The New York Academy of science is the third-oldest scientific society and among the most prestigious in the United States. An independent, non-profit organization with more than 25,000 members in 140 countries, the Academy’s mission is to advance understanding of science and technology. It identifies and promotes scientific advances across disciplines and professional and geographic boundaries, and builds bridges and synergies between institutions and individuals. It helps to expand scientific knowledge by convening leading experts in meetings, seminars, and interdisciplinary conferences, and by disseminating information through both print and electronic media. The president and CEO is Ellis Rubinstein; the current chair of the board of governors of the Academy is Nancy Zimpher, Chancellor, The State University of New York . Wikipedia.
Wu J.H.Y.,University of Sydney |
Lemaitre R.N.,University of Washington |
King I.B.,University of New Mexico |
Song X.,Fred Hutchinson Cancer Research Center |
And 4 more authors.
Circulation | Year: 2014
Background-Although omega-6 polyunsaturated fatty acids (n-6 PUFA) have been recommended to reduce coronary heart disease (CHD), controversy remains about benefits versus harms, including concerns over theorized proinflammatory effects of n-6 PUFA. We investigated associations of circulating n-6 PUFA including linoleic acid (the major dietary PUFA), γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid, with total and cause-specific mortality in the Cardiovascular Health Study, a community-based U.S. cohort. Methods and Results-Among 2792 participants(aged ≥65 years) free of cardiovascular disease at baseline, plasma phospholipid n-6 PUFA were measured at baseline using standardized methods. All-cause and cause-specific mortality, and total incident CHD and stroke, were assessed and adjudicated centrally. Associations of PUFA with risk were assessed by Cox regression. During 34 291 person-years of follow-up (1992-2010), 1994 deaths occurred (678 cardiovascular deaths), with 427 fatal and 418 nonfatal CHD, and 154 fatal and 399 nonfatal strokes. In multivariable models, higher linoleic acid was associated with lower total mortality, with extreme-quintile hazard ratio =0.87 (P trend=0.005). Lower death was largely attributable to cardiovascular disease causes, especially nonarrhythmic CHD mortality (hazard ratio, 0.51; 95% confidence interval, 0.32-0.82; P trend=0.001). Circulating γ-linolenic acid, dihomo-γ-linolenic acid, and arachidonic acid were not significantly associated with total or cause-specific mortality (eg, for arachidonic acid and CHD death, the extreme-quintile hazard ratio was 0.97; 95% confidence interval, 0.70-1.34; P trend=0.87). Evaluated semiparametrically, linoleic acid showed graded inverse associations with total mortality (P=0.005). There was little evidence that associations of n-6 PUFA with total mortality varied by age, sex, race, or plasma n-3 PUFA. Evaluating both n-6 and n-3 PUFA, lowest risk was evident with highest levels of both. Conclusions-High circulating linoleic acid, but not other n-6 PUFA, was inversely associated with total and CHD mortality in older adults. © 2014 American Heart Association, Inc.
Cherepanov G.P.,New York Academy of Sciences
Journal of Applied Mechanics and Technical Physics | Year: 2014
A theory of rolling of round bodies in the normal mode with adhesion conditions satisfied on the entire contact area is proposed. This theory refines the classical Coulomb's theory of rolling in which the rolling moment is directly proportional to the pressing force (e.g., the weight of the rolling body). The rolling moment of cylinders is found to be directly proportional to the pressing force raised to a power of 3/2, and the rolling moment of balls and tori is proportional to the pressing force raised to a power of 4/3. It is shown that the normal mode of uniform rolling can only be provided for a certain ratio of the elastic constants of the materials of the round body and the base forming an ideal pair. The Coulomb problem is solved for the cases of rolling of an elastic cylinder over an elastic half-space, of an elastic ball over an elastic half-space, of an elastic torus over an elastic half-space, and of a cylinder and ball over a tightly stretched membrane. The rolling law is derived for such cases. The rolling friction coefficients, the rolling moment, and the rolling friction force are calculated. © 2014 Pleiades Publishing, Ltd.
