and 60 weeks of age. The cortical and trabecular density of the femur and serum osteocalcin levels were also determined. Results: The fibre SDH staining intensity and muscle SDH activity were higher in the CHD group at 60 weeks of age than in the age-matched CON group. The cortical and trabecular density and serum osteocalcin levels were greater in the CHD group at 60 weeks of age than in the age-matched CON group. Conclusion: CHD inhibited the age-induced decrease in muscle oxidative capacity and bone density of SAMP6 mice. There is a possibility that CHD is effective for inhibition of age-induced degeneration in the musculoskeletal system. © 2016, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
Nh Foods Ltd. | Date: 2014-09-19
Processed meat; Hot dogs, meat only, not sandwiches; Frankfurters, meat only, not sandwiches; Sausages; Fried chicken; Fried meat; Meat; Meat extracts. Hot dog sandwiches; Bread and buns; Flavorings and seasonings; Spices; Mustard. Providing of food and drink; Restaurant services, namely, providing of food and beverages for consumption on and off the premises.
Nh Foods Ltd. | Date: 2015-07-16
Milk products excluding ice cream, ice milk and frozen yogurt; Fresh, chilled or frozen meat for human consumption; Fresh, chilled or frozen edible aquatic animals, not live, namely, seafood; Frozen vegetables; Frozen fruits; Tonkatsu, namely, deep-fried breaded pork; Uncooked hamburger patties; Yakitori, namely, Japanese style char-broiled chicken; Chinese-style barbecued pork; Seasoned beef and pork liver and plucks, namely, packaged seasoned beef and pork liver and plucks used for barbecue or grill; Processed meat products, namely, ham, sausage, bacon, prepared hamburger patty, meat ball, croquette, canned cooked meat, dried cooked meat, bottled cooked meat; Processed seafood products, namely, canned cooked seafood, boiled cooked seafood, smoked seafood, boiled fish paste, dried fish, minced and steamed fish, fish sausage, bottled cooked seafood, seafood products boiled down in soy sauce, Mozuku seaweed,dried wakame seaweed, processed laver; Coconut milk powder; Ham salad; Processed vegetables and fruits; Abura-age, namely, fried tofu pieces; Kohri-dofu, namely, freeze-dried tofu pieces; Jelly made from devils tongue root in the nature of Konnyaku; Soya milk being a milk substitute; Tofu consisting mainly of soya milk and collagen; Tofu; Natto, namely, fermented soybeans; Prepared instant vegetable dish consisting primarily of shrimps, carrots, young corns and seasonings also including and cooked with fresh broccoli; Prepared instant vegetable dish consisting primarily of bacons, carrots, cheese and seasonings, also including and cooked with fresh asparagus; Prepared instant vegetable dish consisting primarily of bacons, carrots and seasonings, also including and cooked with fresh potato; Prepared instant vegetable dish consisting primarily of meats, processed meat products, edible aquatic animals and seasonings, also including and cooked with fresh vegetables; Hashed beef mixes; Instant miso soup; Prepared soup; Pre-cooked curry stew, stew and soup mixes; Ingredients, namely, fried egg and cooked crab for an instant Chinese dish; Prepared Chinese dish consisting primarily of tofu, vegetables and a spicy brown hot sauce; Prepared Chinese dish consisting primarily of eggplant and a spicy sauce; Prepared Szechuan entre consisting primarily of twice cooked pork; Ingredients, namely, meat and seafood for instant Chinese dish, called happosai; Ingredients, namely, pork or chicken for instant Chinese dish of sweet and sour pork; Ingredients, namely, meat for instant Chinese dish of sweet and chili shrimp; Ingredients, namely, chicken for instant Chinese dish of fried chopped chicken with cashew nuts; Ingredients, namely, meat for instant Chinese dish of Green pepper steak called Chinjao Rosu; Prepared instant dish consisting mainly of cooked meats, vegetables, edible seafoods and seasonings; Ochazuke-nori, namely, dried flakes of laver for sprinkling on rice in hot water; Dried flakes of fish, meat, vegetables and processed edible seaweed; Cooked side-dish consisting primarily of fermented soybean also known as Name-mono; Formed textured vegetable protein for use as a meat substitute for human consumption; One-pot dish in the nature of a barbecue meal consisting primarily of meats, edible aquatic animals and/or processed vegetables, and also including assorted ingredients, namely, beef, pork, lamb, chicken, shellfish, fish, carrot, onion, green pepper, pumpkin, green onion, Chinese cabbage and cabbage; Fried chicken; Prepared food kits consisting mainly of meat or processed meat; Prepared food kits consisting mainly of edible seafood; Prepared food kits consisting mainly of vegetables; Prepared food kits consisting mainly of fruits; Prepared food kits consisting mainly of Tofu; Prepared food kits consisting mainly of egg; Processed algae for human consumption; Coconut-based beverage used as a milk substitute; Scotch eggs, namely, prepared dishes consisting