Chennai, India
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Yasmeen M.F.,New College Autonomous | Saboor A.,New College Autonomous
Indian Journal of Ecology | Year: 2016

Puzhal Lake is one of the rain-fed reservoirs and a drinking water source for the Chennai city. The planktonic populations were assessed by qualitative and quantitative analysis before and after the historic heavy rainfall that led to a heavy deluge in this area. Rotifers, cladocerans, ostracods and copepods constitute the foremost groups of zooplankton of Puzhal Lake. Prior to flooding, the total population of the zooplankton groups was recorded as 81/L that was higher compared to that after the flood which recorded as 31/L. The major zooplankton group was Harpacticoida (30/L) followed by Rotifera (10/L) before flood and Rotifera (9/L) followed by Cladocera (6/L) after the flood. The diversity of the zooplankton species was higher (14 species) before flood compared to that of after the flood (8 species).The phytopiankton species were more diverse after the flood. Ecological indices indicated obvious changes.


Basith N.M.,Catalysis and Nanomaterials Research Laboratory | Basith N.M.,New College Autonomous | Vijaya J.J.,Catalysis and Nanomaterials Research Laboratory | Bououdina M.,University of Bahrain
Materials Science in Semiconductor Processing | Year: 2014

In the present paper, we report a facile and rapid microwave-assisted combustion synthesis method for the preparation of pure and Ni-doped CuO nanostructures with different weight ratios (0.5, 1.0, 1.5, and 2.0 at wt% of Ni). The structure and morphology of the pure and Ni-doped CuO samples were investigated by X-ray diffraction (XRD), high resolution scanning electron microscopy (HR-SEM), energy dispersive x-ray analysis (EDX), diffuse reflectance spectroscopy (DRS), photoluminescence (PL) spectroscopy and vibrating sample magnetometry (VSM). XRD patterns refined by the Rietveld method indicated the formation of single-phase monoclinic structure and also confirmed that Ni ions are successfully doped into CuO crystal lattice by occupying Cu ionic sites. Interestingly, the morphology was found to transform substantially from nanoflowers to nanoparticles with close-packed periodic array, and then into nanocrystals with the variation of Ni content. The optical band gap estimated using DRS was found to be 3.9 eV for pure CuO and then increases up to 4.3 eV with increasing Ni content. PL spectra at room temperature showed a strong green emission band, and thereby confirmed the above results. Magnetic measurements reveal a room temperature ferromagnetism (RTFM) with an optimum value of saturation magnetization of 1.3140×10-3 emu/g for 2.0 wt% of Ni. © 2013 Elsevier Ltd.


Gurumoorthy P.,New College Autonomous | Mahendiran D.,New College Autonomous | Prabhu D.,University of Madras | Arulvasu C.,University of Madras | Rahiman A.K.,New College Autonomous
RSC Advances | Year: 2014

A new class of chloro-bridged dinuclear nickel(ii) and copper(ii) phenolate complexes (1-8) were synthesized from 4-substituted-2-((2-(piperazin-1-yl)ethylimino)methyl)phenols (L1-4) and characterized. The XRD analysis of complexes 4 and 8 shows two mononuclear units connected through a bridged chlorine atom that gives dinuclear complexes. The stability of the complexes has been determined using a spectrophotometric method. Complexes 5-8 possess significant antioxidant activity against the DPPH radical. The binding studies of complexes with CT-DNA suggest partial intercalative/electrostatic interaction and the cleavage ability for pBR322 DNA shows the involvement of the hydroxyl radical as an intermediate in the cleavage reaction. The IC50 value of complexes 2, 6 and 8 against the HepG2 cell line is comparable with that of cisplatin. To find the extent of nuclear chromatin cleavage, propidium iodide staining and comet assays were employed. Among the newly synthesized complexes, copper(ii) complexes exhibited superior biological activity when compared to their nickel(ii) analogues. This journal is © the Partner Organisations 2014.


