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Yan X.,Institute of Chongqing Traditional Chinese Medicine | Yan X.,New Medical Science Research Institute | Li F.,The University of Oklahoma Health Sciences Center | Dozmorov I.,Oklahoma Medical Research Foundation | And 5 more authors.
Molecular and Cellular Biochemistry | Year: 2012

Small-cell lung cancer (SCLC) is a highly malignant carcinoma with poor long-term survival. Effective treatment remains highly demanded. In the present study, we demonstrated that External Qi of Yan Xin Qigong (YXQ-EQ) exerted potent cytotoxic effect towards SCLC cell line NCI-H82 via induction of apoptosis. Global gene expression profiling identified 39 genes whose expression was altered by YXQ-EQ in NCI-82 cells. Among them, semi-quantitative RT-PCR and real-time qPCR analyses confirmed that the gene expression levels of apoptotic proteins death-associated protein kinase 2 and cell death-inducing DFFA-like effector b were upregulated, whereas that of oncoproteins DEK and MYCL1, cell migration-promoting proteins CD24 and integrin-alpha 9, and glycolytic enzyme aldolase A were downregulated. These findings suggest that YXQ-EQ may exert anticancer effect through modulating gene expression in a way that facilitates cancer cell apoptosis while represses proliferation, metastasis, and glucose metabolism. © 2011 Springer Science+Business Media, LLC.


Yan X.,Chongqing Institute of Traditional Chinese Medicine | Yan X.,New Medical Science Research Institute | Shen H.,New Medical Science Research Institute | Jiang H.,Harvard University | And 4 more authors.
Cellular Physiology and Biochemistry | Year: 2013

Background/Aims: Colorectal cancer (CRC) is the second leading cause of cancer death in the Western countries. Novel approaches of treatment are needed for CRC. The purpose of the present study was to investigate cytotoxic effect of external Qi of Yan Xin Qigong (YXQ-EQ) on human colorectal cancer cells. Methods: The effect of YXQ-EQ on viability, cell cycle progression and apoptosis in colorectal cancer HT-29 cells was investigated. Phosphorylation of Akt and Erk1/2, activation of NF-κB and the expression of proteins involved in regulation of cell cycle and apoptosis were examined by Western blot analysis. Results: YXQ-EQ markedly decreased viability and blocked colony formation of HT-29 cells. YXQ-EQ downregulated cyclin D1 expression and increased accumulation of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1, resulting in G1 cell cycle arrest. YXQ-EQ induced apoptosis in HT-29 cells in association with decreased expression of antiapoptotic proteins Bcl-xL, XIAP, survivin and Mcl-1 and elevated expression of proapoptotic protein Bax. YXQ-EQ significantly repressed phosphorylation of Akt and Erk1/2 and NF-κB activation in HT-29 cells, suggesting that YXQ-EQ may exert cytotoxic effect through regulating signaling pathways critical for cell proliferation and survival. Furthermore, YXQ-EQ treated PBS and an YXQ-EQ treated plant extract induced apoptosis in HT-29 cells. Conclusion: These findings show that YXQ-EQ has potent cytotoxic effect on HT-29 cells and suggest that YXQ-EQ could be potentially used for colorectal cancer treatment either directly or indirectly via carriers. Copyright © 2013 S. Karger AG, Basel.


Yan X.,Chongqing Institute of Traditional Chinese Medicine | Yan X.,New Medical Science Research Institute | Shen H.,New Medical Science Research Institute | Jiang H.,Harvard University | And 5 more authors.
Cellular Physiology and Biochemistry | Year: 2010

The antitumor effects of external Qi of Yan Xin Qigong (YXQ-EQ) have been widely described over the past three decades. To gain a better understanding of the mechanisms underlying YXQ-EQ's antitumor effects, in the present study we investigated its effects on growth, migration, invasion and apoptosis of breast cancer cells and the underlying molecular mechanisms. We show that YXQ-EQ treatment caused a time-dependent reduction in viability, blocked clonogenic growth and induced apoptosis in estrogen-independent breast cancer MDA-MB-231 cells. Furthermore, YXQ-EQ treatment blocked migration and invasion of MDA-MB-231 cells. Biochemically, YXQ-EQ treatment markedly inhibited constitutive and EGF-induced Akt phosphorylation. YXQ-EQ also substantially repressed NF-κB activity, resulting in decreased expression of anti-apoptotic Bcl-2, Bcl-XL, XIAP and survivin proteins. These findings suggest that YXQ-EQ may induce apoptosis and inhibition of migration and invasion of MDA-MB-231 cells through the repression of Akt/NF-κB signaling. Copyright © 2010 S. Karger AG, Basel.


PubMed | University of Minnesota, Vancouver Yan Xin Life Science & Technology Center, New Medical Science Research Institute and Harvard University
Type: Journal Article | Journal: International journal of economic research | Year: 2015

We use 7-year longitudinal medical claims data and statistical models to study the relationship between practicing Yan Xin Qigong (YXQG), a traditional advanced Chinese Qigong that has been integrated with modern science and technology, and practitioners medical care utilization and the associated costs. We find that for the sampled practitioners, their average monthly medical visits and the associated costs are significantly lower after practicing YXQG. After controlling for other factors, the longer of practicing YXQG, the more likely there was a fall in average medical visits and medical costs. The main findings are robust to various estimation methods.

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