primarily of egg wrapped in meat. Starch-based binding agents for ice cream; Meat tenderizers for household purposes; Starch-based preparations for stiffening whipped cream; Aromatic preparations, namely, flavorings for flavoring food other than from essential oils; Tea; Coffee-based beverage; Cocoa-based beverage; Ice; Breads with sausage in their center core forming a sandwich; Bagels; Naan bread; Tortilla; Ciabatta bread; Chapati bread; English muffin; Scones; Croissant; Focaccia; Pita bread; Pain de champagne, namely, French sourdough bread; Pain viennois, namely, Vienna-style bread; Brioche; Donuts; Curry breads; Sweets consisting mainly of coconut milk; Bread and buns; Seasonings for noodles; Sauce for steam vegetable dish; Sauce for tonkatsu, namely, for deep fried breaded pork; Seasonings other than spices; Spices; Ice cream mixes; Sherbet mixes; Unroasted coffee beans; Noodle-based prepared meals and also including their ingredients in the nature of broth or sauce; Noodle-based prepared meals; Bean-starch vermicelli sold with together with sauces or seasonings for sauted bean-starch vermicelli; Rice noodle sold together with sauces seasoning for sauted rice noodle; doughs; Almond paste; Cooked Gyoza, namely, Chinese stuffed dumplings; Sandwiches; Cooked Shumai, namely, Chinese steamed dumplings; Sushi; Takoyaki, namely, fried stuffed balls of batter mix and also including small pieces of octopus; Chinese-style steamed bun; Prepared hamburger sandwiches; Pizzas; Boxed lunches consisting primarily of rice and also including meat, fish or vegetables; Prepared hot dog sandwiches; Meat pies, prepared; Ravioli, prepared; Prepared croque monsieur sandwiches; Prepared tartine sandwiches; Prepared wraps sandwishes; Bagel sandwiches containing ham and cheese; English muffin sandwiches containing ham and cheese; Sandwiches containing Ciabatta bread with sauce and cheese; Sandwiches containing tortilla with roast chickens; Sandwiches consisting of Naan bread with sausage; Sandwiches made from breads with meats, edible seafood, vegetables, cheese or the like; Xiaolongbao, namely, Shanghai-style steamed dumplings; Steamed Chinese chives bun; Chinese rice cakes wrapped in bamboo leaves; Spring rolls; Yeast powder; Koji, namely, fermenting malted rice; Yeast; Baking powder; Instant bread mixes; Instant confectionery mixes; Sauce for pasta; Sake lees, namely, by-product of rice for food; Husked rice; Husked oats; Husked barley; Wheat flours mixed with seasonings and spices; Flour for food; Instant spicy sauce, namely, mapo sauce mixes for Sichuan style bean curd; Instant spicy sauce, namely, mapo sauce mixes for bean starch vermicelli; Broth for noodles in the form of powder and liquid; Ingredients, namely, rice for instant bowl of rice with a chop-suey-like mixture on it; Bean starch vermicelli salad; Ingredients for instant Chinese dish of bean vermicelli and a spicy sauce, namely, bean starch noodles.
Nh Foods Ltd. | Date: 2015-06-24
Ham; Sausages; Bacon; Meat; Sausages with batter; Livers; Canned cooked meat; Fried chicken; Meat balls; Processed meat; Uncooked hamburger and hamburger patties; Processed pork; Cooked vegetables; Hot dogs in the nature of meat only, not sandwiches; Pre-cooked curry stew in a retort pouch. Pizza; Cooked udon noodles; Cooked spaghetti; Bread and buns; Pre-packaged lunches consisting primarily of rice, and also including meat, fish vegetables; Chinese stuffed dumplings in the nature of cooked gyoza; Dumplings; Seasonings; Sandwiches; Chinese steamed dumplings in the nature of cooked shumai; Sushi; Hamburger sandwiches; Hot dogs sandwiches; Prepared Meat pies; Curry pastes; Curry powder; Curry sauce; Dry seasoning mixes for curry stew, other stew, miso soup and other soup.
PubMed | NH Foods Ltd.
Type: Journal Article | Journal: Journal of musculoskeletal & neuronal interactions | Year: 2016
Effects of collagen hydrolysate (CHD) on the oxidative capacity of the tibialis anterior muscle and the cortical and trabecular density of the femur were investigated in senescence-accelerated mouse prone 6 (SAMP6).Sixteen-week-old male SAMP6 mice were divided into control (CON) and CHD groups. The CON group was given normal water, while the CHD group was given water containing CHD. Fibre cross-sectional areas (CSAs), fibre succinate dehydrogenase (SDH) staining intensity, and SDH activity of the tibialis anterior muscle were determined at 42 and 60 weeks of age. The cortical and trabecular density of the femur and serum osteocalcin levels were also determined.The fibre SDH staining intensity and muscle SDH activity were higher in the CHD group at 60 weeks of age than in the age-matched CON group. The cortical and trabecular density and serum osteocalcin levels were greater in the CHD group at 60 weeks of age than in the age-matched CON group.CHD inhibited th age-induced decrease in muscle oxidative capacity and bone density of SAMP6 mice. There is a possibility that CHD is effective for inhibition of age-induced degeneration in the musculoskeletal system.