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Lai C.-H.,Armed Force Taichung General Hospital | Tsai C.-C.,Hungkuang University | Kuo W.-W.,China Medical University at Taichung | Ho T.-J.,China Medical University at Taichung | And 9 more authors.
International Journal of Medical Sciences | Year: 2016

High-fat diets induce obesity, leading to cardiomyocyte fibrosis and autophagy imbalance. In addition, no previous studies have indicated that probiotics have potential health effects associated with cardiac fibrosis and autophagy in obese rats. This study investigates the effects of probiotics on high-fat (HF) diet-induced obesity and cardiac fibrosis and autophagy in rat hearts. Eight-week-old male Wistar rats were separated randomly into five equally sized experimental groups: Normal diet (control) and high-fat (HF) diet groups and groups fed a high-fat diet supplemented with low (HL), medium (HM) or high (HH) doses of multi-strain probiotic powders. These experiments were designed for an 8-week trial period. The myocardial architecture of the left ventricle was evaluated using Masson’s trichrome staining and immunohistochemistry staining. Key probiotics-related pathway molecules were analyzed using western blotting. Abnormal myocardial architecture and enlarged interstitial spaces were observed in HF hearts. These interstitial spaces were significantly decreased in groups provided with multi-strain probiotics compared with HF hearts. Western blot analysis demonstrated that key components of the TGF/MMP2/MMP9 fibrosis pathways and ERK5/uPA/ANP cardiac hypertrophy pathways were significantly suppressed in probiotic groups compared to the HF group. Autophagy balance is very important in cardiomyocytes. In this study, we observed that the beclin-1/LC3B/Atg7 autophagy pathway in HF was increased after probiotic supplementation was significantly decreased. Together, these results suggest that oral administration of probiotics may attenuate cardiomyocyte fibrosis and cardiac hypertrophy and the autophagy-signaling pathway in obese rats. © Ivyspring International Publisher.


Wu P.-Y.,Taipei Medical University | Lan C.-C.,New Bellus Enterprises Co. | Yang S.-H.,Taipei Medical University
Pakistan Journal of Nutrition | Year: 2015

The objective of this study was to examine the effect of UNECE U-168, an enteral nutrient formula on the nutritional status and renal or hepatic function. During November, 2009 to May, 2011, 30 participants (13 males and 17 females; average age 73.7±15.1 years) were recruited from five nursing homes in New Taipei City, Taiwan. All participants had been on nasogastric tube feeding for three months or more. For four weeks, UNECE U-168 (1500 Kcal) enteral nutritional formula was given to participants as part of their diet. Anthropometric and biochemical measurements were performed. Differences of the measurements before and the nutritional intervention were compared. After 4 weeks of UNECE U-168 enteral nutritional formula as diet, body weight and BMI were stable. Nutritional indicators including serum albumin and total protein levels were maintained at similar levels. Total triglyceride and low-density lipoprotein cholesterol levels had a significant decrease (p<0.05). Aspartate transferase, alanine transaminase and alkaline phosphatase showed normal values. In addition, creatinine and blood urea nitrogen levels were all within the normal range. UNECE U-168 enteral nutritional formula can maintain the nutritional status in diabetic patients and have no adverse effects on the hepatic and renal function. © Asian Network for Scientific Information, 2015.


Chiu H.-F.,Taichung Hospital | Lian J.-D.,Kuang Tien General Hospital | Chang P.-C.,Chung Shan Medical University | Lan C.-C.,New Bellus Enterprises Co. | Wang C.-K.,Chung Shan Medical University
Pakistan Journal of Nutrition | Year: 2015

The study aims to investigate the effect of a liquid supplement UNECE U-99 on the nutritional status of patients receiving maintenance dialysis. For this purpose, 47 participants (27 males and 20 females), aged 29 to 82 (average: 60), who underwent maintenance dialysis were recruited to the study. Two participants were excluded from the analysis as one was unwell for the study and the other was transferred to another hospital. Remaining 45 participants (25 males and 20 females) to be included in the final analysis. The participants were given 4 weeks of UNECE U-99 supplementation. The nutritional evaluation, biochemical tests and anti-oxidant capacity measurements were performed before and after the intervention. After 4 weeks of UNECE U-99, dietary energy intake and uptake of protein, fat and carbohydrate were significantly increased. Plasma albumin levels were elevated (p<0.01). A significant increase in anti-oxidant capacity was also observed. Calcium levels were increased (p<0.05) whereas potassium levels were reduced (p<0.01). Post-dialysis creatinine levels at week 4 compared to the baseline were decreased (p<0.01) and uric acid levels at week 4 were also reduced. It is concluded that UNECE U-99, a nutritional supplement designed for dialysis patients improved their nutritional status in this short term study. © Asian Network for Scientific Information, 2015.


Patent
New Bellus Enterprises Co. | Date: 2014-11-19

This invention discloses a method for treating or preventing heart diseases by using a probiotic composition. The method for treating or preventing heart diseases comprises administering to a subject an effective amount of a probiotic composition to prevent the myocardial cells from myocardial hypertrophy, fibrosis and apoptosis, wherein the probiotic composition comprising


Patent
New Bellus Enterprises Co. | Date: 2015-04-23

This invention provides a method for inhibiting tumor growth caused by cancer stem cells in a subject in need thereof, which comprises administering to the subject an effective amount of 4-acetyl-antroquinonol B.

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