New York City, NY, United States
New York City, NY, United States

New York University is a private, nonsectarian American research university based in New York City. NYU's main campus is located at Greenwich Village in Lower Manhattan. Founded in 1831, NYU is one of the largest private nonprofit institutions of American higher education.NYU was elected to the Association of American Universities in 1950. NYU counts 35 Nobel Prize winners, three Abel Prize winners, 10 National Medal of Science recipients, 16 Pulitzer Prize winners, over 30 Academy Award winners, four Putnam Competition winners, Russ Prize, Gordon Prize, and Draper Prize winners, Turing Award winners, and Emmy, Grammy, and Tony Award winners among its faculty and alumni. NYU also has MacArthur and Guggenheim Fellowship holders as well as National Academy of science and National Academy of Engineering members among its past and present graduates and faculty.NYU is organized into more than 20 schools, colleges, and institutes, located in six centers throughout Manhattan and Downtown Brooklyn, as well as more than a dozen other sites across the world, with plans for further expansion. According to the Institute of International Education, NYU sends more students to study abroad than any other US college or university, and the College Board reports more online searches by international students for "NYU" than for any other university. Wikipedia.


Time filter

Source Type

Patent
New York University | Date: 2015-05-01

The present invention relates, generally, to compositions comprising at least one antigen encapsulated within at least one fibrous polymer matrix and their use in intradermal vaccine delivery. It has been discovered that the intradermal delivery of antigens into the antigenpresenting cell-rich layers of the skin requires less antigen than traditional vaccine delivery methods and is still capable of eliciting an immune response comparable to that observed with traditional vaccine delivery methods.


Patent
New York University and Columbia University | Date: 2015-03-05

The present invention provides a method of determining whether a subject is afflicted with a depressive disorder comprising:


A system includes an implantable body configured for implantation in a subgaleal extracranial position, the implantable body including a first electrode array including a first elongated body comprising first and second electrode contacts separated from one another by a distance selected to facilitate the detection of brain electrical activity and a unit coupled to the first electrode array. The unit includes a processor analyzing the detected brain electrical activity to determine whether an epileptic event has occurred and generating epileptic event data based on this determination and a transceiver controlled by the processor to wirelessly transmit epileptic event data to and from a remote computing device.


Patent
New York University | Date: 2016-09-09

A system and method for in vivo detection and quantification of drusen present in the retina via administering an excitation signal to the retina of the eye and detecting an electromagnetic emissions spectrum from the retina in response to the excitation signal. The electromagnetic emissions spectrum may be used to identify a plurality of component emissions spectra, each component emissions spectrum corresponding to fluorescence from a component of the retina, one of the component emissions spectra corresponding to a target emissions spectrum.


Patent
New York University | Date: 2016-08-15

The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells.


Patent
New York University | Date: 2015-04-27

Described herein are three-dimensional (3D) culture systems that can be used to produce enamel organoids that generate enamel products. The invention features methods of culturing a variety of cell types to produce such enamel organoids; the organoids themselves; enamel products generated by the organoids; and methods of fashioning the enamel products into surgical restorations, including dental restorations and other prostheses.


Patent
Toshiba Corporation and New York University | Date: 2015-07-27

According to one embodiment, a medical image diagnostic apparatus includes an X-ray tube, X-ray detector, image generation circuitry, display, and correction circuitry. The X-ray tube generates X-rays to an object. The X-ray detector detects the X-rays. The image generation circuitry generate an X-ray image based on the detected X-rays. The display displays an incident dose of the X-rays on the object, on an object image indicating the object. The correction circuitry correct a relative positional relationship between the object image and a display area of the incident dose on the object image based on the X-ray image.


Compositions and methods for the treatment of malignancy are disclosed.


Patent
New York University | Date: 2015-03-09

The present invention provides methods for the inhibition of reperfusion injury by treatment with Grammastola spatulata mechanotoxin4 (GsMTx4). The GsMTx4 may be delivered to the ischemic tissue in an individual by any means prior to, during or after ischemia reperfusion injury.


Patent
New York University | Date: 2016-06-21

A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.


The present invention relates generally to molecular printing techniques for use in sensors, assays, and integrated optics and electronics. Specifically, the present invention relates to covalent patterning of graphene surfaces.


Patent
New York University | Date: 2016-09-07

This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.


Patent
New York University | Date: 2015-04-14

Sensory information can be delivered to a subject mammal, for example, for restoring a sense of cutaneous touch and limb motion to the subject mammal. A biomimetic electrical signal is generated based on (a) a stimulation reference signal applied to a somatosensory region of a nervous system of a reference mammal, (b) a stimulated-response signal acquired from a sensory cortex of the reference mammal in response to application of the stimulation reference signal to the thalamic nucleus, and (c) a natural-response signal acquired from the sensory cortex in response to peripheral touch stimuli and/or peripheral nerve stimulation of the reference mammal. The biomimetic electrical signal is applied to a somatosensory region of a nervous system of the subject mammal to induce an activation response, in a sensory cortex of the subject mammal.


Photodynamic therapy methods using near infrared light and visible-light-absorbing photosensitizers and methods of generating visible light in an individual. The methods use upconverted incident near infrared light, for example, to excite the photosensitizer or facilitate drug delivery. The methods can be carried out on humans and non-human animals.


Patent
New York University | Date: 2016-10-10

The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (FGF) and the C-terminus includes a C-terminal portion of an FGF21 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from diabetes, obesity, or metabolic syndrome, and methods of screening for compounds with enhanced binding affinity for the Klotho-FGF receptor complex involving the use of chimeric proteins of the present invention.


Patent
New York University | Date: 2016-10-18

Provided are humanized monoclonal antibodies (mAbs) or fragments thereof that bind with specificity to the Thomsen-Friedenreich (TF) human tumor antigen. Three distinct variable heavy and three variable light chains are provided, and can be combined to make a total of twenty-five distinct heavy and light chain combinations. Methods of using the mAbs and fragments thereof for cancer therapy and diagnostic imaging are provided, as are methods for making the mAbs and fragments thereof. In vitro cell cultures that express the mAbs and fragments thereof, and kits are also provided.


