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Mexico City, Mexico

INTRODUCTION: Hearing loss is a condition that must be diagnosed early considering alarm factors, in order to achieve a proper development of language. OBJECTIVE: To establish the relationship between hearing loss and alarm factors in high-risk infants evaluated by means of auditory evoked potentials. METHODS: This is an observational, longitudinal study in which 8,000 auditory evoked potentials were performed in high-risk infants to diagnose hearing loss. The population comprised 4,000 patients who presented between January 2000 and January 2012 for evaluation of probable hearing loss. A questionnaire on pregnancy and neonatal risk factors was applied. Auditory evoked potentials at 6 and 12 months of age were performed. RESULTS: The semester evaluation reported mild hearing loss in 325 (8.1%) patients, moderate in 85 (2.1%), and severe in 62 (1.5%), with a total of 472 (11.8%). The annual evaluation showed mild hearing loss in 0 (0%), moderate in 28 (0.7%), and severe in 40 (1%), with a total of 68 (1.7%) (p < 0.001). The identified risk factors for severe hearing loss at one year were ototoxic drugs intake, occupational acoustic trauma of the mother, alcohol, cocaine use, TORCH group infection, 5 minutes Apgar < 3, birth weight < 1,500 g, gestational age < 33 weeks, mechanical ventilation > 10 days, NICU stay > 1 month, cranial malformations, family history and subependymal hemorrhage. CONCLUSION: The monitoring of auditory evoked potentials in the first year of life helps in the early diagnosis of hearing loss, which could result in a better prognosis for language development. Source

Rincon-Sanchez A.R.,University of Guadalajara | Arce I.E.,Neonatologia | Tostado-Rabago E.A.,Cirugia Pediatrica | Vargas A.,Oftalmologia | And 9 more authors.
Case Reports in Dermatology | Year: 2012

Ehlers-Danlos syndrome (EDS) is a heterogeneous group of heritable connective tissue disorders whose primary clinical features include soft and extensible skin, articular hypermobility and tissue fragility. EDS type VIIC or 'human dermatosparaxis' is an autosomal recessive disease characterized by severe skin fragility and sagging redundant skin (major criteria) with a soft, doughy texture, easy bruising, premature rupture of fetal membranes and large hernias (minor criteria). Dermatosparaxis (meaning 'tearing of skin'), which has been described in several non-human species, is a disorder of the connective tissue resulting from a deficiency of the enzyme that cleaves the registration peptide off the N-terminal end of collagen after it has been secreted from fibroblasts. We describe a Mexican case from consanguineous parents with all the phenotypical characteristics previously described, plus skeletal abnormalities. Copyright © 2012 S. Karger AG, Basel. Source

Tomos Vila M.,Neuropediatria | Aleu Porez-Gramunt M.,Hospital General Universitario Of Valencia | Beseler Soto B.,Neuropediatria | Benac Prefasi M.,Neuropediatria | And 2 more authors.
Anales de Pediatria | Year: 2010

Introduction: The attention-deficit/hyperactivity disorder (ADHD) is the most common neuro-behavioural disorder in children and adolescents. Methylphenidate (MPH) is the drug most often used in the treatment of this disorder. It is important to know the effects methylphenidate can have on sleep due to the repercussions that insufficient sleep can have on the behaviour and cognitive function of children and adolescents. Objectives: The purpose of this study was to find out the repercussions that methylphenidate can have on sleep, using a questionnaire. Methodology: This is a multicentre study in which six hospitals in the Valencian Community took part. All those patients who were diagnosed with ADHD over a period of 6 months were given a questionnaire, before starting treatment, and after three months of this treatment. The questionnaire was a version of the Paediatric Sleep Questionnaire. The differences found were analysed. Results: A total of 114 children were studied. Significant differences were found in the questions associated with enuresis, somnambulism and night-wakings, these sleep disorders decreasing after starting the treatment. The rest of variables did not show any changes. Conclusions: According to our results we can say that the MPH not only does not make worse the sleep, but that it improves the quality of the sleep in those patients with sleep disorders. © 2009 Asociación Española de Pediatría. Published by Elsevier Española, S.L. All rights reserved. Source

Pascual Sanchez M.T.,Hospital General de Catalonia | Velasco L.H.,Hospital General de Catalonia | Guijarro P.A.,Neuropediatria
Acta Otorrinolaringologica Espanola | Year: 2010

Sleep is a biological mechanism essential to maintaining good health. A series of physiological changes takes place during sleep. From a ventilation point of view, during deep sleep, tidal volume increases, the inhalation and expiration phases become longer, and respiratory frequency slows, while the same volume/time ratio as in wakefulness is maintained. The concept of " sleep-related respiratory disorders" refers to a group of respiratory diseases that are aggravated during sleep. Some of these disorders are almost exclusively manifested during sleep, such as sleep apnea-hypopnea syndrome -undoubtedly the most frequent respiratory disease despite being underdiagnosed- and congenital central hypoventilation syndrome (also called Ondine's curse). However, this concept also encompasses other disorders that occur during the daytime since they worsen while patients are asleep, as seen in many obstructive or restrictive pulmonary diseases. Sleep disorders can be a manifestation of underlying diseases, some of which are highly prevalent such as obesity and gastroesophageal reflux. Likewise, abnormal sleep cycles may be a cause or a result of cognitive disorders and disturbances in children's learning processes. © 2010 Elsevier España S.L. Source

Soto Insuga V.,Neuropediatria | Merino M.,Hospital Universitario La Paz | Losada Del Pozo R.,Neuropediatria | Castano De La Mota C.,Neuropediatria | And 2 more authors.
Acta Pediatrica Espanola | Year: 2013

Obesity and metabolic syndrome are two of the major child health problems in Western society. During the last years, it has been also noticed a decline in sleeping hours among children. Since 1992, many epidemiological studies, both cross-sectional and longitudinal, have shown that chronic sleep deprivation in children relates to an increasing risk of developing overweight-obesity and/or metabolic syndrome (hypertension, increasing resistance to insulin and dyslipidemia). Although precise proccess that make obesity leads to a reduction of sleeping hours are currently unknown, a number of proccess that seem to be somehow involved have been identified. Among others, we may mention the alterations in the hypothalamic-pituitary (several neuropeptides such as leptin and ghrelin), an increasing appetite with special foods high avidity energy, a greater sense of fatigue with consequent reduction in physical activity, and changes in sleep-wake cycle (melatonin rhythm disturbances). This work contains a review of current evidence on the relationship between sleep and obesity within the pediatric population. It is now accepted that children who sleep less hours are more likely to develop overweight and metabolic syndrome, but it has not been possible to demonstrate a clear causality yet. It is necessary to promote adequate sleep among children, not only due to the many beneficial effects already known (cognitive, immunological, behavioral, metabolic and even decrease mortality), but also given its potential ability to prevent obesity and metabolic syndrome. ©2013 Ediciones Mayo, S.A. All rights reserved. Source

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