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West Midlands, United Kingdom

Nolte F.,University of Mannheim | Angelucci E.,Hematology Unit | Beris P.,University of Geneva | Macwhannell A.,New Cross Hospital Wolverhampton | And 8 more authors.
Leukemia Research | Year: 2011

Myelodysplastic syndromes are characterized by ineffective hematopoiesis resulting in peripheral cytopenias. The majority of patients is dependent on regular transfusions of packed red blood cells leading to a secondary iron overload which might result in organ damage. Therefore, sufficient iron chelation therapy in selected patients is mandatory. Deferasirox (DFX) is an orally administered iron chelator which has been highly efficient in the treatment of secondary iron overload. Most frequent side effects of DFX are gastrointestinal disturbances, which leads in some patients to low adherence to the therapy. An expert panel met in Lisbon in July 2010 to develop recommendations on prevention and management of GI disturbances based on existing data and personal experiences. © 2011 Elsevier Ltd. Source

Awais M.,New Cross Hospital Wolverhampton | Nicholas J.,New Cross Hospital Wolverhampton | Al-Saleh A.,New Cross Hospital Wolverhampton | Dyer J.,New Cross Hospital Wolverhampton
Clinical Kidney Journal | Year: 2012

Ischaemic monomelic neuropathy (IMN) is an infrequently recognized type of neuropathy, produced after acute arterial occlusion or reduced blood flow to an extremity. In the upper limb, it usually occurs after vascular access surgery for haemodialysis. IMN has been reported largely in diabetics with peripheral neuropathy and atherosclerotic vascular disease. We report a case of IMN following arteriovenous (AV) fistula formation in a patient with advanced chronic renal failure, who did not have diabetes mellitus and symptoms of peripheral neuropathy or features of atherosclerotic vascular disease. Symptoms improved immediately after the distal revascularization and interval ligation procedure to the AV fistula. © 2012 The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. Source

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