Patent
New York University | Date: 2015-04-21

A gasifier system includes a reactor for receiving a wet feedstock which has a base and a container rotatably connected to the base such that a rotation of the container causes a mixing of the feedstock in an interior of the reactor. The interior is bounded by the base and the container. A space between the base and the container allows an entry of oxygen into the interior. The space has a dimension such that the feedstock is fully oxidized in a combustion area adjacent the base and such that the feedstock avoids combustion in a remainder of the interior. The reactor has a longitudinal axis inclined at an inclination angle relative to a horizontal line to promote the mixing of the feedstock in the interior.


Patent
New York University and Leidos Inc. | Date: 2016-03-14

Mixed-phase TiO_(2 )nanofibers prepared via a sol-gel technique followed by electrospinning and calcination are provided as photocatalysts. The calcination temperature is adjusted to control the rutile phase fraction in TiO_(2 )nanofibers relative to the anatase phase. Post-calcined TiO_(2 )nanofibers composed of 38 wt % rutile and 62 wt % anatase exhibited the highest initial rate constant of UV photocatalysis. This can be attributed to the combined influences of the fibers specific surface areas and their phase compositions.


Patent
New York University | Date: 2015-02-23

The present invention relates to peptides having a stable, internally-constrained HBS -helix, where the peptide mimics at least a portion of the -H helix of the Sos protein and contains a mixture of alpha and beta amino acid residues in the pattern 3/1. Methods using the peptides of the present invention for inhibiting Ras signaling in a cell, promoting cell death, and treating, preventing, and/or diagnosing a cellular proliferative disorder, differentiative disorder, and/or neoplastic condition in a subject in need thereof are also disclosed.


Patent
New York University | Date: 2015-04-15

The present invention relates to oligooxopiperzines for modulating the p53-Mdm2 interaction. Methods of using the oligooxopiperazines are also disclosed.


Patent
New York University | Date: 2016-09-19

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.


Patent
New York University | Date: 2015-05-01

The present disclosure provides for isolated non-naturally occurring, mutant-human IAPP polypeptides. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. The present disclosure also provides methods and compositions for treating amyloid-based disease in a subject in need thereof, comprising administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof.


Patent
The Regents Of The University Of California and New York University | Date: 2016-09-14

The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.


Patent
New York University | Date: 2016-08-01

The present invention is directed to methods of treating T-ALL that involves administering a therapeutic agent that inhibits a NOTCH-1 regulated non-coding RNA (lncRNA). Another embodiment of the invention relates to methods and kits for diagnosing T-ALL that involve detecting and quantifying the expression level of NOTCH1-regulated lncRNAs is a biological sample from a subject.


Patent
New York University and The Board Of Regents Of The University Of Texas System | Date: 2016-10-28

A configurable ME MTJ XOR/XNOR gate includes an insulator separating a top and bottom FM layer, a top ME layer with a first boundary magnetism at an interface of the top ME layer and the top FM layer, a bottom ME layer with a second boundary magnetism at an interface of the bottom ME layer and the bottom FM layer, and a top electrode coupled to the top ME layer and a bottom electrode coupled to the bottom ME layer. A voltage between the top electrode and FM layer is a first input, a voltage between the bottom electrode and FM layer is a second input, and a resistance between the top and bottom FM layer is indicative of the XOR or the XNOR of the inputs. The configurable ME MTJ XOR/XNOR gate has reduced energy consumption, smaller area, faster switching times, is non-volatile, and is configurable.


Patent
University of Michigan and New York University | Date: 2016-09-14

An energy harvester having a plurality of bimorph beams and a plurality of piezoelectric devices, wherein at least two of the piezoelectric devices are mounted to each of the plurality of bimorph beams. A plurality of rigid beams interconnect adjacent ends of the bimorph beams to define a stacked, fan-folded shape having a first end of one of the bimorph beams mounted to a structure. A tip mass is disposed on a free end of another of the plurality of bimorph beams. Upon movement of the energy harvester, the plurality of bimorph beams is caused to deflect and thereby output electrical power from the plurality of piezoelectric devices.


Patent
New York University | Date: 2016-11-18

An adapter is connectable to any one of a plurality of different instrument modules so that the connected adapter and any one of the plurality of different instrument modules is positionable within a centrifuge bucket. The adapter includes, for example, a support positionable in a first portion of the centrifuge bucket so that the any one of the plurality of different instrument modules is positionable in a second portion of the centrifuge bucket, a processor attachable to the support, a power source or a connector to a power source operably electrically connected to the processor, an interface operably connected to the processor for receiving data from the any one of the plurality of different instrument modules, and a transmitter for wirelessly transmitting data from the processor to a remote location.


Patent
New York University | Date: 2016-11-18

A separation sampling module for use within a bucket of a centrifuge for monitoring separation of a sample in a container includes a housing operable for supporting the container for containing the sample and removably positionable within the bucket of the centrifuge, at least one light source for illuminating the sample, at least one light detector for detecting light from the sample, an accelerometer for measuring acceleration of the housing, and at least one of a power source and a connector operably connectable to a power source for use in powering the at least one light source. Light from the at least one light source passing through the sample defines a light path disposed in a direction across the direction of a centrifugal force when the separation sampling module is disposed in the bucket and rotated in the centrifuge.


The present invention relates to high-throughput methods comprising direct infusion electrospray ionization mass spectrometry (ESI-MS), multistep tandem mass spectrometry (MS^(n)), consecutive reaction monitoring (CRM), ion mobility spectrometry mass spectrometry (IMS-MS), high-resolution MS, and IMS-MS, for genome-wide (whole cell or tissue) profiling of DNA and RNA nucleotides/nucleosides having a wide variety of variant structural modifications. In particular, these methods are contemplated for providing a specific profile of variant DNA and/or RNA chemically modified nucleic acids (i.e. structures) associated with specific medical conditions. Medical conditions may include, but are not limited to: cancer; including prostate, lung, uterus, larynx, ovary, breast, kidney, and many other types of cancers; specific stages of cancer; bacterial infections; viral infections; genetic and metabolic disorders; and any condition involving changes in DNA and/or RNA structural modifications.


Patent
New York University | Date: 2016-11-10

Methods, systems and compositions reduce or prevent the formation of asphaltene deposits by controlling the precipitation of asphaltene. An asphaltene inhibitor is utilized comprising an aromatic core. The asphaltene inhibitor is introduced into a well or pipeline. The method of utilizing the inhibitor may include the use of a downhole continuous injection process or squeeze treatment. A method of reducing asphaltene scale deposition including adding an asphaltene scale deposition squeeze treatment inhibitor to a hydrocarbon reservoir is provided. The asphaltene scale deposition squeeze treatment inhibitor may be added to the hydrocarbon reservoir by a squeeze treatment process.


