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PubMed | University of Tennessee at Martin, University of Washington, St Lukes Hospital, New York Obesity Nutrition Research Center and and University of Pittsburgh
Type: Journal Article | Journal: The American journal of clinical nutrition | Year: 2016

The effect of a weight-loss intervention on the masses of lean tissues and organs in humans is not well known.We studied the effects of a diet and exercise weight-loss intervention on skeletal muscle (SM) mass and selected organs over 2 y using MRI in overweight adults with type 2 diabetes.Participants were 53 women and 39 men [mean SD: age 58 7 y; body mass index (BMI; in kg/mAdjusted for baseline weight, height, age, sex, and ethnicity, the ILI group weighed (mean SE) 6.6 0.7 kg less after 1 y and 5.2 0.7 kg less after 2 y, whereas the DSE group did not change significantly (-0.4 0.6 and -1.0 0.7 kg after 1 and 2 y, respectively; P-interaction < 0.001). Total SM decreased in both groups during year 1 (-1.4 0.2 kg; P < 0.001) with appendicular SM regained during year 2. Liver and spleen masses decreased in the ILI group (-0.12 0.02 and -0.006 0.003 kg, respectively) but were unchanged in the DSE group (0.00 0.02 and 0.004 0.003 kg, respectively). Kidney mass decreased by 0.013 0.003 kg (P < 0.001) over 2 y in both groups.Decreases in liver (in Caucasians but not African Americans) and spleen were detected after a 6.2-kg weight reduction compared with a control group. SM and kidney mass decreased in both groups. Appendicular SM was regained during the second year whereas trunk SM was not. No evidence of a disproportionate loss of high-metabolic rate organs (heart, liver, kidney, spleen) compared with SM was found.

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