Tokyo, Japan
Tokyo, Japan
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PubMed | Zen noh Institute of Animal Health, Miyagi University, NEXT Co, Tohoku University and 2 more.
Type: | Journal: Beneficial microbes | Year: 2017

The bovine intestinal epithelial cell line (BIE cells) expresses the Toll-like receptor (TLR)3 and is able to mount an antiviral immune response after the stimulation with poly(I:C). In the present study, we aimed to further characterise the antiviral defence mechanisms in BIE cells by evaluating the innate immune response triggered by rotavirus (RV) infection. In addition, we attempted to determine whether immunobiotic bifidobacteria are able to confer protection of BIE cells against RV infection by beneficially modulating the antiviral immune response. RV OSU (porcine) and UK (bovine) effectively infected BIE cells, while a significant lower capacity to infect BIE cells was observed for human (Wa) and murine (EW) RV. We observed that viral infection in BIE cells triggered TLR3/RIG-I-mediated immune responses with activation of IRF3 and TRAF3, induction of interferon beta (IFN-) and up-regulation of inflammatory cytokines. Our results also demonstrated that preventive treatments with Bifidobacterium infantis MCC12 or Bifidobacterium breve MCC1274 significantly reduced RV titres in infected BIE cells and differentially modulated the innate immune response. Of note, both strains significantly improved the production of the antiviral factor IFN- in RV-infected BIE cells. In conclusion, this work provides comprehensive information on the antiviral immune response of BIE cells against RV, that can be further studied for the development of strategies aimed to improve antiviral defences in bovine intestinal epithelial cells. Our results also demonstrate that BIE cells could be used as a newly immunobiotic evaluation system against RV infection for application in the bovine host.


Kim M.,Seoul National University | Kim J.-W.,NEXT Co | Sung M.-S.,NEXT Co | Hwa Y.,Seoul National University | And 2 more authors.
Journal of Electroanalytical Chemistry | Year: 2012

A Si-TiFeSi2 composite was synthesized in large-scale using arc melting followed by rapid quenching. The composite showed that active Si nanocrystallites of approximately 50 nm were embedded in an inactive TiFeSi 2 hard matrix. Crystalline Si reacted with Li to form the Li 21Si8 phase and transformed into amorphous Si when Li was extracted, while the TiFeSi2 matrix remained inactive to Li and unchanged throughout the electrochemical cycling. The composite showed a reversible capacity of 1200 mAh g-1 over 50 cycles with a Coulombic efficiency of 89% for the first cycle. Nanosized cracks were observed only at the Si crystallites parts within the Si-TiFeSi2 particles, indicating that the TiFeSi2 matrix was hard enough to withstand the stress generated during lithiation which explained the excellent capacity retention. © 2012 Elsevier B.V. All rights reserved.


Colombo A.,University of Milan Bicocca | Tassone F.,Italian Institute of Technology | Santolini F.,NEXT Co | Contiello N.,NEXT Co | And 2 more authors.
Journal of Materials Chemistry C | Year: 2013

Large-area nanocomposite plates (35 cm × 35 cm × 1 cm) with tuned optical diffusion were successfully prepared. The poly(methyl- methacrylate) matrix is synthesized by bulk polymerization, and "doped" with some ppm of commercial TiO2 nanoparticles. These are surface modified with 1-octylphosphonic acid in order to stabilize them in the monomer, as shown by repeated Dynamic Light Scattering measurements over long times. TEM images show that the dispersed TiO2 nanoparticles are aggregated in irregular and porous clusters of about 100 nm in diameter. The size of these aggregates is also confirmed by UV-visible transmission measurements. TEM images of slices prepared from plates confirm that the nanoparticles do not further aggregate during bulk polymerization. Optical diffusion could be characterized in detail, thanks to the large size of the nanocomposites, by using a home-made optical set-up. This allowed the observation of a number of subtle optical effects related to multiple-scattering, and the direct observation of a 'blue sky effect' associated with the small size of the nanoparticles involved in diffusion. © 2013 The Royal Society of Chemistry.


Jinno T.,University of Kitakyushu | Mouri K.,NEXT Co | Okuda M.,University of Kitakyushu
Proceedings - International Conference on Image Processing, ICIP | Year: 2010

In this paper we propose a new tone mapping method for the HDR video. Two types of gamma tone mapping are blended to preserve local contrasts in the entire range of luminance. Our method achieves a high quality tone mapping especially for HDR video that has a non-linear response to scene radiance. We examine the validity of our method through simulation and comparison with conventional work © 2010 IEEE.


Kamegai T.,NEXT Co
IEEJ Transactions on Electronics, Information and Systems | Year: 2013

In Japan, HEMS and cooperation of smart meters has been discussed as a future. In this presentation explains various international standardization trend required for cooperation of HEMS and a smart meter. In addition, to compare the standardization. And HEMS considers the practical use method of the data obtained from a smart meter. © 2013 The Institute of Electrical Engineers of Japan.


