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Nishimura D.,Nissei Bio Co. | Nishimura D.,Gene Trophology Institute | Takahashi C.,Nissei Bio Co. | Takahashi C.,Gene Trophology Institute | Kohzai Y.,New Drug Research Center Inc
Nippon Shokuhin Kagaku Kogaku Kaishi | Year: 2015

Society as a whole is developing a more nocturnal lifestyle as a result of advances in information technology and the increasing number of nighttime jobs. These changes in lifestyle have ledto delayedbed time andd eclining hours of sleep. A relationship between sleep disturbance and the deterioration in physical and mental health has recently been reported; specifically, the negative effects of sleep disturbance on brain and/or immune functions as well as lifestyle disease pathogenesis. Furthermore, the number of individuals with sleep disorders has been increasing with aging, representing a problem that needs to be addressed. We conducted a double-blind crossover study in 10 male subjects (age range, 40-69 years) who reported dissatisfaction with their sleep. Our aim was to determine the effect of asparagus cladophylls intake on sleep disturbance. The Pittsburgh Sleep Quality Index questionnaire revealed a significant reduction in sleep disturbance in response to cladophylls intake. Thus, asparagus cladophylls intake was foundto improve sleep. Copyright © 2015, Japanese Society for Food Science and Technology. Source


Ukawa Y.,Central Research Institute ITO EN Ltd. | Sagesaka Y.,Central Research Institute ITO EN Ltd. | Hatakeyama Y.,New Drug Research Center Inc | Noro A.,New Drug Research Center Inc | Fukuhara I.,Fukuhara Clinic
Japanese Pharmacology and Therapeutics | Year: 2013

Objective: We examined the effect of catechins with a galloyl moiety to reduce dietary lipid absorption in humans. Methods: A randomized double-blind placebo-controlled crossover study was conducted. The beverage (340 mL/bottle) contained 190.9 mg of tea catechins with a galloyl moiety. Fifteen healthy adult subjects were randomly divided into two groups. Group A was requested to consume the drinks, containing catechins with a galloyl moiety, everyday for 10 days and then the placebo for 10 days, after an 11 day interval between these intake periods. On the contrary, Group B consumed the placebo first for 10 days and then the catechin drinks for 10 days, after an 11 day interval between the periods. Each subject in the catechin group was given 3 bottles of the test beverage/day and each subject in the placebo group was given 3 bottles of the placebo beverage/day. During the treatment period, subjects were given the same menu (Male : 2244±35.6 kcal, 84±0.6 g lipids, Female : 1944±35.6 kcal, 66±0.6 g lipids) at each meal. On the last 3 days of each treatment period, feces were collected in order to measure the excretion of lipids. Results: Lipid excretion into feces was found to be significantly higher in the test beverage consumption cases than in the placebo beverage ones on third day. Serum total cholesterol and LDL cholesterol were significantly lower in the test beverage consumption cases than in the placebo beverage ones. Conclusions: Our present observations suggest that consumption of catechins with a galloyl moiety could increase lipid excretion into feces. Source


Fukuhara I.,Fukuhara Clinic | Ikenaga T.,Otsuka Pharmaceutical Factory Inc. | Noguchi H.,Otsuka Pharmaceutical Factory Inc. | Kohashi C.,Otsuka Pharmaceutical Factory Inc. | And 4 more authors.
Japanese Pharmacology and Therapeutics | Year: 2013

Objectives: The aim of the present study was to investigate the effect of cooked rice with β-glucan enriched barley on postprandial glucose response and its second-meal effect. Methods: The study was conducted in randomized crossover design with twenty healthy subjects whose fasting blood glucose was normal level. Subjects consumed test meals at breakfast and blood glucose, insulin and free fatty acid were measured for 120 min after the breakfast. For a subsequent lunch, they consumed standardizes meals and blood glucose was measured for 120 min after the lunch. Results: Cooked rice with β-glucan enriched barley lowered the blood glucose and insulin incremental areas under the curve (IAUC) (0-120 min) at breakfast and the blood glucose IAUC (0-120 min) at a subsequent lunch (P<0.05). The blood free fatty acid was not changed after ingestion of the test meals at breakfast. Conclusions: These findings suggested that cooked rice with β-glucan enriched barley contributed to postprandial glucose response and its second-meal effect. The present study suggested that cooked rice with β-glucan enriched barley has potential to an advantage for diabetes care. Source


Badmaev V.,New Hill | Hatakeyama Y.,New Drug Research Center Inc | Yamazaki N.,New Drug Research Center Inc | Noro A.,New Drug Research Center Inc | And 5 more authors.
Journal of Functional Foods | Year: 2015

The herbal composition of Coleus forskohlii, Salacia reticulata, and Sesamum indicum, standardized for forskolin, mangiferin, and sesamin, respectively, were shown, in vitro, to inhibit pancreatic lipase with differing degrees and dynamics. In the placebo controlled six weeks clinical study the daily intake of 1000 mg C. forskohlii stand-alone standardized for 10% forskolin, showed statistically significant lowering of total body fat vs. baseline and placebo group (p < 0.05). The computerized tomography showed decrease of total body fat and visceral fat in C. forskohlii group in comparison to the baseline. The potential of three herbal extracts preventing dietary fat absorption was emphasized by the in vitro synergy between C. forskohlii and S. reticulata inhibiting pancreatic lipase at higher rate than the fat-blocking activity generated by each component alone. The in vitro addition of S. indicum to the formula was found to synergistically assist inhibition of the pancreatic lipase in a lower dose range, while moderating the pancreatic lipase inhibition in a higher dose range. This dual mechanism of S. indicum was postulated as a safety mechanism preventing any potential side effects resulting from excessive inhibition of pancreatic lipase activity. © 2015 Elsevier Ltd. Source


Badmaev V.,New Hill | Hatakeyama Y.,New Drug Research Center Inc | Yamazaki N.,New Drug Research Center Inc | Noro A.,New Drug Research Center Inc | And 5 more authors.
Journal of Functional Foods | Year: 2015

The herbal compositions of Coleus forskohlii, Salacia reticulata, and Sesamum indicum, standardized for forskolin, mangiferin, and sesamin, respectively, were shown, in vitro, to inhibit pancreatic lipase with differing degrees and dynamics. In the placebo controlled six weeks clinical study the daily intake of 1000 mg C. forskohlii stand-alone standardized for 10% forskolin, showed statistically significant lowering of total body fat vs. baseline and placebo group (p < 0.05). The computerized tomography showed decrease of total body fat and visceral fat in C. forskohlii group in comparison to the baseline. The potential of three herbal extracts preventing dietary fat absorption was emphasized by the in vitro synergy between C. forskohlii and S. reticulata inhibiting pancreatic lipase at higher rate than the fat-blocking activity generated by each component alone. The in vitro addition of S. indicum to the formula was found to synergistically assist inhibition of the pancreatic lipase in a lower dose range, while moderating the pancreatic lipase inhibition in a higher dose range. This dual mechanism of S. indicum was postulated as a safety mechanism preventing any potential side effects resulting from excessive inhibition of pancreatic lipase activity. © 2015 Elsevier Ltd. Source

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