Patent
New York University | Date: 2016-12-07

An electrochemical sensor for sensing a gaseous analyte includes a substrate having at least two electrodes disposed thereon, and a carbon nanotube-polyaniline (CNT/PANI) film disposed on the substrate and in contact with at least two electrodes. The CNT/PANI film includes carbon nanotubes coated with a thin layer of polyaniline. The thickness of the polyaniline coating is such that electron transport can occur along and/or between the carbon nanotubes.


Patent
New York University | Date: 2015-05-15

The current disclosure provides methods for detecting and analyzing KRT17 expression in a sample obtained from a subject. The current disclosure also pertains to methods and kits for identifying a mammalian subject with head and neck squamous cell carcinoma. The current disclosure further provides methods and kits for determining the likelihood of survival of a subject having head and neck squamous cell carcinoma.


A method and system for identification of holographic tracking and identification of features of an object. A holograph is created from scattering off the object, intensity gradients are established for a plurality of pixels in the holograms, the direction of the intensity gradient is determined and those directions analyzed to identify features of the object and enables tracking of the object. Machine learning devices can be trained to estimate particle properties from holographic information.


Patent
Tagasauris Inc. and New York University | Date: 2016-11-06

A system combines inputs from human processing and machine processing, and employs machine learning to improve processing of individual tasks based on comparison of human processing results. Once performance of a particular task by machine processing reaches a threshold, the level of human processing used on that task is reduced.


Patent
New York University and Sematech | Date: 2016-10-20

Methods and compositions are provided for reducing or eliminating charge buildup during scanning electron microscopy (SEM) metrology of a critical dimension (CD) in a structure produced by lithography. An under layer is utilized that comprises silicon in the construction of the structure. When the lithography structure comprising the silicon-comprising under layer is scanned for CDs using SEM, the under layer reduces or eliminates charge buildup during SEM metrological observations.


A novel winding method is described herein which eliminates the circulating currents for wound transformers. A first layer of a wire is wound about the core at a first set of angles. Next, a loop is pulled to form slack in the wire and the wire is continued to be wound at a second set of angles. The loop provides sufficient slack for the cutting and connecting described further below. The winding and loop pulling continues for s sequences to achieve the desired winding. The wire is then cut at each loop.


Patent
Columbia University and New York University | Date: 2016-09-02

The present disclosure is directed to iterative regularized reconstruction methods. In certain embodiments, the methods incorporate locally-weighted total variation denoising to suppress artifacts induced by PSF modeling. In certain embodiments, the methods are useful for suppressing ringing artifacts while contrast recovery is maintained. In certain embodiments, the weighting scheme can be extended to noisy measures introducing a noise-independent weighting scheme. The present disclosure is also directed to a method for quantifying radioligand binding in a subject without collecting arterial blood. In certain embodiments, the methods incorporate using imaging data and electronic health records to predict one or more anchors, which are used to generate an aterial input function (AIF) for the radioligand.


Patent
Brookhaven Science Associates LLC, UChicago Argonne LLC and New York University | Date: 2016-10-31

A method of forming electrical contacts on a diamond substrate comprises producing a plasma ball using a microwave plasma source in the presence of a mixture of gases. The mixture of gases include a source of a p-type or an n-type dopant. The plasma ball is disposed at a first distance from the diamond substrate. The diamond substrate is maintained at a first temperature. The plasma ball is maintained at the first distance from the diamond substrate for a first time, and a UNCD film, which is doped with at least one of a p-type dopant and an n-type dopant, is disposed on the diamond substrate. The doped UNCD film is patterned to define UNCD electrical contacts on the diamond substrate.


Patent
University of Michigan and New York University | Date: 2016-08-11

An energy harvesting system for harvesting energy in response to application of an external force. The energy harvesting system comprises a beam member having a central member and at least one piezoelectric layer joined to the central member for deflection therewith. The beam member includes opposing first and second ends and is elastically deformable in response to application of the external force. A first mount couples the first end of the beam member and is generally stationary. A second mount couples the second end of the beam member. The second mount and the second end of the beam member are generally moveable in response to application of the external force between a first position and a second position, thereby outputting energy from the at least one piezoelectric layer in response to the movement from the first position to the second position.


Patent
New York University | Date: 2016-08-25

Exemplary communication apparatus can comprise a receiver; a computer arrangement; and a non-transitory medium comprising computer-executable instructions that cause the apparatus to: receive a signal comprising a plurality of symbols in a first domain; store a portion of the signal comprising at least one symbol in a buffer; determine a frequency offset parameter relating to the buffered portion; apply a correction signal based on the offset parameter to the buffered portion to generate an at least partially corrected signal in the first domain; and transform the at least partially corrected signal into a second domain. In some embodiments, the first domain is a time domain, the second domain is a frequency domain, and the symbols are OFDM symbols. The corrected signal can be further transformed into a third domain. Further, exemplary methods and computer-readable media can be provided embodying one or more procedures the apparatus is configured to perform.


Patent
New York University | Date: 2016-08-23

A system and method for selection and distribution of information from one or more remote sensing devices that are distributed in a space. Receiving such information from the remote sensing devices and receiving a request for at least some portion of the information received from the remote sensing devices. Sending out at least some portion or all of the information to a requestor (client). The information may be comprised of audio information and may be a custom audio mix. The custom audio mix may be based on a position selected within the designated space or a location based on any location within the sensing range of one or more of the remote sensing devices.


Disclosed herein are isolated and purified Staphylococcus aureus bi-component leukocidin, referred to herein as LukAB, and its components LukA and LukB, antibodies specific to LukA, antibodies specific to LukB, therapeutic compositions containing LukA and/or LukB, or anti-LukA and/or anti-LukB antibodies, uses of the compositions to treat acute inflammatory conditions or S. aureus infection, methods for identifying inhibitors of LukAB-mediated cytotoxicity of human phagocytes, and methods for using LukAB as a marker to predict severity of S. aureus infection.


Patent
New York University | Date: 2017-03-01

The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating Staphylococcus aureus infection by administering a composition comprising a CCR5 antagonist or any molecule that blocks LukE/D interaction with CCR5^(+) cells in an amount effective to treat the S. aurreus infection in the subject.


