Ahosseini A.,University of Kansas |
Sensenich B.,University of Kansas |
Sensenich B.,Neutrogena Corporation |
Weatherley L.R.,University of Kansas |
Scurto A.M.,University of Kansas
Journal of Chemical and Engineering Data | Year: 2010
Biphasic systems involving ionic liquids (ILs) form the basis of many applications in extractions and reactions. In this work, the liquid-liquid phase equilibrium, density, molar volume, excess molar volume, and interfacial and surface tensions are measured for saturated and subsaturated mixtures of 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)amide ([HMIm][Tf 2N]) and 1-octene at four different temperatures, (10, 25, 50, and 75) °C. Many of the properties of the IL phase change significantly with the increasing concentration of 1-octene. The nonrandom two-liquid (NRTL) activity coefficient model was utilized to model the mutual solubility of two liquids. 1-Octene is fairly soluble in the [HMIm][Tf2N], but the IL solubility in the 1-octene is very small. The excess molar volume for the mixture of ILs and 1-octene is slightly negative for all isotherms and becomes more negative with an increase in temperature. The air-liquid surface tension decreases with increasing 1-octene concentration, and the saturated [HMIm][Tf2N] + 1-octene interfacial tension decreases significantly at higher temperatures. © 2009 American Chemical Society.
Cole C.,Johnson and Johnson Consumer and Personal Products Inc. |
Appa Y.,Neutrogena Corporation |
Ou-Yang H.,Johnson and Johnson Consumer and Personal Products Inc.
Photodermatology Photoimmunology and Photomedicine | Year: 2014
Background: Advances in sunscreen technologies have yielded broad spectrum sunscreens at high-sun protection factor (SPF) and ultraviolet A protection factor (UVA-PF) levels that are photostable and powerful in protecting skin from erythema. Questions arise whether these sunscreens protect proportionally against cellular skin damage caused by high ultraviolet exposures. Objective: The objective of this study is to evaluate if high-SPF sunscreen can protect skin at a cellular level under UV exposure doses [>50 minimal erythema dose (MED)] similarly to the SPF value. Methods: Sunburn cells, Langerhans cells, thymine dimers, protein 53 (p53), and matrix metalloproteinase (MMP)-1 and MMP-9 endpoints were evaluated in biopsies from 12 subjects following four treatments: unprotected exposed to 0, 1 and 3 MED and sunscreen (SPF 55) protected exposed to 55 MED of UV radiation. Results: All the markers showed significantly more damage for the 3 MED-untreated sites when compared with non-irradiated control, and majority of the markers showed marked damage following unprotected 1 MED exposure. After 55 MEDs, sunscreen-protected sites showed significantly less p53 and MMP-9 (keratinocyte) staining than the 1 MED-exposed unprotected sites, while all the other biomarkers in sunscreen protected sites showed no statistical differences from 1 MED-exposed unprotected sites. Conclusions: A high-SPF photostable sunscreen with high UVA-PF can provide proportionately high protection against multiple cellular damage markers. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Neutrogena Corporation | Date: 2012-11-27
Neutrogena Corporation | Date: 2013-02-14
Non-medicated ingredients containing zinc that provide sunscreen protection, sold as an integral component of sun protection and self-tanning preparations, namely, sunblock cream, sunblock lotion, sunblock liquid, sunblock spray, sunblock gel, skin bronzing cream, spray and lotion, body moisturizing cream and lotion and facial moisturizing cream and lotion.
Neutrogena Corporation | Date: 2012-04-04
nonmedicated skin care preparations for the face and body.