Gurumoorthy P.,New College Autonomous | Mahendiran D.,New College Autonomous | Prabhu D.,University of Madras | Arulvasu C.,University of Madras | Rahiman A.K.,New College Autonomous
Journal of Molecular Structure | Year: 2015

A series of phenol-based mixed-ligand copper(II) complexes of the type [CuL1-4(diimine)] (1-8), where L1-4 = N1,N2-bis(5-substituted-2-hydroxybenzylidene)-1,2-ethylene/phenylenediimine and diimine = 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen), have been isolated and fully characterized by analytical and spectral techniques. Electronic spectra of complexes suggest Cu(II) cation has a d9 electronic configuration, adopting distorted octahedral geometry with axial elongation, due to Jahn-Teller effect. Electrochemical studies of complexes evidenced one-electron irreversible reduction wave in the cathodic region. The observed rate constant (k) values for the hydrolysis of 4-nitrophenylphosphate (4-NPP) are in the range of 0.25-3.82 × 10-2 min-1. The obtained room temperature magnetic moment values (1.79-1.90 BM) lies within the range observed for octahedral copper(II) complexes. Antioxidant studies revealed that these complexes possess considerable radical scavenging potency against DPPH. The binding studies of complexes with calf thymus DNA (CT-DNA) revealed intercalation with minor-groove binding, and the complex 4 exhibits highest binding activity than the other complexes. The cleavage activity on supercoiled pBR322 DNA revealed the involvement of hydroxyl radical and singlet-oxygen as reactive oxygen species, and complexes encourage binding to minor-groove. Further, the cytotoxicity of complex 4 on human hepatocellular liver carcinoma HepG2 cell line implies the cell death through apoptosis. © 2014 Elsevier B.V. All rights reserved.


Huq C.A.M.A.,New College Autonomous | Fouzia S.,New College Autonomous | Nizammohideen M.,New College Autonomous
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

The asymmetric unit of the title compound, 2C13H 14N2O3·C3H 10NO3 +·Cl-, contains two independent molecules (A and B) of the title pyrimidine derivative and one ion-pair of tris(hydroxymethyl)ammonium chloride. The pyrimidine ring in each pyrimidine derivative has a half-chair conformation. Its mean plane is inclined to the benzene ring by 87.2 (3)° in molecule A and 85.7 (2)° in molecule B. In the crystal, the pyrimidine derivatives are connected to each other by N-H⋯O hydrogen bonds, forming chains propagating along the b-axis direction. The chains are linked via O-H-Cl hydrogen bonds, forming corrugated sheets lying parallel to the bc plane. The sheets are linked via C-H⋯O hydrogen bonds, forming a three-dimensional framework. The tris(hydroxymethyl) ammonium chloride molecules are located in the cages of the framework. There are also further C-H⋯O hydrogen bonds and C-H⋯π interactions present in the three-dimensional framework structure. Both the cation and chloride anion of the tris(hydroxymethyl)ammonium chloride ion pair are disordered over two positions, with a refined occupancy ratio of 0.418 (8):0.582 (8) for the cation and 0.71 (4):0.29 (4) for the anion.


Shihabuddeen Syed A.,Bharathiar University | Rajarajan K.,Rajeswari Vedachalam Government Arts College | Nizammohideen M.,New College Autonomous
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

In the title salt, [Hg(NCS)(CH4N2S)3]Cl, the Hg2+ ion is coordinated in a severely distorted tetrahedral manner by three thiourea groups and one thiocyanate anion through their S atoms. The S - Hg - S angles vary widely from 87.39 (5) to 128.02 (4)°. Weak intramolecular N - H⋯S hydrogen bonds are observed, which form S(6) ring motifs. In the crystal, the ions are linked by N - H⋯N and weak N - H⋯Cl interactions, generating a three-dimensional network. © Shihabuddeen Syed et al. 2013.


Showrilu K.,Bharathiyar University | Rajarajan K.,Rajeswari Vedachalam Government Arts College | Nizammohideen M.,New College Autonomous
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

The title compound, (NH4)2[Zn(NCS)4]·2C12H24O6·H2O, the result of the reaction of ammonium thiocyanate, 18-crown-6 and zinc(II) chloride in aqueous solution, exhibits an unusual supramolecular structure. The Zn atom, two of the thiocyanate chains and a water molecule, disordered over two positions, lie on a mirror plane. The macrocycle adopts a conformation with approximate D 3d symmetry. The ammonium molecules are contained within the bowl of the macrocycle via extensive N - H⋯O hydrogen bonds and the complex molecules are linked via N - H⋯S hydrogen bonds, forming chains along the c-axis direction. The macrocycle is disordered over two positions [refined occupancy ratio = 0.666 (8):0.334 (8)]. The S atoms of two isothiocyanate ligands are disordered within and about the mirror plane.