Aghayeva U.F.,New York Academy of Sciences |
Nikitin M.P.,RAS A.M. Prokhorov General Physics Institute |
Lukash S.V.,RAS Shemyakin Ovchinnikov Institute of Bioorganic Chemistry |
Deyev S.M.,Nizhny Novgorod State Medical Academy
ACS Nano | Year: 2013
To date, a number of biomolecule-mediated nanoparticle self-assembly systems have been developed that are amenable to controllable disassembly under relatively gentle conditions. However, for some applications such as design of self-assembled multifunctional theragnostic agents, high stability of the assembled structures can be of primary importance. Here, we report extraordinarily high durability of protein-assisted nanoparticle self-assembly systems yielding bifunctional colloidal superstructures resistant to extreme denaturing conditions intolerable for most proteins (e.g., high concentrations of chaotropic agents, high temperature). Among the tested systems (barnase-barstar (BBS), streptavidin-biotin, antibody-antigen, and protein A-immunoglobulin), the BBS is notable due to the combination of its high resistance to severe chemical perturbation and unique advantages offered by genetic engineering of this entirely protein-based system. Comparison of the self-assembly systems shows that whereas in all cases the preassembled structures proved essentially resistant to extreme conditions, the ability of the complementary biomolecular pairs to mediate assembly of the initial biomolecule-particle conjugates differs substantially in these conditions. © 2013 American Chemical Society.
Cherepanov G.P.,New York Academy of Sciences
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2015
By way of introduction, the general invariant integral (GI) based on the energy conservation law is presented, with mention of cosmic, gravitational, mass, elastic, thermal and electromagnetic energy of matter application to demonstrate the approach, including Coulomb's Law generalized for moving electric charges, Newton's Law generalized for coupled gravitational/cosmic field, the new Archimedes' Law accounting for gravitational and surface energy, and others. Then using this approach the temperature track behind a moving crack is found, and the coupling of elastic and thermal energies is set up in fracturing. For porous materials saturated with a fluid or gas, the notion of binary continuum is used to introduce the corresponding GIs. As applied to the horizontal drilling and fracturing of boreholes, the field of pressure and flow rate as well as the fluid output from both a horizontal borehole and a fracture are derived in the fluid extraction regime. The theory of fracking in shale gas reservoirs is suggested for three basic regimes of the drill mud permeation, with calculating the shape and volume of the local region of the multiply fractured rock in terms of the pressures of rock, drill mud and shale gas. © 2015 The Author(s) Published by the Royal Society. All rights reserved.
Abraham J.,University of Texas Health Science Center at Houston |
Kannampallil T.G.,University of Texas Health Science Center at Houston |
Patel V.L.,New York Academy of Sciences
Journal of Biomedical Informatics | Year: 2012
Handoff among healthcare providers has been recognized as a major source of medical errors. Most prior research has often focused on the communication aspects of handoff, with limited emphasis on the overall handoff process, especially from a clinician workflow perspective. Such a workflow perspective that is based on the continuity of care model provides a framework required to identify and support an interconnected trajectory of care events affecting handoff communication. To this end, we propose a new methodology, referred to as the clinician-centered approach that allows us to investigate and represent the entire clinician workflow prior to, during and, after handoff communication. This representation of clinician activities supports a comprehensive analysis of the interdependencies in the handoff process across the care continuum, as opposed to a single discrete, information sharing activity. The clinician-centered approach is supported by multifaceted methods for data collection such as observations, shadowing of clinicians, audio recording of handoff communication, semi-structured interviews and artifact identification and collection. The analysis followed a two-stage mixed inductive-deductive method. The iterative development of clinician-centered approach was realized using a multi-faceted study conducted in the Medical Intensive Care Unit (MICU) of an academic hospital. Using the clinician-centered approach, we (a) identify the nature, inherent characteristics and the interdependencies between three phases of the handoff process and (b) develop a descriptive framework of handoff communication in critical care that captures the non-linear, recursive and interactive nature of collaboration and decision-making. The results reported in this paper serve as a " proof of concept" of our approach, emphasizing the importance of capturing a coordinated and uninterrupted succession of clinician information management and transfer activities in relation to patient care events. © 2011 Elsevier Inc.