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Narayanan D.L.,New Age Skin Research Foundation | Saladi R.N.,New Age Skin Research Foundation | Fox J.L.,Advanced Dermatology PC
International Journal of Dermatology | Year: 2010

Skin cancer is the most common type of cancer in fair-skinned populations in many parts of the world. The incidence, morbidity and mortality rates of skin cancers are increasing and, therefore, pose a significant public health concern. Ultraviolet radiation (UVR) is the major etiologic agent in the development of skin cancers. UVR causes DNA damage and genetic mutations, which subsequently lead to skin cancer. A clearer understanding of UVR is crucial in the prevention of skin cancer. This article reviews UVR, its damaging effects on the skin and its relationship to UV immunosuppression and skin cancer. Several factors influence the amount of UVR reaching the earth's surface, including ozone depletion, UV light elevation, latitude, altitude, and weather conditions. The current treatment modalities utilizing UVR (i.e. phototherapy) can also predispose to skin cancers. Unnecessary exposure to the sun and artificial UVR (tanning lamps) are important personal attributable risks. This article aims to provide a comprehensive overview of skin cancer with an emphasis on carefully evaluated statistics, the epidemiology of UVR-induced skin cancers, incidence rates, risk factors, and preventative behaviors & strategies, including personal behavioral modifications and public educational initiatives. © 2010 The International Society of Dermatology. Source


Saladi R.N.,New Age Skin Research Foundation | Nektalova T.,New Age Skin Research Foundation | Fox J.L.,Advanced Dermatolgy Patient Center
Clinical and Experimental Dermatology | Year: 2010

In western societies, casual consumption of alcohol during such outdoor activities as barbecuing and sunbathing is common. The current literature shows that alcohol drinkers have increased episodes of sunburn and a higher prevalence of skin cancer. Moreover, recent evidence suggests that the combination of subcarcinogenic (minimal) ultraviolet (UV) exposure with other behavioural, environmental and xenobiotic factors has resulted in increased incidents of skin-related health problems that also result in skin-cancer formation. We hypothesize that the combination of alcohol consumption with UV radiation can potentiate the skin carcinogenic effects through the intermediate biproducts or metabolites of alcohol, which serve as the photosensitizers, consequently enhancing the cellular damage. We have proposed a mechanism that explains the combined alcohol-UV radiation carcinogenicity and its potential involvement in enhancing skin damage in the multistep skin carcinogenesis process. Previous literature has explored this mutual effect but no studies have definitively ascribed the reasons for increased skin cancer prevalence among alcohol drinkers. Nevertheless, the preceding epidemiological data and clinical studies recognize this matter, making the further testing of this hypothesis necessary. © 2009 British Association of Dermatologists. Source


Soto E.,New Age Skin Research Foundation | Lee H.,New Age Skin Research Foundation | Saladi R.N.,New Age Skin Research Foundation | Gerson Y.,New Age Skin Research Foundation | And 12 more authors.
Melanoma Research | Year: 2010

Melanoma is the deadliest form of all skin cancers and is highly linked to sun-related behavior in patients. However, sun-protection behavior to prevent melanoma in this population has been shown to be inadequate to date. The objective of this study was to compare changes in sun protection habit before and after patients' diagnosis with malignant melanoma. The study also seeks patients' advice on how to improve public education on melanoma prevention. A retrospective survey study was conducted on 68 respondents of patients diagnosed with melanoma from six different dermatologic practices in various boroughs of New York and Long Island in the state of New York by telephone interviews. There was a significant positive change in patients' sun-protection behavior after they were diagnosed with melanoma. Various methods of sun protection, such as avoiding sun exposure, applying and reapplying sunscreen, and wearing protective clothing were practiced more frequently after diagnosis. In addition, the frequency of sunbathing decreased drastically. Most patients were aware about the dangers of sun exposure before their diagnosis. They, however, did not feel the need to adopt sun-protection measures before their diagnosis. Respondents advised that education on dangers to excess sun exposure should be provided at an early age through multiple venues. The study reflected that 71% of diagnosed patients who completed the survey were informed about sun protection before their diagnosis. Many patients did not follow strict guidelines to prevent sun damage as shown by their behaviors before diagnosis. Diagnosis of the disease was apparently the main motivating factor to initiate challenging behavioral changes. Copyright © 2010 Lippincott Williams & Wilkins. Source


Berkowitz J.C.,New Age Skin Research Foundation | Kahtri A.,New Age Skin Research Foundation | Saladi R.N.,New Age Skin Research Foundation | Herskowitz D.,New Age Skin Research Foundation | Fox J.L.,New Age Skin Research Foundation
Cosmetic Dermatology | Year: 2010

Hirsutism is defined as the development of a malelike pattern of excess hair especially in women. Hirsutism often results from raised androgen levels in the body and may indicate the existence of a serious underlying endocrine condition, such as polycystic ovary syndrome (PCOS). Treatment of hirsutism may require both medical and cosmetic actions. Medical therapy aims to counteract any suspected hormonal imbalance and can include administration of oral contraceptives and antiandrogens. Cosmetic treatment directly addresses excess hair and seeks to either remove the hair or diminish its appearance. Cosmetic options range from conventional methods, such as shaving and waxing, to modern techniques, such as laser photoepilation. Copyright Cosmetic Dermatology 2010. Source

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