Feske S.,New York University | Wulff H.,University of California at Davis | Skolnik E.Y.,New York University
Annual Review of Immunology | Year: 2015

Ion channels and transporters mediate the transport of charged ions across hydrophobic lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc have important roles as second messengers to regulate intracellular signaling pathways. By contrast, monovalent cations such as sodium and potassium mainly regulate the membrane potential, which indirectly controls the influx of calcium and immune cell signaling. Studies investigating human patients with mutations in ion channels and transporters, analysis of gene-targeted mice, or pharmacological experiments with ion channel inhibitors have revealed important roles of ionic signals in lymphocyte development and in innate and adaptive immune responses. We here review the mechanisms underlying the function of ion channels and transporters in lymphocytes and innate immune cells and discuss their roles in lymphocyte development, adaptive and innate immune responses, and autoimmunity, as well as recent efforts to develop pharmacological inhibitors of ion channels for immunomodulatory therapy. © 2015 by Annual Reviews. All rights reserved.


Suzuki W.A.,New York University | Naya Y.,Peking University
Annual Review of Neuroscience | Year: 2014

Anatomically, the perirhinal cortex sits at the boundary between the medial temporal lobe and the ventral visual pathway. It has prominent interconnections not only with both these systems, but also with a wide range of unimodal and polymodal association areas. Consistent with these diverse projections, neurophysiological studies reveal a multidimensional set of mnemonic signals that include stimulus familiarity, within- and between-domain associations, associative recall, and delay-based persistence. This wide range of perirhinal memory signals not only includes signals that are largely unique to the perirhinal cortex (i.e., object familiarity), consistent with dual-process theories, but also includes a range of signals (i.e., associative flexibility and recall) that are strongly associated with the hippocampus, consistent with single-process theories. These neurophysiological findings have important implications for bridging the gap between single-process and dual-process models of medial temporal lobe function. © Copyright ©2014 by Annual Reviews. All rights reserved.


Patent
New York University and Tactonic Technologies | Date: 2015-06-18

An MFR sensor array having a first supporting layer. The array has a second supporting layer. The array has a force sensing component disposed between the first and second supporting layers. The array has protrusions combined with the force supporting component, where there are only two supporting layers. When a force is applied to the second supporting layer, the force causes the second supporting layer to contact protrusions so the force is transmitted through the protrusions to the force supporting component and through the force supporting component. An MFR sensor array. A system for sensing. A method for sensing.


Patent
New York University and Tactonic Technologies | Date: 2016-06-01

An apparatus for inputting information into a computer includes a 3d sensor that senses 3d information and produces a 3d output The apparatus includes a 2d sensor that senses 2d information and produces a 2d output The apparatus includes a processing unit which receives the 2d and 3d output and produces a combined output that is a function of the 2d and 3d output. A method for inputting information into a computer. The method includes the steps of producing a 3d output with a 3d sensor that senses 3d information. There is the step of producing a 2d output with a 2d sensor that senses 2d information. There is the step of receiving the 2d and 3d output at a processing unit. There is the step of producing a combined output with the processing unit that is a function of the 2d and 3d output.


Patent
New York University and Tactonic Technologies | Date: 2016-07-29

A sensor having a set of plates that are in contact from their bottom at the corners with a set of protrusions that are in contact from above with a plurality of intersections, each having a sensing element, of a grid of wires disposed on a base, and a top surface layer that is disposed atop the set of plates, so that force imparted from above onto the top surface layer is transmitted to the plates and thence to the protrusions, and thence to the intersections of the grid of wires which are thereby compressed between the base and protrusions; and that the protrusions above thereby focus the imparted force directly onto the intersections. A sensor includes a computer in communication with the grid which causes prompting signals to be sent to the grid and reconstructs a continuous position of force on the surface from interpolation based on data signals received from the grid. A method for sensing.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-03-2015 | Award Amount: 6.19M | Year: 2016

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, and a highly prevalent somatic disease, obesity. ADHD, a childhood-onset disorder, forms the entry into a lifelong negative trajectory characterized by these comorbidities. Common mechanisms underlying this course are unknown, despite their relevance for early detection, prevention, and treatment. Our interdisciplinary team of experts will integrate epidemiologic/genetic approaches with experimental designs to address those issues. We will determine disease burden of comorbidity, calculate its socioeconomic impact, and reveal risk factors. We will study biological pathways of comorbidity and derive biomarkers, prioritizing two candidate mechanisms (circadian rhythm and dopaminergic neurotransmission), but also leveraging large existing data sets to identify new ones. A pilot clinical trial to study non-pharmacologic, dopamine-based and chronobiological treatments will be performed, employing innovative mHealth to monitor and support patients daily life. Integration of findings will lead to prediction algorithms enhancing early diagnosis and prevention of comorbidity. Finally, we will screen to repurpose existing pharmacological compounds. Integrating complementary approaches based on large-scale, existing data and innovative data collection, we maximize value for money in this project, leading to insight into the mechanisms underlying this comorbidity triad with its huge burden for healthcare, economy, and society. This will facilitate early detection and non-invasive, scalable, and low-cost treatment, creating opportunities for substantial and immediate societal impact.


Patent
New York University and Tactonic Technologies | Date: 2016-04-15

An apparatus for sensing includes a computer. The apparatus includes one or more individual sensing tiles in communication with the computer that form a sensor surface that detects force applied to the surface and provides a signal corresponding to the force to the computer which produces from the signal a time varying continuous image of force applied to the surface, where the surface is contiguous, and detected force can be sensed in a manner that is geometrically continuous and seamless on a surface. A method for determining locations of tiles of a sensor.


