Bicu D.,Neuropsychiatry Hospital |
Bondari A.,University of Sfax |
Trifan F.,University of Sfax
Archives of the Balkan Medical Union | Year: 2010
Multiple sclerosis represents a chronic inflammatory and degenerative disease of the central nervous system, that affects the young adult with still unknown etiology. We are given the case of two sister patients, diagnosed with recurrent remissive multiple sclerosis in 2001, respectively in 2006. In the first case, the presence of relapses, but also Magnetic resonance imaging modifications allowed the establishment of the diagnosis and the beginning of the imunomodulator treatment. Despite the imunomodulator treatment and of the autologous stem cell transplantation, the evolution of the disease was unfavorable In the second case, in a first stage an antiphospholipid syndrome was suspected, but further clinical evolution and laboratory tests infirmed the diagnosis. The presence of relapses, but also of the imagistic modifications lead to recurrent remissive multiple sclerosis diagnosis, with an favorable evolution under imunomodulator treatment. The clinical evaluation was made with Expanded Disability Status Scale, and the imagistic was based on Magnetic resonance imaging sequences. Copyright © 2010 CELSIUS.
Pintea I.L.,University of Medicine and Pharmacy of Craiova |
Rolea E.,University of Medicine and Pharmacy of Craiova |
Balseanu A.T.,University of Medicine and Pharmacy of Craiova |
Pirici I.,Neuropsychiatry Hospital |
And 2 more authors.
Romanian Journal of Morphology and Embryology | Year: 2011
Reduced cerebral blood flow beyond the compensatory mechanisms leads to cerebral hypoxia. Hypoxia causes various lesions of neurons, glial cells and cerebral blood vessels, depending on its duration and intensity. In our study, we reduced cerebral blood flow in the experience animal on average by 30%, by right internal carotid artery ligation. Fifteen days after the onset of hypoxia, by histology and immunohistochemical studies, we identified neuronal, glial and vascular damage. Lesions of nerve and glial cells ranged from changes of cytoplasmic tinting with the development of "red neurons", to neuronal and glial cytolysis with areas of focal necrosis. Vascular lesions were represented by the collapse, fragmentation and discontinuity of capillaries, always associated with a marked perivascular edema.
Bicu D.,Neuropsychiatry Hospital |
Bondari A.,University of Medicine and Pharmacy of Craiova |
Bicu M.,Clinical County Emergency Hospital |
Tapu F.,Clinical County Emergency Hospital
Archives of the Balkan Medical Union | Year: 2010
Background: Multiple sclerosis is the most common neurological disease in young adults characterized by recurrent relapses and/or progression within the central nervous system. Method: The study was realized on a group made up of 26 patients with relapsing - remitting multiple sclerosis, 10 men and 16 women, a man of 35.1 ± 5.1 years, that suffers from a disease for 5.6 ± 3.1 years, clinically and imagistically monitored. MS-related disability was clinically assessed using the Expanded Disability Status Scale and Multiple Sclerosis Functional Composite. The imagistic exploration proved its efficiency in completing these methods, representing a sensitive method in sustaining the assessment and progression of disease. Results: Multiple Sclerosis Functional Composite is a good method for assessing the evolution of the disease, a more sensitive one than the Expanded Disability Status Scale, it can reflect with high sensitivity clinical changes and cognitive dysfunctions. Magnetic resonance imaging points out the activity of the disease, new lesions on T1 or T2-weighted sequences appear more frequently than they are detected clinically, presenting clearer advantages for the assessment and therapeutic monitoring. Conclusions: The imagistic parameters together with the clinical markers represent important criteria to sustain the evolution and the progression of the disease. Copyright © 2010 Celsius.
Militaru C.,Craiova Cardiology Center |
Donoiu I.,University of Medicine and Pharmacy of Craiova |
Craciun A.,Craiova Cardiology Center |
Scorei I.D.,Neuropsychiatry Hospital |
And 2 more authors.
