Neuropsychiatry Laboratory

Santa Lucia di Serino, Italy

Neuropsychiatry Laboratory

Santa Lucia di Serino, Italy
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Nemmi F.,Neuropsychology Unit | Nemmi F.,University of Rome La Sapienza | Nemmi F.,University Paul Sabatier | Bianchini F.,Neuropsychology Unit | And 9 more authors.
Neurocase | Year: 2015

Developmental topographical disorientation (DTD) causes impaired spatial orientation and navigation from early childhood with no evidence of cerebral damage. Using fMRI and a landmark sequencing task, we investigated the hypothesis that Dr Wai’s abnormal cerebral activation pattern was related to his peculiar behavioral profile. Although Dr Wai was able to correctly perform landmark sequencing, he showed a lack of activity in regions activated in all control subjects and activity in areas that were not activated in any control subject. These results are discussed in light of cognitive and functional model of navigation, with relevant implications for DTD physiology. © 2014 Taylor & Francis.


Phillips O.R.,Morphology and Morphometry for NeuroImaging Laboratory | Phillips O.R.,University of Rome Tor Vergata | Joshi S.H.,Ahmanson Lovelace Brain Mapping Center | Piras F.,Museo Storico Della Fisica E Centro Of Studi E Ricerche Enrico Fermi | And 9 more authors.
Human Brain Mapping | Year: 2016

White matter abnormalities have been shown in the large deep fibers of Alzheimer's disease patients. However, the late myelinating superficial white matter comprised of intracortical myelin and short-range association fibers has not received much attention. To investigate this area, we extracted a surface corresponding to the superficial white matter beneath the cortex and then applied a cortical pattern-matching approach which allowed us to register and subsequently sample diffusivity along thousands of points at the interface between the gray matter and white matter in 44 patients with Alzheimer's disease (Age: 71.02±5.84, 16M/28F) and 47 healthy controls (Age 69.23±4.45, 19M/28F). In patients we found an overall increase in the axial and radial diffusivity across most of the superficial white matter (P<0.001) with increases in diffusivity of more than 20% in the bilateral parahippocampal regions and the temporal and frontal lobes. Furthermore, diffusivity correlated with the cognitive deficits measured by the Mini-Mental State Examination scores (P<0.001). The superficial white matter has a unique microstructure and is critical for the integration of multimodal information during brain maturation and aging. Here we show that there are major abnormalities in patients and the deterioration of these fibers relates to clinical symptoms in Alzheimer's disease. © 2016 Wiley Periodicals, Inc.


PubMed | Neuropsychiatry Laboratory, University of California at Los Angeles, Morphology and Morphometry for NeuroImaging Laboratory, Museo Storico Della Fisica E Centro Of Studi E Ricerche Enrico Fermi and University of Rome Tor Vergata
Type: Journal Article | Journal: Human brain mapping | Year: 2016

White matter abnormalities have been shown in the large deep fibers of Alzheimers disease patients. However, the late myelinating superficial white matter comprised of intracortical myelin and short-range association fibers has not received much attention. To investigate this area, we extracted a surface corresponding to the superficial white matter beneath the cortex and then applied a cortical pattern-matching approach which allowed us to register and subsequently sample diffusivity along thousands of points at the interface between the gray matter and white matter in 44 patients with Alzheimers disease (Age: 71.025.84, 16M/28F) and 47 healthy controls (Age 69.234.45, 19M/28F). In patients we found an overall increase in the axial and radial diffusivity across most of the superficial white matter (P<0.001) with increases in diffusivity of more than 20% in the bilateral parahippocampal regions and the temporal and frontal lobes. Furthermore, diffusivity correlated with the cognitive deficits measured by the Mini-Mental State Examination scores (P<0.001). The superficial white matter has a unique microstructure and is critical for the integration of multimodal information during brain maturation and aging. Here we show that there are major abnormalities in patients and the deterioration of these fibers relates to clinical symptoms in Alzheimers disease.

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