New York University is a private, nonsectarian American research university based in New York City. NYU's main campus is located at Greenwich Village in Lower Manhattan. Founded in 1831, NYU is one of the largest private nonprofit institutions of American higher education.NYU was elected to the Association of American Universities in 1950. NYU counts 35 Nobel Prize winners, three Abel Prize winners, 10 National Medal of Science recipients, 16 Pulitzer Prize winners, over 30 Academy Award winners, four Putnam Competition winners, Russ Prize, Gordon Prize, and Draper Prize winners, Turing Award winners, and Emmy, Grammy, and Tony Award winners among its faculty and alumni. NYU also has MacArthur and Guggenheim Fellowship holders as well as National Academy of science and National Academy of Engineering members among its past and present graduates and faculty.NYU is organized into more than 20 schools, colleges, and institutes, located in six centers throughout Manhattan and Downtown Brooklyn, as well as more than a dozen other sites across the world, with plans for further expansion. According to the Institute of International Education, NYU sends more students to study abroad than any other US college or university, and the College Board reports more online searches by international students for "NYU" than for any other university. Wikipedia.
New York University | Date: 2016-09-09
A system and method for in vivo detection and quantification of drusen present in the retina via administering an excitation signal to the retina of the eye and detecting an electromagnetic emissions spectrum from the retina in response to the excitation signal. The electromagnetic emissions spectrum may be used to identify a plurality of component emissions spectra, each component emissions spectrum corresponding to fluorescence from a component of the retina, one of the component emissions spectra corresponding to a target emissions spectrum.
New York University | Date: 2016-08-15
The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells.
New York University | Date: 2017-01-25
Disclosed herein are isolated and purified Staphylococcus aureus bi-component leukocidin, referred to herein as LukAB, and its components LukA and LukB, antibodies specific to LukA, antibodies specific to LukB, therapeutic compositions containing LukA and/or LukB, or anti-LukA and/or anti-LukB antibodies, uses of the compositions to treat acute inflammatory conditions or S. aureus infection, methods for identifying inhibitors of LukAB-mediated cytotoxicity of human phagocytes, and methods for using LukAB as a marker to predict severity of S. aureus infection.
New York University | Date: 2017-03-01
The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating Staphylococcus aureus infection by administering a composition comprising a CCR5 antagonist or any molecule that blocks LukE/D interaction with CCR5^(+) cells in an amount effective to treat the S. aurreus infection in the subject.
New York University | Date: 2017-03-08
Described herein are three-dimensional (3D) culture systems that can be used to produce enamel organoids that generate enamel products. The invention features methods of culturing a variety of cell types to produce such enamel organoids; the organoids themselves; enamel products generated by the organoids; and methods of fashioning the enamel products into surgical restorations, including dental restorations and other prostheses.
New York University | Date: 2017-01-04
A system includes an implantable body configured for implantation in a subgaleal extracranial position, the implantable body including a first electrode array including a first elongated body comprising first and second electrode contacts separated from one another by a distance selected to facilitate the detection of brain electrical activity and a unit coupled to the first electrode array. The unit includes a processor analyzing the detected brain electrical activity to determine whether an epileptic event has occurred and generating epileptic event data based on this determination and a transceiver controlled by the processor to wirelessly transmit epileptic event data to and from a remote computing device.
Seeman N.C.,New York University
Annual Review of Biochemistry | Year: 2010
The combination of synthetic stable branched DNA and sticky-ended cohesion has led to the development of structural DNA nanotechnology over the past 30 years. The basis of this enterprise is that it is possible to construct novel DNA-based materials by combining these features in a self-assembly protocol. Thus, simple branched molecules lead directly to the construction of polyhedrons, whose edges consist of double helical DNA and whose vertices correspond to the branch points. Stiffer branched motifs can be used to produce self-assembled two-dimensional and three-dimensional periodic lattices of DNA (crystals). DNA has also been used to make a variety of nanomechanical devices, including molecules that change their shapes and molecules that can walk along a DNA sidewalk. Devices have been incorporated into two-dimensional DNA arrangements; sequence-dependent devices are driven by increases in nucleotide pairing at each step in their machine cycles. © 2010 by Annual Reviews. All rights reserved.
Belasco J.G.,New York University
Nature Reviews Molecular Cell Biology | Year: 2010
Despite its universal importance for controlling gene expression, mRNA degradation was initially thought to occur by disparate mechanisms in eukaryotes and bacteria. This conclusion was based on differences in the structures used by these organisms to protect mRNA termini and in the RNases and modifying enzymes originally implicated in mRNA decay. Subsequent discoveries have identified several striking parallels between the cellular factors and molecular events that govern mRNA degradation in these two kingdoms of life. Nevertheless, some key distinctions remain, the most fundamental of which may be related to the different mechanisms by which eukaryotes and bacteria control translation initiation. © 20 Macmillan Publishers Limited. All rights reserved.
Amodio D.M.,New York University
Nature Reviews Neuroscience | Year: 2014
Despite global increases in diversity, social prejudices continue to fuel intergroup conflict, disparities and discrimination. Moreover, as norms have become more egalitarian, prejudices seem to have 'gone underground', operating covertly and often unconsciously, such that they are difficult to detect and control. Neuroscientists have recently begun to probe the neural basis of prejudice and stereotyping in an effort to identify the processes through which these biases form, influence behaviour and are regulated. This research aims to elucidate basic mechanisms of the social brain while advancing our understanding of intergroup bias in social behaviour. © 2014 Macmillan Publishers Limited. All rights reserved.
Nudler E.,New York University
Cell | Year: 2012
RNA polymerase is a ratchet machine that oscillates between productive and backtracked states at numerous DNA positions. Since its first description 15 years ago, backtracking - the reversible sliding of RNA polymerase along DNA and RNA - has been implicated in many critical processes in bacteria and eukaryotes, including the control of transcription elongation, pausing, termination, fidelity, and genome instability. © 2012 Elsevier Inc.