Nutrition | Year: 2013
Objective: This study aimed to evaluate the effects of short-term (60-d) oral supplementation with calcium fructoborate, resveratrol, and their combination on the clinical and biological statuses of subjects with stable angina pectoris. Methods: A randomized, double-blinded, active-controlled, parallel clinical trial was conducted in three groups of subjects. Of the total number of subjects included in study (n = 166), 87 completed the 60-d test treatment study period and 29 followed in parallel their usual medical care and treatment. The primary outcomes were inflammation biomarkers (high-sensitivity C-reactive protein), left ventricular function markers (N-terminal prohormone of brain natriuretic peptide), and lipid markers (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triacylglycerols). Quality of life was assessed by the Canadian Cardiovascular Society angina class and the number of angina attacks per week. Results: There was a significant decrease of high-sensitivity C-reactive protein in all groups at the 30-d and 60-d visits. This decrease was greater (39.7% at 60 d) for group 3 (calcium fructoborate), followed by group 2 (resveratrol plus calcium fructoborate, 30.3% at 60 d). The N-terminal prohormone of brain natriuretic peptide was significantly lowered by resveratrol (group 1, 59.7% at 60 d) and by calcium fructoborate (group 3, 52.6% at 60 d). However, their combination (group 2) was the most effective and induced a decrease of 65.5%. Lipid markers showed slight changes from baseline in all groups. The improvement in the quality of life was best observed for subjects who received the resveratrol and calcium fructoborate mixture (group 2). Conclusion: The results indicate that the combination of resveratrol and calcium fructoborate has beneficial effects in patients with angina (ClinicalTrials.gov, ISRCTN02337806; March 25, 2010). © 2013 Elsevier Inc.
Scorei R.,University of Craiova |
Mitrut P.,University of Medicine and Pharmacy of Craiova |
Petrisor I.,University of Craiova |
Scorei I.,Neuropsychiatry Hospital
Biological Trace Element Research | Year: 2011
The objective of this pilot study was to determine whether 15 days of dietary supplementation with calcium fructoborate could acutely modulate inflammatory and lipid blood markers in individuals diagnosed with primary osteoarthritis. During 2 weeks, a placebocontrolled, randomized, double-blind study was conducted on 116 subjects that were initially recruited. Seventy-two subjects started the study, being divided into four groups, and only 60 completed the study as designed. The aim was to compare the effects of calciumfructoborate to placebo on subjects diagnosed with knee primary osteoarthritis. The obtained outcomes were inflammation biomarkers (C-reactive protein, fibrinogen, and erythrocyte sedimentation rate) and lipid markers (triglycerides, total cholesterol, LDL cholesterol, and HDL cholesterol). No serious adverse events were reported. The calcium fructoborate showed beneficial effect on the inflammatory markers for all groups subjected to the treatment when compared with the placebo group and slight changes in the lipid metabolism. This study suggests that short-term (2 weeks) calcium fructoborate supplementation in patients with osteoarthritis symptoms has a favorable prognosis on inflammation diseases. © Springer Science+Business Media, LLC 2011.
Mladin C.,Neuropsychiatry Hospital |
Chifiriuc M.-C.,University of Bucharest |
Andi-Palade,National Institute for Research and Development in Microbiology and Immunology Cantacuzino |
Usein C.-R.,National Institute for Research and Development in Microbiology and Immunology Cantacuzino |
And 3 more authors.
