Cheng P.-C.,Taipei Medical University |
Huang C.-C.,New Bellus Enterprises Co. |
Chiang P.-F.,Institute of Nuclear Energy Research of Taiwan |
Lin C.-N.,National Yang Ming University |
And 7 more authors.
International Journal of Radiation Biology | Year: 2014
Purpose: The radioprotective effects of Antrodia cinnamomea (AC) were investigated for understanding the potential usefulness of AC as an adjunct treatment for reducing radiation side-effects. Materials and methods: In this study, we determined the ability of AC extracts (AC539) to reduce radiation side-effects by analyzing cellular viability in normal mouse spleen immune cells and human cancer cells with different radiosensitivity. We further detected the effect of AC on radiation-induced changes in cytokine- and inflammatory-related gene expressions. Furthermore, apoptosis assay was performed to determine whether AC could inhibit radiation-induced cytotoxicity. Results: We found that an AC dose of 100-150 μg/ml in a time-dependent manner was the most effective in blocking radiation-induced cytotoxicity, in vitro. Radiation-induced cytotoxicity was inhibited in spleen immune cells by 37-56%; however, pretreatment of human colorectal cancer cell line HT-29 with AC did not have any effect on radiation-induced cytotoxicity, while pretreatment of radiosensitive human breast cancer cell lines BT-474 with AC caused a moderate enhancement of radiation-induced damage. Furthermore, AC pretreatment differentially regulated the mRNA expression of several important immunomodulatory genes in response to irradiation in normal and cancer cells. Conclusions: Our data indicate that AC may inhibit important immunoregulatory signaling which could be vital in the avoidance of an over-activated cytotoxic and inflammatory response of the immune system caused by radiation-induced tissue damage. Additionally, AC does not provide a radioprotective effect to tumor cells but instead enhances radiation-induced inflammation and cytotoxicity in cancer. © 2014 Informa UK, Ltd.
PubMed | Asia University, Taiwan, National Taichung University of Science and Technology, Hungkuang University and New Bellus Enterprises Co.
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2016
Chiu Y.-J.,Hungkuang University |
Chiu Y.-J.,New Bellus Enterprises Co. |
Nam M.-K.,Super Laboratory Ltd. |
Tsai Y.-T.,Super Laboratory Ltd. |
And 3 more authors.
The Scientific World Journal | Year: 2013
Genotoxicity assessment is carried out on freeze dried powder of cultured probiotics containing Lactobacillus rhamnosus LCR177, Bifidobacterium adolescentis BA286, and Pediococcus acidilactici PA318. Ames tests, in vitro mammalian chromosome aberration assay, and micronucleus tests in mouse peripheral blood are performed. For 5 strains of Salmonella Typhimurium, the Ames tests show no increased reverse mutation upon exposure to the test substance. In CHO cells, the frequency of chromosome aberration does not increase in responding to the treatment of probiotics. Likewise, the frequency of micronucleated reticulocytes in probiotics-fed mice is indistinguishable from that in the negative control group. Taken together, the toxicity assessment studies suggest that the multispecies probiotic mixture does not have mutagenic effects on various organisms. © 2013 Yi-Jen Chiu et al.
Lan C.C.,New Bellus Enterprises Co. |
Tsai Y.T.,Super Laboratory Inc. |
Huang C.C.,New Bellus Enterprises Co.
African Journal of Traditional, Complementary and Alternative Medicines | Year: 2015
Background: Antrodia cinnamomea (AC) mycelia have been traditionally used by majority of the indigenous populace in Taiwan for symptoms including treating alcohol intoxication. Other beneficial effects have been studied at some point. The present study evaluated the hepato-protection effects in Sprague-Dawley rats. Methods: The model used carbon tetrachloride (CCl4) to induce a chronic liver injury in male rats. Animals were treated with silymarin 200 mg/kg and AC mycelia at doses of 206, 619 and 1,032 mg/kg. The effects of AC on hepatic enzyme markers alanine and aspartate aminotransferase (ALT and AST) and other biochemical parameters were measured in the CCl4 -induced rats. Results: AC demonstrated a hepato-protective effect by decreasing ALT and AST levels and increasing albumin levels in CCl4 treated rats. The effects of AC on the activity of antioxidant enzymes were evaluated. AC administration restored the activities of catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GrD). The degree of liver fibrosis was significantly reduced by AC administration in CCl4 -treated rats. Conclusion: These results suggest that AC could protect the hepatocytes from CCl4 -induced liver injury likely via an antioxidant mechanism. © 2015, African Ethnomedicines Network. All rights reserved.
Wu P.-Y.,Taipei Medical University |
Lan C.-C.,New Bellus Enterprises Co. |
Yang S.-H.,Taipei Medical University
Pakistan Journal of Nutrition | Year: 2015
The objective of this study was to examine the effect of UNECE U-168, an enteral nutrient formula on the nutritional status and renal or hepatic function. During November, 2009 to May, 2011, 30 participants (13 males and 17 females; average age 73.7±15.1 years) were recruited from five nursing homes in New Taipei City, Taiwan. All participants had been on nasogastric tube feeding for three months or more. For four weeks, UNECE U-168 (1500 Kcal) enteral nutritional formula was given to participants as part of their diet. Anthropometric and biochemical measurements were performed. Differences of the measurements before and the nutritional intervention were compared. After 4 weeks of UNECE U-168 enteral nutritional formula as diet, body weight and BMI were stable. Nutritional indicators including serum albumin and total protein levels were maintained at similar levels. Total triglyceride and low-density lipoprotein cholesterol levels had a significant decrease (p<0.05). Aspartate transferase, alanine transaminase and alkaline phosphatase showed normal values. In addition, creatinine and blood urea nitrogen levels were all within the normal range. UNECE U-168 enteral nutritional formula can maintain the nutritional status in diabetic patients and have no adverse effects on the hepatic and renal function. © Asian Network for Scientific Information, 2015.
PubMed | Providence University, Hungkuang University and New Bellus Enterprises Co.
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2017
New Bellus Enterprises Co. | Date: 2014-11-19
This invention discloses a method for treating or preventing heart diseases by using a probiotic composition. The method for treating or preventing heart diseases comprises administering to a subject an effective amount of a probiotic composition to prevent the myocardial cells from myocardial hypertrophy, fibrosis and apoptosis, wherein the probiotic composition comprising Lactobacillus rhamnosus LCR177 (BCRC910473), Pediococcus acidilactici PA318 (BCRC910474) and Bifidobacterium adolescentis (BCRC14609).
New Bellus Enterprises Co. | Date: 2015-04-23
This invention provides a method for inhibiting tumor growth caused by cancer stem cells in a subject in need thereof, which comprises administering to the subject an effective amount of 4-acetyl-antroquinonol B.
New Bellus Enterprises Co. | Date: 2012-08-24
A method for assisting an anti-cancer drug comprising administrating an effective amount of Antrodia camphorata fermentation solution to improve life quality of patient suffering from cancers after chemotherapy is provided.
New Bellus Enterprises Co. | Date: 2012-10-11
This invention provides a method for treating a cancer caused by cancer stem cells in a subject in need thereof, comprising administering to the subject an effective amount of Antrodia camphorata extracts. The invention also provides a method for treating a cancer caused by cancer stem cells in a subject in need thereof, comprising administering to the subject an effective amount of 4-acetyl-antroquinonol B.