The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction; localizing a central nervous system lesion; detecting, diagnosing or screening for increased intracranial pressure, pressure or disruption of central nervous system physiology as seen with concussion; or detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure or concussion by tracking eye movement of the subject.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-3 | Award Amount: 8.15M | Year: 2013

Aggression is a basic physiological trait with important roles throughout evolution, both in defence and predation. When expressed in humans in the wrong context, aggression leads to maladjustment, social impairment and crime. Despite this, knowledge about aggression aetiology is limited and current treatment strategies are insufficient. Contingent to a subdivision into impulsive and instrumental subtypes, we investigate the aetiology of maladaptive aggression in paediatric conduct disorders most strongly predisposing to pathological aggression, ADHD and conduct disorder, and in the general population. We employ highly innovative approaches in humans and animal models and maximize the output from the project by optimally balancing the use of large, existing data sets with new data acquisition. Through this, we build a knowledge chain from molecule to behaviour, investigating known and novel genes, gene-networks and their epigenetic interactions, and mapping their mode of action from the molecular via the cellular to the brain-circuit level. This is accompanied by highly powered analyses of the neural substrates of the aggression subtypes. Based on innovative bioinformatic multimodal data integration, our interdisciplinary research will lead to novel, accurate algorithms for reliable aggression prediction, which will be validated in existing longitudinal studies in children and tested for their predictive value in adult outcome. In addition to this approach towards prevention, we test promising non-pharmacological biofeedback for personalised treatment and prevention of overt aggression. For the identification of novel pharmacological compounds in aggression treatment, we introduce a new animal model, the zebrafish. The Aggressotype consortium is based on successful existing collaborations. It includes experts in childhood and adult psychiatry and research-intensive SMEs ensuring maximal dissemination, clinical implementation and business development opportunities.


Patent
FISHER & PAYKEL HEALTHCARE Ltd and New York University | Date: 2014-03-10

A multi-night titration (MNT) process to find an optimal single therapeutic pressure of a CPAP device. This single therapeutic pressure can then be used on an on-going basis by the patient after the titration period. The MNT process differs from current auto adjusting processes used for titration (or ongoing use) in that the MNT process does not respond locally by adjusting pressures to individual events. With existing devices, the continuous adjustment of supplied air pressure always responds to one or a small number of events and thus fails to compensate for a patients adaptation thereto, resulting in the supply of a less than optimal therapeutic pressure to the patient. While auto adjusting processes often capture and respond well to short-term and transient conditions, the MNT process of the current disclosure seeks to capture long term trends and find the most suitable average single pressure for a patient.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.9.1 | Award Amount: 3.00M | Year: 2013

Strong statistical fluctuations in meso- and nano-scale structures make their thermodynamic properties extremely dependent on the information available about them. The most basic process illustrating the importance of information to statistical systems is the information-to-energy conversion in the famous Maxwells Demon (MD). Our primary goal is to study both experimentally and theoretically the statistics of fluctuations and the role of information in thermodynamics of the nano-scale systems. The first milestone will be the experimental realization of the nanoscale MD. We will create an experimental set-up and develop the corresponding theory of the monitored statistical evolution with feedback that optimizes the information-to-energy conversion. Our vision is to develop the nanoelectronic and bio-molecular devices that will allow us to systematically explore the limits of information-powered systems, in particular to test the Szilrds limit relating one bit of information to extracted energy. We will also study statistics of energy fluctuations as revealed via equilibrium and non-equilibrium fluctuations of temperature. Part of these fluctuations has a quantum mechanical origin, but identification of this contribution in practice poses a challenging problem. Another novel extension of the MD work will be the study of thermodynamic constraints on quantum detectors. The principal novelty of our project is that it brings a rigorous experimental component to the field presently dominated by theory. Though the concept of a MD is tremendously important for development of modern statistical mechanics, MD-type experiments are still at their infancy. Our experimental study of MD will naturally lead to further progress in the relevant theoretical concepts.


Dustin M.L.,New York University | Long E.O.,National Institute of Allergy and Infectious Diseases
Immunological Reviews | Year: 2010

One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the capacity for long-term adaptation to chemical and viral insults. These cells integrate multiple positive and negative signals through NK cell cytotoxic or inhibitory synapses. The traditional CD8 +αβ T-cell receptor-positive cells are among the best models for the concept of an immunological synapse, in which vectoral signaling is linked to directed secretion in a stable interface to induce apoptotic cell death in an infected cell. Large-scale molecular organization in synapses generated a number of hypotheses. Studies in the past 5 years have started to provide clear answers regarding the validity of these models. In vivo imaging approaches have provided some hints as to the physiologic relevance of these processes with great promise for the future. This review provides an overview of work on cytotoxic immunological synapses and suggests pathways forward in applying this information to the development of therapeutic agents. © 2010 John Wiley & Sons A/S.


Grant
Agency: Cordis | Branch: FP7 | Program: NoE | Phase: Fission-2010-3.5.1 | Award Amount: 8.04M | Year: 2011

With a renewed interest in nuclear energy and the scientific challenges related to the nuclear fuel cycle, the need for radioecological expertise is increasing world-wide. Concurrently, education related to radioecology has steadily declined, leading experts are approaching retirement, and funding for radioecological research is at a minimum in many European countries. To face this challenge and avoid further fragmentation, nine leading organisations propose to establish a Network of Excellence in radioecology, called STAR. The goal is to efficiently integrate important organisations, infrastructures, and research efforts into a sustainable network that contributes to a European Research Area in radioecology. To achieve this, a Joint Programme of Activities will be implemented covering integration and sharing of infrastructures; training, education and mobility; knowledge management and dissemination; as well as three key research themes (integrating human and non-human radiological risk assessments; radiation protection in a multi-contaminant context; ecologically relevant low-dose effects). The coordinator, IRSN, is one of the largest radioecological research institutes in Europe with an excellent record in large project management. Three STAR partners are members of the High Level Expert Group on Low Dose Risk Research, ensuring that STAR will provide effective links to the wider community of low dose risk research. STAR will interact with other European and international research institutes in radioecology, radiobiology and ecology to produce the best research for addressing the key scientific challenges in radioecology. To address stakeholders needs and policy questions, a strong link with end-users will be achieved via dedicated workshops, conferences and advanced dissemination tools. STAR will promote integration, networking and scientific excellence to benefit human and environmental radiation protection.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 3.91M | Year: 2014