Romanian Biotechnological Letters | Year: 2010
The purpose of this work is to characterize by phenotypic and genotypic analysis the antibiotic resistance patterns in 118 Escherichia (E.) coli strains isolated from urinary tract infections in patients with neurogenic bladder. The E. coli strains have shown high level resistance to aminopenicillins, ampicillin + sulbactam, amoxicillin clavulanate, tetracycline, followed by quinolone, carboxipenicillins, aminoglycosides and cotrimoxazole. Multiple resistance to beta-lactams, aminoglycosides, fluoroquinolones and cotrimoxazol has been registered with high frequency among the studied strains. The phenotypic screening tests for the presence of beta-lactamases, i.e. cefinase and double disk synergism test (DDST) indicated that 65,2% of the tested strains are producing typical beta-lactamases. The synergy test was positive for the strains resistant to clavulanic acid, but susceptible to sulbactam, proving that this inhibitor is more sensitive for this test. Our study indicated a good correlation between the results obtained with DDST and E-test ESBL which confirmed the production of beta-lactamases in strains exhibiting synergism aspects in double disk diffusion test. The IEF analysis of the cellular sonicates revealed the presence of TEM pI 5,2; CTX-M pI 7,5; AmpC pI ≥ 8; SHV pI 7-8. The genotypic analysis by PCR and sequencing showed the presence of bla TEM and group 1 CTX-M genes in 75% of E. coli strains isolated from patients with neurogenic bladder. © 2010 University of Bucharest.
Klc C.,Hacettepe University |
Klc E.Z.,Yeditepe University |
Aydn I.O.,Neuropsychiatry Hospital
Journal of Nervous and Mental Disease | Year: 2011
Earthquakes may increase the risk for psychopathology in children because the disaster may disrupt family functioning through causing psychopathology in the parents or disrupting social network through migration, school changes, or socioeconomic status changes caused by the job losses of the parents. This study aimed to investigate the effects of parental psychopathology on the traumatic stress and depression of earthquake survivor-children 4 years after the earthquake. A convenience sample of 104 earthquake survivor-children (43 boys, 61 girls) and their parents were assessed at their homes for earthquake experience and traumatic stress symptoms. The outcome variables were the factor scores of a child/adolescent traumatic stress questionnaire (Traumatic Stress Symptom Checklist for Children and Adolescents). The predictors of child's factor scores were examined using linear regression analyses. The traumatic stress factor score of the children was predicted two variables: the child's reported fear during the earthquake and the father's traumatic stress factor score. The depression factor score, on the other hand, was predicted using the depression factor score of the mother only. Demographic variables or relocation status were not predictive for either of children's factor scores. The results of the present study show that maternal and paternal psychopathologies have differential effects on the psychological status of earthquake survivor-children. Traumatic stress in the child is predicted using the traumatic stress of father, whereas depression in the child is predicted by mother's depression levels. Social network disruption does not seem to have a negative effect on children once parental psychopathology is taken into account. © 2011 by Lippincott Williams & Wilkins.
Popa-Wagner A.,University of Rostock |
Popa-Wagner A.,University of Medicine and Pharmacy, Cluj-Napoca |
Buga A.M.,University of Rostock |
Buga A.M.,University of Craiova |
And 3 more authors.
Biogerontology | Year: 2014
Major depressive disorder (MDD) is a severe psychiatric illness that is associated with significant morbidity and mortality. Despite advances in the treatment of major depression, one-third of depressed patients fail to respond to conventional antidepressant medication. One pathophysiologic mechanism hypothesized to contribute to treatment resistance in depression is inflammation. Inflammation has been linked to depression by a number of putative mechanisms involving perfusion deficits that can trigger microglial activation and subsequent neuroinflammation in the elderly. However, the pathophysiological mechanisms remain to be further elucidated. This review focusses on recent studies addressing the complex relationships between depression, aging, inflammation and perfusion deficits in the elderly. We expect that a better understanding of neuroinflammatory mechanisms associated with age-related diseases may lead to the discovery of new biomarkers of MDD and development of new therapeutic interventions. © 2014 Springer Science+Business Media.