Ravichandran J.,New College Autonomous | Ravichandran J.,Amrutanjan Healthcare Ltd | Gurumoorthy P.,New College Autonomous | Imran Musthafa M.A.,New College Autonomous | Kalilur Rahiman A.,New College Autonomous
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2014

A series of heteroleptic copper(II) complexes of the type [CuL 1-4(diimine)](ClO4)2 (1-8) [L1-4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, and diimine = 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen)], have been synthesized and characterized by spectroscopic methods. The IR spectra of complexes indicate the presence of uncoordinated perchlorate anions and the electronic spectra revealed the square pyramidal geometry with N4O coordination environment around copper(II) nuclei. Electrochemical studies of the mononuclear complexes evidenced one-electron irreversible reduction wave in the cathodic region. The EPR spectra of complexes with g|| (2.206-2.214) and A|| (154-172 × 10-4 cm- 1) values support the square-based CuN3O coordination chromophore and the presence of unpaired electron localized in d x2-y2 ground state. Antioxidant studies against DPPH revealed effective radical scavenging properties of the synthesized complexes. Binding studies suggest that the heteroleptic copper(II) complexes interact with calf thymus DNA (CT-DNA) through minor-groove and electrostatic interaction, and all the complexes display pronounced nuclease activity against supercoiled pBR322 DNA. © 2014 Elsevier B.V. All rights reserved.


Babu K.S.S.,Presidency College at Chennai | Babu K.S.S.,New College Autonomous | Peramaiyan G.,Presidency College at Chennai | Nizammohideen M.,New College Autonomous | Mohan R.,Presidency College at Chennai
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the asymmetric unit of the title molecular salt, C6H 9N2 +·C2Cl3O2 -, there are two independent 2-amino-6-methylpyridinium cations and two independent trichloroacetate anions. The pyridine N atom of the 2-amino-6-methylpyridine molecule is protonated and the geometries of these cations reveal amine-imine tautomerism. Both protonated 2-amino-6- methylpyridinium cations are essentially planar [maximum deviations = 0.026(2) and 0.012(2)Å]. In the crystal, the protonated N atom and the 2-amino group of the cation are hydrogen bonded to the carboxylate O atoms of the anion via a pair of N-H..O hydrogen bonds, forming an R 2 2(8) ring motif. These motifs are connected via N-H..O and C-H..O hydrogen bonds to form slabs parallel to (101).


Gurumoorthy P.,New College Autonomous | Mahendiran D.,New College Autonomous | Kalilur Rahiman A.,New College Autonomous
Chemico-Biological Interactions | Year: 2016

EightLeu1030 and Arg839. water soluble mixed-ligand nickel(II) complexes of the type [NiL1-4(diimine)H2O]·(ClO4)2, (1-8) where L1-4 = 2-((2-(piperazin-1-yl)ethylimino)methyl)-4-substituted phenols, and diimine = 2,2′-bipyridyl (bpy) or 1,10-phenanthroline (phen) were synthesized and characterized by elemental analysis and spectroscopic methods. The uncoordinated perchlorate anions was ascertained form IR spectra of the complexes, and the absorption spectra reveal the octahedron geometry around nickel(II) ion with tridentate Schiff base ligand, diimine and a coordinated water molecule. Cyclic voltammograms of the complexes indicate the one-electron irreversible processes in the cathodic and anodic region. In vitro antioxidant activity proved the significant radical scavenging activity of the complexes against DPPH radical. The groove/electrostatic binding nature of complexes with CT-DNA (calf thymus deoxyribonucleic acid) were affirmed by absorption, hydrodynamic and voltammetric titration experiments and docking analysis. All the complexes exhibit significant cleavage activity on plasmid DNA via hydrolytic and oxidatively, in which the oxidative mechanism involves hydroxyl radicals and supports the possibility of minor-groove binding. The complex 4 shows significant topoisomerase I (Topo-I) inhibitory activity. The molecular modeling analysis of complexes with phosphatidylinositol-3-kinase (PI3K) receptor indicate the hydrogen bonding with Met1039, Asp837 and Leu1027, and hydrophobic interactions with Ser488, Asn498, Asp500, Gln662, Lys668, Ile844, Ile847, Ile850, Val941, Leu942, Leu1020, Met1034, Leu1035, Thr1037, Met1039, Gln1041 and Ile1051 of subdomain IIA of BSA. The complexes show σ-π interaction between diimines and amino groups of Leu1030 and Arg839. © 2016 Elsevier Ireland Ltd. All rights reserved.

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