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Manjunatha Goud B.K.,Manipal University India | Deepa K.,JSS Medical College | Sarsina Devi O.,New city nursing college | Poornima A.M.,Manipal University India | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2010

Type 2 DM is a global disease and one of its resultant complication is diabetic nephropathy. An accelerated polyol pathway in diabetes contributes to the development of cataract and nephropathy. Microalbuminuria an early indicator of diabetic nephropathy is an independent risk factor for cardiovascular morbidity and mortality. The main aim of this study was to compare the blood sorbitol levels with microalbuminuria in the early prediction of diabetic nephropathy. The study group included 3 groups of subjects aged between 55-68yrs, Group1-Non diabetic senile cataract patients, Group 2-Diabetic cataract patients without nephropathy, Group3- Diabetic cataract patients with nephropathy. The biochemical parameters estimated included sorbitol, glucose and creatinine in blood; albumin and creatinine in urine. A significant increase in blood sorbitol and glucose along with urine albumin creatinine ratio (UACR) was observed in group 2 and 3. Group 3 showed highly significant increase in blood sorbitol (p<0.01) and UACR (p<0.05) as compared to group 2. Blood sorbitol levels could be used as alternative to MA in the early prediction of diabetic nephropathy.


Nayal B.,Manipal University India | Manjunatha Goud B.K.,Manipal University India | Raghuveer C.V.,Manipal University India | Sarsina Devi O.,New city nursing college | And 4 more authors.
International Journal of Pharma and Bio Sciences | Year: 2011

Diabetes mellitus is a chronic metabolic disorder characterized by rise in blood glucose level and derangement in protein and fat metabolism. The measurement of GHb is one of the well established means of monitoring glycemic control in patients with diabetes mellitus. The aim of this study was to understand the significance of calculated HbA 1c by using fasting plasma glucose levels and comparing it with estimated HbA 1c. The study population consisted of 100 subjects. We found significance between the estimated and calculated HbA 1c levels in the study subjects (p<0.001). HbA 1c values calculated on the basis of current blood glucose and past HbA 1c levels are not actually identical to the HbA 1c values present in erythrocytes. However, a good approximation supplied by an appropriate mathematical model would have some advantages over true measurement. Objective of this study was to provide a tool for regular and frequent checking of HbA 1c with proper accuracy. As the formula can be used in well controlled diabetes patients only and is not a replacement for estimated HbA 1c.


Manjunatha Goud B.K.,Manipal University India | Mallick A.K.,Manipal University India | Sarsina Devi O.,New city nursing college | Raghuveer C.V.,Manipal University India | And 4 more authors.
International Journal of Pharma and Bio Sciences | Year: 2011

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defective insulin secretion, action or both. Diabetic nephropathy is a multistage disorder and takes several years to progress from the stage of incipient nephropathy to end stage renal disease. Microalbuminuria is an early indicator of diabetic nephropathy. Urine examination for microalbumin is routinely done to monitor the progression of nephropathy. As many factors can interfere with the estimation of microalbumin, it is very important that high standards are maintained while estimating the MA levels.


Nayal B.,Manipal University India | Raghuveer C.V.,Manipal University India | Goud B.K.M.,Manipal University India | Devi O.S.,New city nursing college | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Type 2 diabetes is the commonest form of diabetes constituting 90% of the diabetic population. The global prevalence of diabetes is estimated to increase from 4% in 1995 to 5.4% by the year 2025. Diabetic nephropathy is a major cause of illness and death in diabetes. The excess of cardiovascular events and mortality occurs already in diabetic patients with persistent microalbuminuria.

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