Amoo G.,Neuropsychiatry Hospital |
Fatoye F.O.,Obafemi Awolowo University
Nigerian Journal of Clinical Practice | Year: 2010
Objectives: To determine the magnitude and pattern of aggressive behaviour among psychiatric in-patients and identity associated socio-demographic and clinical factors. Method: The study was cross-sectional in design. Among patients admitted to the Neuro-psychiatric Hospital, Aro (and its Lantoro annex), Abeokuta between January 1 to December 31, 2005, those who manifested aggressive behaviour were identified. Each was evaluated by the medical team, and a questionnaire detailing socio-demographic and clinic variables was administered on them. Results: A total of 305 patients comprising 213 (69.8%) males and 92(30.2%) females were managed as inpatients during the period of the survey. Out of these, 43 patients manifested aggressive behaviour representing a rate of 13.8%. The aggressive patients consisted of 26 males and 17 females, representing rates of 12.2 and 18.5 percent for the sexes respectively. Of the 11 diagnoses entered for all the patients, only 3 were associated with aggressive behaviour. These included schizophrenia, 21 patients (48.8%); bipolar manic illness, 12 patients (27.9%) and co-morbid substance use (mainly cannabis) and mental disorder, 10 patients (22.3%). Nursing personnel constituted the majority of target of aggression. Unemployment was the only socio demographic variable observed with significant positive relationship with aggressive behaviour. In addition, the commonest probable precipitants of aggressive behaviour included hallucinations, clamouring for discharge and attempting to abscond, reaction to confrontational interview, impulsivity and reaction to unmet demands. Conclusion: Mental health practitioners (especially nurses) should be equipped with necessary skills in managing aggressive and potentially aggressive patients. The present observations may be useful in raising the suspicion of care providers on potential ly aggressive patients for preventive purpose.
News Article | April 25, 2016
A woman's sudden delusions — including becoming wrongly convinced that her husband of 20 years was being unfaithful — turned out to have a surprising cause: a large cyst in her brain, according to a recent report of her case. The 43-year-old woman in Turkey had become suddenly suspicious of her husband's infidelity, and had started looking through his phone and personal belongings, the doctors who treated her wrote in their report of her case, published in March in the journal BMJ Case Reports. The woman came to see doctors in January 2015, seeking medical help for her paranoia about her husband's behavior, said Dr. C. Onur Noyan, a psychiatrist at NPIstanbul Neuropsychiatry Hospital in Istanbul who treated the woman and was the lead author of the case report. [16 Oddest Medical Cases] The woman reported having trouble sleeping and had become anxious and irritable, the authors wrote in the report. She had also recently experienced a stressful event: Her daughter had switched schools because she had been struggling academically, the authors noted. However, the woman had never experienced any psychiatric or neurological problems in the past, nor had anyone in her family, according to the report. The doctors conducted a detailed psychiatric evaluation and concluded that the woman had experienced a brief psychotic attack, Noyan said. In medicine, "psychotic" refers to a loss of contact with reality, such as delusions or hallucinations. Because she had never experienced such an attack before, the doctors ran additional tests, including brain scans, to see if they could find the biological cause of her symptoms, he said. A magnetic resonance imaging (MRI) scan revealed a large cyst, known as a porencephalic cyst, in the right frontal lobe of her brain. Such cysts form in the structural tissue of the brain, and are filled with cerebrospinal fluid, according to the report. "Porencephalic cysts are very rare" and are typically diagnosed in infants, Noyan said. Indeed, babies with porencephalic cysts are usually diagnosed by their first birthday, according to the National Institute of Neurological Disorders and Stroke; some do not live past age 20. The cysts are typically caused by a stroke or brain damage before or after birth, and can lead to symptoms such as seizures, muscle weakness and learning disabilities, according to the report. The cysts can occur anywhere in the brain, Noyan told Live Science. People's symptoms may differ depending on the location of the cyst, he added. In this woman, the cyst's location in her frontal lobe, which is involved in thinking and decision making, may have contributed to her psychosis, according to the report. [10 Things You Didn't Know About the Brain] While Noyan has seen porencephalic cysts in his practice before, he'd never seen one as large as this woman's, he said. In addition, the age at which the woman's first symptoms arose made the case unique, according to the report. There was no safe way to surgically remove the woman's cyst. To treat her, the doctors prescribed an anti-psychotic drug, which the woman will likely have to take for the rest of her life. Noyan last saw the patient about a month ago, and said that she is doing very well. She currently has no symptoms of psychosis and probably will not experience any psychotic attacks in the future, he said. Copyright 2016 LiveScience, a Purch company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.