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Dharbhamulla S.,NGSM Institute of Pharmaceutical science
European Journal of Medicinal Chemistry | Year: 2010

A series of 7-(2-substituted phenylthiazolidinyl)-benzopyran-2-one derivatives have been synthesized by reaction of 7-amino-4-methyl-benzopyran-2-one (1) with an appropriate substituted aldehydes to obtain various Schiff bases (3a-k) which on treatment with thioglycolic acid afforded the title compounds (4a-k). Purity of the compounds has been confirmed by TLC. Structure of these compounds were established on the bases IR, 1H NMR, 13C NMR and Mass spectral data. Schiff bases and title compounds were evaluated for antibacterial and antifungal activities against various bacterial and fungal strains. The results showed that compounds 3d, 3f, 4d, 4f and 4i (100 μg/ml) exhibited good antibacterial and antifungal activity as that of standard antibiotics Ciprofloxacin and Griseofulvin. © 2009 Elsevier Masson SAS. All rights reserved. Source

Ishwar B.K.,NGSM Institute of Pharmaceutical science
International Journal of ChemTech Research | Year: 2010

A series of aminobenzylated mannich bases of pyrazinamide (2a to 2j) have been prepared by mannich reaction of aromatic aldehydes with pyrazinamide and secondary amines. The chemical structure of all the synthesized compounds have been elucidated by spectral studies (IR, H1 NMR). Also they have been assayed in vitro for their biological activity against E.coli, B.substilis, S.aureas bacterial species and A. niger and C. albicans fungal micro organisms. Source

Hunashal R.D.,Karnataka Institute of Medical science | Satyanarayana D.,NGSM Institute of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2012

The reaction of thiocarbohydrazide with substitutedphenoxy acetic acid to obtained 3-substituted-4-amino-5-mercapto-1,2,4-triazoles (1) by condensing compound 1 with aromatic carboxylic acid and substituted phenoxy acetic acids resulted the title compound triazolothiadiazoles 2a-j. The purity of the newly synthesized compounds was confirmed by TLC. Structures of all the newly synthesized compounds were confirmed by spectral data. All the newly synthesized compounds were screened for their in-vitroantimicrobial activity.Among the series the compounds 2e, 2f and 2b, 2c, 2f, 2d, 2i were exhibited equipotent antibacterial and antifungal activity a MIC of 1 μg/mL when compared with standard drugs respectively. From the results the compounds 2c, 2f, 2j were showed comparable antitubercular activity againstM. tuberculosisH37Rv at MIC of 0.50 μg/mL, when compared with standard drug Rifampin and INH which showed MIC of 0.25 μg/mL. Source

Anupama N.,Vellore Institute of Technology | Madhumitha G.,Vellore Institute of Technology | Rajesh K.S.,NGSM Institute of Pharmaceutical science
BioMed Research International | Year: 2014

Inflammation plays an important role in various diseases with high prevalence within populations such as rheumatoid arthritis, ulcer, atherosclerosis, and asthma. Many drugs are available in the market for inflammatory diseases. They exhibit several unwanted side effects to humans. Therefore, alternative treatments with safer compounds are needed. Carissa carandas plant is used in traditional medicinal system for its various diseases curing property. In the present study, we examined the anti-inflammatory effects of dried fruit methanol extract on carrageenan-induced hind paw edema in rats. C. carandas was defatted with petroleum ether, followed by methanol extraction. The methanol extracts of the dried fruits of Carissa carandas were given orally to the experimental rats caused significant activity (P ≤ 0.05) when compared with the control group. The maximum inhibition of paw edema was found to be in Group V, that is, 76.12% with inhibition of paw volume in a dose-dependent manner. The anti-inflammatory activity of the methanol extract of the dried fruits shows that the presence of potential constituents present in this extract may provide assistance in the drug discovery process. The phytochemical compounds of the extract were screened by GC-MS analysis and it was found that 11 compounds are present in methanol extract of dried fruits of Carissa carandas. © 2014 N. Anupama et al. Source

Girisha K.S.,Mangalore University | Kalluraya B.,Mangalore University | Narayana V.,NGSM Institute of Pharmaceutical science | Padmashree,NGSM Institute of Pharmaceutical science
European Journal of Medicinal Chemistry | Year: 2010

A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H- pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively. © 2010 Elsevier Masson SAS. All rights reserved. Source

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