This century is set to be the century of the city. Ever-increasing urbanisation is proceeding against a backdrop of advances in digital technologies and data availability and analysis, which are having profound effects on the ways that the future of cities is unfolding. Emerging from this intersection of urban growth and big data is the discipline of urban science which can assist governments, industry and citizens to move beyond imperfect understanding and use data to undertake tasks such as optimising operations (e.g. service delivery, traffic flow), monitoring the condition of infrastructure (e.g. bridge conditions, water leaks), planning new, more efficient, infrastructure (e.g. public transport, utilities provision), responding to abnormal conditions (e.g. hazard detection, emergency management), developing new and effective policies (e.g. road pricing, energy efficient buildings), enhancing economic performance and, informing and communicating with citizens to improve quality of life. This Centre for Doctoral Training (CDT) is designed to play a leading role in the emergence and development of urban science. It will establish urban science as a field of study and focus of scientific inquiry. This new field needs trained cross-disciplinary researchers, who have the skills to integrate diverse branches of knowledge to address a range of important current and future policy drivers. It will build capacity within the UK HE sector to deliver novel solutions in the urban science domain, both nationally and internationally. Importantly, it will do so in an interdisciplinary environment, e.g. by exploiting synergies between computer science, engineering, mathematics and social science. Solutions to urban issues require a tri-partied relationship between academia, public bodies and the private sector. This CDT will work alongside government agencies and industry partners in the UK and abroad. The importance of urban science and appropriate cross-disciplinary research is central to our CDT approach. The potential benefits and impact are listed by the leader of Birmingham City Council as including mak[ing] a real difference to tens of thousands of Birmingham residents, saving £Ms in operating costs, and deliver[ing] a legacy of change through the training of individuals who have real expertise in their area. The deputy mayor of New York states that the centre can develop scientific solutions that will have direct impact on billions of the worlds population. This CDT provides a UK training environment that is part of a wider international programme, which offers training alongside international city experts, and benefits from the support of leading industry practitioners. No one in the world is tackling urban challenges at this scale. By leading the research agenda on the science of cities, educating the next generation of experts in how to apply that research, bringing innovative ideas to a world market, and creating new, fast-growing industry solutions and the many jobs that go with them, this UK-led CDT will be at the centre of the global stage in this field. The CDT will adopt a 1+3 (MSc+PhD) training model that is high-quality and rigourous, to produce multiple cohorts of successful, highly-employable graduates. It promotes an international student experience; students will work alongside a larger student cohort from NYU, CUNY, Carnegie Mellon University, University of Toronto and IIT Mumbai; it allows our students unprecedented access, in the UK and overseas, to existing city operations, to utilize existing and newly emerging data streams, and to explore and deploy novel urban sensors; it enables students to work alongside industry luminaries, leaders in public service and citizens, to understand, measure and improve urban systems; and it provides value for money to the UK through 50+ PhDs who will receive discipline-defining training from world-class institutions.


Patent
University of Illinois at Urbana - Champaign and New York University | Date: 2015-12-15

Methods and systems of applying physical stimuli to tissue are disclosed. The methods can include reducing or suppressing pancreatitis in a subject by administering a low magnitude, high frequency mechanical signal on a period basis and for a time sufficient to reduce or suppress pancreatitis. The methods can include enhancing healing of damaged tissue in a subject by administering to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to treat the damaged tissue. The systems can include a device for generating a low magnitude, high frequency physical signal and a platform for applying the low magnitude, high frequency physical signal to the subject for a predetermined time.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2012.2.1.1-2 | Award Amount: 17.67M | Year: 2013

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing HF before the onset of symptoms and ii. subsets of patients who are more likely to respond to specifically targeted therapies (personalized medicine). In available cohorts, we will identify the most promising omics-based BM profiles for the pre-symptomatic diagnosis and future prediction of HF in patients at risk. The predictive value of the BMs for other co-morbidities commonly associated with HF and ageing will also be investigated. Furthermore, in a prospective trial, we will investigate the potential for targeting preventive therapy at patients with the greatest likelihood of response and the lowest risk of adverse effects. Our selection of innovative omics-based BMs is based on knowledge of biological pathways of the disease, which may facilitate identification of Biotargets for future therapies. On the economic side, HOMAGE will act as an economic catalyst for European SMEs in the field of cardiovascular and ageing BMs, estimated to peak annual turnovers of up to 800 M.


Patent
New York University and Calregen Inc. | Date: 2015-07-22

The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application of calreticulin to a patient in need of such treatment.


Patent
New York University and Calregen Inc. | Date: 2016-01-22

The invention relates to therapeutic and cosmetic uses of calreticulin including reducing or eliminating wrinkles and/or fine lines, tissue repair and reconstruction, repairing damaged bone and/or cartilage, stimulating regeneration of an epidermal appendage, enhancing phagocytosis of bacteria by phagocytes within a wound, treating a wound in a patient suffering from delayed wound healing, treating a corneal wound, and treating or preventing a surgical adhesion.


Patent
University of Illinois at Urbana - Champaign and New York University | Date: 2016-09-22

Methods and systems of applying physical stimuli to tissue are disclosed. The methods can include reducing or suppressing pancreatitis in a subject by administering a low magnitude, high frequency mechanical signal on a period basis and for a time sufficient to reduce or suppress pancreatitis. The methods can include enhancing healing of damaged tissue in a subject by administering to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to treat the damaged tissue. The systems can include a device for generating a low magnitude, high frequency physical signal and a platform for applying the low magnitude, high frequency physical signal to the subject for a predetermined time.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.5-01 | Award Amount: 12.44M | Year: 2013

KillSpill delivers innovative (bio)technologies, which can be integrated to the real sequences of state-of-the-art actions used currently to cleanup oil spills. The catalogue of KillSpill products & technologies is based on a review of technology & knowledge gaps in approaches of oil spill disasters and brings appropriate tools for 1st response, follow-up, and longer-term actions, specifically tailored to the versatility of oil spills. KillSpill develops chemicals & biochemicals to be used for 1st response actions to disperse/emulsify oil and materials enabling the containment and sorption of oil, preparing the field for the follow-up actions. KillSpill develops (Bio)technologies aiming at intensified biodegradation processes by bioaugmentation/biostimulation as follow-up and longer term actions in aerobic/slight anoxic compartments. KillSpill develops (bio)technologies adapted for the remediation of anoxic/anaerobic fresh & chronically polluted sediments. KillSpill compiles knowledge on dispersion/sorption and biodegradation processes to produce multifunctional products, which are suited for follow-up and longer term actions. The multifunctional products address the necessity for integrated bioremediation (bioavailability, metabolic requirements, etc.) and are efficient along the whole redox gradient from surface water to sediments. The products/technologies are field-tested in open sea oil spills and large mesocosms to unravel the champions products & technologies. The (bio)tools are benchmarked with existing solutions using cutting-edge analytics, biosensors, and omics and checked for eco-efficiency to merit green label. KillSpill consortium is multidisciplinary and gathers 33 partners from 12 EU and EU-associated countries and USA; 18 research & academic institutions, 14 SMEs, and 1 association of oil spill companies work together with the support of a high level advisory board to cover the whole chain of oil spill (bio)remediation.