Soejima T.,Food Ingredients and Technology Institute | Minami J.-I.,Food Ingredients and Technology Institute | Xiao J.-Z.,NEXT Co | Abe F.,Food Ingredients and Technology Institute
Biotechnology and Bioengineering | Year: 2016

PCR cannot distinguish live microorganisms from dead ones. To circumvent this disadvantage, ethidium/propidium-monoazide (EMA/PMA) and psoralen to discriminate live from dead bacteria have been used for 2 decades. These methods require the use of numerous laborious procedures. We introduce an innovative method that uses platinum compounds, which are primarily used as catalysts in organic chemistry and partly used as anti-cancer drugs. Microorganisms are briefly exposed to platinum compounds in vivo, and these compounds penetrate dead (compromised) microorganisms but not live ones and are chelated by chromosomal DNA. The use of platinum compounds permits clear discrimination between live and dead microorganisms in water and milk (including Cronobacter sakazakii and Escherichia coli) via PCR compared with typically used PMA. This platinum-PCR method could enable the specific detection of viable coliforms in milk at a concentration of 5-10 CFU mL-1 specified by EU/USA regulations after a 4-h process. For sample components, environmental water contains lower levels of PCR inhibitors than milk does, and milk is similar to infant formula, skim milk and blood; thus, the use of the platinum-PCR method could also prevent food poisoning due to the presence of C. sakazakii in dairy products. This method could provide outstanding rapidity for use in environmental/food/clinical tests. Platinum-PCR could also be a substitute for the typical culture-based methods currently used. © 2015 Wiley Periodicals, Inc.


Hideki T.,NEXT Co
Lecture Notes in Electrical Engineering | Year: 2013

Making vehicles lighter leads to improved fuel efficiency and fuel savings. Impact absorbers play an important role in improving car safety, and improving their performance while reducing their weight will help lower the risk of accidents and support the environmental goal of reduced fuel usage. Polypropylene is used to make impact absorbers, since it is a lightweight and recyclable material. By processing polypropylene into an optimal form, it can be designed to undergo compression buckling when an impact is applied. The impact energy that a material can absorb corresponds to the integral value of the buckling load and displacement when plastic compression buckling arises in the absorber. Consequently, causing more compression buckling can increase the amount of impact absorption. This study considers the optimal form of an absorber to maximize the amount of impact absorption. A crash analysis was performed via computer simulation that compared the amount of impact absorption of a cylindrical shell and polygonal tube. A comparison between the polygonal tube and a pyramidshaped absorber was also performed. The analysis found that polygonal tubes are superior to cylindrical shells in impact absorption performance. This is because decreasing the width of the planar sections and increasing the number of ridgelines will improve the compression buckling of the impact absorber. It was also found that pyramid-shaped designs are superior to polygonal tubes as impact absorbers. This is because the cross-sectional areas become smaller near the apex, and the pyramid shape gives rise to regular compression buckling from near the apex. Based on these results a new form of impact absorber is proposed that attaches concavo-convex projections on the side of a pyramid shape. These results suggest that by processing into an optimal form to absorb the shock, lightweight polypropylene can provide sufficient amounts of impact absorption. © Springer-Verlag 2013.


Yook S.-H.,Hanyang University | Kim S.-H.,Hanyang University | Park C.-H.,NEXT Co | Kim D.-W.,Hanyang University
RSC Advances | Year: 2016

A new silicon alloy material composed of silicon nanoparticles embedded in Al-Fe-Ti-Ni matrix phases was synthesized and characterized. Using this alloy material, graphite-silicon alloy composite electrodes were prepared and investigated as anodes for lithium-ion batteries. Poly(vinyl alcohol)s (PVAs) with different degrees of cross-linking were used as polymer binders in these composite anodes. A systematic study demonstrated that the cross-linking of PVA with an appropriate amount of fumaric acid made the electrodes mechanically strong and remarkably improved the electrochemical performance of the composite electrodes. Their superior cycling performance could be attributed to strong adhesion of the three-dimensional PVA networks, which maintained good electrical contacts between the active materials, electronic conductors and current collectors during cycling. The graphite-silicon alloy composite electrodes exhibiting high capacities and good cycling stability showed promise as anodes for high-energy density lithium-ion batteries. © 2016 The Royal Society of Chemistry.


Trademark
NEXT Co | Date: 2016-07-20

Aromatics for household purposes; air fragrancing preparations; aromatics for automobiles; face mask packs (cosmetics); make-up; cosmetic preparations for baths; liquid perfumes; cosmetic preparations for skin care; cosmetics for the face and body; lip balm; hand cleansers; hand cream; perfume; soap; hair shampoo; hair essences; hair essence mists; hair conditioners; cosmetics; bases for flower perfumes.


Trademark
NEXT Co | Date: 2016-12-21

Antennas; Cabinets for loudspeakers; Chargers for electric batteries; Computer game software; Computer mice; Computer programs and computer software for electronically trading securities; Data processing apparatus; Downloadable music files; Downloadable image file containing artwork, text, audio, video, games and Internet Web links relating to sporting and cultural activities; Electrical connectors; Laptop computers; Portable media players; Receivers for audio; Tablet computers; Video game cartridges; Mounts and mounting brackets adapted for audio speakers with swiveling bases therefor.

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