Grant
Agency: GTR | Branch: NERC | Program: | Phase: Research Grant | Award Amount: 150.55K | Year: 2013

Forecasting the weather from days to two weeks in advance has typically focused on the troposphere, the layer of the atmosphere closest to the ground. A typical weather forecast first attempts to estimate what the atmosphere is like now, and then extrapolates forward in time, using a complex model of the atmosphere based on the basic physical laws of motion. Over the last 15 years, evidence has been growing that different parts of the atmosphere and Earth system can also be exploited to improve weather forecasts. One of these regions is the stratosphere, the layer directly above the troposphere. Because, temperatures increase with height in the stratosphere, winds and weather systems are quite different, and a distinct community of scientific researchers who study the stratosphere exists around the world. Through the work of this community, many weather forecasting centres have been encouraged to look to the stratosphere to improve their weather forecasts and have been modifying their weather forecasting models accordingly. What has been missing, however, is a concerted effort to understand how best to make use of the stratosphere to improve weather forecasts and to determine how much weather forecasts might benefit. This proposal will fund a new international scientific network which will bring scientists from around the world together to study the stratosphere and how it might be used to improve weather forecasts. The network is made up of scientists from universities and weather forecasting centres around the world and is supported by two other international scientific research bodies. The network will allow scientists to come together to discuss current research in this area and to plan and carry out a new experiment which will compare the stratosphere and its impact on weather forecasts in their weather forecasting models. At the end of the research project, the network members will work together to produce a report which will provide guidance to all weather forecasting centres on the use of the stratosphere for weather forecasting.


Patent
New York University and University of Connecticut | Date: 2016-05-19

The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.


Patent
Hocuslocus, Llc and New York University | Date: 2014-09-17

Disclosed are RNA constructs which function to bind and/or inhibit a non-coding RNA (e.g., a miRNA). Such RNA constructs include an optionally weakened stem-loop structure stabilized by binding to a non-coding RNA. The non-coding RNA preferentially binds to the RNA construct as compared to a natural target (e.g., a mRNA). In certain embodiments, the RNA construct inhibits the function of the non-coding RNA. Such RNA constructs also have three-way junction joining regions 3 and 5 of the stem-loop structure.


Patent
New York University and Guangzhou University of Chinese Medicine | Date: 2014-05-06

Provided is a method for inhibiting the growth of tumor cells comprising administering to an individual in need of treatment, a composition comprising a therapeutically effective amount of Lappaol F. Also provided are compositions comprising Lappaol F and a pharmaceutically acceptable carrier.


Taouli B.,New York University | Koh D.-M.,Royal Marsden Hospital
Radiology | Year: 2010

Magnetic resonance (MR) imaging plays an increasingly important role in the evaluation of patients with liver disease because of its high contrast resolution, lack of ionizing radiation, and the possibility of performing functional imaging sequences. With advances in hardware and coil systems, diffusion-weighted (DW) MR imaging can now be applied to liver imaging with improved image quality. DW MR imaging enables qualitative and quantitative assessment of tissue diffusivity (apparent diffusion coefficient) without the use of gadolinium chelates, which makes it a highly attractive technique, particularly in patients with severe renal dysfunction at risk for nephrogenic systemic fibrosis. In this review, acquisition parameters, postprocessing, and quantification methods applied to liver DW MR imaging will be discussed. The current clinical uses of DW MR imaging (liver lesion detection and characterization, compared and combined with conventional sequences) and the emerging applications of DW MR imaging (tumor treatment response and diagnosis of liver fibrosis and cirrhosis) will be reviewed. Also, limitations, mainly image quality and reproducibility of diffusion parameters, and future directions of liver DW MR imaging will be discussed. © RSNA, 2010.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: STTR | Phase: Phase II | Award Amount: 988.84K | Year: 2015

DESCRIPTION provided by applicant Mass spectrometry has become a method of choice for identifying and characterizing small quantities of proteins in complex mixtures However the ability to perform the identification in a high throughput fashion has depended on the availability of high quality protein sequence databases This means that proteins from organisms with unsequenced or poorly sequenced genomes e g peptide toxins and proteins that modify their primary sequences rapidly in response to the environment e g antibodies have been excluded from high throughput analysis Widespread availability of Next Generation Sequencing NGS has not alleviated this problem but rather NGS has led to a proliferation of lower quality uncurated protein sequence databases including personalized databases cancer databases and databases with uncertain assembly The traditional division between database search proteomics and de novo peptide sequencing no longer holds many of the most interesting biological questions are now best addressed by data analysis that combines the best of both techniques In this Phase II STTR project we propose to develop two commercial software products for sequencing biologically interesting peptides and proteins regardless of the quality of sequence databases One product will be aimed at the peptide level with applications to variable regions of circulating antibodies peptide toxins and human leukocyte antigens The other product will be aimed at the protein level with applications to end to end sequencing of purified proteins especially therapeutic monoclonal antibodies This system will include the peptide level sequencer as a component as well as tools for assembly of the peptides into the full sequence and for visualization and manual validation The proposed project has the potential for great impact on human health in areas such as vaccine development therapeutic antibody development and cancer immunotherapies PUBLIC HEALTH RELEVANCE We propose to develop commercial software products for sequencing biologically important peptides and proteins regardless of the existence or quality of available protein sequence databases The proposed project has the potential for great impact on human health in areas such as vaccine development therapeutic antibody development and cancer immunotherapies


Nixon R.A.,Nathan S Kline Institute | Nixon R.A.,New York University
Nature Medicine | Year: 2013

Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and protein aggregates. These substrates reach lysosomes by several distinct mechanisms, including delivery within endosomes as well as autophagosomes. Completion of digestion involves dynamic interactions among compartments of the autophagic and endocytic pathways. Neurons are particularly vulnerable to disruptions of these interactions, especially as the brain ages. Not surprisingly, mutations of genes regulating autophagy cause neurodegenerative diseases across the age spectrum with exceptional frequency. In late-onset disorders such as Alzheimer's disease, amyotrophic lateral sclerosis and familial Parkinson's disease, defects arise at different stages of the autophagy pathway and have different implications for pathogenesis and therapy. This Review provides an overview of the role of autophagy in neurodegenerative disease, focusing particularly on less frequently considered lysosomal clearance mechanisms and their considerable impact on disease. Various therapeutic strategies for modulating specific stages of autophagy and the current state of drug development for this purpose are also evaluated. © 2013 Nature America, Inc. All rights reserved.


Brataas A.,Norwegian University of Science and Technology | Kent A.D.,New York University | Ohno H.,Tohoku University
Nature Materials | Year: 2012

The magnetization of a magnetic material can be reversed by using electric currents that transport spin angular momentum. In the reciprocal process a changing magnetization orientation produces currents that transport spin angular momentum. Understanding how these processes occur reveals the intricate connection between magnetization and spin transport, and can transform technologies that generate, store or process information via the magnetization direction. Here we explain how currents can generate torques that affect the magnetic orientation and the reciprocal effect in a wide variety of magnetic materials and structures. We also discuss recent state-of-the-art demonstrations of current-induced torque devices that show great promise for enhancing the functionality of semiconductor devices. © 2012 Macmillan Publishers Limited. All rights reserved.


Muller M.,Abdus Salam International Center For Theoretical Physics | Wyart M.,New York University
Annual Review of Condensed Matter Physics | Year: 2015

We revisit the concept of marginal stability in glasses and determine its range of applicability in the context of an avalanche-type response to slow external driving. We argue that there is an intimate connection between a pseudogap in the distribution of local fields and crackling in systems with long-range interactions. We classify glassy systems according to the presence or absence of marginal stability, providing a unifying perspective on the phenomenology of systems as diverse as spin and electron glasses, hard spheres, pinned elastic interfaces, and soft amorphous solids undergoing plastic deformation. © 2015 by Annual Reviews.


Patent
New York University and Cornell University | Date: 2014-09-10

The invention provides methods and compositions for stimulating or promoting bone generation and regeneration, for stimulating or increasing differentiation, activation or function of osteoblasts, for inhibiting or decreasing differentiation, activation or function of osteoclasts, and for treating bone diseases such as osteonecrosis by administering to a subject a therapeutically effective amount of a pro-nerve growth factor (proNGF) or a pro-brain derived neurotrophic factor (proBDNF) or an analog, homolog, fragment or derivative thereof. The pro-nerve growth factor (proNGF) or a pro-brain derived neurotrophic factor (proBDNF) or an analog, homolog, fragment or derivative thereof may be a mutated or poorly hydrolyzed form of proNGF or proBDNF.


Patent
University of Rochester and New York University | Date: 2015-02-26

A free-standing membrane comprises a plurality of vertically aligned carbon nanotubes, each of the plurality of vertically aligned carbon nanotubes having a first terminus at a first side of the membrane and a second terminus at a second side of the membrane. The first and second terminuses are exposed. The free-standing membrane comprises a non-conducting, inert filler material disposed in the interstitial space between the nanotubes such that a barrier to electron, proton, and/or ion transport is formed, and so that conduction of electrons, protons, and/or ions only occurs through the plurality of vertically aligned carbon nanotubes and not through the inert filler material. Methods for fabricating the membrane comprise nanotube growth, epoxy coating, and exposure of the terminuses of the nanotubes.


Methods are provided for measuring glio-vascular pathway (glymphatic system) function in the brain of a mammal which include performing imaging of the brain and measuring cerebrospinal fluid-interstitial fluid (CSF-ISF) exchange in the brain. The methods can be used to track the exchange between CSF and ISF compartments. An imaging agent is optionally administered intrathecally. The imaging agent can be a negative or positive (paramagnetic) contrast agent and dynamic or contrast-enhanced magnetic resonance imaging (MRI) of the brain can be performed. The imaging agent can be a positron-emitting radionuclide tracer and positron emission tomography (PET) can be performed. Methods for treating diseases or disorders of the mammalian brain are also provided, in which the methods increase or decrease glymphatic clearance.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.1.7 | Award Amount: 6.49M | Year: 2013

We must learn to both sustainably exploit & protect our vast oceans, provider of oxygen, food, hydrocarbons & other resources. A solution lies in sensing & interacting through an Internet of Things, with distributed networks of intelligent sensors & actuators. Unfortunately, we currently lack a marine Internet, crucial to achieve distributed, coordinated & adaptive control, due to the rapid absorption of light & radio waves in seawater.\n\nThe SUNRISE objectives are to develop:\n5 federated underwater (UW) communication networks (CommsNet), based on pilot infrastructure already designed, built & deployed by consortium partners, in diverse environments, web-accessible & interfaced with existing FIRE facilities to experiment with Future Internet technologies.\nA software-defined open-architecture modem & protocol stack that will empower open collaborative developments.\nStandard platforms for simulation, emulation & replay testing to estimate CommsNet performance at a fraction of current at-sea experiments, validated by tests conducted on the SUNRISE networks over a variety of applications & environments.\nA user-friendly interface for diverse users to interact with SUNRISE systems to conduct trials & benefit from databases of CommsNet performance data gathered over long periods from the SUNRISE infrastructure.\n\nSUNRISE directly addresses FIRE objectives by combining technology with novel paradigms in new, open experimental facilities, integrating physical systems with software development in a new physical domain. SUNRISE will provide a way to select UW CommsNet standards based on objective measures of performance, strengthening as more sites are added in the future. The SUNRISE network will remain key for UW Internet development long after the project ends, with broad involvement of researchers, manufacturers & users ensuring that appropriate technologies are developed, selected & implemented in products that support sustainable maritime exploitation and management.


Vandersickel N.,Ghent University | Zwanziger D.,New York University
Physics Reports | Year: 2012

In 1967, Faddeev and Popov were able to quantize the Yang-Mills theory by introducing new particles called ghost through the introduction of a gauge. Ever since, this quantization has become a standard textbook item. Some years later, Gribov discovered that the gauge fixing was not complete, gauge copies called Gribov copies were still present and could affect the infrared region of quantities like the gauge dependent gluon and ghost propagator. This feature was often in the literature related to confinement. Some years later, the semi-classical approach of Gribov was generalized to all orders and the GZ action was born. Ever since, many related articles were published. This review tends to give a pedagogic review of the ideas of Gribov and the subsequent construction of the GZ action, including many other topics related to the Gribov region. It is shown how the GZ action can be viewed as a non-perturbative tool which has relations with other approaches toward confinement. Many different features related to the GZ action shall be discussed in detail, such as BRST breaking, the KO criterion, the propagators, etc. We shall also compare with the lattice data and other non-perturbative approaches, including stochastic quantization. © 2012 Elsevier B.V.

Loading New York University collaborators
Loading New York University collaborators